Introduction to Intracellular Pressure
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Actin polymerization is the best studied mechanism of force generation, but growing interest in how variable molecular conditions and microenvironments alter morphogenesis has revealed other mechanisms, including intracellular pressure.
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We recently discovered that actomyosin contractility can increase intracellular pressure and switch tumor cells from low-pressure lamellipodia to high-pressure lobopodial protrusions during three-dimensional (3D) migration.
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These processes, together, increase interstitial and intracellular pressure as revealed by magnetic resonance spectroscopy and diffusion-weighted imaging.
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Blebs are extruded by intracellular pressure and are initially cytoskeleton-free, but they subsequently assemble the cytoskeleton, which can drive bleb retraction.
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Also, based on the fact that increased intracellular pressure may lead to a number of neuronal disorders, temperature-dependent ionic diffusivities can be further fine-tuned to reduce the intracellular pressure and hence avoiding neuronal disorders.
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In this study, kinetic models for microwave extraction of APS were established, scanning electron micrograph revealed that microwave treatment could generate Astragalus intracellular pressure, which caused destruction of the Astragalus cellular structure, thus improving the extraction efficiency.
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