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Minimal physiologically based pharmacokinetic-pharmacodynamic (mPBPK-PD) model of GalNAc-conjugated siRNA disposition and gene silencing in preclinical species and humans.



The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man.



Impact of Serum Proteins on the Uptake and RNA Interference Activity of N-Acetylgalactosamine-Conjugated Small Interfering RNAs.



Development of siRNA Therapeutics for the Treatment of Liver Diseases.



Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs


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