Introduction to Imprinted Nanoparticles

What is/are Imprinted Nanoparticles?

Imprinted Nanoparticles - This work was aimed at preparing electrospun poly (l-lactide-co-D, l-lactide) (PLDLLA) containing multi-walled carbon nanotubes (MWCNTs) and 4-aminopyridine (4-AP)-loaded molecularly imprinted nanoparticles (MIP4-AP) as well as evaluating their performance in in vitro and in vivo assessments. ^[1] The surface characterization of imprinted nanoparticles indicated that a thin polymer layer was grafted on the silica nanoparticles. ^[2] Magnetic solid-phase extraction (MSPE) based on molecularly imprinted nanoparticles (MINs) has attracted wide attention in sample pretreatment because it combines the merits of high selectivity and quick extraction procedures. ^[3] To verify the feasibility of this approach, we selected a typical phosphoprotein lysozyme (Lys) as template and magnetic TiO2 as substrate to prepare the molecularly imprinted nanoparticles (denoted as Fe3O4@TiO2@Lys MIPs). ^[4] Finally, the imprinted nanoparticles were used to extract dCas9 from transfected cell homogenates. ^[5] An innovative approach to imprinted nanoparticles (nanoMIPs) is represented by solid-phase synthesis. ^[6] Molecularly imprinted nanoparticles were eletrodeposited on gold coated quartz crystal electrode of electrochemical quartz crystal microbalance (EQCM). ^[7] After in silico analysis, imprinted nanoparticles were synthesized by inverse microemulsion polymerization and their ability to prevent the interaction between ACE2 and the receptor-binding domain of SARS-CoV-2 was investigated. ^[8] In this work, we designed and synthesized the Gal-NAc-imprinted nanoparticles (GIPs) via boronate-affinity glycan-oriented surface imprinting strategy. ^[9] Dual-fluorescent molecularly imprinted nanoparticles with a red-emissive carbon nanodot-doped silica core and a chlorogenic acid-imprinted fluorescent polymer layer are prepared and their use in ratiometric fluorometric analysis is described. ^[10] In this paper, computer simulation was used to assist in the rapid preparation of Myclobutanil (MYC) molecularly imprinted nanoparticles (MYC-MINs), which involved screening the best functional monomers and solvents, determining the optimal polymerization ratio, and estimating the MYC-2-(Trifluoromethyl)acrylic acid (MYC-TFMAA) self-assembly process and its infrared spectrum. ^[11] Herein, a cost-efficient and easy-to-use approach, which called dual molecular imprinting immunosandwich colorimetric strategy (DMI-ICS) was constructed for detection alpha-2-macroglobulin (α2MG) by janus imprinted nanoparticles. ^[12] Imprinted nanoparticles present several advantages respect to bulk imprinted materials, but, when prepared by traditional methods, their usefulness is limited as the approaches are costly or require complex optimization steps, while the purification from template molecules is challenging. ^[13] Here, an abiotic mimic based on molecularly imprinted nanoparticles has been designed as an inhibitor for MMP-9. ^[14] This paper describes a low-cost, easy-to-use method for the detection of Pseudomonas aeruginosa infections by specifically identifying a biomarker pyocyanin, using surface-molecularly imprinted nanoparticles or "plastibodies". ^[15] In this study, the patulin imprinted and the non-imprinted nanoparticles are synthesized by the two-phase mini emulsion polymerization method and characterized by zeta-size analysis, Fourier transform infrared spectroscopy, and scanning electron microscopy. ^[16] The double-mesoporous-layer imprinted polymer of mesoporous silica/mesoporous molecularly imprinted nanoparticles (MIP), with high specific surface area, rich porosity, excellent mass transfer rate and selectivity, were synthesized using imidacloprid (IDP) as a template. ^[17] Imprinted nanoparticles with an average diameter between 0. ^[18] Most molecularly imprinted nanoparticles (MIP-NPs) are currently made of soft matter, such as polyacrylamide and derivatives. ^[19] A novel molecularly imprinted fluorescent optical fiber sensor (MIFOFS) by merging the optical fiber sensor and replaceable molecularly imprinted nanoparticles composite polyethyleneglycol diacrylate hydrogel (MINs@PEGDA) detector was fabricated for rapid and highly selective detection of antibiotics. ^[20] The iron-imprinted nanoparticles were prepared by using functional monomer N-methacryloyl-l-glutamic acid (MAGA) and comonomer 2-hydroxyethyl methacrylate by mini-emulsion polymerization techniques. ^[21] The imprinted nanoparticles with the size of 86. ^[22] Here, we show the application of molecularly imprinted nanoparticles (nanoMIPs) against an extracellular epitope of one of these markers, B2M, to detect senescent cells in vitro and in vivo. ^[23] The results of RLS analysis proved that the obtained imprinted nanoparticles exhibited excellent specific recognition ability and high selectivity for the template virus (JEV). ^[24] To demonstrate the viability of the approach, two types of nanoparticles - inorganic silica nanoparticles and organic molecularly imprinted nanoparticles functionalized with boronic acid on their surface - were used as models. ^[25] Molecularly imprinted nanoparticles (nanoMIPs) represents more robust and cost-effective alternative to antibodies. ^[26] Herein, we describe the use of molecularly imprinted nanoparticles (nanoMIPs) as sequestering (masking) agents, to suppress the signal coming from interfering molecules and facilitate the detection of the target analyte. ^[27] In present work, molecularly imprinted nanoparticles (MINPs) were applied as selective adsorbent for ultrasound-assisted micro-solid phase extraction (UAMSPE) of doxepin (DP) from human plasma samples followed by high performance liquid chromatography (HPLC). ^[28] To date, no molecular imprinted nanoparticles has been integrated with optical microwire platform in the literature. ^[29] Hb was concentrated and immobilized with magnetic molecularly imprinted nanoparticles (MMIPs NPs). ^[30] For the first time the degradation of N-l-hexanoyl homoserine lactone (C6-AHL), a Gram-negative quorum sensing autoinducer, has been enhanced using molecularly imprinted nanoparticles (MIP NPs) which were prepared using transition state analogue of the γ-lactone ring hydrolysis as template. ^[31] First, HSA-imprinted nanoparticles were synthesized, which consist of ethylene glycol dimethacrylate and N-methacryloyl-L-leucine methyl ester as a cross-linker and functional monomer. ^[32] To address the shortcomings of the existing glycoprotein assays, we propose a new approach using protein-imprinted nanoparticles to replace the traditional lectins and antibodies. ^[33] Extremely strong imprinting effects were consistently observed, with the imprinting factor >100:1 in comparison to nonimprinted nanoparticles prepared without the templates. ^[34] MethodsMolecular imprinted nanoparticles were prepared by precipitation polymerization technique using 1:4:20 mmol ratio of the template, functional monomer, and cross-linker, respectively, as well as 80 mL of chloroform as progen solvent. ^[35] With inspiration from highly specific protein-protein and protein-ligand interactions, protein-sized, water-soluble imprinted nanoparticles were prepared via templated polymerization of peptides within cross-linked micelles. ^[36] Surface‐core double cross‐linking of template‐containing surfactant micelles by the click reaction and free radical polymerization yields molecularly imprinted nanoparticles (MINPs) with guest‐complementary binding sites. ^[37] The PANI layer was subsequently coated with an ion-selective membrane (ISM) containing uniform-sized molecularly imprinted nanoparticles to produce a solid-contact ion-selective electrode (SC/ISE) for bispyribac herbicide (sensor I). ^[38] Magnetic molecularly imprinted nanoparticles (NPs) of type Fe3O4@SiO2 were prepared via surface imprinting with CAP. ^[39] Imprinted nanoparticles were electropolymerized on gold coated quartz electrode. ^[40] Here, we demonstrate a novel strategy for the controlled synthesis of PEGylated surface protein-imprinted nanoparticles with reduced nonspecific binding, which is based on sequential two steps of surface-initiated reversible addition-fragmentation chain transfer aqueous precipitation polymerization (SI-RAFT APP). ^[41] Graphene quantum dots (GQDs) were immobilized on molecularly imprinted nanoparticles which then were placed on nitrocellulose paper. ^[42] This assay relies on fluorescent molecularly imprinted nanoparticles (nanoMIPs) which, upon interaction with the target analytes, generate a reduction in fluorescence emission intensity (quenching). ^[43] In this work, glycoprotein imprinted nanoparticles (SiO2-MIPs) based on multi-boronic acid sites are prepared via surface imprinting processes. ^[44] The selective electrochemical determination of casein from bovine milk (consisting of α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein) was developed based on magnetic molecularly imprinted nanoparticles (MMIPs) modified on the carbon paste electrode. ^[45] The adsorption, recognition and reusability of the molecularly imprinted nanoparticles were analyzed by static/dynamic adsorption, competitive adsorption and reproducibility experiment. ^[46] The imprinted nanoparticles were applied to the analysis of rice and wheat samples spiked with both herbicides. ^[47] When performed within cross-linked micelles, the resulting molecularly imprinted nanoparticles (MINPs) exhibited an extraordinary ability to distinguish subtle structural changes in the guest, including the shift of a hydrophilic or hydrophobic group by 1 carbon and addition of a single methylene/methyl group. ^[48] Experimental results confirmed the GDMI-NPs has hardly retained in liver and spleen tissue, and its circulated time was longer than that of non-imprinted nanoparticles in blood. ^[49]

Molecularly Imprinted Nanoparticles

This work was aimed at preparing electrospun poly (l-lactide-co-D, l-lactide) (PLDLLA) containing multi-walled carbon nanotubes (MWCNTs) and 4-aminopyridine (4-AP)-loaded molecularly imprinted nanoparticles (MIP4-AP) as well as evaluating their performance in in vitro and in vivo assessments. ^[1] Magnetic solid-phase extraction (MSPE) based on molecularly imprinted nanoparticles (MINs) has attracted wide attention in sample pretreatment because it combines the merits of high selectivity and quick extraction procedures. ^[2] To verify the feasibility of this approach, we selected a typical phosphoprotein lysozyme (Lys) as template and magnetic TiO2 as substrate to prepare the molecularly imprinted nanoparticles (denoted as Fe3O4@TiO2@Lys MIPs). ^[3] Molecularly imprinted nanoparticles were eletrodeposited on gold coated quartz crystal electrode of electrochemical quartz crystal microbalance (EQCM). ^[4] Dual-fluorescent molecularly imprinted nanoparticles with a red-emissive carbon nanodot-doped silica core and a chlorogenic acid-imprinted fluorescent polymer layer are prepared and their use in ratiometric fluorometric analysis is described. ^[5] In this paper, computer simulation was used to assist in the rapid preparation of Myclobutanil (MYC) molecularly imprinted nanoparticles (MYC-MINs), which involved screening the best functional monomers and solvents, determining the optimal polymerization ratio, and estimating the MYC-2-(Trifluoromethyl)acrylic acid (MYC-TFMAA) self-assembly process and its infrared spectrum. ^[6] Here, an abiotic mimic based on molecularly imprinted nanoparticles has been designed as an inhibitor for MMP-9. ^[7] This paper describes a low-cost, easy-to-use method for the detection of Pseudomonas aeruginosa infections by specifically identifying a biomarker pyocyanin, using surface-molecularly imprinted nanoparticles or "plastibodies". ^[8] The double-mesoporous-layer imprinted polymer of mesoporous silica/mesoporous molecularly imprinted nanoparticles (MIP), with high specific surface area, rich porosity, excellent mass transfer rate and selectivity, were synthesized using imidacloprid (IDP) as a template. ^[9] Most molecularly imprinted nanoparticles (MIP-NPs) are currently made of soft matter, such as polyacrylamide and derivatives. ^[10] A novel molecularly imprinted fluorescent optical fiber sensor (MIFOFS) by merging the optical fiber sensor and replaceable molecularly imprinted nanoparticles composite polyethyleneglycol diacrylate hydrogel (MINs@PEGDA) detector was fabricated for rapid and highly selective detection of antibiotics. ^[11] Here, we show the application of molecularly imprinted nanoparticles (nanoMIPs) against an extracellular epitope of one of these markers, B2M, to detect senescent cells in vitro and in vivo. ^[12] To demonstrate the viability of the approach, two types of nanoparticles - inorganic silica nanoparticles and organic molecularly imprinted nanoparticles functionalized with boronic acid on their surface - were used as models. ^[13] Molecularly imprinted nanoparticles (nanoMIPs) represents more robust and cost-effective alternative to antibodies. ^[14] Herein, we describe the use of molecularly imprinted nanoparticles (nanoMIPs) as sequestering (masking) agents, to suppress the signal coming from interfering molecules and facilitate the detection of the target analyte. ^[15] In present work, molecularly imprinted nanoparticles (MINPs) were applied as selective adsorbent for ultrasound-assisted micro-solid phase extraction (UAMSPE) of doxepin (DP) from human plasma samples followed by high performance liquid chromatography (HPLC). ^[16] Hb was concentrated and immobilized with magnetic molecularly imprinted nanoparticles (MMIPs NPs). ^[17] For the first time the degradation of N-l-hexanoyl homoserine lactone (C6-AHL), a Gram-negative quorum sensing autoinducer, has been enhanced using molecularly imprinted nanoparticles (MIP NPs) which were prepared using transition state analogue of the γ-lactone ring hydrolysis as template. ^[18] Surface‐core double cross‐linking of template‐containing surfactant micelles by the click reaction and free radical polymerization yields molecularly imprinted nanoparticles (MINPs) with guest‐complementary binding sites. ^[19] The PANI layer was subsequently coated with an ion-selective membrane (ISM) containing uniform-sized molecularly imprinted nanoparticles to produce a solid-contact ion-selective electrode (SC/ISE) for bispyribac herbicide (sensor I). ^[20] Magnetic molecularly imprinted nanoparticles (NPs) of type Fe3O4@SiO2 were prepared via surface imprinting with CAP. ^[21] Graphene quantum dots (GQDs) were immobilized on molecularly imprinted nanoparticles which then were placed on nitrocellulose paper. ^[22] This assay relies on fluorescent molecularly imprinted nanoparticles (nanoMIPs) which, upon interaction with the target analytes, generate a reduction in fluorescence emission intensity (quenching). ^[23] The selective electrochemical determination of casein from bovine milk (consisting of α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein) was developed based on magnetic molecularly imprinted nanoparticles (MMIPs) modified on the carbon paste electrode. ^[24] The adsorption, recognition and reusability of the molecularly imprinted nanoparticles were analyzed by static/dynamic adsorption, competitive adsorption and reproducibility experiment. ^[25] When performed within cross-linked micelles, the resulting molecularly imprinted nanoparticles (MINPs) exhibited an extraordinary ability to distinguish subtle structural changes in the guest, including the shift of a hydrophilic or hydrophobic group by 1 carbon and addition of a single methylene/methyl group. ^[26]