Introduction to Functionalized Nanoparticles
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The functionalized nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), electron paramagnetic resonance (EPR), vibrating sample magnetometry (VSM), Mössbauer spectroscopy (MS), magnetic hyperthermia (MH), dynamic light scattering and zeta potential.
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The prepared TiO2NPs/PPy and hybrid material of functionalized nanoparticles/silane (PPy/TiO2NPs/silicone nanocomposite) were envisaged by scanning electron microscopy (SEM) and transmission electron microscopy (TEM).
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Functionalized Nanoparticles sentence examples within functionalized nanoparticles could
In vitro cell studies showed that HA-functionalized nanoparticles could enhance the cellular uptake in tumor cells.
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In this context, phytoantioxidant functionalized nanoparticles could be a novel and effective alternative.
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The binding affinities of FC to both multimodal-functionalized nanoparticles decreased in the presence of salt due to the screening of multiple weak interactions of polar and positively charged residues.
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Acting as anti-adhesive, trehalose-functionalized nanoparticles decreased the binding of S.
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Functionalized Nanoparticles sentence examples within functionalized nanoparticles loaded
Biodegradable polymeric nanofibrous scaffold imitating extracellular matrix (ECM) delivering functionalized nanoparticles loaded with therapeutic drug have the ability to support cellular functions thereby enhancing regeneration.
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The neonatal Fc receptor-mediated transport of albumin-functionalized nanoparticles loaded with insulin showed no significant changes when increasing the g-levels.
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In order to compare the optimized biomolecule-functionalized nanoparticles against current standards (which require synthetic linkers, heating, or pH manipulation), we employed metabolic and live/dead assays as well as light-based microscopy/spectroscopy in vitro.
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Here we show functionalized nanoparticles, termed “Nanotraps”, completely inhibited SARS-CoV-2 infection by blocking the interaction between the spike protein of SARS-CoV-2 and the ACE2 of host cells.
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For the first time, this work deals with the mathematical modeling of the use of magnetic scaffolds and functionalized nanoparticles to evaluate the enhancement of osteogenesis and bone repair.
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Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy.
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Functionalized nanoparticles are widely used in drug targeted delivery and immune microenvironment regulation.
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Human serum transferrin (HST) is a glycoprotein involved in iron transport that may be a candidate for functionalized nanoparticles to bind and target cancer cells.
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Results: Thiol-functionalized nanoparticles displayed chemo responsive release and greater cytotoxicity to cancer cells when compared with unmodified carriers.
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Here, we tested whether the combination of a PD-L1 blockade and therapeutic vaccination with functionalized nanoparticles is a potent therapy during chronic Friend retrovirus infection.
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Biofunctionalized nanoparticles exhibit improved stability and higher efficiency.
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To this end, we first synthesize magnetic dimers by coating dopamine-functionalized nanoparticles on geometrically asymmetric polystyrene dimers.
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It is noteworthy that polyHIPEs studied here were obtained using a green synthetic protocol where nonfunctionalized nanoparticles can be selectively incorporated into a scaffolds' inner walls.
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In the present study, functionalized nanoparticles (NPs) were used for MALDI-MS and laser desorption/ionization mass spectrometry (LDI-MS) experiments in order to evaluate the effect of the surface properties of NPs on tailoring the intensity of mass signals.
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Trimethylolpropane triacrylate (TMPTA) as a photoactive crosslinker is grafted onto hydrophobic nanosilica surface through click chemical reactions of mercapto double bonds to prepare the functionalized nanoparticles (TMPTA-s-SiO2), which are used to develop TMPTA-s-SiO2/XLPE nanocomposites with improvements in mechanical strength and electrical resistance.
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The binding affinities of FC to both multimodal-functionalized nanoparticles decreased in the presence of salt due to the screening of multiple weak interactions of polar and positively charged residues.
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Smooth Lipopolysaccharide (LPS) was extracted from Brucella melitensis via a modified hot phenol water method and fixed on the surface of the gold nanoparticles by covalent interactions with the functionalized nanoparticles.
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The enzyme was immobilized by five covalent procedures and by hydrophobicity on functionalized nanoparticles of magnetite or of a novel Zn/Mn oxide named G1.
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Acting as anti-adhesive, trehalose-functionalized nanoparticles decreased the binding of S.
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The study of hydrogen bonding interactions at the level of functionalized nanoparticles remains highly challenging and poorly explored area.
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Therefore, the insulation failure rate is reduced owing to doping of the functionalized nanoparticles of the m-ABA-grafted nano-SiO2 (m-ABA-SiO2) into the CE.
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Curcumin encapsulation around 65% for SLNs and 80% for NLCs was accomplished, while the functionalized nanoparticles presented a value around 70-75%.
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It was found that the migratory behavior of CD4+ TEM cells carrying carboxylic acid-, biotin-, or Wheat germ agglutinin (WGA)-functionalized nanoparticles was not affected by the presence of the nanoparticle payload.
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Aptamer-functionalized nanoparticles have been widely studied as targeted probes in biomedical applications for targeted therapy and imaging.
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In addition, we report the possibility to combine the use of 3D cultures with functionalized nanoparticles to obtain highly predictive in vitro models for use in the nanomedicine field.
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Oligonucleotide-functionalized nanoparticles (NPs), also known as "programmable atom equivalents" (PAEs), have emerged as a class of versatile building blocks for generating colloidal crystals with tailorable structures and properties.
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Vanadium-based compounds with anticancer activity against melanoma include: (1) oxidovanadium(IV);(2) XMenes;(3) vanadium pentoxide, (4) oxidovanadium(IV) pyridinonate compounds;(5) vanadate;(6) polysaccharides vanadium(IV/V) complexes;(7) mixed-metal binuclear ruthenium(II)–vanadium(IV) complexes;(8) pyridoxal-based oxidovanadium(IV) complexes and (9) functionalized nanoparticles of yttrium vanadate doped with europium.
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In these regards, topical administration of functionalized nanoparticles capable of sustainably releasing bioactive agents to the wound site may significantly accelerate wound repair.
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In vitro cell studies showed that HA-functionalized nanoparticles could enhance the cellular uptake in tumor cells.
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Results Polyethylene glycol (PEG) functionalized nanoparticles composed of the metallic elements Au and Pt were designed to increase synergistic radiosensitivity.
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By using these AS1411-functionalized nanoparticles we aimed to improve the anticancer effect of two molecules with promising effects that can be improved.
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Foremost, separately from steady-state fluorescence imaging, we found that, via utilizing FLIM investigations, the differences in fluorescence lifetimes of antibody biofunctionalized and non-functionalized nanoparticles can be correlated to different intracellular localization and internalization pathways of the fluorescent agent, which is relevant for the development of a cutting-edge method for the detection of cancer cells that overexpress folate receptors at their surfaces.
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negatively charged unfunctionalized nanoparticles (Bare-PS) and carboxylated nanoparticles (COOH-PS), and positively charged amino-functionalized nanoparticles (NH2-PS), with two model natural colloids, positively charged hematite and negatively charged kaolin, respectively.
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We specifically review the major technology developments addressing these challenges with an emphasis on our research group's efforts, including the development of top-down MS-compatible surfactants for protein solubilization, functionalized nanoparticles for the enrichment of low-abundance proteoforms, strategies for multidimensional chromatography separation of proteins, and a new comprehensive user-friendly software package for top-down proteomics.
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In contrast to functionalized nanoparticles which showed a max attachment efficiency of 99.
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In fact, it means that, by modifying the size of antibody-functionalized nanoparticles, the levels of membrane-bound ErbB2 can be changed.
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Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that selectively target specific cell types, their systemic application often results in unwanted liver accumulation.
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Another emergent technology is the ligand-harvesting of secondary metabolites using surface-functionalized nanoparticles, which is also mentioned.
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Besides, the obtained results indicated that the functionalized nanoparticles could cross the intestinal epithelial barrier successfully.
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The biomedical translational applications of functionalized nanoparticles require comprehensive studies on their effect on human stem cells.
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In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies.
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Dimerization of the HMC-functionalized nanoparticles was investigated by ultraviolet–visible spectrophotometer and fluorescence spectroscopy.
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The biological results show, as expected, that Sn-based materials are more active than the Ti-based systems with some of the tin-functionalized nanoparticles being almost 50 times more active than carboplatin.
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Here, curcumin-loaded silk fibroin nanoparticles (SFNs) have been functionalized on the surface with cRGD to provide active targeting towards tumor cells; a “click reaction” between the RGD-based cyclopentapeptide carrying an azide group and triple-bond-functionalized nanoparticles has been exploited.
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The functionalized nanoparticles behave as a magnetic trilayer-like system formed by ferrimagnetic spinel-like grains, a spin-glass-like layer as a spacer, and a cover layer of an iron hydroxide phase with antiferromagnetic interactions.
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Over the past few years, we have witnessed an increased use of nanoparticles and biological moiety-functionalized nanoparticles to fabricate new bioinks.
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However, the administration of functionalized nanoparticles to living beings is still challenging due to the rapid detection and blood and tissue clearance by the mononuclear phagocytic system.
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Also, the rheological behavior of HPAM solutions at 500 mg L−1 with and without 3000 mg L−1 of raw and functionalized nanoparticles was evaluated at a temperature of 70 °C through steady-state rheometry and dynamic oscillatory measurements at the day zero and after 15 days of aging.
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Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups.
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NLS-functionalized nanoparticles form larger intraendosomal aggregates than unmodified gold nanoparticles.
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Functionalized nanoparticles (NPs) have become part of almost all the nano-based products.
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Here, we explored the use of functionalized nanoparticles for the detection of estrogen receptor alpha (ERα) expression in a 3D tumor model, using the ERα-positive human breast cancer cell line MCF-7.
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Together, these results demonstrate that low molecular weight protamine–functionalized nanoparticles may serve as a universal platform to deliver protein therapeutics into erythrocytes.
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Although there is a tremendous body of work dedicated to PK and the biological effects of various nanoparticles, little is known about the fate of different components of functionalized nanoparticles in a biological environment such as in live cells.
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Herein, we report on a discovery of the intrinsic capability of polyethyleneimine-functionalized nanoparticles (PEI-NPs) to selectively eradicate glioblastoma stem cells (GSCs), contrary to current drug-based approaches to target and successfully eradicate GB.
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Here we present a generalizable assay platform, nanobody-functionalized nanoparticles for rapid, electronic detection (Nano2RED), demonstrated in the detection of Ebola and COVID-19 antigens.
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Functionalized nanoparticles demonstrated more significant drug entrapment with (97%) while undecorated MSNs only showed (63%).
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Functionalized nanoparticles (NPs) reveal new frontiers in simultaneous therapeutics and diagnostics, often termed as theranostics.
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Functionalized nanoparticles with 3-aminopropyl triethoxysilane increased anticorrosive and adhesion properties.
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The results show that the combination of metal oxide and functionalized nanoparticles presents better efficiency in sulfur removal.
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The objective of this research was to apply the concepts of nanotechnology to develop a multi-drug therapy, TMZ and idasanutlin (RG7388, a potent mouse double minute 2 (MDM2) antagonist), loaded in functionalized nanoparticles (NPs) that target the GBM CSC subpopulation, reduce the cell viability and provide possibility of in vivo preclinical imaging.
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Hence, the biofunctionalized nanoparticles can be safely used by selecting the required size and dose in medicines and drug delivery systems.
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