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hereditary colon cancer 10.2174/1389450122666210325121322

The microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer.

hereditary colon cancer 10.1159/000518683

The APC gene contributes to a small percentage of hereditary colon cancer, with most pathogenic APC variants causing familial adenomatous polyposis syndrome.

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10.2174/1389450122666210325121322

The microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer.

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10.1159/000518683

The APC gene contributes to a small percentage of hereditary colon cancer, with most pathogenic APC variants causing familial adenomatous polyposis syndrome.

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10.4251/wjgo.v13.i9.1121

The colorectal cancer risk is at such a high level that CF has now been declared a hereditary colon cancer syndrome by the Cystic Fibrosis Foundation.

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10.17235/reed.2021.7952/2021

Fifteen percent had a history of hereditary colon cancer syndrome.

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10.1111/imj.15485

In this article, we consider genetic variant interpretation with reference to efforts to better understand variation in the mismatch repair genes and their relation to Lynch syndrome – the most common cause of hereditary colon cancer.

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Hereditary Colon

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Aug 16, 2022

What is/are Hereditary Colon?

Hereditary Colon - The microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. ^[1] The APC gene contributes to a small percentage of hereditary colon cancer, with most pathogenic APC variants causing familial adenomatous polyposis syndrome. ^[2] The colorectal cancer risk is at such a high level that CF has now been declared a hereditary colon cancer syndrome by the Cystic Fibrosis Foundation. ^[3] Fifteen percent had a history of hereditary colon cancer syndrome. ^[4] In this article, we consider genetic variant interpretation with reference to efforts to better understand variation in the mismatch repair genes and their relation to Lynch syndrome – the most common cause of hereditary colon cancer. ^[5]

hereditary colon cancer

The microsatellite instable phenotype resulting from errors in DNA mismatch repair proteins accounts for as far as 15 to 20% of non-hereditary colon cancers but is scarce in rectal cancer. ^[1] The APC gene contributes to a small percentage of hereditary colon cancer, with most pathogenic APC variants causing familial adenomatous polyposis syndrome. ^[2] The colorectal cancer risk is at such a high level that CF has now been declared a hereditary colon cancer syndrome by the Cystic Fibrosis Foundation. ^[3] Fifteen percent had a history of hereditary colon cancer syndrome. ^[4] In this article, we consider genetic variant interpretation with reference to efforts to better understand variation in the mismatch repair genes and their relation to Lynch syndrome – the most common cause of hereditary colon cancer. ^[5]