Introduction to Landmark Trials
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Landmark Trials sentence examples within reduced ejection fraction
We aim to explore the risk of non-fatal events (HFH, MI, stroke) and subsequent death in 3 landmark trials, COMMANDER-HF, EPHESUS and EXAMINE that, together, included patients with CAD with and without reduced ejection fraction and acute MI.
We aim to explore the risk of non-fatal events (HFH, MI, stroke) and subsequent death in 3 landmark trials, COMMANDER-HF, EPHESUS and EXAMINE that, together, included patients with CAD with and without reduced ejection fraction and acute MI.
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Based on positive results from the landmark trials (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure [DAPA-HF] [7] and The Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction [EMPEROR-Reduced] [8]), dapagliflozin and empagliflozin were approved for reducing the risk of CV death and hospitalization in patients with heart failure with reduced ejection fraction (HFrEF), both with and without type 2 diabetes mellitus [9].
Based on positive results from the landmark trials (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure [DAPA-HF] [7] and The Empagliflozin Outcome Trial in Patients with Chronic Heart Failure and a Reduced Ejection Fraction [EMPEROR-Reduced] [8]), dapagliflozin and empagliflozin were approved for reducing the risk of CV death and hospitalization in patients with heart failure with reduced ejection fraction (HFrEF), both with and without type 2 diabetes mellitus [9].
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Landmark Trials sentence examples within Two Landmark Trials
Two landmark trials conducted in patients with earlystage T1DM and T2DM showed that intensive blood glucose control early in the course of disease demonstrates a long-lasting favorable effect on the risk for developing diabetic kidney disease.
Two landmark trials conducted in patients with earlystage T1DM and T2DM showed that intensive blood glucose control early in the course of disease demonstrates a long-lasting favorable effect on the risk for developing diabetic kidney disease.
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327Background: Sorafenib was first approved by the US FDA to treat patients with advanced hepatocellular carcinoma (HCC) after two landmark trials (SHARP and Asia-Pacific) showed improved overall s.
327Background: Sorafenib was first approved by the US FDA to treat patients with advanced hepatocellular carcinoma (HCC) after two landmark trials (SHARP and Asia-Pacific) showed improved overall s.
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Landmark Trials sentence examples within Recent Landmark Trials
PURPOSE/OBJECTIVE(S)
Recent landmark trials have suggested a survival benefit to definitive tumor directed therapies (DTDT) for selected patients with metastatic disease for various malignancies.
PURPOSE/OBJECTIVE(S)
Recent landmark trials have suggested a survival benefit to definitive tumor directed therapies (DTDT) for selected patients with metastatic disease for various malignancies.
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Background and Purpose— Recent landmark trials provided overwhelming evidence for effectiveness of endovascular stroke therapy (EST).
Background and Purpose— Recent landmark trials provided overwhelming evidence for effectiveness of endovascular stroke therapy (EST).
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Landmark Trials sentence examples within Variou Landmark Trials
416Background: Over the last decade, various landmark trials have demonstrated the impact of multi-agent chemotherapy in the treatment of PDAC.
416Background: Over the last decade, various landmark trials have demonstrated the impact of multi-agent chemotherapy in the treatment of PDAC.
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Although the inclusion of sodium-glucose cotransporter-2 inhibitors (SGLT2i) among diuretics is a controversial issue, their renoprotective and cardioprotective properties, confirmed in various landmark trials, constitute a true revolution in the treatment of patients with kidney disease.
Although the inclusion of sodium-glucose cotransporter-2 inhibitors (SGLT2i) among diuretics is a controversial issue, their renoprotective and cardioprotective properties, confirmed in various landmark trials, constitute a true revolution in the treatment of patients with kidney disease.
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Landmark Trials sentence examples within Several Landmark Trials
Several landmark trials [1–3] have shaped current guidelines [4, 5] to recommend the implantation of implantable cardioverter defibrillator (ICD) in patients with reduced left ventricular ejection fraction (LVEF) < 35% for primary prevention.
Several landmark trials [1–3] have shaped current guidelines [4, 5] to recommend the implantation of implantable cardioverter defibrillator (ICD) in patients with reduced left ventricular ejection fraction (LVEF) < 35% for primary prevention.
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Several landmark trials have demonstrated the effectiveness of endovascular techniques leading to continued technological development and applications for various diseases.
Several landmark trials have demonstrated the effectiveness of endovascular techniques leading to continued technological development and applications for various diseases.
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Landmark Trials sentence examples within Previou Landmark Trials
The results in the lowrisk group seem counterintuitive to previous landmark trials (including the BeSt and the TEAR) that found longterm outcomes to be essentially determined by treatingtotarget, with the intensity of initial treatment only guiding the rapidity of response achieved.
The results in the lowrisk group seem counterintuitive to previous landmark trials (including the BeSt and the TEAR) that found longterm outcomes to be essentially determined by treatingtotarget, with the intensity of initial treatment only guiding the rapidity of response achieved.
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The two previous landmark trials (SMASH-VT and VTACH) [2, 3] with similar design evaluating prophylactic VT ablation were * Luigi Di Biase [email protected]
The two previous landmark trials (SMASH-VT and VTACH) [2, 3] with similar design evaluating prophylactic VT ablation were * Luigi Di Biase [email protected]
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Landmark Trials sentence examples within Major Landmark Trials
We reviewed the major landmark trials that compare PCI vs CBAG as a treatment option for left main disease along with important meta-analysis.
We reviewed the major landmark trials that compare PCI vs CBAG as a treatment option for left main disease along with important meta-analysis.
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There are now major landmark trials that describe the epidemiology, prevention, and management guidelines in this field and health care professionals need to be aware they should diagnose AKI early.
There are now major landmark trials that describe the epidemiology, prevention, and management guidelines in this field and health care professionals need to be aware they should diagnose AKI early.
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Landmark Trials sentence examples within landmark trials establishing
Intravitreal anti-vascular endothelial growth factor therapy (anti-VEGF) is now considered the mainstay of treatment, with landmark trials establishing its efficacy with mean visual gains of between +9.
Intravitreal anti-vascular endothelial growth factor therapy (anti-VEGF) is now considered the mainstay of treatment, with landmark trials establishing its efficacy with mean visual gains of between +9.
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A review was performed of salient articles identifying radiation technologies used in lung cancer which were summarized and expounded upon with focus on integrating their history, evolution, and landmark trials establishing basis of their use.
A review was performed of salient articles identifying radiation technologies used in lung cancer which were summarized and expounded upon with focus on integrating their history, evolution, and landmark trials establishing basis of their use.
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10.3390/vaccines9080919
This article reviews the landmark trials that have led to the approval of IO therapies, including the Checkmate 214 trial and combination IO/VEGF TKI therapies with Checkmate 9ER, CLEAR, and Keynote-426, and it includes a discussion on promising therapies moving in the future.
This article reviews the landmark trials that have led to the approval of IO therapies, including the Checkmate 214 trial and combination IO/VEGF TKI therapies with Checkmate 9ER, CLEAR, and Keynote-426, and it includes a discussion on promising therapies moving in the future.
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10.1111/nyas.14676
In the 1980s, hypothermia underwent a resurgence through Peter Safar's critical studies in large animals, which quickly translated into feasibility studies and the landmark trials of 2002 that paved the way for postcardiac arrest care as we currently know it.
In the 1980s, hypothermia underwent a resurgence through Peter Safar's critical studies in large animals, which quickly translated into feasibility studies and the landmark trials of 2002 that paved the way for postcardiac arrest care as we currently know it.
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10.1161/JAHA.121.020448
Although CTOs are highly prevalent among patients with SIHD, CTO PCI was typically excluded from these landmark trials.
Although CTOs are highly prevalent among patients with SIHD, CTO PCI was typically excluded from these landmark trials.
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10.1200/JCO.2021.39.15_SUPPL.E13029
e13029 Background: First-line treatment with a CDK4/6 inhibitor in combination with an aromatase inhibitor for HR+/HER2- postmenopausal metastatic breast cancer (mBC) is considered as a standard of care based on the compelling data across all landmark trials.
e13029 Background: First-line treatment with a CDK4/6 inhibitor in combination with an aromatase inhibitor for HR+/HER2- postmenopausal metastatic breast cancer (mBC) is considered as a standard of care based on the compelling data across all landmark trials.
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10.1111/pace.14284
We also provide a brief outline of the landmark trials supporting this approach as well as the ongoing research and future prospects of left atrial appendage occlusion.
We also provide a brief outline of the landmark trials supporting this approach as well as the ongoing research and future prospects of left atrial appendage occlusion.
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10.1155/2021/8870015
Although the direct oral anticoagulants (DOACs) have become preferred for treatment of VTE in the general population, patients with advanced CKD were excluded from the landmark trials.
Although the direct oral anticoagulants (DOACs) have become preferred for treatment of VTE in the general population, patients with advanced CKD were excluded from the landmark trials.
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10.1007/s40620-021-01137-4
Current guidelines recommend DOAC use as the preferred anticoagulant strategy in patients with moderately to severely reduced renal function following dose reduction criteria specified in landmark trials.
Current guidelines recommend DOAC use as the preferred anticoagulant strategy in patients with moderately to severely reduced renal function following dose reduction criteria specified in landmark trials.
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10.1093/eurheartj/ehab724.0559
Generalisability of patient selection in the landmark trials for the approval of apixaban (ARISTOTLE) and rivaroxaban (ROCKET AF) for use in non-valvular atrial fibrillation (AF) is limited.
Generalisability of patient selection in the landmark trials for the approval of apixaban (ARISTOTLE) and rivaroxaban (ROCKET AF) for use in non-valvular atrial fibrillation (AF) is limited.
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10.1245/s10434-021-10838-w
This paradigm shift has occurred despite the landmark trials for modern adjuvant therapies including only patients who underwent CLND prior to enrollment.
This paradigm shift has occurred despite the landmark trials for modern adjuvant therapies including only patients who underwent CLND prior to enrollment.
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10.1038/s41433-021-01627-6
Intravitreal anti-vascular endothelial growth factor therapy (anti-VEGF) is now considered the mainstay of treatment, with landmark trials establishing its efficacy with mean visual gains of between +9.
Intravitreal anti-vascular endothelial growth factor therapy (anti-VEGF) is now considered the mainstay of treatment, with landmark trials establishing its efficacy with mean visual gains of between +9.
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10.1097/SPV.0000000000001002
Our examination of landmark trials in female pelvic medicine and reconstructive surgery demonstrates an overall overrepresentation of White study participants compared with the National Health and Nutritional Examination Survey prevalence data and a possible underrepresentation of Black and Hispanic subgroups that did not meet statistical significance.
Our examination of landmark trials in female pelvic medicine and reconstructive surgery demonstrates an overall overrepresentation of White study participants compared with the National Health and Nutritional Examination Survey prevalence data and a possible underrepresentation of Black and Hispanic subgroups that did not meet statistical significance.
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10.1200/JCO.2021.39.15_SUPPL.E21192
e21192 Background: Landmark trials have shown increased survival in pts who receive IO for NSCLC as compared to chemotherapy (chemo).
e21192 Background: Landmark trials have shown increased survival in pts who receive IO for NSCLC as compared to chemotherapy (chemo).
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10.1007/s00415-020-10392-7
From 2015, landmark trials subsequently demonstrated efficacy and safety for monoclonal antibodies targeting CGRP (fremanezumab, erenumab, galcanezumab), but largely recruited participants with standard migraine rather than the resistant and difficult to treat migraineurs, who would represent the most likely clinical target for these therapies.
From 2015, landmark trials subsequently demonstrated efficacy and safety for monoclonal antibodies targeting CGRP (fremanezumab, erenumab, galcanezumab), but largely recruited participants with standard migraine rather than the resistant and difficult to treat migraineurs, who would represent the most likely clinical target for these therapies.
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10.1093/ehjcvp/pvab056
This has been established by landmark trials such as EMPEROR-Reduced, EMPA-TROPISM, CREDENCE, DAPA-CKD, DAPA-HF, and DEFINE-HF.
This has been established by landmark trials such as EMPEROR-Reduced, EMPA-TROPISM, CREDENCE, DAPA-CKD, DAPA-HF, and DEFINE-HF.
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10.1053/j.semtcvs.2021.02.023
A review was performed of salient articles identifying radiation technologies used in lung cancer which were summarized and expounded upon with focus on integrating their history, evolution, and landmark trials establishing basis of their use.
A review was performed of salient articles identifying radiation technologies used in lung cancer which were summarized and expounded upon with focus on integrating their history, evolution, and landmark trials establishing basis of their use.
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10.1007/s40257-021-00614-7
Although many landmark trials on checkpoint inhibitors included mucosal and vulvar melanomas, the results were often not reported separately.
Although many landmark trials on checkpoint inhibitors included mucosal and vulvar melanomas, the results were often not reported separately.
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10.1016/j.rdc.2021.07.004
Landmark trials over the past decade in adult SSc have led to 2 Food and Drug Administration-approved therapies for SSc-associated interstitial lung disease, and several ongoing trials of other biological agents are underway.
Landmark trials over the past decade in adult SSc have led to 2 Food and Drug Administration-approved therapies for SSc-associated interstitial lung disease, and several ongoing trials of other biological agents are underway.
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10.1016/j.cjca.2021.01.024
However, medical therapy for HFrEF has significantly evolved since the publication of these landmark trials.
However, medical therapy for HFrEF has significantly evolved since the publication of these landmark trials.
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10.1016/j.nic.2020.12.002
Landmark trials have used computed tomography imaging to select patients for intravenous thrombolysis and endovascular treatment.
Landmark trials have used computed tomography imaging to select patients for intravenous thrombolysis and endovascular treatment.
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10.1007/978-3-030-74462-5_2
Landmark trials in the last decade have demonstrated the superior safety of direct acting oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation.
Landmark trials in the last decade have demonstrated the superior safety of direct acting oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation.
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10.1007/s00384-021-03846-5
Patients with stage I anal squamous cell carcinoma (SCC) have been underrepresented in landmark trials showing superiority of chemoradiotherapy over radiotherapy for definitive treatment.
Patients with stage I anal squamous cell carcinoma (SCC) have been underrepresented in landmark trials showing superiority of chemoradiotherapy over radiotherapy for definitive treatment.
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10.1111/1754-9485.13260
In the landmark trials, MT was only performed for those with no functional disability prior to stroke (mRS 0-2).
In the landmark trials, MT was only performed for those with no functional disability prior to stroke (mRS 0-2).
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10.1200/JCO.2021.39.15_SUPPL.E21519
Conclusions: Experience with pembrolizumab at our institution suggests a similar irAE profile compared to landmark trials, though we observed a higher percentage of patients who required discontinuation of pembrolizumab (11% versus 5% in Phase III trials).
Conclusions: Experience with pembrolizumab at our institution suggests a similar irAE profile compared to landmark trials, though we observed a higher percentage of patients who required discontinuation of pembrolizumab (11% versus 5% in Phase III trials).
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10.1002/jso.26432
Notably, authors of all these landmark trials have used the word ‘debulking’ to describe the surgery for advanced oral cancer.
Notably, authors of all these landmark trials have used the word ‘debulking’ to describe the surgery for advanced oral cancer.
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10.2217/fon-2021-0262
In this review, we summarize the landmark trials that established venetoclax-based combinations as a new standard of care for patients with acute myeloid leukemia not suitable for intense chemotherapy, provide practical clinical pearls for managing patients on these therapies, and offer a brief overview of modifications to these regimens under development to improve their efficacy and/or applicability.
In this review, we summarize the landmark trials that established venetoclax-based combinations as a new standard of care for patients with acute myeloid leukemia not suitable for intense chemotherapy, provide practical clinical pearls for managing patients on these therapies, and offer a brief overview of modifications to these regimens under development to improve their efficacy and/or applicability.
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10.1513/AnnalsATS.202102-123ED
Food andDrug Administration (FDA) for treatment of idiopathic pulmonary fibrosis (IPF) after landmark trials showed a significant reduction in the decline in lung function as measured by forced vital capacity compared with placebo over 1 year (1, 2).
Food andDrug Administration (FDA) for treatment of idiopathic pulmonary fibrosis (IPF) after landmark trials showed a significant reduction in the decline in lung function as measured by forced vital capacity compared with placebo over 1 year (1, 2).
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10.3390/medicina57050422
73 m2 were actively excluded from landmark trials, thus representing a major clinical limitation for the currently available agents.
73 m2 were actively excluded from landmark trials, thus representing a major clinical limitation for the currently available agents.
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10.1002/ags3.12438
The results of many landmark trials have been published or presented in the past year, many of which have changed or will change current clinical practice.
The results of many landmark trials have been published or presented in the past year, many of which have changed or will change current clinical practice.
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10.1093/ajhp/zxab041
This review focuses on the landmark trials that led to each FDA-approved indication, as well as common toxicities seen with use of these agents.
This review focuses on the landmark trials that led to each FDA-approved indication, as well as common toxicities seen with use of these agents.
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10.1007/s40266-021-00871-5
Even though age is not an exclusion criterion per se, most of the landmark trials enrolled a limited number of senior patients, raising some concerns on the potential benefit of active treatments in this group.
Even though age is not an exclusion criterion per se, most of the landmark trials enrolled a limited number of senior patients, raising some concerns on the potential benefit of active treatments in this group.
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10.1016/j.jacbts.2020.10.005
In a major step forward, landmark trials with renin-angiotensin system (RAS) inhibitors demonstrated that these therapies reduce the composite of significant eGFR decline, renal replacement therapy, or death in albuminuric CKD patients with and without diabetes (1).
In a major step forward, landmark trials with renin-angiotensin system (RAS) inhibitors demonstrated that these therapies reduce the composite of significant eGFR decline, renal replacement therapy, or death in albuminuric CKD patients with and without diabetes (1).
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10.1158/1538-7445.SABCS20-PS9-64
As data from clinical trials become available, landmark trials are published, and FDA approvals and guidelines incorporate novel therapies, continuing medical education (CME) for oncologists is necessary to facilitate the translation of evidence to their clinical practice.
As data from clinical trials become available, landmark trials are published, and FDA approvals and guidelines incorporate novel therapies, continuing medical education (CME) for oncologists is necessary to facilitate the translation of evidence to their clinical practice.
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10.36255/exonpublications.stroke.devicesandtechniques.2021
These first-generation devices gave way to the stent retriever, which would change the standard of care for acute large vessel occlusion stroke following a series of landmark trials in 2015.
These first-generation devices gave way to the stent retriever, which would change the standard of care for acute large vessel occlusion stroke following a series of landmark trials in 2015.
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10.1093/BJS/ZNAB134.309
The NICE melanoma CPGs are higher quality than alternatives but should be updated to reflect recent landmark trials.
The NICE melanoma CPGs are higher quality than alternatives but should be updated to reflect recent landmark trials.
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10.1097/TP.0000000000003762
For metastatic RCC, recent landmark trials in the nontransplanted population demonstrate that immunotherapy combinations improve survival.
For metastatic RCC, recent landmark trials in the nontransplanted population demonstrate that immunotherapy combinations improve survival.
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10.1016/j.suc.2021.03.007
This article discusses the landmark trials and most current data to understand the concepts, applications, and outcomes from trimodality therapy in locally advanced esophageal cancer.
This article discusses the landmark trials and most current data to understand the concepts, applications, and outcomes from trimodality therapy in locally advanced esophageal cancer.
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10.1053/j.jvca.2021.07.032
Landmark trials examining vascular access in STEMI (ST elevation myocardial infarction), the management of multivessel disease, acute myocardial infarction and cardiac arrest are discussed.
Landmark trials examining vascular access in STEMI (ST elevation myocardial infarction), the management of multivessel disease, acute myocardial infarction and cardiac arrest are discussed.
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10.1136/jim-2020-001702
In this pooled analysis of landmark trials, we coalesced individual data from 5001 such subjects randomized to intensive versus standard BP targets.
In this pooled analysis of landmark trials, we coalesced individual data from 5001 such subjects randomized to intensive versus standard BP targets.
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10.3389/fonc.2021.622621
A number of landmark trials have established lumpectomy followed by radiation as the standard of care for many patients.
A number of landmark trials have established lumpectomy followed by radiation as the standard of care for many patients.
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10.1080/14740338.2021.1954158
We provide an overview of findings from recent meta-analyses, important observational studies, and a detailed description of landmark trials, including the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT).
We provide an overview of findings from recent meta-analyses, important observational studies, and a detailed description of landmark trials, including the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT).
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10.24875/RECICE.M21000203
Introduction and objectives: Transcatheter aortic valve implantation (TAVI) has proven safe and effective in low-to-high risk patients, but emergency procedures have been excluded from the landmark trials.
Introduction and objectives: Transcatheter aortic valve implantation (TAVI) has proven safe and effective in low-to-high risk patients, but emergency procedures have been excluded from the landmark trials.
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