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10.1186/s12886-019-1059-4

BackgroundTo evaluate the efficacy, complications, and clinical characteristics, including the ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients.

Ocular toxicity of intravitreal melphalan for retinoblastoma in Chinese patients

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10.1016/j.jaapos.2019.03.002

We report 2 cases of iris heterochromia secondary to profound iris stromal depigmentation following intravitreal melphalan and topotecan injections.

Heterochromia following intravitreal chemotherapy in two cases.

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10.1111/ceo.13711

This study compares the efficacy and toxicity of intravitreal melphalan, topotecan and carboplatin, alone or in combination (sequential administration), in the LHBetaTag retinoblastoma mice.

Low retinal toxicity of intravitreal carboplatin associated with good retinal tumour control in transgenic murine retinoblastoma

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10.1016/J.ORET.2018.09.020

ABSTRACT: PURPOSE To quantify changes in central retinal thickness (CRT) on intraoperative spectral domain optical coherence tomography (SD-OCT) pre- and post- intravitreal melphalan (IVM) injection for retinoblastoma (Rb).

Changes in Retinal Thickness on OCT from Intravitreal Melphalan.

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10.1038/s41433-019-0539-3

Persistent disease was treated initially by ocular radiotherapy or intravitreal melphalan and latterly by vitrectomy.

An audit of retinal lymphoma treatment at the University of California San Francisco

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Intravitreal Melphalan
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What is/are Intravitreal Melphalan?

Intravitreal Melphalan - BackgroundTo evaluate the efficacy, complications, and clinical characteristics, including the ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients. [1] We report 2 cases of iris heterochromia secondary to profound iris stromal depigmentation following intravitreal melphalan and topotecan injections. [2] This study compares the efficacy and toxicity of intravitreal melphalan, topotecan and carboplatin, alone or in combination (sequential administration), in the LHBetaTag retinoblastoma mice. [3] ABSTRACT: PURPOSE To quantify changes in central retinal thickness (CRT) on intraoperative spectral domain optical coherence tomography (SD-OCT) pre- and post- intravitreal melphalan (IVM) injection for retinoblastoma (Rb). [4] Persistent disease was treated initially by ocular radiotherapy or intravitreal melphalan and latterly by vitrectomy. [5]