Introduction to Incomplete Response

Corticosteroids are the mainstay of therapy, but because of an incomplete response and the need for long-term treatment, corticosteroid sparing agents are often associated.

The progression-free survival (PFS) and overall survival (OS) were compared between patients with complete and incomplete responses, before and after a one-to-one propensity score-matching (PSM), and between patients in whom repeated ablation or TACE was performed after a first attempt incomplete ablation.

02) and incomplete response to treatment (HR 4.

This study aimed to evaluate the effects of obeticholic acid (OCA) on categorical shifts in GLOBE score, APRI, and both combined, based on data from POISE, a phase III placebo-controlled trial in patients with PBC who had an incomplete response or were intolerant to ursodeoxycholic acid.

Incomplete responses and notes showed limitations of the instruments in this population.

Moreover, AILD patients may have a poor prognosis, especially those with an incomplete response to first-line treatment.

Although the authors demonstrated that metabolic parameters could be used to distinguish patients with incomplete responses, a few points need to be clarified.

In the follow-up, C4d negative group had also a greater number with partial/incomplete response compared to the C4d positive group.

This study excludes 36 responses for further analyzes due to incomplete responses (five responses) and responses from lower-level employees (31 responses).

Due to incomplete response to wound care and oral prednisolone, treatment with infliximab was initiated.

Results Cases with incomplete response presented higher STg level [225.

1%), and an incomplete response in 14 (60.

Incomplete response was significantly associated with older age, lower PD-L1 expression (tumor and stroma), lower levels of CD8-positive TILs in stroma, but higher level of CD163-positive macrophages, with the level of CD163-positive M2 macrophages in peritumoral area as the strongest factor.

However, the variant sensitivity and incomplete response to DZNep are very common in different AML cell lines as well as primary leukemia cells from AML patients.

The poor survival rate stems from incomplete response to NAC and the lack of alternative tailored therapy against the chemo-resistant disease that recurs.

Incomplete response is associated with a greater risk of metastatic progression.

Surgeons were more accurate in identifying patients with a complete response (82%) than in identifying patients with an incomplete response (68%).

The independent predictors of incomplete response were evaluated with multivariable regression analysis.

45% of patients were on anti-reflux medications at the time of study and had incomplete response to treatment for reflux.

Despite favorable results of CAR T-cell therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), several challenges remain, including incomplete response, immune-mediated toxicity, and antigen-loss relapse.

The results showed that the level of students with moderate initial statistical thinking abilities was at level 2: Transitional, in which students tried to present their ideas through quantitative and subjective thinking, indicated by naive thinking, hesitant, incomplete responses in counting, and only focus on one aspect of the data display.

Patients with MA have an incomplete response even to high doses of anti-cytokine drugs as anakinra or canakinumab and stem cell transplantation (SCT) represents a possible therapy for this severe disease.

Results Out of 384 participants, three hundred and four participants were included in the final analyses after the exclusion of incomplete responses.

RESULTS Strong recommendations are made for using EBRT as a potential first-line treatment in patients with liver-confined HCC who are not candidates for curative therapy, consolidative therapy after incomplete response to liver-directed therapies, and as a salvage option for local recurrences.

In patients with incomplete response additionally ICS were given (12 weeks).

While the majority of patients with advanced testicular germ cell tumors (GCT) achieve complete responses after chemotherapy and if indicated after postchemotherapy resection of residual lesions, about 20% of patients have incomplete responses or show relapses.

The proliferation of MCF-7/Akt cells is partially independent of estradiol (E2) and exhibits an incomplete response to the anti-estrogen agent 4-hydroxytamoxifen, demonstrating the resistance of these cells to hormone therapy.

Baseline gMTV, gTLG, tMTV, and TLG were significantly higher in patients with incomplete response (partial response and progression) compared to complete response group.

This involved an evaluation of 16 statements, which means considerable survey time and cost, particularly if administered by a third party, as well as cognitive burden on respondents, increasing the chance of incomplete responses.

0 months) in the incomplete response group (p =.

In this paper we describe the evolution of three recipients treated with long-term plasmapheresis therapy after a recurrence of FSGS with a bad or incomplete response to other treatments.

All patients had incomplete response to amiodarone, lidocaine or overdrive pacing, before being proposed to catheter ablation.

Typically, incomplete response caused by right-censoring and covariate measurement error are often accompanying with survival analysis.

Response to RRA were evaluated as complete response (including excellent and indeterminate response) and incomplete response (including biochemical and structural incomplete response) after a follow-up of 6–8 months.

As the authors observed, the discrepancy in defining response outcome (optimal response, incomplete response, and none response) between the two radiologists occurred in 12 cases (18.

In a realworldexperience study, over half of patients with AIH who used calcineurin inhibitor as secondline/thirdline therapy (due to azathioprine/steroid intolerance or incomplete response) achieved normalization of serum aminotransferases.

In a clinical cohort of 127 rectal patients, using a validated mRNA signature, higher baseline NRF2 signalling was associated with incomplete responses to radiation higher final neoadjuvant rectal (NAR) score (OR 1.

We report a case with rare complication of cerebral venous thrombosis, as well as an incomplete response, after sigmoid sinus resurfacing surgery for pulsatile tinnitus (PT).

Preliminary data suggests that cycling through Jaki in patients with incomplete response to initial Jaki treatment may be an appropriate strategy.

Results: Total of 542 responses were received and 23 were excluded due to incomplete responses.

Data from the MyoCite registry (Dec2017–May2020), a prospective dataset of IIM was extracted for the clinical profile, and MSAs, immunosuppressants received, disease activity (relapses and incomplete response), and treatment-related (drugs ADRs and infections) adverse events (DRAE and TRAE) were collected and analyzed between groups.

After 6-8 months, response to RAI was evaluated as complete response (excellent response) and incomplete response (indeterminate, biochemical, and structural incomplete response).

RESULTS Of 655 screened parents, 162 had no minor children, 43 had incomplete responses or failed an attention check question.

One-way sensitivity analyses were conducted to individually investigate the effect of (i) lower complete response (CR) rates of olanzapine, closer to non-olanzapine-containing regimens; (ii) higher FLIE scores for patients who achieved no/incomplete response, closer to FLIE scores of patients achieving a complete response; (iii) differing costs of olanzapine to reflect different costs per hospitals, globally, due to different insurance systems and drug costs; and (iv) varying costs for uncontrolled CINV, to account for varying durations of chemotherapy and accompanying uncontrolled CINV.

A 4-week follow-up contrast enhanced CT showed an incomplete response.

Additionally, discuss the possible causes of HCC after NAs therapy, including the types of drugs, treatment timing, incomplete response, etc.

This nursing home is in Miami and a total of 40 participants were used in the data collection, though two were later omitted due to incomplete responses.

EBRT can be considered for HCC patients ineligible for resection, LT, RFA, PEIT, or TACE; show incomplete response to TACE; with portal vein invasion when the dose-volume criteria are met; and to alleviate symptoms.

Hence, the presence of atypical clinical and radiologic manifestations and incomplete responses, despite receiving adequate antimicrobial treatment, should raise concerns regarding the combined emerging and re-emerging opportunistic infections and the possibility of unusual radiologic manifestations of cryptococcosis in a ruxolitinib-treated patient.

Incomplete response to initial LDT was associated with tumor progression precluding liver transplantation (OR: 7.

After excluding duplicates as well as participants with missing or incomplete responses, we had data from 2386 participants (1183 autistic and 1203 non-autistic participants; 1571 female and 815 male participants) for the quantitative analyses and data from 919 participants (429 autistic and 490 non-autistic participants; 569 female and 350 male participants) in the qualitative analyses.

Methods: HR-NB patients with primary refractory disease or incomplete response to salvage treatment following relapse or progressive disease (PD) (in both cases including SD, MR and PR) with disease limited to bone and/or BM were eligible.

Importance Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown.

Conversely, EPF should be considered in cases of demodicosis with incomplete responses to antiparasitic treatment.

A total of 400 respondents participated in a self-administered survey, of which 375 questionnaires were retained after discarding questionnaires with incomplete responses.

However, studies have seen no significant difference in tumor recurrence, and instances of incomplete response have been attributable to the larger size of the tumor, irrespective of location [3].

Acne therapeutic options such as topical or systemic antimicrobial treatments often show incomplete responses.

Serial TgAb levels, excellent response (ER), incomplete response (IR), and anatomical recurrence were evaluated.

The proposed method was an improvement method based on the time domain substructural identification method, which can identify the damage with a reduced structural model, and explicit force identification method, which can give convergent force identification result with incomplete response measurements, and it can assess one or more target substructures without knowing the conditions of the other parts of the structure.

However, many patients suffer from incomplete response to anti-VEGF therapy (IRT), which is defined as (1) persistent (plasma) fluid exudation; (2) unresolved or new hemorrhage; (3) progressive lesion fibrosis; and/or (4) suboptimal vision recovery.

Given his history of incomplete response with medication, his severe depression, and his high suicide risk, aggressive treatment was warranted.

The MES is easy, simple, and practical but is suboptimal at providing an accurate depiction of segmental healing and/or at measuring a substantial but incomplete response across the spectrum of endoscopic inflammation.

Preliminary data suggests that cycling through Jaki in patients with incomplete response to initial Jaki treatment may be an appropriate strategy.

Of the patients with incomplete response, ypT+N+ patients (32% of total population) had the lowest estimated 5-year OS rate, followed by ypT0N+ and ypT+ N0 (22%, 47%, and 49%, respectively, p<.

Objective This work aims to study the natural course and predictive factors of incomplete response to therapy in low- and intermediate-risk DTC.

Of the 23 patients managed by a WW strategy after SCRT-TNT completion, 19 had a clinical complete response (cCR), 3 had a near-CR, and 1 had an incomplete response.

Due to delay in initiating treatment efficacy and the incomplete response to mono-drug therapy in one-third of patients, new approaches need to be considered.

2 µg/dL, consistent with incomplete response attributed to the supraphysiologic dexamethasone versus chronic ICS.

PURPOSE The beta-blocker propranolol is the standard medical therapy for subglottic hemangioma (SGH), but side effects and incomplete response rates require close monitoring.

Ketoacidosis relapsed 2 years later, and the patient showed an incomplete response to glucocorticoids.

CZP was discontinued in 15 patients due to remission (n=2), ocular insufficient response (2) and incomplete response of extraocular manifestations (11).

Since then, several case reports and pilot studies have demonstrated the efficacy of fibrates in reducing serum biomarkers of cholestasis in patients with incomplete response to ursodeoxycholic acid(UDCA)monotherapy.

Those with incomplete response or with absent naïve B-cells should be retreated at 6 months.

Although achieving these criteria may be associated with improved clinical outcomes, the benefit in patients (pts) with an incomplete response to treatment may be underestimated.

Incomplete response occurred in 10/36 (27.

This may be attributed to an incomplete response of IRF3 in activating the IFN-β promoter in the infected patients.

0%) achieved total necrosis with better RFS compared with patients who had an incomplete response to TACE (P=0.

A total of 594 questionnaires were collected and 566 (269 from males, 297 from females) were statistically analyzed, except 28 with incomplete responses.

One-year after first RAIT, 146/276 (53%) patients had excellent response, 37/276 (14%) indeterminate response, and 91/276 (33%) incomplete response.

Because of her strong family history and incomplete response to oral hypoglycemic agents, additional testing was performed.

About 10 to 15% of patients treated with R-CHOP have primary refractory disease (an incomplete response or a relapse within six months after completing treatment) and an additional 20 to 25% will relapse after an initial response, typically within the first two years [2].

This retrospective study examines the utility of a repeat PET/CT scan in HNSCC patients following an incomplete response on initial post-treatment imaging.

However, approximately 25% of patients show an incomplete response to chemotherapy or tumours relapse.

Lingual tonsillectomy may be an alternative treatment strategy in select patients with PFAPA, prominent lingual hypertrophy, and incomplete response to steroids.

Thus, we aimed at identifying possible risk factors associated with an incomplete response to therapy in TMC.

We aimed to report clinical outcomes in Chinese patients with low/intermediate risk of recurrence DTC after long‐term follow‐up, and evaluate the risk factors that influence the presence or absence of incomplete response at the final follow‐up.

A total of 26 responses were collected from all participants in the workshop (incomplete responses were not considered).

Pancreatic ductal adenocarcinoma (PDAC) is associated with poor clinical outcomes, largely attributed to incomplete responses to standard therapeutic approaches.

She received pulse and oral steroids (methylprednisolone 1 g for three days and prednisolone 1 mg/kg/d) along with azathioprine (2 mg/kg/d), as standard treatment for the pemphigus, with incomplete response at 6 weeks.