Introduction to Genetic Response

The cellular and genetic responses to the application of different NPs were evaluated.

Morphogenetic responses were observed only in the presence of cytokinins, especially thidiazuron.

Heat stress is a major abiotic stress for plants which can generate a range of biochemical and genetic responses.

On the other hand, we did not observe any changes in the epigenetic response of Y.

The genetic response underlying this adaptation to nitrogen deficiency, however, remains to be determined.

This assumption, which is compatible with the tenets of modern neuroscience and genetics, is challenged by new insights regarding inheritance of transgenerational epigenetic responses.

The majority of population genetic studies focus on single species, which inflicts limitations for direct comparisons of genetic responses of avian populations to urbanization.

Motivation: Trait variation within species can reveal plastic and/or genetic responses to environmental gradients, and may indicate where local adaptation has occurred.

Background: Lack of adherence to tyrosine kinase inhibitors (TKIs) is a significant problem resulting in incomplete cytogenetic response and increased mortality in patients with chronic myeloid leukemia (CML).

obovata , offering scientific advice for the development of restoration strategy with long-term efficacy, also explored phenotypic, transcript, and epigenetic responses of plants to transplanting events between latitudes.

Patients with JAK2-positive BCR-ABL-positive CML had a good hematological and cytogenetic response to dasatinib.

The resilience of foundation species and the ecosystem functions they provide depends on their phenotypic and genetic responses to spatial and temporal shifts in environmental conditions.

This study aimed to determine the agronomic and genetic response of cayenne pepper against periodic flooding and find whether RAPD profile reflects periodic flooding endurance.

Nilotinib was switched because of failure to achieve complete cytogenetic response at 6 months following Imatinib.

By adding BA 3µmol the organogenetic response was inhibited since neither shoot nor root were developed.

The aim of this COST action launched in 2020 is: (1) to define standardized pipelines and methods used in the study of epigenetic mechanisms in plants, (2) update, share, and exchange findings in epigenetic responses to environmental stresses in plants, (3) develop new concepts and frontiers in plant epigenetics and epigenomics, (4) enhance dissemination, communication, and transfer of knowledge in plant epigenetics and epigenomics.

Objectives We examined taxonomic, functional and phylogenetic responses to habitat loss and insular fragmentation of small mammals and lizards within (α) and between sites (β).

The present work was designed for to know the cytotoxic and genetic responses against liver cancer cells and was compared with the artificial bone implanted material hydroxyapatite (HA).

This review outlines the mechanisms by which epigenetic responses to pathogen infection shape the plant immune system across expanding time scales.

The recognition and appropriate morphogenetic responses to prey-derived signals are essential for successful mycoparasitism.

In particular, the withering conditions applied and grape genotype play an important role in the changing amounts of phenolic acids, but there is still much to be understood, especially related to the combined effect of both factors through genetic responses to environmental stresses and their respective chemical implications.

To investigate the impact of HIV and ART on the transcriptomic and epigenetic response of AM to Mtb, we obtained AM by bronchoalveolar lavage from 20 PLWH receiving ART, 16 control subjects who were HIV-free (HC), and 14 subjects who received ART as pre-exposure prophylaxis (PrEP) to prevent HIV infection.

Such environmentally induced responses can also be expressed by the offspring of attacked plants via DNA methylation—an epigenetic response—but little is known about if and how epigenetic induction varies with plant ontogeny (e.

A key tool in its arsenal, is the HBx protein which can manipulate the epigenetic landscape to decrease its own viral load and enhance persistence, as well as manage host genome epigenetic responses to the presence of viral infection.

We postulate that ecogenetic response, phenotypic plasticity, and genotypic variation of hybrid poplars (Populus L.

Complementary to genetic responses to selection, faster epigenetic variations such as modifications of DNA methylation may play a substantial role in rapid adaptation.

These results demonstrate a polygenetic response that involves detoxification activities, and maintenance of energy and cellular homeostasis.

Importantly, many similar changes to methylation distal to the rDNA promoter were also observed in a mouse model of resistance exercise, suggesting a degree of conservation of the epigenetic responses associated with mechanically-induced muscle hypertrophy (Figueiredo et al.

001) and complete cytogenetic response by 6 months (P =.

Boron toxicity is a worldwide problem for crops, yet we have a limited understanding of the genetic responses and adaptive mechanisms to this stress in plants.

Among 144 patients who dose-reduced to bosutinib 400 mg/day (without reduction to 300 mg/day), 22 (15 %) had complete cytogenetic response (CCyR) before and after reduction, 40 (28 %) initially achieved CCyR after reduction, and 4 (3 %) only had CCyR before reduction.

Finally, we show that the optogenetic response initiated in V1 spreads to downstream (LGN) and upstream (V2) visual areas.

These results indicate that high  genetic response is expected from selection for  BWT, while low response is expected for LBWT.

3%) achieved a complete cytogenetic response (CCyR), 35/45 (77.

mansoni at 25°C become susceptible by the F2 generation when maintained at 32°C, indicating an epigenetic response.

Many studies report no genetic responses due to pre-existing plasticity, while others point towards epigenetics and microbiota effects.

A maladaptive epigenetic response may be a cardiovascular risk driver and amenable to modification with apabetalone, a selective modulator of the bromodomain and extraterminal domain transcription system.

Second-line therapy is effective (by achievement of complete cytogenetic response) in only approximately 50% of patients, and available third-generation TKI has been marred by concerns of arterio-occlusive events.

However, after 12 months, the cytogenetic response had been lost.

The patients were evaluated for cytogenetic response by standard chromosome banding analysis (CBA).

In this study, we explore the electrophysiological, transcriptional and epigenetic responses that are induced by CI-994, a class I HDAC inhibitor, combined with contextual fear conditioning (CFC) in mice.

Our results also indicated that both the level and patterns of methylation varied substantially with the climatic treatments, with the combination of D and W inducing a clearly different epigenetic response compared to that promoted by D and W separately.

Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine.

The genetic response might have been masked by an increased D.

To investigate the impact of HIV and ART on the transcriptomic and epigenetic response of AM to Mtb, we obtained AM by bronchoalveolar lavage from 20 PLWH receiving ART, 16 control subjects who were HIV-free (HC), and 14 subjects who received ART as pre-exposure prophylaxis (PrEP) to prevent HIV infection.

As a first step toward understanding the epigenetic responses to environmental stresses in Chinese cabbage, our results provide a solid foundation for functional analysis of the BraHDAC family.

Sexual conflict, (re)mating rates, and genetic responses to sexual selection differ among ecological settings, mating systems and species.

Of patients with MDS, 73% (n = 29) responded with 50% (n = 20) achieving CR and 58% (23/40) a cytogenetic response.

0% achieved complete cytogenetic response at 12 months, and 64.

mansoni at 25°C become susceptible by the F2 generation when maintained at 32°C, indicating an epigenetic response.

05), a higher complete cytogenetic response rate (45% vs 10.

Intra-specific variation in genetic response to the pathogen, presence of invasive species or other taxa, salinity, and even the presence of Bd predators can also underpin the observed pathogen occurrence.

The biological mechanisms leading to the generation of anticancer treatment resistance include alterations in transmembrane proteins, DNA damage and repair mechanisms, alterations in target molecules, and genetic responses, among others.

The rates of complete hematological response, complete cytogenetic response, major molecular remission, and 5-year overall survival (OS) were not significantly different between the non-high-risk ACA and non-ACA groups (P>0.

Despite the superiority of dasatinib in CML hematologic and cytogenetic responses compared to imatinib, its potentially harmful pulmonary complications including pleural effusion (PE) and pulmonary arterial hypertension (PAH) may limit its use.

In summary, our study identified key stages during gamete and embryo development with temperature-sensitive reprogramming and epigenetic gene regulation, reflecting potential "windows of opportunity" for adaptive epigenetic responses under future climate change.

We assess their transcriptional and epigenetic response to T cell receptor stimulation and link this to genetic factors associated with celiac disease.

The "G allele" of GSTP1*B, is associated with later cytogenetic response in imatinib therapy.

To address these limitations, we used an upper airway epithelial cell (AEC) culture model to assess transcriptional and epigenetic responses to rhinovirus (RV), an asthma-promoting pathogen, and provide context-specific functional annotations to variants discovered in GWASs of asthma.

Genetic responses to rapid environmental changes are often characterized by selective sweeps, whereby a newly beneficial allele increases in frequency and becomes fixed in response to selection imposed by the novel stressor.

Here, we report our experience of patients with CML treated at a single center who did not achieve a complete cytogenetic response (CCyR) at 24 months.

This study describes a sensory and control system to simulate drought conditions for wheat, within a framework to study this crop's genetic responses under drought stress.

This study investigated the complex phenotypic and genetic response of Monterey pine (Pinus radiata) seedlings to co-infections by F.

Randomization was stratified by major cytogenetic response (MCyR) status at baseline.

Profiling early host epigenetic responses in neutrophils may aid in disease recognition.

There were no differences in the cumulative incidence of cytogenetic responses nor in the acquisition of DMR and sDMR between the two groups, but the e14a2 transcript had a positive impact on molecular response during the first 6 months, whereas the e13a2 was associated with improved long-term OS.

6%) patients, as did the complete cytogenetic response rate by 24 months (86.

In order to obtain a deep insight into the genetic response of chickpeas to management in relation to agronomic and quality traits, a two-year field trial was carried out with eight chickpea genotypes under an organic and conventional cropping system.

Therefore, earlier reliable genetic evaluation of unproven sires trough genomic selection is appealing in order to increase the genetic response for carcass traits in the Nellore (Bos taurus indicus) beef cattle.

Populations can avoid extinction through evolutionary rescue (ER), which occurs when an adaptive, genetic response to selection allows a population to recover from an environmental change that would otherwise cause extinction.

Although some genes demonstrated differential DNA methylation post‐loading in bioengineered SkM, such changes across the majority of genes analyzed did not closely mimic the epigenetic response to acute‐RE in humans.

Catchment scale morphometric analyses deliver insights into dynamics, erosion capacity, probability of flood occurrence, lithological and structural control, and genetic response to the tectonics.

We identified EP300, MOV10, RELA, and TRIM25 as top candidates, and more than 60 additional proteins involved in the epigenetic response during viral infection that has therapeutic potential.

wrightii to these two distinct environments, as well as the genetic responses behind them.

Similar trends were seen for complete cytogenetic response.

He achieved a complete cytogenetic response three months after dasatinib therapy but developed AML with normal karyotype 1 year later.

Instead, we observed a high degree of genus‐specific variation in genetic responses to road impacts and human density.

Objective: To elicit the pathogenetic response to Cu acet.

Over the past two decades, the field of environmental epigenetics has investigated epigenetic responses to environmental pollutants, including redox-active pollutants.

We intend to describe the genetic response of Mycobacterium tuberculosis from its migratory journey throughout decades from areas of Europa and Asia to Latin America, its genetic transformation secondary to inadequate drug exposure and the characteristics of the infected host, and how a change in the healthcare system and tuberculosis control strategies access are needed to change the surge of multidrug resistance tuberculosis.

Genetic changes underlying adaptation vary greatly in terms of complexity and, within the same species, genetic responses to similar selective pressures may or may not be the same.

Spear-ATAC profiling of 104,592 cells representing 414 sgRNA knock-down populations reveals the temporal dynamics of epigenetic responses to regulatory perturbations in cancer cells and the associations between transcription factor binding profiles.

Epigenetic responses and other transgenerational effects will undoubtedly play a role in climate change adaptation, but further, well-designed, studies are required to test their importance relative to DNA-encoded changes.

However, significant genotype-specific morphogenetic responses constitute a considerable on rice regeneration in plant biotechnology contexts.

The invertebrate Daphnia magna is an excellent choice for testing the epigenetic response to the environment: parthenogenetic offspring are identical to their siblings (making for powerful genetic comparisons), they are relatively short lived and have well-characterised inter-strain life-history trait differences.

CONCLUSION The results suggest the genetic response of these populations may be partially linked to geographic location and corresponding management practices.

Objectives Determine if COPD ASM cells have a unique epigenetic response to profibrotic cytokine transforming growth factor β1 (TGF-β1).

Optogenetic responses of RGCs in primate persisted for at least one year after the loss of photoreceptor input, with a sensitivity index similar to optogenetic responses recorded in intact retina.

As a result, both stimulatory (timentin, amoxicillin, and Amoxiclav®) and inhibitory (Claforan®) effects of β-lactam antibiotics on in vitro morphogenetic responses of tomato were noted.

This study investigates the phenotypic and genetic responses of five Pseudomonas aeruginosa strains (PAO1, A5803, AA43, CHA, and PAK) to the infection by seven phages with distinct evolutionary backgrounds and recognised receptors (LPS/T4P).

Although experiments and models have shown a high potential for both genetic and phenotypic change in response to fishing, empirical examples of genetic responses in wild populations are rare.

A number of chromatin modifying enzymes orchestrate epigenetic responses to environmental stimuli, with a growing body of research examining how changes in metabolic substrates or co-factors alter epigenetic modifications.