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Two Independent Randomized

We investigated cross-domain effects in two independent randomized-controlled samples, receiving either PMTO or BPT, which differed with regard to treatment mode, intensity, and target groups.

Parent training: Effects beyond conduct problems

Two Independent Randomized

Methods Genomic DNA from blood samples of patients enrolled in two independent randomized phase III trials, TRIBE and FIRE-3, was genotyped through the OncoArray, a custom array manufactured by Illumina, including approximately 530K SNP markers.

Genetic variants in the one-carbon metabolism pathway to predict outcome in patients with metastatic colorectal cancer (mCRC): Data from TRIBE and FIRE-3 phase III trials

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independent randomized controlled

Here we show—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.

GDF15 mediates the effects of metformin on body weight and energy balance

independent randomized controlled

This study consisted of secondary data analysis of information collected from inmates who had participated in an earlier independent randomized controlled trial testing the effects of the Growing Pro-Social (GPS) program.

Personality Pathology Profiles as Moderators of the Growing Pro-Social Program: Outcomes on Cognitive, Emotion, and Behavior Regulation in Male Prison Inmates.

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independent randomized clinical

Methods and Results Genome‐wide association analysis for systolic BP and diastolic BP response to β1‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with P<10−4 were tested for replication in 2 independent randomized clinical trials of β1‐blocker–treated patients of European ancestry (n=1552).

Genome‐Wide Meta‐Analysis of Blood Pressure Response to β1‐Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies)

independent randomized clinical

Accordingly, investigators of FOCUS deserved commendations: this independent randomized clinical trial, which recruited 3,127 patients from 103 hospitals in the UK with a follow-up of 6–12 months, failed to demonstrate any benefit of fluoxetine after acute stroke [7].

Meta-Analyses and the Janus Effect

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10.1016/J.PMIP.2019.03.001

Independent randomized sham-controlled trials and meta- and mega-analyses demonstrate that tDCS targeted to the left dorsolateral prefrontal cortex can produce a clinically meaningful response in patients with major depressive disorder (MDD), but effects are small to moderate in size.

A review of transcranial direct current stimulation (tDCS) for the individualized treatment of depressive symptoms.

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10.1016/J.CHILDYOUTH.2019.03.009

We investigated cross-domain effects in two independent randomized-controlled samples, receiving either PMTO or BPT, which differed with regard to treatment mode, intensity, and target groups.

Parent training: Effects beyond conduct problems

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10.1093/annonc/mdz268.007

Methods Genomic DNA from blood samples of patients enrolled in two independent randomized phase III trials, TRIBE and FIRE-3, was genotyped through the OncoArray, a custom array manufactured by Illumina, including approximately 530K SNP markers.

Genetic variants in the one-carbon metabolism pathway to predict outcome in patients with metastatic colorectal cancer (mCRC): Data from TRIBE and FIRE-3 phase III trials

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10.1200/JCO.2019.37.4_SUPPL.566

Methods: The impact on outcome of 21 selected SNPs within 13 genes (TERT, TERC, CLPTM1L, TERF1/2, POT1, ACD, NOP10, NHP2, GAR1, STN1, CTC1) was analyzed through the OncoArray, a custom array manufactured by Illumina, on genomic DNA from blood samples of 451 pts enrolled in two independent randomized trials.

Polymorphisms in the telomerase complex to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from TRIBE and FIRE-3 phase III trials.

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10.26355/eurrev_201912_19657

RESULTS In this meta-analysis, 231 patients with acute mesenteric ischemic disease and 651 patients in the control group in 8 independent randomized case-control studies were enrolled.

Evaluation of the diagnostic value of multi-slice spiral CT in acute mesenteric ischemic diseases: a meta-analysis of randomized controlled trials.

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10.1038/s41586-019-1911-y

Here we show—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor.

GDF15 mediates the effects of metformin on body weight and energy balance

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10.1161/JAHA.119.013115

Methods and Results Genome‐wide association analysis for systolic BP and diastolic BP response to β1‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with P<10−4 were tested for replication in 2 independent randomized clinical trials of β1‐blocker–treated patients of European ancestry (n=1552).

Genome‐Wide Meta‐Analysis of Blood Pressure Response to β1‐Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies)

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10.1521/pedi_2019_33_424

This study consisted of secondary data analysis of information collected from inmates who had participated in an earlier independent randomized controlled trial testing the effects of the Growing Pro-Social (GPS) program.

Personality Pathology Profiles as Moderators of the Growing Pro-Social Program: Outcomes on Cognitive, Emotion, and Behavior Regulation in Male Prison Inmates.

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10.1159/000504201

Accordingly, investigators of FOCUS deserved commendations: this independent randomized clinical trial, which recruited 3,127 patients from 103 hospitals in the UK with a follow-up of 6–12 months, failed to demonstrate any benefit of fluoxetine after acute stroke [7].

Meta-Analyses and the Janus Effect

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10.1186/s13063-019-3189-7

DiscussionHECTO-AF is an independent randomized study aiming to detect the incidence of silent AF in all-comers hospitalized in general medicine wards.

Handheld ECG Tracking of in-hOspital Atrial Fibrillation The HECTO-AF trial Clinical Study Protocol

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10.1016/j.copsyc.2019.01.006

We outline how these challenges can be addressed in future studies using the example of an ongoing project, Medit-Ageing (public name: Silver Santé Study), including two independent randomized controlled trials (RCT) as well as one cross-sectional study with meditation experts.

The impact of meditation on healthy ageing - the current state of knowledge and a roadmap to future directions.

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10.1016/j.wneu.2019.10.024

BACKGROUND and Importance: Several independent randomized control trials have shown the superior efficacy of mechanical thrombectomy for acute ischemic stroke (AIS).

Mechanical Thrombectomy in Acute Ischemic Stroke Patients Greater than 90 years of age experience in 26 patients in a Large Tertiary Care Center: Outcome comparison with younger patients.

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10.1177/1352458519849513

Methods: Data from two independent randomized controlled trials (RCTs) were used to build and validate an individual treatment response (ITR) score, regressing annualized relapse rates (ARRs) on a set of baseline predictors.

A proof-of-concept application of a novel scoring approach for personalized medicine in multiple sclerosis

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Independent Randomized - Independent randomized sham-controlled trials and meta- and mega-analyses demonstrate that tDCS targeted to the left dorsolateral prefrontal cortex can produce a clinically meaningful response in patients with major depressive disorder (MDD), but effects are small to moderate in size. [1] We investigated cross-domain effects in two independent randomized-controlled samples, receiving either PMTO or BPT, which differed with regard to treatment mode, intensity, and target groups. [2] Methods Genomic DNA from blood samples of patients enrolled in two independent randomized phase III trials, TRIBE and FIRE-3, was genotyped through the OncoArray, a custom array manufactured by Illumina, including approximately 530K SNP markers. [3] Methods: The impact on outcome of 21 selected SNPs within 13 genes (TERT, TERC, CLPTM1L, TERF1/2, POT1, ACD, NOP10, NHP2, GAR1, STN1, CTC1) was analyzed through the OncoArray, a custom array manufactured by Illumina, on genomic DNA from blood samples of 451 pts enrolled in two independent randomized trials. [4] RESULTS In this meta-analysis, 231 patients with acute mesenteric ischemic disease and 651 patients in the control group in 8 independent randomized case-control studies were enrolled. [5] Here we show—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor. [6] Methods and Results Genome‐wide association analysis for systolic BP and diastolic BP response to β1‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with P<10−4 were tested for replication in 2 independent randomized clinical trials of β1‐blocker–treated patients of European ancestry (n=1552). [7] This study consisted of secondary data analysis of information collected from inmates who had participated in an earlier independent randomized controlled trial testing the effects of the Growing Pro-Social (GPS) program. [8] Accordingly, investigators of FOCUS deserved commendations: this independent randomized clinical trial, which recruited 3,127 patients from 103 hospitals in the UK with a follow-up of 6–12 months, failed to demonstrate any benefit of fluoxetine after acute stroke [7]. [9] DiscussionHECTO-AF is an independent randomized study aiming to detect the incidence of silent AF in all-comers hospitalized in general medicine wards. [10] We outline how these challenges can be addressed in future studies using the example of an ongoing project, Medit-Ageing (public name: Silver Santé Study), including two independent randomized controlled trials (RCT) as well as one cross-sectional study with meditation experts. [11] BACKGROUND and Importance: Several independent randomized control trials have shown the superior efficacy of mechanical thrombectomy for acute ischemic stroke (AIS). [12] Methods: Data from two independent randomized controlled trials (RCTs) were used to build and validate an individual treatment response (ITR) score, regressing annualized relapse rates (ARRs) on a set of baseline predictors. [13]

Two Independent Randomized

We investigated cross-domain effects in two independent randomized-controlled samples, receiving either PMTO or BPT, which differed with regard to treatment mode, intensity, and target groups. [1] Methods Genomic DNA from blood samples of patients enrolled in two independent randomized phase III trials, TRIBE and FIRE-3, was genotyped through the OncoArray, a custom array manufactured by Illumina, including approximately 530K SNP markers. [2] Methods: The impact on outcome of 21 selected SNPs within 13 genes (TERT, TERC, CLPTM1L, TERF1/2, POT1, ACD, NOP10, NHP2, GAR1, STN1, CTC1) was analyzed through the OncoArray, a custom array manufactured by Illumina, on genomic DNA from blood samples of 451 pts enrolled in two independent randomized trials. [3] Here we show—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor. [4] We outline how these challenges can be addressed in future studies using the example of an ongoing project, Medit-Ageing (public name: Silver Santé Study), including two independent randomized controlled trials (RCT) as well as one cross-sectional study with meditation experts. [5] Methods: Data from two independent randomized controlled trials (RCTs) were used to build and validate an individual treatment response (ITR) score, regressing annualized relapse rates (ARRs) on a set of baseline predictors. [6]

independent randomized controlled

Here we show—in two independent randomized controlled clinical trials—that metformin increases circulating levels of the peptide hormone growth/differentiation factor 15 (GDF15), which has been shown to reduce food intake and lower body weight through a brain-stem-restricted receptor. [1] This study consisted of secondary data analysis of information collected from inmates who had participated in an earlier independent randomized controlled trial testing the effects of the Growing Pro-Social (GPS) program. [2] We outline how these challenges can be addressed in future studies using the example of an ongoing project, Medit-Ageing (public name: Silver Santé Study), including two independent randomized controlled trials (RCT) as well as one cross-sectional study with meditation experts. [3] Methods: Data from two independent randomized controlled trials (RCTs) were used to build and validate an individual treatment response (ITR) score, regressing annualized relapse rates (ARRs) on a set of baseline predictors. [4]

independent randomized clinical

Methods and Results Genome‐wide association analysis for systolic BP and diastolic BP response to β1‐blockers from 5 randomized clinical trials consisting of 1254 patients with hypertension of European ancestry were combined in meta‐analysis and single nucleotide polymorphisms (SNPs) with P<10−4 were tested for replication in 2 independent randomized clinical trials of β1‐blocker–treated patients of European ancestry (n=1552). [1] Accordingly, investigators of FOCUS deserved commendations: this independent randomized clinical trial, which recruited 3,127 patients from 103 hospitals in the UK with a follow-up of 6–12 months, failed to demonstrate any benefit of fluoxetine after acute stroke [7]. [2]