Introduction to Intravitreal Administration
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Intravitreal Administration sentence examples within vascular endothelial growth
Given the role the vascular endothelial growth factor (VEGF) plays in controlling and preserving the integrity of the vascular endothelium intravitreal administration of anti-VEGF agents may affect the risk of thromboembolic events.
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Material and methods: This clinical study retrospectively examined 771 eyes of 392 patients who received no intravitreal administration of vascular endothelial growth factor (VEGF) inhibitors or corticosteroids for non-proliferative DR (NPDR) and proliferative DR (PDR).
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Intravitreal Administration sentence examples within diabetic macular edema
Intravitreal administration of aflibercept has been shown to be highly effective in the treatment of diabetic macular edema and allowed to increase visual acuity to 0.
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In fact, intravitreal administration of a siRNA targeting the REDD1 mRNA has demonstrated promise for improving visual function in patients with diabetic macular edema.
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Intravitreal Administration sentence examples within age related macular
The “gold standard” of the neovascular age-related macular degeneration treatment is the intravitreal administration of angiogenesis inhibitors.
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Tiny nanoparticles of dexamethasone palmitate (DXP) were designed as transparent suspensions for intravitreal administration to treat age-related macular degeneration (AMD).
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Intravitreal Administration sentence examples within Following Intravitreal Administration
Intravitreal Administration sentence examples within Single Intravitreal Administration
The objective of this study was to evaluate the ocular toxicity and toxicokinetics of RabFab-NLP after a single intravitreal administration in New Zealand White rabbits.
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Animals received daily intraperitoneal injections of R7050, and/or a single intravitreal administration the day of the surgery.
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Intravitreal Administration sentence examples within Frequent Intravitreal Administration
Reduction of frequent intravitreal administrations may be accomplished with delivery systems that provide sustained drug release.
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Unfortunately, VEGF blockers are expensive biological therapeutics that necessitate frequent intravitreal administration and are associated with multiple adverse effects.
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Depending on the choice of surgical treatment, the patients were divided into two groups: Group 1 – 11 patients (11 eyes) – patients receiving anti-VEGF therapy as the main treatment according to the treat and extend regimen; Group 2 – 9 patients (9 eyes) – patients who underwent translocation of submacular hemorrhage followed by intravitreal administration of anti-VEGF drugs according to the treat and extend regimen.
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The location of retinal hypoxia was imaged before and after the intravitreal administration of PNPs at a concentration of 2.
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Intravitreal administration of L-AMB was introduced for probable candida endophthalmitis.
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Eye drop formulations allowing topical treatment of retinal pathologies have long been sought as alternatives to intravitreal administration.
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This can be safely managed with lensectomy and anterior vitrectomy and the use of intravitreal administration of melphalan and topotecan at the conclusion of the surgery as a precautionary measure against the potential risk of extraocular spread.
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Intravitreal administration of (R)-WIN55,212-2 reversed the AMPA induced loss of bNOS expressing amacrine cells, an effect that was blocked by both AM251 and AM630.
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In the course of this work, we have shown a positive effect of intravitreal administration of the anti-VEGF drug aflibercept in patients with retinal angiomatous proliferation.
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Conclusions: Intravitreal administration of hUCMSCs triggers an effective cytoprotective microenvironment in the retina of diabetic mice.
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These results suggest that HPβCD is a safer option than RMβCD for retinal drug delivery and may advance the use of CDs in the development of drugs designed for intravitreal administration.
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In the H2O2-injured rat model, intravitreal administration of PD-MSCsPEDF restored total retinal layer thickness compared to that of naïve PD-MSCs.
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This clinical case demonstrates that intravitreal administration of inhibitor VEGF with traditional methods of treatment can be used as a treatment for patients with Coates retinitis.
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Intravitreal administration of rapamycin, a negative regulator of mTOR, inhibits the mTOR pathway in rd1 photoreceptors.
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In addition, less invasive techniques rather than intravitreal administration routes, such as topical, subconjunctival, suprachoroidal, subretinal, and trans-scleral, have been evaluated to reduce the treatment burden.
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The results of our results demonstrated that intravitreal administration of MSC-exos ameliorates ONC-induced injury in a rat model.
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In retinopathy model, CS-PLGA NPs by SCJ route showed more reduction of VEGF level in retina than the topical and intravitreal administration of formulation.
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Intravitreal administration of antiviral drugs under the control of polymerase chain reaction is a more effective method of treating cytomegalovirus retinitis than intravitreal administration under ophthalmoscopic control.
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This research was also designed to assess the ability of TPH-TCs-NPs to improve cell association, increase treatment efficacy in retinoblastoma cells and xenograft-rat-model of retinoblastoma, and overcome current topotecan hydrochloride (TPH) intravitreal administration challenges, including stability loss and poor cellular uptake.
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Intravitreal administration of a cell‐penetrating CD40‐TRAF2,3 blocking peptide impaired ICAM‐1 upregulation in retinal endothelial cells and CXCL1 upregulation in endothelial and Müller cells.
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Polymeric microparticles (MPs) designed for the intravitreal administration of therapeutic proteins result in a prolonged half-life in the vitreous and can delay or discourage the onset of adverse effects inevitably related to this route of administration.
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On the other hand, it is known that intravitreal administration of anti-VEGF agents lowers VEGF levels in the blood and raises the theoretical concerns of intraocular anti-VEGF causing deleterious effects in other organ systems, including the brain.
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A laser-induced choroidal neovascularization (CNV) and subretinal fibrosis model indicated that the intravitreal administration of hucMSC-Exo effectively alleviated subretinal fibrosis in vivo.
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Intravitreal administration of ADVM-022 was well tolerated and resulted in sustained aflibercept levels in ocular tissues.
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Intravitreal administration of antifungal agents is one of the dominant therapeutic approaches in these ocular diseases.
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Additionally, it has been reported the off-label use of bevacizumab, commonly associated with oncology, in this condition through intravitreal administrations, demonstrating efficacy allied with a lower cost in comparison to other agents used, which makes it a new possible pharmacological approach.
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Finally, intravitreal administration of IGF-2 (mature and pro-forms) increased retinal IR and Akt kinase activity in diabetic rats.
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The discovery of new small-molecule drugs for intravitreal administration would benefit from simple models to predict vitreal clearance (CL).
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However, intravitreal administration of these agents is also associated with several inflammatory and non-inflammatory adverse events.
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In this study, we demonstrated that simple mixing with adenosine tetraphosphate (ATP) has the potential to greatly enhance the transport and permeation of a polymeric nanocarrier across the retina via intravitreal administration.
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Twenty-three eyes were treated with intravitreal administration of methotrexate, 4 eyes could not receive ocular treatment due to life-threatening lymphoma, and 1 eye did not require ocular treatment because the fundus lesions regressed after systematic chemotherapy.
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However, melphalan hydrochloride (MH) degrades rapidly in solution, increasing logistical complexity with respect to time between medication preparation and administration for intravitreal administration under anesthesia for retinoblastoma.
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Intravitreal administration of dimeric GX1 resulted in a greater reduction in the retinal neovascularization in vivo than administration of the GX1 monomer (P < 0.
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The intravitreal administration of rapamycin at different time-points after the application of the circumlimbal suture indicated that autophagy induction early during OHT development had potent survival-promoting effects in RGCs.
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Intravitreal administration of MSCs or their secretome (MSCs-conditioned media [MSCs-CM]) significantly curtailed vasoobliteration as well as aberrant preretinal NV in a model of oxygen-induced retinopathy (OIR).
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The review presents information on the main anti-angiogenic drugs for intravitreal administration, used in ophthalmology.
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The ability of intravitreal administration of mesenchymal stem cells (MSCs) to repair the retinal vasculature and neurons of the inner retina in DR has been explored.
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Surgical treatment included taking intraocular material for examination, performing vitrectomy in the maximum possible volume, tamponade of the vitreal cavity with perfluorodecalin (for 5-14 days) and intravitreal administration of amphotericin B in 10 mcg in 0.
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Intravitreal administration of sCD146 in normal rats significantly increased retinal vascular permeability and induced significant upregulation of phospho-ERK1/2, intercellular adhesion molecule-1 and VEGF in the retina.
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To evaluate the effectiveness of combined treatment of chronic central serous chorioretinopathy (CCSCRP) complicated by 1st type choroidal neovascularization (CNV), using subthreshold micropulse laser exposure (SMILV) on the retina and intravitreal administration of angiogenesis inhibitors (IAOAI).
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Further the pharmacokinetic study of optimized formulation after intravitreal administration was evaluated in Wister rats.
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Conclusion These study findings indicate that the intravitreal administration of aflibercept (2 mg) might very slightly alter the corneal endothelium within 6 months of the first injection.
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The data from real clinical practice was used to develop the indications for intravitreal administration of a glucocorticoid as the therapy of first choice for diabetic macular edema.
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The absence of statistically significant changes of intraocular pressure level and volumetric ocular blood flow additionally confirms information about the safety of intravitreal administration of aflibercept to patients with a wet form of age-related macular degeneration.
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Intravitreal administration of UPARANT successfully and rapidly reduced RI to non-induced control levels.
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PURPOSE
To study the effectiveness of the combination of intravitreal administration of the drug Ozurdex with subsequent individually selected laser therapy in the treatment of the proliferative stage of diabetic retinopathy in patients with concomitant chronic DME, and its relationship with morphological changes in the retina observed with optical coherence tomography.
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Surgeons need to be cautious of the toxicity when antibiotics are used prophylactically especially by intravitreal administration.
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Control experiments demonstrated virtually nonexisting ability of this capsid to transduce retinal cells via intravitreal administration but high efficiency to transduce photoreceptors via subretinal route.
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Conclusion: The Simoa VEGF-A assay is a valuable tool for the reliable monitoring of VEGF-A suppression after intravitreal administration of anti-VEGF-A drugs.
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Herein, we aimed to determine the effect of intravitreal administration of ranibizumab in aged, spontaneously dysmetabolic non-human primate with increased average retinal thickness (329 ± 6 µm, vs.
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The protective effects of 8-OH-DPAT were blocked by intravitreal administration of the selective 5-HT1A antagonist WAY-100635 or the selective GABAA receptor antagonist SR95531.
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Intravitreal administration can cause some side effects such as increased intraocular pressure and endophthalmitis.
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They were present in the vitreous humor for four weeks after intravitreal administration, with saturable binding to vitreous humor components.
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In streptozotocin-induced diabetic rats, intravitreal administration of Dnmt1-siRNA attenuated Mfn2 promoter hypermethylation and restored its expression.
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Intravitreal administration of MIF in normal rats induced increased retinal vascular permeability and significant upregulation of phospho-ERK1/2, NF-κB, ICAM-1 and vascular cell adhesion molecule-1 expression in the retina.
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However, intravitreal administration of non-modified AAV serotypes tends to transduce only ganglion cells and inner nuclear layer cells.
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However, selective repression of retinal GSK3β by intravitreal administration of si-GSK3β rescued the neuroprotective properties of GRg1 when Akt was inactivated.
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Moreover, here we tease out the ocular tissue distribution of RC28-E after intravitreal administration, and we also determine the systemic bioavailability after both intravitreal and intravenous administration.
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ABSTRACT Purpose To describe a case of retinal occlusive vasculopathy associated with intravitreal administration of rituximab.
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CONCLUSION
Intravitreal administration of bevacizumab in diabetic macular edema affects the measurement of retinal ganglion cell complex thickness on OCT.
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Intravitreal administration of rat BMSCs and human ASCs in both SD and TGR eyes induced cataract, loss of pericytes, and increased formation of acellular capillaries.
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Intravitreal administration of bevacizumab had been a matter of legal dispute in several countries.
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