Introduction to Mesencephalic Dopaminergic

We implanted fetal mesencephalic dopaminergic tissue into the putamina bilaterally in 34 patients with advanced PD.

Successful cell therapy for Parkinson’s disease (PD) requires large numbers of homogeneous ventral mesencephalic dopaminergic (vmDA) precursors.

Here, we investigated the role of mesencephalic dopaminergic neurons in modafinil-promoted arousal.

Development and validation of the assay was conducted with differentiated SH-SY5Y cells and primary mesencephalic dopaminergic neurons (MDN) treated with the neurotoxic lesioning compound Rotenone.

Altogether, toxin-based rodent models of PD indicate a significant but non-exclusive contribution of mesencephalic dopaminergic loss in anxiety, apathy, and depressive-like behaviors, as well as in learning and memory deficits.

Rat primary immortalized mesencephalic dopaminergic cells (N27) were treated with fipronil (0.

Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related behaviors but also with stress-induced mental disorders.

In mice, we reveal two distinct novel mechanisms by which mesencephalic dopaminergic afferents control ITCs.

The differentiation of human pluripotent stem cells (hPSCs) into mesencephalic dopaminergic (mesDA) neurons requires a precise combination of extrinsic factors that recapitulates the in vivo environment and timing.

Rat primary immortalized mesencephalic dopaminergic cells (N27) were treated with fipronil (0.

Studies on Parkinson disease (PD) have mostly focused on the central nervous system—specifically, on the loss of mesencephalic dopaminergic neurons and associated motor dysfunction.