Introduction to G1 Phase

Sentence Examples

Discover more insights into G1 Phase

Keywords frequently search together with G1 Phase

Narrow sentence examples with built-in keyword filters

G1 Phase sentence examples within cell cycle arrest

cell cycle arrest

We observed an anti-cancerous effect of this drug as shown by the G0/G1 phase cell cycle arrest, inhibition of PC cell viability, colony formation, and migration.

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

cell cycle arrest

SiO2NPs also caused inflammation as indicated by upregulation of the inflammation-related genes [interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), cyclooxygenase 2 (COX2), and transforming growth factor-beta 1 (TGFβ1)] as well as cell cycle arrest in the G0/G1 phase of lung cells.

Ginseng ameliorates pulmonary toxicity induced by silicon dioxide nanoparticles in rats

More cell cycle arrest sentences More Sentences

G1 Phase sentence examples within induced cell cycle

induced cell cycle

We found that metformin induced cell cycle arrest at the G0/G1 phase, suppressed cell migration, and affected cytoskeleton distribution.

Proteomic Analysis Reveals That Metformin Suppresses PSMD2, STIP1, and CAP1 for Preventing Gastric Cancer AGS Cell Proliferation and Migration

induced cell cycle

In our cell‐based assays, ectopic expression of PWAR6 dramatically repressed PDAC cells proliferation, invasion and migration, accelerated apoptosis, and induced cell cycle arrest at G0/G1 phase.

LncRNA PWAR6 regulates proliferation and migration by epigenetically silencing YAP1 in tumorigenesis of pancreatic ductal adenocarcinoma

More induced cell cycle sentences More Sentences

G1 Phase sentence examples within inhibited cell proliferation

inhibited cell proliferation

Results: Trigonelline inhibited cell proliferation by blocking cell-cycle progression at the G1 phase and decreased apoptosis via the Wnt/β-catenin pathway.

Trigonelline regulates Wnt/β-catenin signaling in glomerular mesangial cells under high glucose conditions

inhibited cell proliferation

CPX inhibited cell proliferation, clonogenicity and spheroid formation, and increased cell cycle arrest at S and G0/G1 phases.

Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting the γ-secretase complex

More inhibited cell proliferation sentences More Sentences

G1 Phase sentence examples within cell cycle progression

cell cycle progression

The overexpressed LpCat1 promoted the proliferation, migration and invasion of HCC cells, and accelerated cell cycle progression, while knocking down LpCat1 significantly inhibited cell proliferation, migration and invasion in vitro and in vivo, and arrested HCC cells at G0/G1 phase.

LpCat1 Promotes Malignant Transformation of Hepatocellular Carcinoma Cells by Directly Suppressing STAT1

cell cycle progression

The porous PLA scaffolds stimulated cell cycle progression of hASCs but led to an arrest in the G1 phase and reduced proliferation of expanded CD133+ cells.

3D Poly(Lactic Acid) Scaffolds Promote Different Behaviors on Endothelial Progenitors and Adipose-Derived Stromal Cells in Comparison With Standard 2D Cultures

More cell cycle progression sentences More Sentences

G1 Phase sentence examples within caused cell cycle

caused cell cycle

Here, we report that human wild-type Fused in Sarcoma (WT FUS), exogenously expressed in mouse embryonic spinal cord-derived NSPCs, was localized in the nucleus, caused cell cycle arrest in G1 phase by affecting cell cycle regulator expression, and strongly reduced neuronal differentiation.

Wild-Type and Mutant FUS Expression Reduce Proliferation and Neuronal Differentiation Properties of Neural Stem Progenitor Cells

caused cell cycle

166 mM) Compounds 11 and 20 showed significant activation of AMPK protein and oxidative stress, which led to elevated expression of p53 and Bax, reduced Bcl-2 expression, and caused cell cycle arrest at the sub-G0/G1 phase.

New Amino Acid Schiff Bases as Anticancer Agents via Potential Mitochondrial Complex I-Associated Hexokinase Inhibition and Targeting AMP-Protein Kinases/mTOR Signaling Pathway

More caused cell cycle sentences More Sentences

G1 Phase sentence examples within mitochondrial membrane potential

mitochondrial membrane potential

Detailed mechanistic studies revealed that MA induced apoptosis on MCF-7 cell line through ROS generation; a dose-dependent drop in mitochondrial membrane potential was found to be associated with cell cycle arrest at G0/G1 phase.

Myricanol-9-acetate, a novel naturally occurring derivative of myricanol, induces ROS-dependent mitochondrial-mediated Apoptosis in MCF-7 cancer cells.

mitochondrial membrane potential

It could activate the ROS production in a NQO1-dependent manner, arrest tumor cell cycle at G0/G1 phase, promote tumor cell apoptosis, and decrease the mitochondrial membrane potential.

Design, synthesis, and biological evaluation of 3-(1-benzotriazole)-nor-β-lapachones as NQO1-directed antitumor agents.

More mitochondrial membrane potential sentences More Sentences

G1 Phase sentence examples within cycle analysis showed

cycle analysis showed

Furthermore, cell cycle analysis showed that, in contrast to S phase arrest induced by 5-FU, 9 caused G0/G1 phase arrest, which might block cancer cell growth by arresting them in quiescence.

Azobenzene derivatives show anti-cancer activity against pancreatic cancer cells only under nutrient starvation conditions via G0/G1 cell cycle arrest

cycle analysis showed

The cell cycle analysis showed PTXNR-TTZ arrested > 80% of BT-474 breast cancer cells in the G2/M phase, while > 70% of untreated cells were found in the G0/G1 phase indicating that G2/M arrest induced apoptosis.

Antibody–drug nanoparticle induces synergistic treatment efficacies in HER2 positive breast cancer cells

More cycle analysis showed sentences More Sentences

G1 Phase sentence examples within arrested cell cycle

arrested cell cycle

Degradation of NEAT1 by CRISPR/cas9 significantly suppressed the gene’s expression rate, arrested cell cycle in the G0/G1 phase, and a significant reduction in cell number in the S phase (P < 0.

Evaluation of CRISPR/Cas9 System Effects on Knocking Out NEAT1 Gene in AGS Gastric Cancer Cell Line with Therapeutic Perspective

arrested cell cycle

Ectopic expression of miR-30e-3p inhibited the growth of glioma cells and arrested cell cycle at G0/G1 phase.

MicroRNA-30e-3p inhibits glioma development and promotes drug sensitivity to temozolomide treatment via targeting canopy FGF signaling regulator 2.

More arrested cell cycle sentences More Sentences

G1 Phase sentence examples within cyclin dependent kinase

cyclin dependent kinase

Mechanism of anticancer activity of andrographolide includes suppression of cyclins and cyclin-dependent kinases, induction of tumour suppressor proteins p53 and p21, increased level of Bax protein and decreased level of Bcl-2 proteins in a leukaemia cell line (HL-60 cells), G0/G1 phase arrest in breast cancer cell line (MCF-7 cells), cell cycle arrest in G2/M phase in human glioblastoma cell lines (glioblastoma U251 and U87), breast cancer, human leukaemia K562 cells.

Isolation of Andrographolide from Andrographis lineata Wall. ex Nees var. lawii C.B. Clarke and its Anticancer Activity against Human Ovarian Teratocarcinoma

cyclin dependent kinase

Cyclin B1, which acts in complex with cyclin-dependent kinase CDK1 to regulate mitotic entry and associated mitochondrial fission by phosphorylating mitochondrial fission protein Drp1, fails to be fully degraded in BLM-deficient cells and shows unscheduled expression in G1 phase cells.

Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes

More cyclin dependent kinase sentences More Sentences

G1 Phase sentence examples within arrest cell cycle

arrest cell cycle

Flow cytometric analysis revealed enhanced ROS level, decreased MMP and arrest cell cycle at the G0/G1 phase further strengthened cell death by apoptosis.

Induction of apoptosis in A431 cells via ROS generation and p53-mediated pathway by chloroform fraction of Argemone mexicana (Pepaveraceae)

arrest cell cycle

Further in vitro study indicated 1 could arrest cell cycle at G0/G1 phase and reduce the migration of HUVECs.

Ptehoosines a and B: Two new sesamin-type sesquilignans with antiangiogenic activity from Pterocephalus hookeri (C.B. Clarke) Höeck.

More arrest cell cycle sentences More Sentences

G1 Phase sentence examples within cell proliferation migration

cell proliferation migration

Downregulation of NEK2 inhibited A549 and H1299 cell proliferation, migration, and invasion, blocking cell cycle at the G0/G1 phase.

NEK2 plays an active role in Tumorigenesis and Tumor Microenvironment in Non-Small Cell Lung Cancer

cell proliferation migration

Further functional experiments indicated that inhibition of SNHG17 significantly inhibited HCC cell proliferation, migration and invasion, caused cell cycle G0/G1 phase arrest and apoptosis.

LncRNA SNHG17 predicts poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma.

More cell proliferation migration sentences More Sentences

G1 Phase sentence examples within dose dependent manner

dose dependent manner

Dasabuvir inhibited the growth of the KYSE150 and KYSE450 ESCC cell lines in a time and dose-dependent manner and arrested cell cycle at the G0/G1 phase.

Dasabuvir Suppresses Esophageal Squamous Cell Carcinoma Growth As a Novel ROCK1 Inhibitor

dose dependent manner

PGPIPN significantly changed the cell cycles in all human ovarian cancer cells, which leaded to a significant increase in the percentage of cells blocked at G2/M phase and decrease the percentage of cells at G1 phases in a dose-dependent manner.

Bioactive Hexapeptide Reduced the Resistance of Ovarian Cancer Cells to DDP by Affecting HSF1/HSP70 Signaling Pathway

More dose dependent manner sentences More Sentences

G1 Phase sentence examples within blocked cell cycle

blocked cell cycle

Luteolin treatment increased the G0-G1 phase ratio of the C918 and OCM-1 cells, blocked cell cycle progression, and increased the apoptosis rate of the C918 and OCM-1 cells.

Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.

blocked cell cycle

Further study confirmed that ZY0511 blocked cell cycle at G0/G1 phase and expression of CDK4 and cyclin D1.

The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy

More blocked cell cycle sentences More Sentences

G1 Phase sentence examples within breast cancer cell

breast cancer cell

Moreover, cell migration was inhibited following overexpression of miR-497, which also led to the arrest of the breast cancer cells in the G0/G1 phase of the cell cycle.

miR-497 inhibits proliferation and invasion in triple-negative breast cancer cells via YAP1

breast cancer cell

Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase.

Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy

More breast cancer cell sentences More Sentences

G1 Phase sentence examples within inducing cell cycle

inducing cell cycle

flavescens and/or its constituent compounds have been reported to inhibit CRC cell proliferation by inducing cell-cycle arrest at the G1 phase, inducing apoptosis via the intrinsic pathway, interfering in cancer metabolism, inhibiting metastasis and angiogenesis, regulating senescence and telomeres, regulating the tumour microenvironment and down-regulating cancer-related inflammation.

Biological effects and mechanisms of matrine and other constituents of Sophora flavescens in colorectal cancer.

inducing cell cycle

A more profound proliferative inhibition and a higher rate of apoptosis were obtained in OS cells via inducing cell cycle arrest at G1 phase upon gemcitabine treatment combined with EGFR knockdown, as compared to gemcitabine alone.

Epidermal growth factor receptor promotes tumor progression and contributes to gemcitabine resistance in osteosarcoma.

More inducing cell cycle sentences More Sentences

G1 Phase sentence examples within cell cycle transition

cell cycle transition

We find that two waves of mRNA decay occur sequentially during the mitosis-to-G1 phase transition, and identify the deadenylase CNOT1 as a factor that contributes to mRNA decay during this cell cycle transition.

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during mitotic exit

cell cycle transition

We found that silence of SGK1 largely blunted hypotonic challenge-induced increase in cell viability and cell cycle transition from G0/G1 phase to S phase, whereas overexpression of SGK1 showed the opposite effects.

SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway.

More cell cycle transition sentences More Sentences

G1 Phase sentence examples within cell cycle distribution

cell cycle distribution

Cell cycle distribution was disrupted from the combination of AZD1775 with SN38 or 5-FU which was recorded as G2M arrest and decreased G1 phase.

WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma

cell cycle distribution

Cell cycle distribution stated that the complexes depress cell growth at G0/G1 phase.

Iridium(III)-BBIP complexes induce apoptosis via PI3K/AKT/mTOR pathway and inhibit A549 lung tumor growth in vivo.

More cell cycle distribution sentences More Sentences

G1 Phase sentence examples within could induce cell

could induce cell

The results showed that 10−9–10−4 mol/L fenofibrate could induce cell growth and 10−4, 10−5, 10−6 mol/L fenofibrate could reduce the number of G0/G1 phase cells and increased in the number of cells in S and G2/M phase of cell cycle in SMMC-7721 cells.

Effect of fenofibrate on proliferation of SMMC-7721 cells via regulating cell cycle

could induce cell

SMO inhibition could induce cell apoptosis, cell cycle arrest at the G0/G1 phase, and a reduction of tissue fibrosis markers, both in vitro and in vivo.

Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia

More could induce cell sentences More Sentences

G1 Phase sentence examples within suppressed cell proliferation

suppressed cell proliferation

Results: ONC201 significantly suppressed cell proliferation, induced arrest in G1 phase, and increased cellular stress and apoptosis, accompanied by dual inhibition of the AKT/mTOR/S6 and MAPK pathways in OC cells.

Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer

suppressed cell proliferation

Overexpression of miR-20a-5p suppressed cell proliferation, induced cell cycle G0/G1 phase arrest and apoptosis in two AML cell lines (THP-1 and U937) using CCK-8 assay and flow cytometry analysis.

MiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia

More suppressed cell proliferation sentences More Sentences

G1 Phase sentence examples within cytometry analysis showed

cytometry analysis showed

Flow cytometry analysis showed that prunetin induced apoptosis and cell cycle arrested in G0/G1 phase.

Prunetin Inhibits Nitric Oxide Activity, Proliferation and Induces Apoptosis in Urinary Bladder Cancer Cells (RT-4) Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved

cytometry analysis showed

Flow cytometry analysis showed that prunetin induced apoptosis and arrested th cell cycle in the G0/G1 phase.

Prunetin inhibits nitric oxide activity and induces apoptosis in urinary bladder cancer cells via CASP3 and TNF-α genes.

More cytometry analysis showed sentences More Sentences

G1 Phase sentence examples within promoted cell cycle

promoted cell cycle

Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators.

IFNγ‐mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells

promoted cell cycle

Material and methods: Treatment with epidermal growth factor (EGF) to quiescent JB6 cells, which were serum-starved for 36 h, promoted cell cycle progression from the G0/G1 phase to the S phase.

6-Methylsulfinylhexyl Isothiocyanate Inhibits Cell Cycle Progression in Quiescent Jb6 Cells Stimulated with Epidermal Growth Factor

More promoted cell cycle sentences More Sentences

G1 Phase sentence examples within extract induced cell

extract induced cell

JCo extract induced cell cycle arrest at the G0/G1 phase via regulation of p53/p21 and CDK4/cyclin D1 and induced cell apoptosis via the extrinsic (FasL/Fas/caspase-8) and intrinsic (Bax/Bcl-2/caspase-9) apoptotic pathways.

Juniperus communis extract induces cell cycle arrest and apoptosis of colorectal adenocarcinoma in vitro and in vivo

extract induced cell

JIB extract induced cell cycle arrest at the G0/G1 phase and decreased cyclin and cdk protein expressions.

Juniperus indica Bertol. extract synergized with cisplatin against melanoma cells via the suppression of AKT/mTOR and MAPK signaling and induction of cell apoptosis

More extract induced cell sentences More Sentences

G1 Phase sentence examples within flow cytometry showed

flow cytometry showed

Flow cytometry showed that the ratio of G0/G1 phase in Jurkat/Ara-C cells increased but G2/M phase decreased (P<0.

[Establishment of Cytarabine-resistant Acute Lymphoblastic Leukemia Cell Lines and Its Resistance Mechanism].

flow cytometry showed

However, the flow cytometry showed that the G0/G1 phase number of cells was not significantly different.

Construction of Adenovirus Vector Expressing Duck Sclerostin and its Induction Effect on Myogenic Proliferation and Differentiation In Vitro

More flow cytometry showed sentences More Sentences

G1 Phase sentence examples within cycle analysis indicated

cycle analysis indicated

Cell cycle analysis indicated that miR-30a overexpression increased the proportion of G1 phase cells and decreased the proportion of S phase cells.

miR-30a attenuates drug sensitivity to 5-FU by modulating cell proliferation possibly by downregulating cyclin E2 in oral squamous cell carcinoma

cycle analysis indicated

Cell cycle analysis indicated that single cells within these two populations remained mostly in the G0/G1 phase.

A Subpopulation of Schwann Cell-Like Cells With Nerve Regeneration Signatures Is Identified Through Single-Cell RNA Sequencing

More cycle analysis indicated sentences More Sentences

G1 Phase sentence examples within induced cell death

induced cell death

Results demonstrated that AGE induced cell death by apoptosis pathway and autophagy, and inhibited cell proliferation via cell cycle arrest in G0-G1 phase mediated by Wnt signaling pathway.

A Bioactive Compound from Sanguisorba officinalis L. Inhibits Cell Proliferation and Induces Cell Death in 5-Fluorouracil-Sensitive/Resistant Colorectal Cancer Cells

induced cell death

Furthermore, curcumin pre-treatment enhanced iAs-induced cell death and promoted cell cycle arrest in G1 phase.

Curcumin sensitizes Epstein-Barr-immortalized lymphoblastoid cell lines to inorganic arsenic toxicity.

More induced cell death sentences More Sentences

G1 Phase sentence examples within cytometry analysis revealed

cytometry analysis revealed

Flow cytometry analysis revealed a superior G1 phase arresting potential of the optimized EA-loaded PLGA-PEG micelles (PLGA-PEG-EA-F3), with a concomitant increased apoptotic potential.

Encapsulation of Ellagic Acid in Di-Block Copolymeric Micelle for Non-Small Cell Lung Cancer Therapy

cytometry analysis revealed

The flow cytometry analysis revealed that UVC increased the number of cells at the sub-G1 phase in a dose dependent manner, and when pre-treated with OGE the changes were partially reversed.

Protective Effects of Ocimum gratissimumAqueous Extracts on HaCaT Cells Against UVC-Induced Inhibition of Cell Viability and Migration

More cytometry analysis revealed sentences More Sentences

G1 Phase sentence examples within inhibit cell proliferation

inhibit cell proliferation

CircFAM114A2 could inhibit cell proliferation and block more urothelial carcinoma cells in the G1 phase and then increase the sensitivity of urothelial carcinoma to cisplatin chemotherapy.

CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma

inhibit cell proliferation

Overexpression of miR-515-5p using the miR-515 mimic was found to reduce cell viability, facilitate cell apoptosis, inhibit cell proliferation and arrest cell cycle progressio at G1 phase.

miR-515-5p inhibits the proliferation, migration and invasion of human breast cancer cells by targeting CBX4

More inhibit cell proliferation sentences More Sentences

G1 Phase sentence examples within induced cell arrest

induced cell arrest

Functional experiments demonstrated that silencing FoxD2-AS1 inhibited proliferation and induced cell arrest at G0/G1 phase in CRC cells, while the overexpression of FoxD2-AS1 showed opposite results.

miR-4306 inhibits the malignant behaviors of colorectal cancer by regulating lncRNA FoxD2-AS1

induced cell arrest

Circ_0007031 knockdown repressed proliferation, whereas induced cell arrest at G0/G1 phase and apoptosis.

Circ_0007031 Silencing Inhibits Cell Proliferation and Induces Cell Apoptosis via Downregulating MELK at a miR-485-3p-Dependent Way in Colorectal Cancer.

More induced cell arrest sentences More Sentences

G1 Phase sentence examples within induce cell cycle

induce cell cycle

Bafilomycin A1 targeted cell cycle regulators cyclin D1 and cyclin E2 to induce cell cycle arrest in G0/G1 phase.

Bafilomycin A1 Induces Caspase-Dependent Apoptosis and Inhibits Autophagy Flux in Diffuse Large B Cell Lymphoma

induce cell cycle

In addition, complexes Ir1, Ir2 and Ir3 induce cell cycle arrest at the G0/G1 phase and regulate the cell cycle mediators such as cyclin D1, CDK6 (cyclin-dependent kinase 6), CDK4 and p21, leading to the inhibition of B16 cells proliferation.

DNA binding and evaluation of anticancer activity in vitro and in vivo of iridium(III) polypyridyl complexes.

More induce cell cycle sentences More Sentences

G1 Phase sentence examples within decreased cell viability

decreased cell viability

Results Hypoxia treatment resulted in a decreased cell viability and cell membrane integrity in JEG-3 and BeWo cell lines, and an increased expression of HIF1α, cell cycle arrest in the G1 phase, and massive cell apoptosis, which were alleviated after NOB treatment.

Nobiletin, a hexamethoxyflavonoid from citrus pomace, attenuates G1 cell cycle arrest and apoptosis in hypoxia-induced human trophoblast cells of JEG-3 and BeWo via regulating the p53 signaling pathway

decreased cell viability

Functional studies proved that RNA interference-mediated silencing of KLF1 inhibited GC cell growth, as evidenced by the decreased cell viability, DNA synthesis, and arrested cell cycle in G1 phase.

Krüppel-like factor 1 serves as a facilitator in gastric cancer progression via activating the Wnt/β-catenin pathway.

More decreased cell viability sentences More Sentences

G1 Phase sentence examples within cycle analysis demonstrated

cycle analysis demonstrated

Cell cycle analysis demonstrated that compound 8 induce cell cycle arrest at G1 phase with apoptosis inducing activity marked by increase in G0 phase.