Introduction to Growing Teratoma

What is/are Growing Teratoma?

Growing Teratoma - Growing teratoma syndrome (GTS) is a rare and often unrecognised phenomenon generally associated with less than 5% of germ cell tumour. ^[1] Growing teratoma syndrome is a rare condition described in both testicular and ovarian cancer. ^[2] Growing teratoma syndrome (GTS) is defined as conversion of a metastatic immature tumor to a mature tumor after adjuvant chemotherapy and remains an area of investigation due to its unclear pathogenesis. ^[3] Growing teratoma syndrome is a relatively rare phenomenon defined as an enlarging residual mass histologically proven to be a mature teratoma in the setting of normal serum tumor markers. ^[4] Four patients had growing teratoma syndrome. ^[5] Wie entsteht und wie behandelt man ein „growing teratoma syndrome“? MargarethaA. ^[6] We report the first case of growing teratoma syndrome (GTS) in the coccygeal region. ^[7] Growing teratoma syndrome may occur after treatment of recurrent IT. ^[8] The authors describe these features and assign them to one of the following categories: (a) unusual manifestations of metastatic disease (growing teratoma syndrome, choriocarcinoma syndrome, ossified metastases, and gliomatosis peritonei); (b) autoimmune manifestations (sarcoidlike reaction and paraneoplastic syndromes); (c) endocrine syndromes (sex hormone production, struma ovarii, and struma carcinoid); or (d) miscellaneous conditions (ruptured dermoid cyst, squamous cell carcinoma arising from a mature teratoma, Currarino triad, fetus in fetu, pseudo-Meigs syndrome, and pancreatitis). ^[9] Growing teratoma syndrome (GTS) is a rare entity which consists of benign enlarging teratoma after chemotherapy. ^[10] A few unique entities related to ovarian tumors, such as growing teratoma syndrome, anti– N -methyl- d -aspartate receptor encephalitis, and hereditary ovarian tumor syndromes, are also discussed. ^[11] We report the first case of a liver teratoma suggestive of growing teratoma syndrome treated with myelosuppressive chemotherapy and major hepatectomy without the use of any blood products. ^[12] Growing teratoma syndrome is a rare entity of tumors, it arises seldomly from ovarian and testicular carcinoma. ^[13] Although a recognized condition, growing teratoma syndrome (GTS) has no guidelines for management, and patients diagnosed with the condition are managed empirically by the most appropriate teams. ^[14] BACKGROUND Growing teratoma syndrome (GTS) is an uncommon clinical finding in patients treated for testicular cancer. ^[15]

germ cell tumor

Growing teratoma syndrome (GTS) is documented in literature to be a rare complication of non-seminomatous germ cell tumors that arises following chemotherapeutic treatment. ^[1] Growing teratoma syndrome (GTS) is described as an uncommon phenomenon which could be related to the incidence of non-seminomatous germ cell tumors. ^[2] BACKGROUND The term "growing teratoma syndrome (GTS)" has been used as follows: patients with germ cell tumor (GCT) who present with enlarging original/metastatic masses during or after appropriate systemic chemotherapy despite normalized serum markers. ^[3] Case reportWe report a 19-year patient with testicular germ cell tumor after first line chemotherapy with giant growing teratoma syndrome in retroperitoneum. ^[4] Results The primary ovarian neoplasms were pure mature cystic teratoma with malignant transformation (n=6, including 5 of mucinous adenocarcinoma), mixed germ cell tumor with mature cystic teratoma and yolk sac tumor (YST) (n=1), pure immature teratoma (n=1), immature teratoma with growing teratoma syndrome (GTS) (n=1), and immature teratoma mixed YST with GTS (n=1). ^[5] Intracranial growing teratoma syndrome (iGTS) is rare phenomenon which is observed in non-germinomatous germ cell tumor (NGGCT) after chemotherapy. ^[6] Growing teratoma syndrome (GTS) is a condition in which mature teratoma with negative tumor markers arises at the site of a treated malignant germ cell tumor. ^[7] Herein, we report a case of an angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. ^[8]

nonseminomatous germ cell

In this article, we review the current indications for postchemotherapy resection in nonseminomatous germ cell tumors, including masses greater than 1 cm, resection after salvage chemotherapy, with elevated markers, after late relapse, and for growing teratoma syndrome. ^[1] Background Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. ^[2] Growing teratoma syndrome (GTS) is a rare clinical phenomenon in patients with nonseminomatous germ cell cancer defined by growing metastatic mass during ongoing or directly after completed chemotherapy with timely decreasing tumor markers and postpubertal teratoma exclusively after resection. ^[3] Background Growing teratoma syndrome is a rare condition defined by the presence of enlarging metastatic lesions on serial imaging that arise after or during systemic chemotherapy for nonseminomatous germ cell tumors. ^[4]

Background Growing Teratoma

Background Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. ^[1] Background Growing teratoma syndrome is a rare condition defined by the presence of enlarging metastatic lesions on serial imaging that arise after or during systemic chemotherapy for nonseminomatous germ cell tumors. ^[2]

Developed Growing Teratoma

Growing teratoma syndrome secondary to recurrent teratoma: case report A man in his 50s [age at the time of reaction onset not clearly stated] developed growing teratoma syndrome secondary to recurrent teratoma following treatment with bleomycin, cisplatin and etoposide for left testicular cancer. ^[1] Growing teratoma syndrome: case report A 28-year-old woman developed growing teratoma syndrome following treatment with bleomycin, etoposide and cisplatin for mixed germ cell tumour of the ovary [routes and dosages not stated]. ^[2]

growing teratoma syndrome

Growing teratoma syndrome (GTS) is a rare and often unrecognised phenomenon generally associated with less than 5% of germ cell tumour. ^[1] Growing teratoma syndrome secondary to recurrent teratoma: case report A man in his 50s [age at the time of reaction onset not clearly stated] developed growing teratoma syndrome secondary to recurrent teratoma following treatment with bleomycin, cisplatin and etoposide for left testicular cancer. ^[2] Given the final pathological diagnosis of the mature teratoma, this was considered growing teratoma syndrome where surgery is the only treatment option. ^[3] Growing teratoma syndrome is a rare condition described in both testicular and ovarian cancer. ^[4] Growing teratoma syndrome (GTS) is defined as conversion of a metastatic immature tumor to a mature tumor after adjuvant chemotherapy and remains an area of investigation due to its unclear pathogenesis. ^[5] Growing teratoma syndrome is a relatively rare phenomenon defined as an enlarging residual mass histologically proven to be a mature teratoma in the setting of normal serum tumor markers. ^[6] Growing teratoma syndrome (GTS) is documented in literature to be a rare complication of non-seminomatous germ cell tumors that arises following chemotherapeutic treatment. ^[7] Growing teratoma syndrome (GTS) is described as an uncommon phenomenon which could be related to the incidence of non-seminomatous germ cell tumors. ^[8] Four patients had growing teratoma syndrome. ^[9] Growing teratoma syndrome: case report A 28-year-old woman developed growing teratoma syndrome following treatment with bleomycin, etoposide and cisplatin for mixed germ cell tumour of the ovary [routes and dosages not stated]. ^[10] Wie entsteht und wie behandelt man ein „growing teratoma syndrome“? MargarethaA. ^[11] We report the first case of growing teratoma syndrome (GTS) in the coccygeal region. ^[12] Growing teratoma syndrome may occur after treatment of recurrent IT. ^[13] The authors describe these features and assign them to one of the following categories: (a) unusual manifestations of metastatic disease (growing teratoma syndrome, choriocarcinoma syndrome, ossified metastases, and gliomatosis peritonei); (b) autoimmune manifestations (sarcoidlike reaction and paraneoplastic syndromes); (c) endocrine syndromes (sex hormone production, struma ovarii, and struma carcinoid); or (d) miscellaneous conditions (ruptured dermoid cyst, squamous cell carcinoma arising from a mature teratoma, Currarino triad, fetus in fetu, pseudo-Meigs syndrome, and pancreatitis). ^[14] BACKGROUND The term "growing teratoma syndrome (GTS)" has been used as follows: patients with germ cell tumor (GCT) who present with enlarging original/metastatic masses during or after appropriate systemic chemotherapy despite normalized serum markers. ^[15] In this article, we review the current indications for postchemotherapy resection in nonseminomatous germ cell tumors, including masses greater than 1 cm, resection after salvage chemotherapy, with elevated markers, after late relapse, and for growing teratoma syndrome. ^[16] Growing teratoma syndrome (GTS) is a rare entity which consists of benign enlarging teratoma after chemotherapy. ^[17] Case reportWe report a 19-year patient with testicular germ cell tumor after first line chemotherapy with giant growing teratoma syndrome in retroperitoneum. ^[18] A few unique entities related to ovarian tumors, such as growing teratoma syndrome, anti– N -methyl- d -aspartate receptor encephalitis, and hereditary ovarian tumor syndromes, are also discussed. ^[19] Results The primary ovarian neoplasms were pure mature cystic teratoma with malignant transformation (n=6, including 5 of mucinous adenocarcinoma), mixed germ cell tumor with mature cystic teratoma and yolk sac tumor (YST) (n=1), pure immature teratoma (n=1), immature teratoma with growing teratoma syndrome (GTS) (n=1), and immature teratoma mixed YST with GTS (n=1). ^[20] Background Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. ^[21] Growing teratoma syndrome (GTS) is a rare clinical phenomenon in patients with nonseminomatous germ cell cancer defined by growing metastatic mass during ongoing or directly after completed chemotherapy with timely decreasing tumor markers and postpubertal teratoma exclusively after resection. ^[22] Intracranial growing teratoma syndrome (iGTS) is rare phenomenon which is observed in non-germinomatous germ cell tumor (NGGCT) after chemotherapy. ^[23] Background Growing teratoma syndrome is a rare condition defined by the presence of enlarging metastatic lesions on serial imaging that arise after or during systemic chemotherapy for nonseminomatous germ cell tumors. ^[24] We report the first case of a liver teratoma suggestive of growing teratoma syndrome treated with myelosuppressive chemotherapy and major hepatectomy without the use of any blood products. ^[25] Growing teratoma syndrome is a rare entity of tumors, it arises seldomly from ovarian and testicular carcinoma. ^[26] Growing teratoma syndrome (GTS) is a condition in which mature teratoma with negative tumor markers arises at the site of a treated malignant germ cell tumor. ^[27] Herein, we report a case of an angiosarcoma in a mediastinal non‐seminomatous germ cell tumor that exhibited growing teratoma syndrome during chemotherapy. ^[28] Although a recognized condition, growing teratoma syndrome (GTS) has no guidelines for management, and patients diagnosed with the condition are managed empirically by the most appropriate teams. ^[29] BACKGROUND Growing teratoma syndrome (GTS) is an uncommon clinical finding in patients treated for testicular cancer. ^[30]