Introduction to Meta Analysis Across

The primary meta-analysis across 41 studies and 1838 patients revealed a favorable moderate effect size (ES = −0.

Methods: Using GWAS summary statistics generated from BioVU, the UK Biobank, and Finngen, we performed fixed-effect meta-analysis across 490,912 individuals (1,188 TN cases and 489,724 controls) to identify genetic risk factors for TN.

We further explored the specificity of these SNV markers in a broader background by performing a meta-analysis across 4 metabolic disease cohorts.

Including 33 articles with k = 49 experimental studies we performed a bare-bones and an artefact-corrected meta-analysis across all included primary studies and for five a-priori moderators.

Using comparative meta-analysis across plants, animals and bacteria (nspecies= 56), we show that high within-group relatedness increases mortality when pathogens are present.

Furthermore, meta-analysis across ancestrally and behaviorally diverse populations may allow for more robust discoveries.

The results of the individual studies and a meta-analysis across them showed that positive impact increased well-being, but even though participants were aware of the negative impact they were having, there was no increased ill-being in the negative impact condition.

If estimates were homogeneous (I2 < 40%), a meta-analysis across databases was performed and pooled hazard ratios reported.

We recently performed an outlier-based meta-analysis across a number of independent gene expression microarray datasets to identify novel markers that differentiate NEPC from AdCa, including up-regulation of Insulinoma-associated protein 1 (INSM1) and loss of Yes-associated protein 1 (YAP1).

Two of the eligible RCTs were placebo-controlled; we performed a meta-analysis across those two trials for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG).

MAIN RESULTS AND THE ROLE OF CHANCE Meta-analysis across the three independent cohorts showed a significant interaction effect (P = 3.

Conclusions Both baseline SUA and longitudinal SUA changes were positively associated with risk of MetS among middle-aged and elderly Chinese, which was supported by findings from a comprehensive meta-analysis across multiple populations.

This raises two fundamental questions that can best be investigated with a meta-analysis: First, can free will beliefs be manipulated and, second, do such manipulations have downstream consequences? In a meta-analysis across 146 experiments (95 unpublished) with a total of 26,305 participants, we show that exposing individuals to anti-free will manipulations decreases belief in free will, g = -0.

Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn’s disease and UC (FDR<0.

We found 915 experimental replicates from 20 blood studies to be suitable for coexpression analysis and used orthologs for meta-analysis across different host-parasite systems.

Here we report two pre-registered direct replications (N = 530) of Study 2 from Thomae and Viki (2013) and assess replicability via (i) statistical significance, (ii) Bayes factors, (iii) the small-telescope approach, and (iv) an internal meta-analysis across the original and replication studies.

We replicated our analyses using a second independent set of blood RNA-seq data from 1,065 COPDGene study subjects and performed a meta-analysis across the two studies.

Finally, a meta-analysis across the three studies examined the strength of the associations between ghosting experiences and attachment.

The fixed-effect meta-analysis across the 17 cohorts showed that Se was significantly associated with PTB and gestational duration with effect size estimates of an OR=0.

Based on our meta-analysis across the four datasets, 10 innate and adaptive immune cell types associated with disease relapse of which 2 were internally validated using multiplex immunofluorescence.

Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before.

Of these, 57 were included in the meta-analysis across six anatomical locations with 488,594 patients.

A meta-analysis across the three studies confirmed the following pattern: a small to moderate stereotype-contrasting grading bias, if the evaluators endorsed stereotypes, but no bias if they did not.

07 × 10-17), which was replicated in a meta-analysis across the 4 health care systems (β, 0.

METHODS We performed allelic association with SLE followed by meta-analysis across 11 independent cohorts (n=28,872).

Analyses were performed within each dataset, followed by meta-analysis across the studies (N=1090 European ancestry participants).

We performed a well-powered meta-analysis across 5 independent studies, comprising 3581 pre-clinical participants ages 60-80, to investigate whether KL∗VSHET+ reduces the risk of having an amyloid-positive positron emission tomography scan.

Moreover, 61 individual foods and nutrients were associated with 61 species and 249 metabolic pathways in the meta-analysis across healthy individuals and patients with IBS, Crohn’s disease and UC (false discovery rate<0.

However, a pooled meta-analysis across these studies was not feasible across the retrospective studies due to differing surgical populations and varying definitions of the considered outcomes.

We performed multi-trait joint analyses and meta-analysis across five neuropsychiatric disorders based on their summary statistics from the Psychiatric Genomics Consortium (PGC), and further carried out a replication study of ADHD among 2726 cases and 16299 controls in an independent pediatric cohort.

A random effects meta-analysis across trials was conducted to generate the combined rHR.

We conducted a multi-level meta-analysis across 1,600 observations from 32 publications.

We tested this hypothesis using phylogenetic meta-analysis across 23 cooperatively breeding bird species.

Analyses were performed within each dataset, followed by meta-analysis across the studies (N = 1083 European ancestry participants).

Furthermore, trans-ethnic meta-analysis across our own meta-analysis and the Global Urate Genetics Consortium has revealed 15 more novel loci associated with SUA.

ConclusionsThis is the first study to identify gene expression differences in cord blood specific to ASD through a meta-analysis across two prospective pregnancy cohorts.

However, a continuously cumulative meta-analysis across past and present experiments showed that our results do not refute the irrelevance-induced effects entirely.

Meta-analysis across population groups (N = 274,424) identified 18 genome-wide significant loci, 5 of which were associated with both traits and 13 with either AUDIT-C (N = 8) or AUD (N = 5).

In a 10-day daily experience study (Study 4) as well as an internal meta-analysis across all four studies, each goal was found to be uniquely related to parents’ emotional well-being, relationship quality with their child, and feelings of responsiveness to their child’s needs.

To determine which type of differentiation is most predictive of well-being, we performed a comprehensive meta-analysis across six datasets.

Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders.

Meta-analysis across all tasks reveals a very small effect of hunger on prosociality in non-interdependent tasks (d = 0.

A significant association was also identified in a trans-ethnic meta-analysis across cohorts that included an additional 708 European American ARIC study participants (fully adjusted model: β = -0.

In a multi-ethnic sample of non-Hispanic white, Hispanic, African-American and Asian/Pacific Islander children (537 cases, 2165 controls), we performed association analyses assessing previously-reported loci for osteosarcoma risk and metastasis, including meta-analysis across racial/ethnic groups.

Dynamic reporting and meta-analysis across data assets is enabled.

An important distinction has been made between descriptive norms (what most others do) and injunctive norms (what others approve of), and this meta-analysis across 297 studies examines the effects of these types of social norms on consumer decision-making processes.

Four loci identified in the meta-analysis are also associated with endometriosis risk; an epidemiological meta-analysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a history of endometriosis.

Furthermore, we performed a quantitative meta-analysis across 14 structural MRI MDD studies by applying the anatomical likelihood estimation technique to identify concordant volume reductions in MDD in the insula cortex.

Gene-based GWAS meta-analysis across ADHD, ASD, OCD, and TS identified 21 genes significantly associated under Bonferroni correction.

Effects were combined through meta-analysis across sites.

Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders.

We performed a meta-analysis across six Asian and European cohorts (9,529 cases; 22,462 controls), followed by in silico bioinformatic and epigenetic analyses to prioritize potentially functional SNPs.

Hazard ratios (HRs) were independently extracted by two investigators and synthesized through meta-analysis across selected studies.

We performed a phylogenetic-independent meta-analysis across 102 Neotropical plants to test the hypothesis that plant species with megafaunal seed dispersal syndrome have a lower genetic diversity and a higher genetic differentiation than those without it.

To evaluate the consistency across these molecular models, a consensus atlas of the human brain transcriptome was developed through coexpression meta-analysis across the AMP-AD consortium.

81 × 10-6) after meta-analysis across the 3 studies.

Furthermore, we use the data compendium to create the first gene signature that is prognostic in a meta-analysis across 3 cancer types.

Event rates were pooled in a meta-analysis across studies using the random-effects model; descriptive statistics were reported when relevant.

METHODS A Bayesian statistical model for culpability study counts is developed to provide inference for both culpable and total crash risks, with a hierarchical effect specification to allow for meta-analysis across studies with potentially heterogeneous risk parameter values.