Introduction to Intracellular Sirna

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intracellular sirna delivery

MDA-MB-231 and BT549 cells treated with the therapeutic RGD-PEG-ECO/siDANCR nanoparticles exhibited 80-90% knockdown in the expression of DANCR for up to 7 days, indicating efficient intracellular siRNA delivery and sustained target silencing.

Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy.

intracellular sirna delivery

What's more, gel retardation electrophoresis experiments, confocal microscopy analysis and cell viability assay have demonstrated that the nanocapsules are able to protect the siRNA from enzymatic degradation and have exhibited advantages for intracellular siRNA delivery such as high cellular uptake and low cytotoxicity.

Cucurbit[8]uril-based supramolecular polymer nanocapsules as an effective siRNA delivery platform for gene therapy

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10.1039/c9bm00494g

Cationic liposomes have shown great potential in efficient siRNA delivery, and their positive charge is crucial for tight extracellular siRNA binding, effective intracellular siRNA disassembly and physiological toxicity.

The development of tertiary amine cationic lipids for safe and efficient siRNA delivery.

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10.1021/acs.bioconjchem.9b00028

MDA-MB-231 and BT549 cells treated with the therapeutic RGD-PEG-ECO/siDANCR nanoparticles exhibited 80-90% knockdown in the expression of DANCR for up to 7 days, indicating efficient intracellular siRNA delivery and sustained target silencing.

Systemic Delivery of Tumor-Targeting siRNA Nanoparticles against an Oncogenic LncRNA Facilitates Effective Triple-Negative Breast Cancer Therapy.

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10.1021/acsnano.8b05482

95 and p < 10-4) with intracellular siRNA bioactivity.

Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability.

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10.1039/c9nr02301a

At this time point, intracellular siRNA levels were comparable to those provided by a lipid-based transfection reagent that achieved significant gene silencing.

Graphene oxide as a 2D platform for complexation and intracellular delivery of siRNA.

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10.1039/c9py01062a

What's more, gel retardation electrophoresis experiments, confocal microscopy analysis and cell viability assay have demonstrated that the nanocapsules are able to protect the siRNA from enzymatic degradation and have exhibited advantages for intracellular siRNA delivery such as high cellular uptake and low cytotoxicity.

Cucurbit[8]uril-based supramolecular polymer nanocapsules as an effective siRNA delivery platform for gene therapy

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10.1039/c9cc00175a

DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery.

DNA tetrahedron-based nanogels for siRNA delivery and gene silencing.

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10.1007/978-1-4939-9220-1_5

Non-viral vectors can provide specific cellular uptake, stable siRNA complex formation, and intracellular siRNA release.

VEGFA Gene Silencing in CXCR4-Expressing Cells via siRNA Delivery by Means of Targeted Peptide Carrier.

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Intracellular Sirna - Cationic liposomes have shown great potential in efficient siRNA delivery, and their positive charge is crucial for tight extracellular siRNA binding, effective intracellular siRNA disassembly and physiological toxicity. [1] MDA-MB-231 and BT549 cells treated with the therapeutic RGD-PEG-ECO/siDANCR nanoparticles exhibited 80-90% knockdown in the expression of DANCR for up to 7 days, indicating efficient intracellular siRNA delivery and sustained target silencing. [2] 95 and p < 10-4) with intracellular siRNA bioactivity. [3] At this time point, intracellular siRNA levels were comparable to those provided by a lipid-based transfection reagent that achieved significant gene silencing. [4] What's more, gel retardation electrophoresis experiments, confocal microscopy analysis and cell viability assay have demonstrated that the nanocapsules are able to protect the siRNA from enzymatic degradation and have exhibited advantages for intracellular siRNA delivery such as high cellular uptake and low cytotoxicity. [5] DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. [6] Non-viral vectors can provide specific cellular uptake, stable siRNA complex formation, and intracellular siRNA release. [7]

intracellular sirna delivery

MDA-MB-231 and BT549 cells treated with the therapeutic RGD-PEG-ECO/siDANCR nanoparticles exhibited 80-90% knockdown in the expression of DANCR for up to 7 days, indicating efficient intracellular siRNA delivery and sustained target silencing. [1] What's more, gel retardation electrophoresis experiments, confocal microscopy analysis and cell viability assay have demonstrated that the nanocapsules are able to protect the siRNA from enzymatic degradation and have exhibited advantages for intracellular siRNA delivery such as high cellular uptake and low cytotoxicity. [2] DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. [3]