Introduction to Intracellular Drug
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Intracellular Drug sentence examples within Controlled Intracellular Drug
The stability of self-assembled drug nanocarriers during blood circulation and the controlled intracellular drug delivery are two challenges in cancer therapy.
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The intracellular experiment shows that the HA-azo/PDADMAC nanocapsules with CD44 targeting ability and UV-controlled intracellular drug release are promising for cancer chemotherapy.
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Intracellular Drug sentence examples within Efficient Intracellular Drug
This strategy could be used to prepare redox-ultrasensitive nanocarriers for efficient intracellular drug delivery.
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With the synergistic effect of the pH-triggered protonation of piperidine groups and reduction triggered break of disulfide bonds, the polymeric micelles will disintegrate and achieve efficient intracellular drug release.
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Intracellular Drug sentence examples within Enhanced Intracellular Drug
As compared with the CUR loaded nanoparticles without TPGS decoration, CUR@TPNP with TPGS decoration results in significantly enhanced intracellular drug accumulation to efficiently induce cell apoptosis in drug resistant tumor cells.
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Upon NIR irradiation, the nanocarriers apparently endowed higher cell uptake, resulting in an enhanced intracellular drug accumulation.
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Intracellular Drug sentence examples within Effective Intracellular Drug
These results, combined with in vitro cell toxicity and cellular uptake, suggest the versatility of the dual location acid-degradation strategy in the design and development of effective intracellular drug delivery nanocarriers.
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Acid-responsive degradable nanoassemblies self-assembled from amphiphilic block copolymers with acid-labile linkages have been extensively explored as effective intracellular drug delivery vehicles for chemotherapy.
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Intracellular Drug sentence examples within Triggered Intracellular Drug
Compared to the control group, the NQO1-responsive micelle showed NQO1-triggered intracellular drug release and enhanced anticancer effects.
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In this study, transferrin (Tf), which can target cancer cells, is covalently anchored onto the surface of MSNPs via disulfide linkage, which is used for glutathione-triggered intracellular drug release in tumor cells.
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Intracellular Drug sentence examples within Targeted Intracellular Drug
This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.
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As a new alternative to antibody-drug conjugates, we generated “ligand-targeting” peptide-drug conjugates (PDCs), which utilize receptor-mediated endocytosis for targeted intracellular drug delivery.
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Intracellular Drug sentence examples within Rapid Intracellular Drug
In cancer cells pretreated with GSH-OEt, PTX-ss-TMP NPs exhibited higher cytotoxicity, apoptosis rate, and cell-cycle arrest than monotherapy or combination therapy with free drugs, which was attributed to their improved cellular uptake and rapid intracellular drug release.
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The co-delivery system exhibited active tumor targeting, effective endo/lysosomal escape, and rapid intracellular drug release.
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Intracellular Drug sentence examples within High Intracellular Drug
The in vivo therapeutic potential of Ph-glu-Oxa was confirmed in oxaliplatin-resistant xenograft model demonstrating the reversibility of the drug resistance by the new complex and the efficacy was associated with the unimpaired high intracellular drug accumulation in HT29/Oxa.
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The system demonstrated prolonged and sustained release in pH-dependent manner with high intracellular drug delivery capacity.
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Intracellular Drug sentence examples within Low Intracellular Drug
Chemotherapy efficiency of platinum(II) (Pt(II)) is often attenuated owing to the low intracellular drugs concentration and glutathione (GSH)-mediated detoxification.
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Low intracellular drugs concentration is one of the main representations of multidrug resistance (MDR), which often results in a weak or failed chemotherapy on cancer treatment.
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Intracellular Drug sentence examples within Enhance Intracellular Drug
Promoting drug delivery efficacy by targeting tumor and concurrently suppressing drug efflux through down-regulating P-gp emerges as an effective strategy to enhance intracellular drug accumulation for combating MDR tumor.
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To enhance intracellular drug delivery, βCD was chemically conjugated to an 18-carbon chain cationic gemini surfactant which undergoes self-assembly to form nanoscale complexes.
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Intracellular Drug sentence examples within Demand Intracellular Drug
Efficient accumulation and on-demand intracellular drug release in the desired site are a crucial issue in developing ideal drug delivery systems (DDSs).
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Strikingly, these NPs exhibited excellent bioresponsibility when triggered with the intrinsic stimuli (acidity, glutathione and reactive oxygen species) within activated macrophages, indicating that they could conceivably confer the on-demand intracellular drug release.
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Intracellular Drug sentence examples within Increase Intracellular Drug
This strategy leverages the assembly principle to promote penetration of peptide molecules into cells and increase intracellular drug bioavailability, which is of great significance for the development of PDC drugs in the future.
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Our findings further suggest that many naturally evolved genes involved in resistance to multiple classes of antibiotics may increase intracellular drug concentrations to modulate their own expression, acting as a form of regulatory feedback.
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Intracellular Drug sentence examples within intracellular drug delivery
These results, combined with in vitro cell toxicity and cellular uptake, suggest the versatility of the dual location acid-degradation strategy in the design and development of effective intracellular drug delivery nanocarriers.
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In order to understand related pathogenesis of some diseases and design new intracellular drug delivery systems, investigation of pH change in living cells in real time is important.
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Intracellular Drug sentence examples within intracellular drug release
Most importantly, surface-enhanced Raman scattering (SERS) was utilized for the first time to evaluate the critical micelle concentration during the formation, cellular uptake and intracellular drug release.
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Then the dimeric prodrug of PTX (diPTX, diP) was loaded into the core of the star-shaped polymeric prodrug micelles of PSSP by hydrophobic interaction forming the redox-responsive prodrug micelles of diPTX@PSSP for intracellular drug release in tumor cells.
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Intracellular Drug sentence examples within intracellular drug accumulation
The in vivo therapeutic potential of Ph-glu-Oxa was confirmed in oxaliplatin-resistant xenograft model demonstrating the reversibility of the drug resistance by the new complex and the efficacy was associated with the unimpaired high intracellular drug accumulation in HT29/Oxa.
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The MDR phenotype is often linked to the overexpression of ATP-binding cassette (ABC) transporters, that pumps out and decreased intracellular drug accumulation.
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Intracellular Drug sentence examples within intracellular drug concentration
Our findings further suggest that many naturally evolved genes involved in resistance to multiple classes of antibiotics may increase intracellular drug concentrations to modulate their own expression, acting as a form of regulatory feedback.
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From the results of cell uptake experiments, we found that NF-6-MP was easier to be absorbed by EC109 cells compared with free 6-MP, showing higher intracellular drug concentrations after incubation for 4 h, which confirmed the cytotoxicity result that nanofibrous NF-SS-MP has better ability to kill EC109 cells in a short incubation time.
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Intracellular Drug sentence examples within intracellular drug distribution
The results demonstrate the capability of our single-cell analysis pipeline for quantitatively measuring the intracellular drug distribution and its longitudinal uptake using a multimodal optical imaging platform, which can provide novel insights into the uptake pathways and target-sites.
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Pre-treatment of samples with l-tyrosine was found not to increase the uptake of BPA, nor change the intracellular drug distribution.
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Intracellular Drug sentence examples within intracellular drug uptake
To these ends, we transformed tenofovir (TFV) into LA surfactant stabilized aqueous prodrug nanocrystals (referred to as NM1TFV and NM2TFV), enhancing intracellular drug uptake and retention.
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Next, nanocomposite intracellular drug uptake was analyzed using a transmission electron microscope.
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Intracellular Drug sentence examples within intracellular drug level
Distinct heterogeneous mechanisms underlying the resistance to PARPi have been described, including a decrease in intracellular drug levels due to upregulation of multidrug efflux pumps, loss of expression/inactivating mutations in the PARP1 protein, restoration of HR and the protection of the replicative fork.
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We studied the effects of drug encapsulated NPs on cellular accumulation, intracellular drug levels, oxidative stress status, cellular viability, drug resistance, 20S proteasome activity, cytosolic Nuclear Factor Kappa B (NF-κB-p65), and apoptosis in breast cancer and normal cells.
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Intracellular Drug sentence examples within intracellular drug molecule
The fundamental causes of multidrug resistance (MDR) have been studied for decades, and can be generally classified into two types: one is associated with the activation of diverse drug efflux pumps, which are responsible for translocating intracellular drug molecules out of the cells; the other is linked with some non-efflux pump-related mechanisms, such as antiapoptotic defense, enhanced DNA repair ability, and powerful antioxidant systems.
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This is the first successful attempt to detect and quantify the change of FRET signals in A549 cells via three methods to monitor the cellular uptake of nanoprobes and intracellular drug molecule release intuitively.
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Intracellular Drug sentence examples within intracellular drug target
Intracellular Drug sentence examples within intracellular drug retention
More importantly, the apoptotic inducer α-TOS could elevate the reactive oxygen species (ROS) generation, disrupt mitochondrial function and reduce adenosine 5'-triphosphate (ATP) production, which facilitate the intracellular drug retention while decreasing its efflux.
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In conclusion, our study demonstrates that AEA interferes with cell division, alters the membrane properties of MDRSA, and leads to increased intracellular drug retention, which can contribute to the sensitization of MDRSA to antibiotics.
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This strategy leverages the assembly principle to promote penetration of peptide molecules into cells and increase intracellular drug bioavailability, which is of great significance for the development of PDC drugs in the future.
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These results, combined with in vitro cell toxicity and cellular uptake, suggest the versatility of the dual location acid-degradation strategy in the design and development of effective intracellular drug delivery nanocarriers.
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Sonoporation as a method of intracellular drug and gene delivery has not yet progressed to being used in vivo.
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Most importantly, surface-enhanced Raman scattering (SERS) was utilized for the first time to evaluate the critical micelle concentration during the formation, cellular uptake and intracellular drug release.
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Then the dimeric prodrug of PTX (diPTX, diP) was loaded into the core of the star-shaped polymeric prodrug micelles of PSSP by hydrophobic interaction forming the redox-responsive prodrug micelles of diPTX@PSSP for intracellular drug release in tumor cells.
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The in vivo therapeutic potential of Ph-glu-Oxa was confirmed in oxaliplatin-resistant xenograft model demonstrating the reversibility of the drug resistance by the new complex and the efficacy was associated with the unimpaired high intracellular drug accumulation in HT29/Oxa.
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5 which guarantees rapid endosomal escape and faster intracellular drug release.
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The MDR phenotype is often linked to the overexpression of ATP-binding cassette (ABC) transporters, that pumps out and decreased intracellular drug accumulation.
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Using this qSCMS system, quantitative analysis of the intracellular drug gemcitabine present in individual bladder cancer cells is reported, including in bladder cancer cells isolated from patients undergoing standard-of-care gemcitabine chemotherapy.
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The fundamental causes of multidrug resistance (MDR) have been studied for decades, and can be generally classified into two types: one is associated with the activation of diverse drug efflux pumps, which are responsible for translocating intracellular drug molecules out of the cells; the other is linked with some non-efflux pump-related mechanisms, such as antiapoptotic defense, enhanced DNA repair ability, and powerful antioxidant systems.
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Intracellular drug metabolism involves transport, bioactivation, conjugation, and other biochemical steps.
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The failure of chemotherapy in HCC patients is partly due to inadequate intracellular drug accumulation caused by abnormally expressed drug transporters.
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The intracellular drug accumulation study revealed that the intracellular DDP concentration in the DDP/OA‐Nsi group was also higher than that in free DDP and DDP‐Nsi groups.
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Therefore, the in vitro cytotoxicity of SS-linked CPT-OA NAs could not be ascribed to the glutathione-trigged intracellular drug release but rather to the SS-accelerated extracellular CPT release.
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Our findings further suggest that many naturally evolved genes involved in resistance to multiple classes of antibiotics may increase intracellular drug concentrations to modulate their own expression, acting as a form of regulatory feedback.
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Chemotherapy efficiency of platinum(II) (Pt(II)) is often attenuated owing to the low intracellular drugs concentration and glutathione (GSH)-mediated detoxification.
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This review highlights current strategies for intracellular drug targeting which includes the use of small molecules, peptides, and pH sensitive liposomes and other nanoformulations.
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In order to understand related pathogenesis of some diseases and design new intracellular drug delivery systems, investigation of pH change in living cells in real time is important.
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This work has provided a facile microwave-assisted fabrication of ChrGO as a controlled and targeted intracellular drug delivery nanosystem, which is expected to be a novel promising therapy for treating HER2-overexpressing breast cancer cells.
Full Text
Acid-responsive degradable nanoassemblies self-assembled from amphiphilic block copolymers with acid-labile linkages have been extensively explored as effective intracellular drug delivery vehicles for chemotherapy.
Full Text