## What is/are Four Randomized?

Four Randomized - Twenty-four randomized controlled trials were extracted.^{[1]}RESULTS Eight studies (four randomized controlled trials and four descriptive designs) met the inclusion criteria and were published between 2003 and 2017.

^{[2]}Four randomized controlled trials (RCTs) had a high risk of bias (RoB), 1 had “some concerns”, and 2 had a low RoB.

^{[3]}FINDINGS Four randomized controlled trials and two case-controlled studies with a total of 769 patients were enrolled.

^{[4]}Content For this review, four cohort studies, four randomized clinical trials, one case report, and one case series were obtained from PubMed within the last 10 years.

^{[5]}Four randomized clinical trials (RCTs) were included with human subjects, investigating the effect of cranberry on Helicobacter pylori eradication.

^{[6]}Results: Four randomized controlled trials and seven subgroup analyses of larger randomized controlled trials, including a total of 21,344 patients with acute coronary syndrome, met our inclusion criteria.

^{[7]}Meta-analysis of the association between EGFR mutation status and overall survival (OS) in NSCLC with immunotherapy was calculated from four randomized controlled trials.

^{[8]}An individual participant data (IPD) meta-analysis of four randomized controlled trials (RCTs) demonstrated that hemodiafiltration (HDF) reduced overall mortality compared to hemodialysis (HD) in patients with end-stage kidney disease (ESKD).

^{[9]}Results: Four randomized control trials and one retrospective comparative study were included in the analyses.

^{[10]}In this library, the peptides were designed to form α-helical structures, and one cysteine, the probe modification site, was located at the center of four randomized residues on the same face of the helix.

^{[11]}RESULTS Four randomized control trials (RCTs) were retrieved, including 145 randomized participants.

^{[12]}Four randomized trials met criteria for inclusion in the current analysis.

^{[13]}Four randomized trials were included in the meta-analysis, and compared to placebo or comparator medication, SGLT2 inhibitors had a 2.

^{[14]}Four randomized controlled trials reported the outcomes of extended thromboprophylaxis in 3655 medically ill patients with active or history of cancer.

^{[15]}Four randomized controlled trials, 2 propensity‐score matched studies, and 1 observational study were identified, yielding a total of 2498 patients who underwent TAVR assigned to the single antiplatelet therapy group (n=1249), 3‐month DAPT group (n=485), or 6‐month DAPT group (n=764).

^{[16]}Four randomized clinical trials obtained an acceptable quality assessment, the others being classified as low quality, with methodological limitations in randomization, concealment and blinding.

^{[17]}Four randomized, controlled clinical trials comparing single antiplatelet therapy versus dual antiplatelet therapy for post TAVR patients were included in this study.

^{[18]}RESULTS Twenty-four randomized controlled trials and 3 prospective nonrandomized experimental trials were included (n = 2432).

^{[19]}Four randomized trials have attempted to compare efficacy of surgical and nonsurgical treatment with one trial showing improved results with surgery and the others showing comparable results.

^{[20]}RESULTS Four randomized controlled trials aimed to compare the impact of the second withdrawal from the right colon in RV versus FV following a standard colonoscopy.

^{[21]}Patients and Methods Pooled analysis examined safety outcomes from four randomized, double-masked, placebo-controlled clinical trials conducted at 6, 16, 27, and 35 sites, respectively, in the United States.

^{[22]}Results: Four randomized controlled trials, 19 prospective clinical studies, 20 retrospective studies, and 3 case series were included in the meta-analysis.

^{[23]}Results: Four randomized controlled trials, five prospective clinical studies, four retrospective studies, and three case series were included in the meta-analysis.

^{[24]}METHODS This is a secondary analysis of pooled data from four randomized control trials on IOL.

^{[25]}Four randomized clinical trial, 17 case series and 9 single case reports were founded.

^{[26]}RESULTS Four randomized controlled trials and 23 propensity-score matched studies comprising a total of 4,945 patients were included for analysis.

^{[27]}Four randomized clinical trials were included, providing a total of 63987 patients, 18860 with DM and 45127 without DM.

^{[28]}Over the years, four randomized trials (RCTs) have addressed the role of surgery in dMBC.

^{[29]}Four randomized clinical trials of 1086 TAVI patients were included.

^{[30]}METHODS Nine adults with unilateral transfemoral amputation completed the two-minute walk test, the timed up-and-go test, the L-test, and a custom locomotion course in four randomized prosthetic conditions.

^{[31]}We performed a two-location trial in which 19 dented corn hybrids and five corn controls grew in four randomized blocks within two experimental areas located in the Northern (Campos dos Goytacazes) and Northwestern (Itaocara) Rio de Janeiro State, Brazil.

^{[32]}Methods: We extracted data from four randomized controlled trials, including a total of 2924 patients (1475 in the ceftolozane-tazobactam group and 1449 in the control group).

^{[33]}RESULTS Four randomized controlled trials and nine observational studies with a total of 1683 patients comprising 2715 groin accesses were eligible for the meta-analysis.

^{[34]}RESULTS Fourteen studies were identified including four randomized controlled trials (RCTs) and 10 observational studies reporting a total of 2 031 patients.

^{[35]}Results The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants.

^{[36]}RESULTS Four randomized clinical trials involving 423 participants were eligible.

^{[37]}Four randomized controlled trials among 7,056 subjects receiving 2 doses of HEPLISAV-B and 3,214 subjects receiving 3 doses of Engerix-B showed superior seroprotection rate (SPR) (anti-HBs ≥10 mIU/mL) of 90–100%, compared with 71–90% in those receiving Engerix-B.

^{[38]}Data were pooled from four randomized trials in which female interpersonal trauma survivors completed CPT (N = 179).

^{[39]}These benches were divided into four randomized blocks.

^{[40]}RESULTS We initially screened 2,118 articles; ultimately, four randomized controlled trials (RCTs) with 518 patients were included.

^{[41]}Results: Four randomized clinical trials (RCTs) and 5 retrospective studies with 790 eyes were included in this meta-analysis after study selection.

^{[42]}After searching Medline and Embase, meta‐analysis of results of four randomized and five observational studies demonstrated significantly lower risks of stroke or systemic embolism (RR 0.

^{[43]}We identified common genetic variants of CYPs (CYP2D6, CYP1A2, CYP2C9, CYP2C19, and CYP2B6) in 81 healthy subjects who were pooled from four randomized, placebo-controlled, double-blind Phase 1 studies.

^{[44]}The efficacy and safety of guselkumab were demonstrated in four randomized, double-blind, Phase III trials (VOYAGE 1 and 2, NAVIGATE, and ECLIPSE), which demonstrated high levels of clinical response over three years of continuous treatment, regardless of sex, age, body weight, and race, maintaining a favourable safety profile and long-term tolerability.

^{[45]}Results: Eleven quantitative studies were included in the review: four randomized controlled trials, six quasi-experimental studies and one cohort study.

^{[46]}RESULTS Twenty-four randomized controlled trials (RCT) were included in the meta-analysis.

^{[47]}Methods Recruitment was conducted for four randomized controlled trials (RCTs) of mHealth HIV prevention interventions for YMSM living in 10 US cities.

^{[48]}Of these, 23 studies were clinical trials (four randomized).

^{[49]}METHOD Integrative Data Analysis (IDA) was used to pool data from four randomized controlled trials of adolescent ADHD treatment with participants (N=854) receiving various evidence-based behavior therapy packages (standard; STANDARD, comprehensive; COMP, engagement-focused; ENGAGE), community-based usual care (UC), or no treatment (NOTX).

^{[50]}

## controlled trials involving

Results Four randomized controlled trials involving 7201 patients were included.^{[1]}Four randomized controlled trials involving 570 participants were included.

^{[2]}Twenty-four randomized controlled trials involving 3406 participants met review inclusion.

^{[3]}A total of four randomized controlled trials involving 14,694 patients were included in this meta-analysis.

^{[4]}Twenty-four randomized controlled trials involving a total of 2,692 participants were included in this review.

^{[5]}RESULTS Four randomized controlled trials involving 160 patients were included in the meta-analysis.

^{[6]}RESULTS Four randomized controlled trials involving a total of 1230 smokers were included.

^{[7]}Results: Four randomized controlled trials involving 351 patients are included in the meta-analysis.

^{[8]}

## double blind placebo

Here, we report the effect of viloxazine extended-release capsules (viloxazine ER), a novel nonstimulant treatment for ADHD in children and adolescents (ages 6–17 years), on FI from a post hoc analysis of four randomized, double-blind, placebo-controlled Phase 3 clinical trials (N=1354).^{[1]}To investigate the presence of a placebo dose–response effect in four randomized, double-blind, placebo-controlled, multi-dose hot flash clinical trials conducted at Mayo Clinic.

^{[2]}Methods Data were pooled from four randomized, double-blind, placebo-controlled studies and the first year of one open-label study.

^{[3]}This post hoc analysis included 1553 patients randomized to placebo or dupilumab (300 mg q2w) as monotherapy for 16 weeks, or with concomitant topical corticosteroids (TCS) for 16/52 weeks, from four randomized, double-blind, placebo-controlled, phase 3 trials.

^{[4]}

## controlled trials comprising

RESULTS The analysis included 51 studies (46 observational studies, one nonrandomized trial, and four randomized controlled trials) comprising 2361 patients.^{[1]}A total of four randomized controlled trials, comprising 2783 patients of whom 69.

^{[2]}Results Four randomized controlled trials comprising 375 patients were included.

^{[3]}Four randomized controlled trials comprising 1633 patients (817 direct mechanical thrombectomy, 816 bridging therapy) were included.

^{[4]}

## Result Four Randomized

Results Four randomized controlled trials involving 7201 patients were included.^{[1]}Methods and Results Four randomized studies were included (n=75167; THEMIS [Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study], COMPASS [Cardiovascular Outcomes for People Using Anticoagulation Strategies], PEGASUS‐TIMI 54 [Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis in Myocardial Infarction 54], and DAPT [Dual Anti‐platelet Therapy]).

^{[2]}Results Four randomized, controlled clinical trials involving 5199 patients were included in this study.

^{[3]}Results Four randomized controlled trials comprising 375 patients were included.

^{[4]}Results Four randomized control trials, two quasi-experiments, and five one group pre-posttest designed studies, were included in the review with a total of 425 participants.

^{[5]}Results Four randomized trials and 11 observational studies with a total of 2,169 patients met the inclusion criteria.

^{[6]}Results Four randomized controlled trials (RCTs) including 1005 patients met the inclusion criteria.

^{[7]}Results Four randomized controlled studies and three non-randomized controlled studies were selected; six studies were combined for FOC and four studies were combined for CS rate.

^{[8]}Results Four randomized controlled studies were included.

^{[9]}

## Included Four Randomized

We finally included four randomized controlled trials with 456 patients in quantitative syntheses.^{[1]}Results Of 733 searched studies, we included four randomized and eleven non-randomized trials.

^{[2]}We included four randomized trials (IMpower133, CASPIAN, KEYNOTE-604, and EA5161) with a total of 1553 patients.

^{[3]}The trauma-informed interventions were small case series and the non-trauma focused therapies included four randomized controlled trials, were generally ineffective.

^{[4]}Results This analysis included four randomized controlled trials with 3106 patients.

^{[5]}The analysis included four randomized, double-blind, crossover, single-dose studies (healthy subjects [n = 74], patients with type 1 diabetes [n = 78], and type 2 diabetes [n = 38]) evaluating subcutaneous doses of 7, 15, or 30 U of URLi and Humalog during an 8- to 10-h euglycemic clamp procedure.

^{[6]}The studies included four randomized clinical trials of interim methadone (with three follow-up reports and five secondary analyses), one prospective cohort of interim methadone, one retrospective cohort of interim methadone, one randomized trial of low threshold services and two pre-post assessments of changes in program or state policies.

^{[7]}Results: We included four randomized controlled trials on the effect of mobile health as compared to usual care on blood glucose control among women with gestational diabetes mellitus.

^{[8]}RESULTS The 12 articles selected included four randomized control trials (RCTs) (two were double-blinded placebo-controlled RCTs, one was a prospective partially masked RCT, and one was an open-label RCT), two retrospective observational studies, and six laboratory-based studies including two studies having in vivo and in vitro experiments, one was in vivo study, one was ex vivo study, and the last two were in vitro studies.

^{[9]}

## Completed Four Randomized

METHODS Thirteen healthy men completed four randomized trials: two trials for the control condition (without exercise), one with capsiate supplementation (CTRLcap) and one with a placebo (CTRLpla), and two trials for the exercise condition, one with capsiate supplementation (EXcap) and one with placebo (EXpla).^{[1]}RESEARCH QUESTIONS How do spatiotemporal gait measures differ between indoor overground walking, outdoor walking, and treadmill walking in healthy adults? Do different walking environments exaggerate age-related alterations in gait performance in older compared to young adults? METHODS 30 young (18-30yrs) and 28 older adults (60-80yrs) completed four randomized conditions at their typical, comfortable walking pace: 1) 8 m of indoor walking, 2) continuous indoor walking, 3) treadmill walking, and 4) outdoor walking on a sidewalk.

^{[2]}Twelve subjects completed four randomized, double-blinded trials in which they drank 500 mL of water or commercially available soft drinks matched for taste and caffeine content.

^{[3]}0 mL∙min-1∙kg-1) completed four randomized trials with acetaminophen (1500 mg), caffeine (5 mg∙kgbw-1), combined caffeine and acetaminophen (caffeine+acetaminophen) or placebo.

^{[4]}Methods: Participants completed four randomized meal trials.

^{[5]}

## Identified Four Randomized

RESULTS The literature search identified four randomized controlled trials (n = 173 participants) comparing belatacept with tacrolimus.^{[1]}A systematic review of Scopus, Web of Science, Pubmed Central, clinical trial databases and recent international rheumatology conferences for interventional and observational studies reporting the effectiveness of DMARDs in TAK identified four randomized controlled trials (RCTs, with another longer-term follow-up of one RCT) and 63 observational studies.

^{[2]}Results We identified four randomized controlled trials (RCTs) and four observational studies with 2,063 COVID-19 cases.

^{[3]}A recent meta-analysis identified four randomized controlled trials and found an association with reduced mortality in adults (risk ratio 0.

^{[4]}

## Analyzed Four Randomized

Discussion: The current systematic review analyzed four randomized controlled trials, applying strict inclusion selection criteria.^{[1]}Results We analyzed four randomized, controlled trials, including 1672 patients, of whom 1224 (73.

^{[2]}

## four randomized controlled

Twenty-four randomized controlled trials were extracted.^{[1]}RESULTS Eight studies (four randomized controlled trials and four descriptive designs) met the inclusion criteria and were published between 2003 and 2017.

^{[2]}Four randomized controlled trials (RCTs) had a high risk of bias (RoB), 1 had “some concerns”, and 2 had a low RoB.

^{[3]}FINDINGS Four randomized controlled trials and two case-controlled studies with a total of 769 patients were enrolled.

^{[4]}RESULTS The analysis included 51 studies (46 observational studies, one nonrandomized trial, and four randomized controlled trials) comprising 2361 patients.

^{[5]}Results: Four randomized controlled trials and seven subgroup analyses of larger randomized controlled trials, including a total of 21,344 patients with acute coronary syndrome, met our inclusion criteria.

^{[6]}Meta-analysis of the association between EGFR mutation status and overall survival (OS) in NSCLC with immunotherapy was calculated from four randomized controlled trials.

^{[7]}Discussion: The current systematic review analyzed four randomized controlled trials, applying strict inclusion selection criteria.

^{[8]}Results Four randomized controlled trials involving 7201 patients were included.

^{[9]}An individual participant data (IPD) meta-analysis of four randomized controlled trials (RCTs) demonstrated that hemodiafiltration (HDF) reduced overall mortality compared to hemodialysis (HD) in patients with end-stage kidney disease (ESKD).

^{[10]}A total of four randomized controlled trials, comprising 2783 patients of whom 69.

^{[11]}Four randomized controlled trials reported the outcomes of extended thromboprophylaxis in 3655 medically ill patients with active or history of cancer.

^{[12]}Four randomized controlled trials, 2 propensity‐score matched studies, and 1 observational study were identified, yielding a total of 2498 patients who underwent TAVR assigned to the single antiplatelet therapy group (n=1249), 3‐month DAPT group (n=485), or 6‐month DAPT group (n=764).

^{[13]}RESULTS Twenty-four randomized controlled trials and 3 prospective nonrandomized experimental trials were included (n = 2432).

^{[14]}RESULTS Four randomized controlled trials aimed to compare the impact of the second withdrawal from the right colon in RV versus FV following a standard colonoscopy.

^{[15]}Results: Four randomized controlled trials, 19 prospective clinical studies, 20 retrospective studies, and 3 case series were included in the meta-analysis.

^{[16]}Results: Four randomized controlled trials, five prospective clinical studies, four retrospective studies, and three case series were included in the meta-analysis.

^{[17]}RESULTS Four randomized controlled trials and 23 propensity-score matched studies comprising a total of 4,945 patients were included for analysis.

^{[18]}RESULTS A total four randomized controlled trials were included in this meta-analysis.

^{[19]}Methods: We extracted data from four randomized controlled trials, including a total of 2924 patients (1475 in the ceftolozane-tazobactam group and 1449 in the control group).

^{[20]}RESULTS Four randomized controlled trials and nine observational studies with a total of 1683 patients comprising 2715 groin accesses were eligible for the meta-analysis.

^{[21]}We finally included four randomized controlled trials with 456 patients in quantitative syntheses.

^{[22]}RESULTS Fourteen studies were identified including four randomized controlled trials (RCTs) and 10 observational studies reporting a total of 2 031 patients.

^{[23]}Results The meta-analysis included 19 studies (four randomized controlled trials and 15 non-randomized studies) with 1,514 participants.

^{[24]}Four randomized controlled trials among 7,056 subjects receiving 2 doses of HEPLISAV-B and 3,214 subjects receiving 3 doses of Engerix-B showed superior seroprotection rate (SPR) (anti-HBs ≥10 mIU/mL) of 90–100%, compared with 71–90% in those receiving Engerix-B.

^{[25]}RESULTS We initially screened 2,118 articles; ultimately, four randomized controlled trials (RCTs) with 518 patients were included.

^{[26]}Results: Eleven quantitative studies were included in the review: four randomized controlled trials, six quasi-experimental studies and one cohort study.

^{[27]}RESULTS Twenty-four randomized controlled trials (RCT) were included in the meta-analysis.

^{[28]}Methods Recruitment was conducted for four randomized controlled trials (RCTs) of mHealth HIV prevention interventions for YMSM living in 10 US cities.

^{[29]}Four randomized controlled trials involving 570 participants were included.

^{[30]}Interventional SRs with a statistically significant meta-analysis of at least four randomized controlled trials in advanced cancer patients were included.

^{[31]}METHOD Integrative Data Analysis (IDA) was used to pool data from four randomized controlled trials of adolescent ADHD treatment with participants (N=854) receiving various evidence-based behavior therapy packages (standard; STANDARD, comprehensive; COMP, engagement-focused; ENGAGE), community-based usual care (UC), or no treatment (NOTX).

^{[32]}Till now, we have four randomized controlled trials (RCTs)—JCOG0602, SCORPION, CHORUS, and EORTC/NCIC group trial—that have compared oncological outcomes in advanced ovarian cancer patients who were treated with either upfront surgery or neoadjuvant chemotherapy (NACT).

^{[33]}Main results Five retrospective cohort studies and four randomized controlled studies with a total of 610 participants were included in the meta-analysis.

^{[34]}Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK.

^{[35]}There were four randomized controlled trials and three uncontrolled pilot studies on new VR interventions.

^{[36]}SAMPLE Eight studies, including four randomized controlled trials (RCTs) and four quasi-experimental studies were included, with a total of 348 participants.

^{[37]}Results: Four randomized controlled trials were included.

^{[38]}A total of 126 articles were yielded by the search, out of which four randomized controlled trials (RCTs) were included according to our eligibility criteria and irrelevant articles were excluded.

^{[39]}The trauma-informed interventions were small case series and the non-trauma focused therapies included four randomized controlled trials, were generally ineffective.

^{[40]}Four randomized controlled trials met the inclusion criteria for this review.

^{[41]}In our systematic search, we found finally six prospective studies with the minimum follow-up of two years: four randomized controlled trials and two cohort studies.

^{[42]}RESULTS Four randomized controlled trials enrolling 33718 patients were included.

^{[43]}Results: Four randomized controlled trials (N = 590 patients) were included.

^{[44]}Four randomized controlled trials and 4 observational studies were included (n: 615 patients).

^{[45]}Twenty-four randomized controlled trials involving 3406 participants met review inclusion.

^{[46]}A pooled cohort of four randomized controlled trials investigating the vasodilator serelaxin versus placebo in patients admitted with AHF and an SBP from 125 to 180 mmHg.

^{[47]}We included 19 original articles on biologic tapering in psoriasis patients: four randomized controlled trials and 15 observational studies.

^{[48]}Results This analysis included four randomized controlled trials with 3106 patients.

^{[49]}Clinical efficacy data were based on results from four randomized controlled trials of erenumab against placebo.

^{[50]}

## four randomized trial

Four randomized trials met criteria for inclusion in the current analysis.^{[1]}Four randomized trials were included in the meta-analysis, and compared to placebo or comparator medication, SGLT2 inhibitors had a 2.

^{[2]}Four randomized trials have attempted to compare efficacy of surgical and nonsurgical treatment with one trial showing improved results with surgery and the others showing comparable results.

^{[3]}METHODS Thirteen healthy men completed four randomized trials: two trials for the control condition (without exercise), one with capsiate supplementation (CTRLcap) and one with a placebo (CTRLpla), and two trials for the exercise condition, one with capsiate supplementation (EXcap) and one with placebo (EXpla).

^{[4]}Over the years, four randomized trials (RCTs) have addressed the role of surgery in dMBC.

^{[5]}Data were pooled from four randomized trials in which female interpersonal trauma survivors completed CPT (N = 179).

^{[6]}We included four randomized trials (IMpower133, CASPIAN, KEYNOTE-604, and EA5161) with a total of 1553 patients.

^{[7]}Methods From four randomized trials comparing outcomes between IVUS and angiography-guidance for long or chronic total occlusion (CTO) lesions, 1396 patients who underwent IVUS-guided new-generation DES implantation were enrolled.

^{[8]}In total, 11,594 patients from four randomized trials were included of whom 2278 (19.

^{[9]}CEA in symptomatic patients were examined using pre-planned pooled analysis of individual patient data from four randomized trials, the risk of death or stroke within 120 days of the index procedure was 5.

^{[10]}METHODS Patient-level data were pooled from four randomized trials, including 52-week studies PALLADIUM (n = 2216) and IRIDIUM (n = 3092), 24-week study ARGON (n = 1426), and 12-week study QUARTZ (n = 802).

^{[11]}The review was based on eighteen randomized controlled trials, four randomized trials without control, and four case studies.

^{[12]}Of these seven case reports and four randomized trials met the inclusion criteria (1999–2017).

^{[13]}Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food (RUSF), and oral arginine on health outcomes.

^{[14]}Recent findings Since the start of the pandemic, there have been four randomized trials of remdesivir in treating patients hospitalized with COVID-19.

^{[15]}RESULTS In the four randomized trials included (n=29,779 patients), the net clinical benefit - with or without the inclusion of myocardial infarction - of low-dose DOACs, compared to warfarin, was a 12% (95% CI, 7%-16%) or a 10% (95% CI, 5%-13%) reduction of events, respectively.

^{[16]}0 mL∙min-1∙kg-1) completed four randomized trials with acetaminophen (1500 mg), caffeine (5 mg∙kgbw-1), combined caffeine and acetaminophen (caffeine+acetaminophen) or placebo.

^{[17]}Four randomized trials demonstrated statistically significant increase in pCR rates when an immune checkpoint inhibitor (ICI) was added to neoadjuvant chemotherapy in triple negative breast cancer (TNBC), these include the KN-522, Impassion-031, I-SPY2 pembrolizumab, and I-SPY2 durvalumab/oleparib arms.

^{[18]}With respect to their point about the differences in survival found between our study and the four randomized trials they cited, these trials had relatively short follow-up on survival, which could have limited the ability to detect longer-term survival benefits.

^{[19]}Inclusion criteria were met by four randomized trials of problem-solving therapy (524 participants); four secondary analyses of problem-solving-related concepts as predictors, moderators, or mediators; and 23 practice guidelines.

^{[20]}Results Four randomized trials and 11 observational studies with a total of 2,169 patients met the inclusion criteria.

^{[21]}Four randomized trials were included in the meta-analysis and, compared with placebo or comparator medication, SGLT2 inhibitors had a 2.

^{[22]}METHODS Data from four randomized trials of therapeutic interventions in participants with PAD that measured both 6-minute walk and treadmill walking performance at baseline and the 6-month follow-up were combined.

^{[23]}There was a positive correlation between the addition of PC and ACP in 25 studies, among them four randomized trials.

^{[24]}

## four randomized clinical

Content For this review, four cohort studies, four randomized clinical trials, one case report, and one case series were obtained from PubMed within the last 10 years.^{[1]}Four randomized clinical trials (RCTs) were included with human subjects, investigating the effect of cranberry on Helicobacter pylori eradication.

^{[2]}Four randomized clinical trials obtained an acceptable quality assessment, the others being classified as low quality, with methodological limitations in randomization, concealment and blinding.

^{[3]}Four randomized clinical trial, 17 case series and 9 single case reports were founded.

^{[4]}Four randomized clinical trials were included, providing a total of 63987 patients, 18860 with DM and 45127 without DM.

^{[5]}Four randomized clinical trials of 1086 TAVI patients were included.

^{[6]}RESULTS Four randomized clinical trials involving 423 participants were eligible.

^{[7]}Results: Four randomized clinical trials (RCTs) and 5 retrospective studies with 790 eyes were included in this meta-analysis after study selection.

^{[8]}Four randomized clinical trials with 213 subjects worked on the effect of pistachio on blood lipids were included.

^{[9]}RESULTS Four randomized clinical trials were included comprising a total of 1085 patients.

^{[10]}The studies included four randomized clinical trials of interim methadone (with three follow-up reports and five secondary analyses), one prospective cohort of interim methadone, one retrospective cohort of interim methadone, one randomized trial of low threshold services and two pre-post assessments of changes in program or state policies.

^{[11]}Four randomized clinical trials with 296 patients showed that statins play a neuroprotective role and improve cognitive outcomes through different mechanisms, especially their anti-inflammatory effect; they were shown to lower tumor necrosis factor (TNF)-α and C-reactive protein (CRP) levels.

^{[12]}After applying the exclusion criteria, we selected four randomized clinical trials, five reviews and one meta-analysis.

^{[13]}Methods: We performed a secondary analysis of four randomized clinical trials for the chemoprevention of colorectal adenomas.

^{[14]}RESULTS Sixteen relevant studies were ultimately selected by two independent reviewers: four randomized clinical trials (RCTs), four case-control studies, and eight retrospective studies.

^{[15]}RESULTS Four randomized clinical trials (RCT) and five prospective cohort studies were included, for a total of 1299 patients aged from 3 months to 14 years.

^{[16]}RESULTS Four randomized clinical trials and two quasi-experimental studies (n=296) were included.

^{[17]}RESULTS Four randomized clinical trials representing 2461 patients were identified.

^{[18]}Four randomized clinical trials were found: two with BUP implant and two with subcutaneous injectable BUP.

^{[19]}

## four randomized control

Results: Four randomized control trials and one retrospective comparative study were included in the analyses.^{[1]}RESULTS Four randomized control trials (RCTs) were retrieved, including 145 randomized participants.

^{[2]}METHODS This is a secondary analysis of pooled data from four randomized control trials on IOL.

^{[3]}Among the 40 articles were 14 acute exercise studies, four randomized control trials (RCTs), 18 cross-sectional studies, and four longitudinal studies.

^{[4]}Results Four randomized control trials, two quasi-experiments, and five one group pre-posttest designed studies, were included in the review with a total of 425 participants.

^{[5]}RESULTS A total of 12 studies (including four randomized control trials) with 1634 patients who underwent DTRA vs.

^{[6]}RESULTS The 12 articles selected included four randomized control trials (RCTs) (two were double-blinded placebo-controlled RCTs, one was a prospective partially masked RCT, and one was an open-label RCT), two retrospective observational studies, and six laboratory-based studies including two studies having in vivo and in vitro experiments, one was in vivo study, one was ex vivo study, and the last two were in vitro studies.

^{[7]}

## four randomized block

We performed a two-location trial in which 19 dented corn hybrids and five corn controls grew in four randomized blocks within two experimental areas located in the Northern (Campos dos Goytacazes) and Northwestern (Itaocara) Rio de Janeiro State, Brazil.^{[1]}These benches were divided into four randomized blocks.

^{[2]}In this controlled clinical trial, 72 patients with breast cancer were selected through consecutive sampling and randomly assigned to two control and intervention groups (n = 36 in each group) based on four randomized blocks.

^{[3]}

## four randomized meal

Subjects were provided one of four randomized meals on separate occasions (high carbohydrate, high protein, ad libitum or fasted baseline) prior to body composition and metabolic assessments.^{[1]}Methods: Participants completed four randomized meal trials.

^{[2]}

## four randomized condition

RESEARCH QUESTIONS How do spatiotemporal gait measures differ between indoor overground walking, outdoor walking, and treadmill walking in healthy adults? Do different walking environments exaggerate age-related alterations in gait performance in older compared to young adults? METHODS 30 young (18-30yrs) and 28 older adults (60-80yrs) completed four randomized conditions at their typical, comfortable walking pace: 1) 8 m of indoor walking, 2) continuous indoor walking, 3) treadmill walking, and 4) outdoor walking on a sidewalk.^{[1]}Male soccer athletes participated in four randomized conditions throughout the four visits: control (CON), 15-min smartphone (15SMA), 30-min smartphone (30SMA), and 45-min smartphone (45SMA).

^{[2]}

## four randomized complete

The treatments were applied in four randomized complete blocks with six peach trees as the experimental unit.^{[1]}) as the test crop in four randomized complete blocks each year.

^{[2]}

## four randomized study

Methods and Results Four randomized studies were included (n=75167; THEMIS [Ticagrelor on Health Outcomes in Diabetes Mellitus Patients Intervention Study], COMPASS [Cardiovascular Outcomes for People Using Anticoagulation Strategies], PEGASUS‐TIMI 54 [Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis in Myocardial Infarction 54], and DAPT [Dual Anti‐platelet Therapy]).^{[1]}9 kg/m2) during four randomized study visits; the HF meal was administered twice for reproducibility.

^{[2]}

## four randomized group

The trial included 181 patients discharged from acute psychiatric care and distributed into four randomized groups.^{[1]}In four randomized groups, the reduction of avoidance by incentives for non-avoidance, instructions to refrain from avoidance, and social observation of non-avoidance was compared to no intervention before removing the aversive outcome.

^{[2]}