Introduction to Drug Trials
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Drug Trials sentence examples within Clinical Drug Trials
An innovative approach to patient management, evidence-based policy development, and clinical drug trials is required to provide personalized care and to improve the likelihood of finding an effective treatment for Motor Neurone Disease (MND).
An innovative approach to patient management, evidence-based policy development, and clinical drug trials is required to provide personalized care and to improve the likelihood of finding an effective treatment for Motor Neurone Disease (MND).
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Although MEP measurements have been correlated with clinical scores and other measures of neurodegeneration, further validation of MEP amplitude measurements is needed regarding their validity, reliability, and sensitivity before they can be routinely used in clinical drug trials in MS.
Although MEP measurements have been correlated with clinical scores and other measures of neurodegeneration, further validation of MEP amplitude measurements is needed regarding their validity, reliability, and sensitivity before they can be routinely used in clinical drug trials in MS.
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Drug Trials sentence examples within Pediatric Drug Trials
The existence of an early LV mechanical dyssynchrony visualized using 2D-STE analysis in children with DMD before the onset of cardiomyopathy represents a perspective for future pediatric drug trials in the DMD-related cardiomyopathy prevention.
The existence of an early LV mechanical dyssynchrony visualized using 2D-STE analysis in children with DMD before the onset of cardiomyopathy represents a perspective for future pediatric drug trials in the DMD-related cardiomyopathy prevention.
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Results: During the six years 349 pediatric clinical trials were registered on the platform, including 162 pediatric drug trials and 187 vaccine trials.
Results: During the six years 349 pediatric clinical trials were registered on the platform, including 162 pediatric drug trials and 187 vaccine trials.
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Drug Trials sentence examples within Cancer Drug Trials
METHODS
We examined editorials published in 2018 alongside trial reports in the top 5 journals that publish cancer drug trials (New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, and Journal of Clinical Oncology).
METHODS
We examined editorials published in 2018 alongside trial reports in the top 5 journals that publish cancer drug trials (New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, and Journal of Clinical Oncology).
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RESULTS
Although there exist many levels of guidance for HRQoL measures in cancer drug trials, challenges to operational implementation, the current inconsistent adherence to reporting standards, and the lack of consensus and understanding of analyses limit the value and potential of the resulting data collected.
RESULTS
Although there exist many levels of guidance for HRQoL measures in cancer drug trials, challenges to operational implementation, the current inconsistent adherence to reporting standards, and the lack of consensus and understanding of analyses limit the value and potential of the resulting data collected.
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Drug Trials sentence examples within Preclinical Drug Trials
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
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This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
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Drug Trials sentence examples within Randomized Drug Trials
Although several large randomized drug trials are underway, current survival from severe COVID-19 de- pends entirely on providing the best possible supportive care.
Although several large randomized drug trials are underway, current survival from severe COVID-19 de- pends entirely on providing the best possible supportive care.
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For pulmonary arterial hypertension, a disease once characterized by a particularly grim prognosis, prospective randomized drug trials with aggressive single (or combined) pharmacotherapy have measurably improved survival and quality of life for many patients.
For pulmonary arterial hypertension, a disease once characterized by a particularly grim prognosis, prospective randomized drug trials with aggressive single (or combined) pharmacotherapy have measurably improved survival and quality of life for many patients.
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Drug Trials sentence examples within Experimental Drug Trials
I study the ways in which Guibert’s autobiographical narrator habitually marks time in each book—particularly the terminal interval of its composition—and frustrates distinction between text and author, whose viability is likewise tracked and measured in HIV latency periods, Tcell drawdown, and eligibility thresholds for experimental drug trials.
I study the ways in which Guibert’s autobiographical narrator habitually marks time in each book—particularly the terminal interval of its composition—and frustrates distinction between text and author, whose viability is likewise tracked and measured in HIV latency periods, Tcell drawdown, and eligibility thresholds for experimental drug trials.
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Through an analysis of multiple case studies collected within a comprehensive cancer centre in Ontario, Canada, we examine how people with late-stage cancer and their healthcare providers enacted the process of medicalisation through engaging in the search for oncological treatments, such as experimental drug trials, despite the incurability of their disease.
Through an analysis of multiple case studies collected within a comprehensive cancer centre in Ontario, Canada, we examine how people with late-stage cancer and their healthcare providers enacted the process of medicalisation through engaging in the search for oncological treatments, such as experimental drug trials, despite the incurability of their disease.
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Drug Trials sentence examples within Silico Drug Trials
Here we describe the translation process that led to the development and uptake of Virtual Assay, a user-friendly software to perform in silico drug trials in population of human cardiac models.
Here we describe the translation process that led to the development and uptake of Virtual Assay, a user-friendly software to perform in silico drug trials in population of human cardiac models.
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Significance We demonstrate the integration of human in silico drug trials and optically-recorded simultaneous action potential and calcium transient data from human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) for prediction and mechanistic investigations of drug action.
Significance We demonstrate the integration of human in silico drug trials and optically-recorded simultaneous action potential and calcium transient data from human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) for prediction and mechanistic investigations of drug action.
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Drug Trials sentence examples within Antidepressant Drug Trials
BACKGROUND
To investigate the powerful placebo effects in antidepressant drug trials and their mechanisms, recent pioneering experimental studies showed that expectation manipulation combined with an active placebo attenuated induced sadness.
BACKGROUND
To investigate the powerful placebo effects in antidepressant drug trials and their mechanisms, recent pioneering experimental studies showed that expectation manipulation combined with an active placebo attenuated induced sadness.
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The present study examined the extent to which issues concerning antidepressant drug trials and the efficacy of antidepressants are covered in abnormal psychology textbooks.
The present study examined the extent to which issues concerning antidepressant drug trials and the efficacy of antidepressants are covered in abnormal psychology textbooks.
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Drug Trials sentence examples within Therapeutic Drug Trials
However, the addition of quantitative sequences to MRE examinations has potential drawbacks, including increased scan time and the need for further validation before being used in therapeutic drug trials as well as the clinic.
However, the addition of quantitative sequences to MRE examinations has potential drawbacks, including increased scan time and the need for further validation before being used in therapeutic drug trials as well as the clinic.
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137Background: Evidence is conflicting as to whether enrollment in therapeutic drug trials confers a survival benefit for NSCLC patients.
137Background: Evidence is conflicting as to whether enrollment in therapeutic drug trials confers a survival benefit for NSCLC patients.
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Drug Trials sentence examples within Controlled Drug Trials
OBJECTIVES
To further explore the EGFR-I/NP association and to inform planning of controlled drug trials in patients with NCP.
OBJECTIVES
To further explore the EGFR-I/NP association and to inform planning of controlled drug trials in patients with NCP.
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At present multiple therapeutic compounds/drugs are available targeting GABBR1 and ADRA1A, which could be tested for their effectiveness against CD in controlled drug trials.
At present multiple therapeutic compounds/drugs are available targeting GABBR1 and ADRA1A, which could be tested for their effectiveness against CD in controlled drug trials.
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Drug Trials sentence examples within Psychiatric Drug Trials
Aims The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) produce guidelines for the design of pivotal psychiatric drug trials used in new drug applications.
Aims The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) produce guidelines for the design of pivotal psychiatric drug trials used in new drug applications.
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Moreover, in psychiatric drug trials, a pattern of elevated early relapses following randomisation to placebo or no treatment is common.
Moreover, in psychiatric drug trials, a pattern of elevated early relapses following randomisation to placebo or no treatment is common.
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Drug Trials sentence examples within Multiple Drug Trials
Drug Trials sentence examples within Upcoming Drug Trials
This makes respiratory muscle imaging suitable to use as tool in clinical respiratory management and as outcome parameter in upcoming drug trials for neuromuscular disorders, particularly in children.
This makes respiratory muscle imaging suitable to use as tool in clinical respiratory management and as outcome parameter in upcoming drug trials for neuromuscular disorders, particularly in children.
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We aim to discuss their strengths and limitations, in relation to their current development and suitability as outcome measures for use in a clinical setting and as in upcoming drug trials in DMD.
We aim to discuss their strengths and limitations, in relation to their current development and suitability as outcome measures for use in a clinical setting and as in upcoming drug trials in DMD.
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Drug Trials sentence examples within Pharmaceutical Drug Trials
In 1998, long before Silicon Valley became known for its entrepreneurial spirit, Professor Genant co-founded Synarc (now Synarc-BioClinica), a global contract research organization specializing in management of quantitative imaging and biomarkers in large, multicenter, multinational, pharmaceutical drug trials.
In 1998, long before Silicon Valley became known for its entrepreneurial spirit, Professor Genant co-founded Synarc (now Synarc-BioClinica), a global contract research organization specializing in management of quantitative imaging and biomarkers in large, multicenter, multinational, pharmaceutical drug trials.
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In particular, we explore the speculative practices of healthy individuals who enroll in pharmaceutical drug trials as their primary or critical source of income.
In particular, we explore the speculative practices of healthy individuals who enroll in pharmaceutical drug trials as their primary or critical source of income.
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Drug Trials sentence examples within Celebrity Drug Trials
Aim: We aimed to examine and interpret the changes in internet search volumes for keywords representing different drug use-related themes before and after the drug use started being discussed in the Indian news media during recent celebrity drug trials.
Aim: We aimed to examine and interpret the changes in internet search volumes for keywords representing different drug use-related themes before and after the drug use started being discussed in the Indian news media during recent celebrity drug trials.
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Drug Trials sentence examples within drug trials snapshot
The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.
The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.
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To determine whether there has been equitable representation of Black individuals in the clinical trials for dermatologic new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analyzed data from the FDA Drug Trials Snapshots program from January 2015 to the present.
To determine whether there has been equitable representation of Black individuals in the clinical trials for dermatologic new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analyzed data from the FDA Drug Trials Snapshots program from January 2015 to the present.
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Drug Trials sentence examples within drug trials showed
Effect size analysis for simulated clinical longitudinal <sup>18</sup>F-AV-1451 drug trials showed that uncorrected 20-min offset SUVRs would require up to 20% more participants to detect treatment effects compared with using SLS.
Effect size analysis for simulated clinical longitudinal <sup>18</sup>F-AV-1451 drug trials showed that uncorrected 20-min offset SUVRs would require up to 20% more participants to detect treatment effects compared with using SLS.
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Drug trials showed neutral mortality in post–myocardial infarction patients and those with heart failure.
Drug trials showed neutral mortality in post–myocardial infarction patients and those with heart failure.
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Drug Trials sentence examples within drug trials toward
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
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This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
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More Drug Trials sentence examples
10.1080/21678421.2021.1980889
An innovative approach to patient management, evidence-based policy development, and clinical drug trials is required to provide personalized care and to improve the likelihood of finding an effective treatment for Motor Neurone Disease (MND).
An innovative approach to patient management, evidence-based policy development, and clinical drug trials is required to provide personalized care and to improve the likelihood of finding an effective treatment for Motor Neurone Disease (MND).
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More Drug Trials sentence examples
10.1097/WNP.0000000000000734
Although MEP measurements have been correlated with clinical scores and other measures of neurodegeneration, further validation of MEP amplitude measurements is needed regarding their validity, reliability, and sensitivity before they can be routinely used in clinical drug trials in MS.
Although MEP measurements have been correlated with clinical scores and other measures of neurodegeneration, further validation of MEP amplitude measurements is needed regarding their validity, reliability, and sensitivity before they can be routinely used in clinical drug trials in MS.
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More Drug Trials sentence examples
10.3390/cancers13133330
Recent drug trials have shown promise, but only improved TNBC survival by several months.
Recent drug trials have shown promise, but only improved TNBC survival by several months.
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10.1080/14737175.2021.1886082
Expert opinion: There is an age discrepancy between pwMS included in regulatory drug trials and an aging real-world MS population.
Expert opinion: There is an age discrepancy between pwMS included in regulatory drug trials and an aging real-world MS population.
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10.1017/S2045796021000147
Aims The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) produce guidelines for the design of pivotal psychiatric drug trials used in new drug applications.
Aims The European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) produce guidelines for the design of pivotal psychiatric drug trials used in new drug applications.
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More Drug Trials sentence examples
10.1186/s12866-021-02245-8
We recommend that future antibiotic drug trials include similar exploratory investigations into the duration and context of microbiome modification and recovery.
We recommend that future antibiotic drug trials include similar exploratory investigations into the duration and context of microbiome modification and recovery.
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10.1007/978-981-16-5248-6_35
However, with the increasing number of publications (in print and on the electronic media), medical books, promotions of drugs and devices, and writing designs for drug trials the requirement for medical writers is increasing [1].
However, with the increasing number of publications (in print and on the electronic media), medical books, promotions of drugs and devices, and writing designs for drug trials the requirement for medical writers is increasing [1].
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10.1136/bmj.n387
It seems strange that thousands of patients with covid-19 have been randomised in drug trials but so few in non-drug interventions trials (though of course that has long been a general difficulty, perhaps reflecting a reluctance to evaluate non-drug interventions).
It seems strange that thousands of patients with covid-19 have been randomised in drug trials but so few in non-drug interventions trials (though of course that has long been a general difficulty, perhaps reflecting a reluctance to evaluate non-drug interventions).
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10.1186/s12859-021-04082-y
Existing data and modern computational methods allow to identify potentially beneficial and harmful interactions, and therefore, narrow drug trials ahead of actual clinical trials.
Existing data and modern computational methods allow to identify potentially beneficial and harmful interactions, and therefore, narrow drug trials ahead of actual clinical trials.
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10.22034/iji.2021.88526.1874
Multiple drug trials are ongoing and several putative candidates for vaccination against the virus have been approved and are in the pipeline.
Multiple drug trials are ongoing and several putative candidates for vaccination against the virus have been approved and are in the pipeline.
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10.1097/DBP.0000000000000900
METHOD
Parents completed an online survey (N = 37) assessing family/child sociodemographic factors and to capture thoughts on cognitive enhancement and participation in clinical drug trials.
METHOD
Parents completed an online survey (N = 37) assessing family/child sociodemographic factors and to capture thoughts on cognitive enhancement and participation in clinical drug trials.
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10.1093/bjs/znab035
Meta-epidemiological studies of drug trials have demonstrated exaggerated treatment effects in RCTs where such methods were not employed.
Meta-epidemiological studies of drug trials have demonstrated exaggerated treatment effects in RCTs where such methods were not employed.
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10.1101/2021.01.28.428530
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
This behavioural screening platform should prove useful for preclinical drug trials towards improved treatments in HD and other neurological disorders.
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10.3760/cma.j.cn112152-20201221-01089
Research progress of oncology drug trials and approved cancer drugs in China in 2020 were systematically summarized and compared with 2019.
Research progress of oncology drug trials and approved cancer drugs in China in 2020 were systematically summarized and compared with 2019.
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10.1016/j.anai.2021.03.022
OBJECTIVE
The coreASTHMA project sought to develop a core set of outcomes to be measured in phase 3 and phase 4 clinical drug trials in patients with moderate-to-severe asthma.
OBJECTIVE
The coreASTHMA project sought to develop a core set of outcomes to be measured in phase 3 and phase 4 clinical drug trials in patients with moderate-to-severe asthma.
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10.1093/cid/ciab025
Thus, although adequate and well-controlled trials in NC are often unfeasible due to difficulty enrolling patients, extrapolation of efficacy from antifungal drug trials in adults is generally not appropriate.
Thus, although adequate and well-controlled trials in NC are often unfeasible due to difficulty enrolling patients, extrapolation of efficacy from antifungal drug trials in adults is generally not appropriate.
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10.6004/jnccn.2021.7016
METHODS
We examined editorials published in 2018 alongside trial reports in the top 5 journals that publish cancer drug trials (New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, and Journal of Clinical Oncology).
METHODS
We examined editorials published in 2018 alongside trial reports in the top 5 journals that publish cancer drug trials (New England Journal of Medicine, Lancet, Lancet Oncology, JAMA Oncology, and Journal of Clinical Oncology).
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10.1111/jcpt.13532
The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.
The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.
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10.3390/ijms22083933
Identification of potential peripheral biomarker candidates for AD may be useful, not only for early disease diagnosis but also in drug trials and to monitor disease progression, allowing for a timely therapeutic intervention, which will positively impact the patient’s quality of life.
Identification of potential peripheral biomarker candidates for AD may be useful, not only for early disease diagnosis but also in drug trials and to monitor disease progression, allowing for a timely therapeutic intervention, which will positively impact the patient’s quality of life.
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10.1177/03331024211014625
The International Headache Society recommends pain free at 2 h as the primary pain parameter; whereas headache relief at 2 h should be a secondary endpoint (4) used mainly to compare current results with results in previous clinical drug trials in migraine.
The International Headache Society recommends pain free at 2 h as the primary pain parameter; whereas headache relief at 2 h should be a secondary endpoint (4) used mainly to compare current results with results in previous clinical drug trials in migraine.
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10.1016/j.msard.2021.102966
OBJECTIVES
To identify longitudinal patterns of disability progression, as measured by changes in the Multiple Sclerosis Functional Composite (MSFC), of young people in MS drug trials and to estimate the extent to which disability progression differ in two age groups (≤25 years and 26 - 35 years).
OBJECTIVES
To identify longitudinal patterns of disability progression, as measured by changes in the Multiple Sclerosis Functional Composite (MSFC), of young people in MS drug trials and to estimate the extent to which disability progression differ in two age groups (≤25 years and 26 - 35 years).
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10.1556/2006.2021.00044
Methods
Men with Compulsive Sexual Behavior Disorder (n = 20), and Pedophilic Disorder (n = 55), enrolled in two separate drug trials in a specialized Swedish sexual medicine outpatient clinic, as well as healthy male controls (n = 57) were assessed with the Hypersexual Behavior Inventory (HBI) for sexual compulsivity, and with the Barratt Impulsiveness Scale (BIS) and Connors' Continuous Performance Test-II (CPT-II) for impulsivity.
Methods
Men with Compulsive Sexual Behavior Disorder (n = 20), and Pedophilic Disorder (n = 55), enrolled in two separate drug trials in a specialized Swedish sexual medicine outpatient clinic, as well as healthy male controls (n = 57) were assessed with the Hypersexual Behavior Inventory (HBI) for sexual compulsivity, and with the Barratt Impulsiveness Scale (BIS) and Connors' Continuous Performance Test-II (CPT-II) for impulsivity.
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10.1186/s12887-021-02658-4
Drug trials decreased from 48.
Drug trials decreased from 48.
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10.1177/23743735211039319
Pediatric new drug trials are federally mandated, but family perspectives in multiple sclerosis (MS) research are limited.
Pediatric new drug trials are federally mandated, but family perspectives in multiple sclerosis (MS) research are limited.
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10.1002/ejhf.2139
Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) approved the use of the Kansas City Cardiomyopathy Questionnaire (KCCQ) as a primary endpoint in drug trials for patients with heart failure (HF).
Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) approved the use of the Kansas City Cardiomyopathy Questionnaire (KCCQ) as a primary endpoint in drug trials for patients with heart failure (HF).
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10.1093/MED/9780190097653.003.0067
Trials have usually been rated as low to moderate in quality, and although double-blinding will always be an issue in behavioral trials, there is a need to approach exercise studies with the rigor applied to drug trials if it is to be considered an adjuvant cancer therapy.
Trials have usually been rated as low to moderate in quality, and although double-blinding will always be an issue in behavioral trials, there is a need to approach exercise studies with the rigor applied to drug trials if it is to be considered an adjuvant cancer therapy.
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10.21203/RS.3.RS-353024/V1
Background In drug trials, clinical adverse events (AEs), concomitant medication and laboratory safety outcomes are repeatedly collected to support drug safety evidence.
Background In drug trials, clinical adverse events (AEs), concomitant medication and laboratory safety outcomes are repeatedly collected to support drug safety evidence.
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10.1016/j.jocs.2020.101202
Here we describe the translation process that led to the development and uptake of Virtual Assay, a user-friendly software to perform in silico drug trials in population of human cardiac models.
Here we describe the translation process that led to the development and uptake of Virtual Assay, a user-friendly software to perform in silico drug trials in population of human cardiac models.
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10.12932/AP-270820-0948
Most drug trials in CSU have focused on omalizumab or cyclosporine monotherapy.
Most drug trials in CSU have focused on omalizumab or cyclosporine monotherapy.
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10.1200/JCO.2021.39.15_SUPPL.E18642
However, in a review conducted of clinical drug trials in oncology, one-third of oncologist authors did not disclose their industry payments.
However, in a review conducted of clinical drug trials in oncology, one-third of oncologist authors did not disclose their industry payments.
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10.1016/j.jad.2021.05.041
Clinician administered scales are dominating in drug trials, while self-report questionnaires are primarily used in behavioral trials.
Clinician administered scales are dominating in drug trials, while self-report questionnaires are primarily used in behavioral trials.
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10.1183/13993003.00137-2021
This makes respiratory muscle imaging suitable to use as tool in clinical respiratory management and as outcome parameter in upcoming drug trials for neuromuscular disorders, particularly in children.
This makes respiratory muscle imaging suitable to use as tool in clinical respiratory management and as outcome parameter in upcoming drug trials for neuromuscular disorders, particularly in children.
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10.1016/S2666-7568(21)00092-1
Summary Background Representativeness of antihypertensive drug trials is uncertain, as many trials recruit few or no older people.
Summary Background Representativeness of antihypertensive drug trials is uncertain, as many trials recruit few or no older people.
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10.1073/pnas.2019132118
This preponderance of mutations—some activating, some silent—in a known target protein make clinical decisions for enrolling patients in drug trials challenging since the relevance of the target and its drug sensitivity often depend on the mutational status in a given patient.
This preponderance of mutations—some activating, some silent—in a known target protein make clinical decisions for enrolling patients in drug trials challenging since the relevance of the target and its drug sensitivity often depend on the mutational status in a given patient.
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10.1111/ced.14871
To determine whether there has been equitable representation of Black individuals in the clinical trials for dermatologic new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analyzed data from the FDA Drug Trials Snapshots program from January 2015 to the present.
To determine whether there has been equitable representation of Black individuals in the clinical trials for dermatologic new molecular entities (NMEs) approved by the US Food and Drug Administration (FDA) since 2015, we analyzed data from the FDA Drug Trials Snapshots program from January 2015 to the present.
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10.1016/j.eprac.2021.06.015
RESULTS
There were 24 RCT's of drug-versus-placebo (73,862 women) and 10 drug-versus-drug trials.
RESULTS
There were 24 RCT's of drug-versus-placebo (73,862 women) and 10 drug-versus-drug trials.
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10.2147/PPA.S328969
Moreover, a significant number of full-time employed pregnant women believed that clinical drug trials will increase the possibility of disease cure, relative to part-time/not employed pregnant women (98.
Moreover, a significant number of full-time employed pregnant women believed that clinical drug trials will increase the possibility of disease cure, relative to part-time/not employed pregnant women (98.
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10.3389/fimmu.2021.704173
In this review we discuss the current evidence to support the trafficking cell as an immunotherapeutic target in lung disease, and which potential mechanisms or pathways have shown promise in early drug trials, with a focus on the neutrophil, as the quintessential trafficking immune cell.
In this review we discuss the current evidence to support the trafficking cell as an immunotherapeutic target in lung disease, and which potential mechanisms or pathways have shown promise in early drug trials, with a focus on the neutrophil, as the quintessential trafficking immune cell.
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10.1109/MPULS.2021.3066715
The committee would review drug trials of Biogen’s aducanumab, and conclude with a vote on the drug’s safety and efficacy in treating AD.
The committee would review drug trials of Biogen’s aducanumab, and conclude with a vote on the drug’s safety and efficacy in treating AD.
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10.1186/s12874-021-01412-9
Background In drug trials, clinical adverse events (AEs), concomitant medication and laboratory safety outcomes are repeatedly collected to support drug safety evidence.
Background In drug trials, clinical adverse events (AEs), concomitant medication and laboratory safety outcomes are repeatedly collected to support drug safety evidence.
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10.1016/j.jad.2021.07.037
BACKGROUND
To investigate the powerful placebo effects in antidepressant drug trials and their mechanisms, recent pioneering experimental studies showed that expectation manipulation combined with an active placebo attenuated induced sadness.
BACKGROUND
To investigate the powerful placebo effects in antidepressant drug trials and their mechanisms, recent pioneering experimental studies showed that expectation manipulation combined with an active placebo attenuated induced sadness.
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10.9734/JPRI/2021/V33I931219
02% of them agreed that the majority of non-prescription medicines are supported by scientific evidence from drug trials to prove they are effective.
02% of them agreed that the majority of non-prescription medicines are supported by scientific evidence from drug trials to prove they are effective.
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10.1007/s00330-021-07822-z
In 1998, long before Silicon Valley became known for its entrepreneurial spirit, Professor Genant co-founded Synarc (now Synarc-BioClinica), a global contract research organization specializing in management of quantitative imaging and biomarkers in large, multicenter, multinational, pharmaceutical drug trials.
In 1998, long before Silicon Valley became known for its entrepreneurial spirit, Professor Genant co-founded Synarc (now Synarc-BioClinica), a global contract research organization specializing in management of quantitative imaging and biomarkers in large, multicenter, multinational, pharmaceutical drug trials.
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10.1093/AGEING/AFAB029.11
Frailty is identifiable and prevalent among middle aged and older participants in phase 3/4 drug trials and has clinically important safety implications.
Frailty is identifiable and prevalent among middle aged and older participants in phase 3/4 drug trials and has clinically important safety implications.
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10.3389/fneur.2021.674483
Most patients are able to achieve seizure freedom by the first two appropriate drug trials.
Most patients are able to achieve seizure freedom by the first two appropriate drug trials.
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10.17116/labs20211002155
In the scientific debate on vitamin D, we should consider that nutrient trials differ from drug trials and that apart from the opposed positions regarding indications for vitamin D treatment we still have to better characterize the precise role of vitamin D for human health.
In the scientific debate on vitamin D, we should consider that nutrient trials differ from drug trials and that apart from the opposed positions regarding indications for vitamin D treatment we still have to better characterize the precise role of vitamin D for human health.
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10.1192/bjb.2021.47
CGI scales in psychiatry were initially used to assess efficacy in clinical drug trials and have since been adapted for use in liaison psychiatry as a part of a nationwide evaluation.
CGI scales in psychiatry were initially used to assess efficacy in clinical drug trials and have since been adapted for use in liaison psychiatry as a part of a nationwide evaluation.
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10.1161/STROKEAHA.120.032025
CONCLUSIONS
Patients either with excellent outcomes after endovascular thrombectomy or with large infarcts may dilute the treatment effect in stroke neuroprotective drug trials.
CONCLUSIONS
Patients either with excellent outcomes after endovascular thrombectomy or with large infarcts may dilute the treatment effect in stroke neuroprotective drug trials.
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10.1139/cjpp-2021-0038
Over the past year, our knowledge of this novel disease has grown and has led to the initiation of a number of clinical vaccine and drug trials for the prevention and treatment of COVID-19.
Over the past year, our knowledge of this novel disease has grown and has led to the initiation of a number of clinical vaccine and drug trials for the prevention and treatment of COVID-19.
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10.1136/jnnp-2021-326553
It is also the most prevalent mutation in neighbouring Belgium, making this a particular suitable mutation to study in drug trials.
It is also the most prevalent mutation in neighbouring Belgium, making this a particular suitable mutation to study in drug trials.
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10.1016/j.schres.2021.08.005
The aim was to analyse whether baseline patient and study characteristics predict treatment response in TRS in drug trials.
The aim was to analyse whether baseline patient and study characteristics predict treatment response in TRS in drug trials.
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10.46883/ONC.2021.3503.0107
The estimated extent of racial disparities in clinical trial access varies in the literature, yet recent reports-such as the FDA's 2018 Drug Trials Snapshots-indicate the presence of a remarkable imbalance.
The estimated extent of racial disparities in clinical trial access varies in the literature, yet recent reports-such as the FDA's 2018 Drug Trials Snapshots-indicate the presence of a remarkable imbalance.
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10.1136/bmjebm-2021-111743
Moreover, in psychiatric drug trials, a pattern of elevated early relapses following randomisation to placebo or no treatment is common.
Moreover, in psychiatric drug trials, a pattern of elevated early relapses following randomisation to placebo or no treatment is common.
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10.1111/ped.14525
The concept of informed assent in drug trials was first widely recognized when ICH Topic E-11 was implemented in Japan in 2000, and discussion on comprehensive ethical principles for pediatric clinical research did not occur in a coordinated fashion.
The concept of informed assent in drug trials was first widely recognized when ICH Topic E-11 was implemented in Japan in 2000, and discussion on comprehensive ethical principles for pediatric clinical research did not occur in a coordinated fashion.
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10.1186/s12874-021-01359-x
Drug trials and larger trials were associated with a higher probability to be published and to have an impact than non-drug trials and smaller trials.
Drug trials and larger trials were associated with a higher probability to be published and to have an impact than non-drug trials and smaller trials.
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10.1128/Spectrum.00481-21
ABSTRACT There is a critical need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials.
ABSTRACT There is a critical need for improved pharmacodynamic markers for use in human tuberculosis (TB) drug trials.
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10.1007/s00431-021-03933-3
The ages of consent relating to data privacy and clinical trial participation are different in a number of countries, but the distinction is often not recognised in non-drug trials.
The ages of consent relating to data privacy and clinical trial participation are different in a number of countries, but the distinction is often not recognised in non-drug trials.
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10.1080/14737140.2021.1880326
Additionally, with new combination drug trials, exciting avenues for treatment are also discussed with the FIRST (NCT03016338) trial.
Additionally, with new combination drug trials, exciting avenues for treatment are also discussed with the FIRST (NCT03016338) trial.
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10.3138/JCS-2020-0003
Since the 1960s, celebrity drug trials have usually involved actors or musicians.
Since the 1960s, celebrity drug trials have usually involved actors or musicians.
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10.1523/JNEUROSCI.0165-21.2021
This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
This behavioral screening platform should prove useful for preclinical drug trials toward improved treatments in HD and other neurologic disorders.
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10.1016/j.conctc.2021.100783
Introduction For more than two decades several initiatives have emerged to increase recruitment of paediatric patients in drug trials.
Introduction For more than two decades several initiatives have emerged to increase recruitment of paediatric patients in drug trials.
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10.20517/2347-9264.2020.220
Tracking productivity of individual hair follicular units from longitudinal studies challenged the application of our methods during drug trials.
Tracking productivity of individual hair follicular units from longitudinal studies challenged the application of our methods during drug trials.
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10.1176/appi.ajp.2021.20121776
OBJECTIVE
Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent.
OBJECTIVE
Evidence from anti-inflammatory drug trials for the treatment of depression has been inconsistent.
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10.1080/17530350.2020.1850504
In particular, we explore the speculative practices of healthy individuals who enroll in pharmaceutical drug trials as their primary or critical source of income.
In particular, we explore the speculative practices of healthy individuals who enroll in pharmaceutical drug trials as their primary or critical source of income.
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