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Dopaminergic Dysfunction sentence examples within drug related stimuli

drug related stimuli

We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli.

A salience misattribution model for addictive-like behaviors

drug related stimuli

We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli.

The neural and computational processes driving maladaptive decision-making in addiction

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Dopaminergic Dysfunction sentence examples within Striatal Dopaminergic Dysfunction

Striatal Dopaminergic Dysfunction

Conclusions This prospective interventional study highlights the pathophysiologic relevance of striatal dopaminergic dysfunction in the motor phenotypic expression of iNPH.

Clinical Outcome and Striatal Dopaminergic Function After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus

Striatal Dopaminergic Dysfunction

Objective To investigate the effect of polygenic load on the progression of striatal dopaminergic dysfunction in patients with Parkinson disease (PD).

Effect of polygenic load on striatal dopaminergic deterioration in Parkinson disease

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Dopaminergic Dysfunction sentence examples within Subcortical Dopaminergic Dysfunction

Subcortical Dopaminergic Dysfunction

Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors.

Interactions between hippocampal activity and striatal dopamine in people at clinical high risk for psychosis: relationship to adverse outcomes

Subcortical Dopaminergic Dysfunction

A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment.

The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal 18F-DOPA PET and voxel-based morphometry study

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Dopaminergic Dysfunction sentence examples within Nigrostriatal Dopaminergic Dysfunction

Nigrostriatal Dopaminergic Dysfunction

To explore the association between parkinsonism and SCA31, five patients with SCA31 with concomitant nigrostriatal dopaminergic dysfunction (NSDD) development, including three cases of L-DOPA responsive parkinsonism, were analyzed.

Midbrain atrophy related to parkinsonism in a non-coding repeat expansion disorder: five cases of spinocerebellar ataxia type 31 with nigrostriatal dopaminergic dysfunction

Nigrostriatal Dopaminergic Dysfunction

Our results show that mild motor impairment in rapid eye movement sleep behavior disorder evaluated by finger tapping task presented mild nigrostriatal dopaminergic dysfunction as well as alterations in resting state sensorimotor network.

Nigrostriatal Dopaminergic Dysfunction and Altered Functional Connectivity in REM Sleep Behavior Disorder With Mild Motor Impairment

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Dopaminergic Dysfunction sentence examples within dopaminergic dysfunction may

dopaminergic dysfunction may

Depression, NeuroHIV and many of the neuropsychiatric therapeutics used to treat them impact the dopaminergic system, suggesting that dopaminergic dysfunction may be a common factor in the development of these disorders.

Dopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults

dopaminergic dysfunction may

The present study examined spontaneous eye-blink rate (EBR), an indirect, non-invasive measure of central dopaminergic activity, and theta power in children with ASD to determine: 1) whether ASD may be associated with atypical DA levels, and 2) whether dopaminergic dysfunction may be associated with aberrant theta-band activation.

Dopaminergic hypo-activity and reduced theta-band power in autism spectrum disorder: A resting-state EEG study.

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10.23937/2378-3516/1410154

Prior research of SRED implicates a dopaminergic dysfunction in the pathogenesis of SRED.

The Mysterious Case of Missing Food from the Fridge: Sleep Eating on a Combination of Melatonin and Eszopiclone

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10.1007/s12640-021-00371-9

Dopaminergic dysfunction is a part of Alzheimer's disease pathology.

Differential Influence of Amyloid-β on the Kinetics of Dopamine Release in the Dorsal and Ventral Striatum of Rats.

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10.1101/2021.03.11.21253426

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction is driven by aberrant bottom-up subcortical signaling or impaired top-down cortical regulation.

Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy Controls

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10.1016/j.neuroimage.2021.118006

For instance, dopaminergic dysfunction of the human striatum is considered to be a pathophysiological underpinning of different disorders, such as Parkinson's disease (PD) and schizophrenia (SCZ).

Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate

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10.1016/j.biopha.2021.112100

The potential mechanisms that link 5-ARIs and depression include alteration in neuroactive steroids, dopaminergic dysfunction, reduced hippocampal neurogenesis, increased neuroinflammation, alteration of the HPA axis, and epigenetic modifications.

The connection of 5-alpha reductase inhibitors to the development of depression.

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10.1038/s41386-021-01016-3

Taken together, our findings suggest that symptomatic treatment with BI 409306 can restore social interaction deficits and dopaminergic dysfunctions in a MIA model of neurodevelopmental disruption, lending preclinical support to current clinical trials of BI 409306 in patients with schizophrenia.

Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders

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10.1038/s42003-021-02705-x

PD groups exhibited asymmetric pattern of dopaminergic dysfunction in putamen, impaired integrity in the microstructures (nigral FA, putaminal MD, and FA of nigrostriatal projection).

Hybrid PET-MRI for early detection of dopaminergic dysfunction and microstructural degradation involved in Parkinson’s disease

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10.1101/2021.09.10.459766

Our study reveals that recruiting different brain networks is an early response to the dopaminergic dysfunction preceding neuronal cell loss.

Combining CRISPR/Cas9 and brain imaging: from genes to molecules to networks

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10.1016/j.brainresbull.2021.07.008

Studies have shown that both aging and dopaminergic dysfunction affected spatial learning and memory.

The effects of aging and dopaminergic inhibition on large scale maze learning in rhesus monkeys

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10.1007/s40473-021-00234-9

Neuroimaging studies have elucidated parallel mechanisms in food addiction and substance-use disorders, including dopaminergic dysfunction, emotion dysregulation, and impulsivity.

Advances in the Neurobiology of Food Addiction

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10.1038/s41380-021-01108-y

Our findings suggest that genetic risk for psychosis is associated with dopaminergic dysfunction and identify dopamine synthesis as a potential target for treatment or prevention of psychosis in 22q11.

Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study

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10.3390/bs11100141

Findings point to (1) dopaminergic dysfunction (based on biochemical and genetic studies), (2) serotonergic dysfunction (based on partial agonism/antagonism of drugs), and (3) brain structure/function impairment, especially in the temporal and parietal lobes, as crucial factors in treatment response.

Dopamine, Serotonin, and Structure/Function Brain Defects as Biological Bases for Treatment Response in Delusional Disorder: A Systematic Review of Cases and Cohort Studies

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10.1038/s41598-021-99025-1

Dopaminergic system involvement in AD has been suggested, particularly through the appearance of dopaminergic dysfunction-related neuropsychiatric symptoms and an overall worsening of cognitive and behavioral symptoms.

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer’s disease

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10.3390/ijms22136974

Imbalance of this ratio may result in dopaminergic dysfunctions related to several brain disorders, including psychotic diseases and drug dependence.

A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity

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10.1093/hmg/ddab118

ASYN(d)/Nurr1+/− (2-hit) mice, contrary to the individual genetic traits, developed phenotypes consistent with dopaminergic dysfunction.

Nurr1 repression mediates cardinal features of Parkinson’s disease in α-synuclein transgenic mice

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10.1080/14737175.2021.1880896

ABSTRACT Introduction It is now accepted that Parkinson’s disease (PD) is not simply due to dopaminergic dysfunction, and there is interest in developing non-dopaminergic approaches to disease management.

Istradefylline – a first generation adenosine A2A antagonist for the treatment of Parkinson’s disease

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10.3389/fpsyt.2021.770282

Our results support neuromelanin as a candidate biomarker for dopaminergic dysfunction in schizophrenia.

Neuromelanin-Sensitive Magnetic Resonance Imaging in Schizophrenia: A Meta-Analysis of Case-Control Studies

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10.1016/j.bios.2021.113100

Accurate quantitative detection of dopamine (DA) in blood is essential for the early diagnosis and the pathogenesis analysis of dopaminergic dysfunction, which still remains a great challenge because of the extremely low concentration in patients.

Ultra-sensitive surface enhanced Raman spectroscopy sensor for in-situ monitoring of dopamine release using zipper-like ortho-nanodimers.

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10.1093/gerona/glab098

In this article, we provide an overview of some mechanisms that mediate neural regulation of muscle contraction and control, and highlight the specific contributions of neural hypoexcitability, dopaminergic dysfunction, and degradation of functional and structural brain connectivity in relation to sarcopenia.

Sarcopenia and Neuroscience: Learning to Communicate.

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10.3389/fnhum.2021.639269

Purpose Childhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction.

Enlarged Area of Mesencephalic Iron Deposits in Adults Who Stutter

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10.1101/2021.09.16.460471

Dopaminergic dysfunction is implicated in an equally multidimensional spectrum of neurological and neuropsychiatric diseases.

Multimodal Detection of Dopamine by Sniffer Cells Expressing Genetically Encoded Fluorescence Sensors

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10.21203/RS.3.RS-691589/V1

ConclusionsWe establish, therefore, that VAP-1 inhibition has an anti-inflammatory profile that may have beneficial in the treatment of dopaminergic dysfunction caused by an acute inflammatory state in the brain.

Inhibition of Vascular Adhesion Protein 1 Protects Dopamine Neurons From the Effects of Acute Inflammation and Restores Habit Learning in the Striatum

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10.1016/j.encep.2021.01.008

Our review aims to explain the « dynamic » model of dopaminergic dysfunctions and propose some guidance for pharmacological treatment of ADHD, with or without psychotic disorder.

[ADHD during childhood and subsequent psychotic disorder: A link?]

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10.3390/brainsci11101293

Given the patient’s genetic condition, we hypothesized that the dopaminergic dysfunction had been aggravated by COMT involvement, thus causing dystonia.

Role of COMT V158M Polymorphism in the Development of Dystonia after Administration of Antipsychotic Drugs

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Dopaminergic Dysfunction
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What is/are Dopaminergic Dysfunction?

Dopaminergic Dysfunction - Prior research of SRED implicates a dopaminergic dysfunction in the pathogenesis of SRED. [1] Dopaminergic dysfunction is a part of Alzheimer's disease pathology. [2] Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction is driven by aberrant bottom-up subcortical signaling or impaired top-down cortical regulation. [3] For instance, dopaminergic dysfunction of the human striatum is considered to be a pathophysiological underpinning of different disorders, such as Parkinson's disease (PD) and schizophrenia (SCZ). [4] The potential mechanisms that link 5-ARIs and depression include alteration in neuroactive steroids, dopaminergic dysfunction, reduced hippocampal neurogenesis, increased neuroinflammation, alteration of the HPA axis, and epigenetic modifications. [5] Taken together, our findings suggest that symptomatic treatment with BI 409306 can restore social interaction deficits and dopaminergic dysfunctions in a MIA model of neurodevelopmental disruption, lending preclinical support to current clinical trials of BI 409306 in patients with schizophrenia. [6] PD groups exhibited asymmetric pattern of dopaminergic dysfunction in putamen, impaired integrity in the microstructures (nigral FA, putaminal MD, and FA of nigrostriatal projection). [7] Our study reveals that recruiting different brain networks is an early response to the dopaminergic dysfunction preceding neuronal cell loss. [8] Studies have shown that both aging and dopaminergic dysfunction affected spatial learning and memory. [9] Neuroimaging studies have elucidated parallel mechanisms in food addiction and substance-use disorders, including dopaminergic dysfunction, emotion dysregulation, and impulsivity. [10] Our findings suggest that genetic risk for psychosis is associated with dopaminergic dysfunction and identify dopamine synthesis as a potential target for treatment or prevention of psychosis in 22q11. [11] Findings point to (1) dopaminergic dysfunction (based on biochemical and genetic studies), (2) serotonergic dysfunction (based on partial agonism/antagonism of drugs), and (3) brain structure/function impairment, especially in the temporal and parietal lobes, as crucial factors in treatment response. [12] Dopaminergic system involvement in AD has been suggested, particularly through the appearance of dopaminergic dysfunction-related neuropsychiatric symptoms and an overall worsening of cognitive and behavioral symptoms. [13] Imbalance of this ratio may result in dopaminergic dysfunctions related to several brain disorders, including psychotic diseases and drug dependence. [14] ASYN(d)/Nurr1+/− (2-hit) mice, contrary to the individual genetic traits, developed phenotypes consistent with dopaminergic dysfunction. [15] ABSTRACT Introduction It is now accepted that Parkinson’s disease (PD) is not simply due to dopaminergic dysfunction, and there is interest in developing non-dopaminergic approaches to disease management. [16] Our results support neuromelanin as a candidate biomarker for dopaminergic dysfunction in schizophrenia. [17] Accurate quantitative detection of dopamine (DA) in blood is essential for the early diagnosis and the pathogenesis analysis of dopaminergic dysfunction, which still remains a great challenge because of the extremely low concentration in patients. [18] In this article, we provide an overview of some mechanisms that mediate neural regulation of muscle contraction and control, and highlight the specific contributions of neural hypoexcitability, dopaminergic dysfunction, and degradation of functional and structural brain connectivity in relation to sarcopenia. [19] Purpose Childhood onset speech fluency disorder (stuttering) is possibly related to dopaminergic dysfunction. [20] Dopaminergic dysfunction is implicated in an equally multidimensional spectrum of neurological and neuropsychiatric diseases. [21] ConclusionsWe establish, therefore, that VAP-1 inhibition has an anti-inflammatory profile that may have beneficial in the treatment of dopaminergic dysfunction caused by an acute inflammatory state in the brain. [22] Our review aims to explain the « dynamic » model of dopaminergic dysfunctions and propose some guidance for pharmacological treatment of ADHD, with or without psychotic disorder. [23] Given the patient’s genetic condition, we hypothesized that the dopaminergic dysfunction had been aggravated by COMT involvement, thus causing dystonia. [24]

drug related stimuli

We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli. [1] We argue that ACC and dopaminergic dysfunction in dependents may produce misaligned internal-models such that drug-related stimuli are misattributed with a higher salience compared to non-drug related stimuli. [2]

Striatal Dopaminergic Dysfunction

Conclusions This prospective interventional study highlights the pathophysiologic relevance of striatal dopaminergic dysfunction in the motor phenotypic expression of iNPH. [1] Objective To investigate the effect of polygenic load on the progression of striatal dopaminergic dysfunction in patients with Parkinson disease (PD). [2] OF DISSERTATION NEUROPSYCHOLOGICAL CORRELATES OF STRIATAL DOPAMINERGIC DYSFUNCTION IN PARKINSON’S DISEASE Parkinson’s disease (PD) is a common neurodegenerative disorder associated with dysfunction of the basal ganglia, which contributes to a range of motor, cognitive, and affective symptoms. [3]

Subcortical Dopaminergic Dysfunction

Preclinical models propose that increased hippocampal activity drives subcortical dopaminergic dysfunction and leads to psychosis-like symptoms and behaviors. [1] A leading hypothesis for schizophrenia and related psychotic disorders proposes that cortical brain disruption leads to subcortical dopaminergic dysfunction, which underlies psychosis in the majority of patients who respond to treatment. [2]

Nigrostriatal Dopaminergic Dysfunction

To explore the association between parkinsonism and SCA31, five patients with SCA31 with concomitant nigrostriatal dopaminergic dysfunction (NSDD) development, including three cases of L-DOPA responsive parkinsonism, were analyzed. [1] Our results show that mild motor impairment in rapid eye movement sleep behavior disorder evaluated by finger tapping task presented mild nigrostriatal dopaminergic dysfunction as well as alterations in resting state sensorimotor network. [2]

dopaminergic dysfunction may

Depression, NeuroHIV and many of the neuropsychiatric therapeutics used to treat them impact the dopaminergic system, suggesting that dopaminergic dysfunction may be a common factor in the development of these disorders. [1] The present study examined spontaneous eye-blink rate (EBR), an indirect, non-invasive measure of central dopaminergic activity, and theta power in children with ASD to determine: 1) whether ASD may be associated with atypical DA levels, and 2) whether dopaminergic dysfunction may be associated with aberrant theta-band activation. [2] Dopaminergic dysfunction may thereby cause a decreased inhibition, resulting in a higher sensory input to the cortex, increased sensory activation of the reflex arc of the spinal cord * Amée F. [3] Our results establish a critical role for Tsc1-mTORC1 signaling in setting the functional properties of dopamine neurons, and indicate that dopaminergic dysfunction may contribute to cognitive inflexibility in TSC. [4]