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Iia Trial sentence examples within Phase Iia Trial



Abstract CT192: Phase IIa open-label clinical study of intratumoural administration of BO-112 in combination with pembrolizumab in subjects with liver metastasis from colorectal cancer or gastric/gastro-oesophageal junction cancer



Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study


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10.1158/1538-7445.AM2021-CT192

Abstract CT192: Phase IIa open-label clinical study of intratumoural administration of BO-112 in combination with pembrolizumab in subjects with liver metastasis from colorectal cancer or gastric/gastro-oesophageal junction cancer


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10.1093/noajnl/vdab075

A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3


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10.1128/AAC.01237-21

Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study


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10.1038/s41574-021-00590-2

Phase IIa results for potential NAFLD therapy


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10.1101/2021.01.24.21250414

Antigen-specific tolerization in human autoimmunity: Inhibition of interferon-beta1a anti-drug antibodies in multiple sclerosis


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10.1200/JCO.2021.39.15_SUPPL.8558

A phase II trial of abemaciclib in patients with p16ink4a negative, relapsed mesothelioma.



Potential of novel colchicine dosage schedule for the palliative treatment of advanced hepatocellular carcinoma


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10.1172/jci.insight.145188

A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome


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10.1200/JCO.2021.39.15_SUPPL.TPS7053

A prospective phase I/IIa trial to evaluate the safety and efficacy of GTA002, an off-the-shelf, ex vivo-cultured allogeneic NK cell preparation in patients with acute myeloid leukemia in complete morphological remission who have measurable residual disease.


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10.1007/s40262-021-01048-4

Characterization of the Population Pharmacokinetics of Moxidectin in Adults Infected with Strongyloides Stercoralis: Support for a Fixed-Dose Treatment Regimen


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10.21203/RS.3.RS-254137/V1

A Signal-seeking Phase Iia Trial of Palbociclib in Advanced Cancers With Cell Cycle Pathway Alterations – A Substudy of the Molecular Screening and Therapeutics (Most) Program


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10.1124/jpet.120.000307

Identification of a Human Whole Blood–Based Endothelial Cell Impedance Assay for Assessing Clinical Transient Receptor Potential Vanilloid 4 Target Engagement Ex Vivo


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10.1007/s40259-021-00490-x

Novel Targeted Biological Agents for the Treatment of Atopic Dermatitis.



A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation


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10.1161/CIRCINTERVENTIONS.120.010437

Incidence and Clinical Significance of Worsening Tricuspid Regurgitation Following Surgical or Transcatheter Aortic Valve Replacement


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10.1016/j.msard.2021.103284

Antigen-specific tolerization in human autoimmunity: Inhibition of interferon-beta1a anti-drug antibodies in multiple sclerosis: A case report.


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10.2139/SSRN.3824765

A First-in-Human Phase I/IIa Study of Allogeneic Double Negative T Cell for the Treatment of Relapsed AML Post Allo-HSCT


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10.1172/jci.insight.143606

Intravenous allogeneic umbilical cord blood–derived mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa patients



Editorial: felcisetrag—forward movement as a novel prokinetic for gastroparesis


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10.1002/1878-0261.12950

Analysing the attributes of Comprehensive Cancer Centres and Cancer Centres across Europe to identify key hallmarks


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10.1136/LUPUS-2021-LA.27

27 Translational insights into the pathogenesis transforming SLE treatment


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10.1186/s13195-021-00897-2

Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial


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10.1016/j.ejps.2021.105904

Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: Phase IIa and IIb multi-center clinical trials.


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10.1200/JCO.2021.39.15_SUPPL.E19001

The potential treatment of antroquinonol in adult patients with relapsed acute myeloid leukemia (AML).


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10.1053/j.gastro.2021.02.062

Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease.


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10.1016/S1465324921002747

Mesenchymal stromal cells reprogram macrophages with processing bodies


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10.1093/annonc/mdz253.005

Natural dendritic cell vaccinations generate immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer


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10.1371/journal.pone.0226320

Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial


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10.1136/archdischild-2019-esdppp.39

O39 Defining serum CCL22 and trefoil factor 3 (TFF3) as pharmacodynamic biomarkers for use in a proof-of-concept clinical trial of vamorolone in paediatric ulcerative colitis


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10.3389/fneur.2019.00293

ROCK-ALS: Protocol for a Randomized, Placebo-Controlled, Double-Blind Phase IIa Trial of Safety, Tolerability and Efficacy of the Rho Kinase (ROCK) Inhibitor Fasudil in Amyotrophic Lateral Sclerosis



Correlation of Immune Markers With Outcomes in Biliary Atresia Following Intravenous Immunoglobulin Therapy


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10.1021/CEN-09729-BUSCON16

Astellas licenses hearing-loss drug


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10.1002/sctm.18-0183

Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation


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10.2147/CEG.S184016

Development and psychometric evaluation of the Diabetic Gastroparesis Symptom Severity Diary


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10.1186/s12931-018-0968-8

Modulation of blood inflammatory markers by benralizumab in patients with eosinophilic airway diseases


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10.1093/annonc/mdz451.019

Pilot Study on the Feasibility, Safety and Immunogenicity of a Personalized Neoantigen-Targeted Immunotherapy (NeoPepVac) in Combination with Anti-PD-1 or Anti-PD-L1 in Advanced Solid Tumors


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10.1136/annrheumdis-2019-eular.3934

THU0026 TARGETING SYNOVIAL FIBROBLASTS IN RHEUMATOID ARTHRITIS BY PEFICITINIB AND FILGOTINIB


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10.2139/SSRN.3335037

Safety and Preliminary Efficacy of Allogeneic Neural Stem Cell Transplantation in Chronic Spinal Cord Injury: A Translational Phase I/IIa Trial


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10.1002/sctm.18-0012

Autologous Endothelial Progenitor Cells Transplantation for Acute Ischemic Stroke: A 4‐Year Follow‐Up Study



Final analysis of a phase I/IIa trial of the folate‐binding protein‐derived E39 peptide vaccine to prevent recurrence in ovarian and endometrial cancer patients


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10.1158/1538-7445.SABCS18-P2-09-09

Abstract P2-09-09: Initial safety and efficacy of a phase I/IIa trial of a modified whole tumor cell targeted immunotherapy in patients with advanced breast cancer


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10.1097/MPG.0000000000002256

A Phase I/IIa Trial of Intravenous Immunoglobulin Following Portoenterostomy in Biliary Atresia


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10.3390/cancers11010088

The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA


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10.1186/s12885-019-5413-y

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol


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10.1136/archdischild-2019-esdppp.60

P22 ADME properties of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug


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10.1186/s12885-019-5444-4

A prospective, single-arm, open-label, non-randomized, phase IIa trial of a nonavalent prophylactic HPV vaccine to assess immunogenicity of a prime and deferred-booster dosing schedule among 9–11 year-old girls and boys – clinical protocol


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10.1136/bmjopen-2018-024523

Bortezomib in antibody-mediated autoimmune diseases (TAVAB): study protocol for a unicentric, non-randomised, non-placebo controlled trial



Clinical proof of concept for a safe and effective NF‐κB‐targeting strategy in multiple myeloma


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10.1158/1538-7445.AM2019-4998

Abstract 4998: Development of a personalized off-the-shelf whole-cell immunotherapy for breast cancer


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10.1080/2162402X.2019.1615817

Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE)


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10.1186/s13027-019-0242-9

Three year survival among patients with aids-related Kaposi sarcoma treated with chemotherapy and combination antiretroviral therapy at Moi teaching and referral hospital, Kenya


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10.1186/s40425-019-0787-6

Blood-derived dendritic cell vaccinations induce immune responses that correlate with clinical outcome in patients with chemo-naive castration-resistant prostate cancer


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10.1038/s41582-019-0141-0

Stroke trial drug is effective in Alzheimer disease mouse model


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