Introduction to Disease Trials
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Disease Trials sentence examples within Rare Disease Trials
These limitations aside, the framework presented provides a proof of concept for the utility of Bayesian model-based methods for decision making in rare disease trials.
These limitations aside, the framework presented provides a proof of concept for the utility of Bayesian model-based methods for decision making in rare disease trials.
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Characterized by small, highly heterogeneous patient populations, rare disease trials magnify the challenges often encountered in traditional clinical trials.
Characterized by small, highly heterogeneous patient populations, rare disease trials magnify the challenges often encountered in traditional clinical trials.
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Disease Trials sentence examples within Bowel Disease Trials
Our aim is to clarify the advantages and drawbacks of cluster randomized trials in order to properly interpret study results and to identify their role in upcoming inflammatory bowel disease trials.
Our aim is to clarify the advantages and drawbacks of cluster randomized trials in order to properly interpret study results and to identify their role in upcoming inflammatory bowel disease trials.
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BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel disease trials and recently in a multiple sclerosis trial.
BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel disease trials and recently in a multiple sclerosis trial.
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Disease Trials sentence examples within Alzheimer Disease Trials
This decision is of course their ethical privilege, and if aducanumab were effective, their collective action could revolutionize Alzheimer disease trials (8).
This decision is of course their ethical privilege, and if aducanumab were effective, their collective action could revolutionize Alzheimer disease trials (8).
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Meaning Blood-based β-amyloid 42 and β-amyloid 40 ratio together with APOE genotype may be used as prescreening tests in primary care and in clinical Alzheimer disease trials to lower the costs and number of positron emission tomography scans and lumbar punctures.
Meaning Blood-based β-amyloid 42 and β-amyloid 40 ratio together with APOE genotype may be used as prescreening tests in primary care and in clinical Alzheimer disease trials to lower the costs and number of positron emission tomography scans and lumbar punctures.
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Disease Trials sentence examples within Infectiou Disease Trials
In 2018, minority subjects were generally well represented in infectious disease product approvals (23% of subjects in infectious disease trials were African American, 17% were Hispanic, and 10%were Asian) but not in oncology product approvals (4% of subjects in oncology trials were African American, 4% were Hispanic, and 15% were Asian, although several trials had less than 5% Asian subjects).
In 2018, minority subjects were generally well represented in infectious disease product approvals (23% of subjects in infectious disease trials were African American, 17% were Hispanic, and 10%were Asian) but not in oncology product approvals (4% of subjects in oncology trials were African American, 4% were Hispanic, and 15% were Asian, although several trials had less than 5% Asian subjects).
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The non-inferiority trial design and recent infectious disease trials of relevance are discussed in this viewpoint.
The non-inferiority trial design and recent infectious disease trials of relevance are discussed in this viewpoint.
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Disease Trials sentence examples within Heart Disease Trials
Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials.
Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials.
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We assessed whether billing claims accurately identify CVEs in place of clinical event adjudication in structural heart disease trials.
We assessed whether billing claims accurately identify CVEs in place of clinical event adjudication in structural heart disease trials.
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Disease Trials sentence examples within Metastatic Disease Trials
CONCLUSIONS
Comprehensive genomic profiling reveals GA that may be predictive of both targeted and immunotherapy benefit in patients with advanced UrthCa and that could potentially be used in future adjuvant, neoadjuvant, and metastatic disease trials.
CONCLUSIONS
Comprehensive genomic profiling reveals GA that may be predictive of both targeted and immunotherapy benefit in patients with advanced UrthCa and that could potentially be used in future adjuvant, neoadjuvant, and metastatic disease trials.
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However, African American men were under enrolled in metastatic disease trials (enrollment difference –5.
However, African American men were under enrolled in metastatic disease trials (enrollment difference –5.
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Disease Trials sentence examples within Cardiovascular Disease Trials
Methods: In this pooled analysis, we assessed renal outcome data from high-risk patients aged 55 years or older with a history of cardiovascular disease, 70% of whom had hypertension, randomized to The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and to Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease trials investigating telmisartan, ramipril and their combination with a median follow-up of 56 months.
Methods: In this pooled analysis, we assessed renal outcome data from high-risk patients aged 55 years or older with a history of cardiovascular disease, 70% of whom had hypertension, randomized to The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and to Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease trials investigating telmisartan, ramipril and their combination with a median follow-up of 56 months.
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This strategy has been used successfully in cardiovascular disease trials and therefore is applicable to the current trial.
This strategy has been used successfully in cardiovascular disease trials and therefore is applicable to the current trial.
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More Disease Trials sentence examples
10.1101/2021.02.05.429907
These limitations aside, the framework presented provides a proof of concept for the utility of Bayesian model-based methods for decision making in rare disease trials.
These limitations aside, the framework presented provides a proof of concept for the utility of Bayesian model-based methods for decision making in rare disease trials.
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More Disease Trials sentence examples
10.1093/ecco-jcc/jjab149
Our aim is to clarify the advantages and drawbacks of cluster randomized trials in order to properly interpret study results and to identify their role in upcoming inflammatory bowel disease trials.
Our aim is to clarify the advantages and drawbacks of cluster randomized trials in order to properly interpret study results and to identify their role in upcoming inflammatory bowel disease trials.
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More Disease Trials sentence examples
10.1097/HJH.0000000000002697
Methods: In this pooled analysis, we assessed renal outcome data from high-risk patients aged 55 years or older with a history of cardiovascular disease, 70% of whom had hypertension, randomized to The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and to Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease trials investigating telmisartan, ramipril and their combination with a median follow-up of 56 months.
Methods: In this pooled analysis, we assessed renal outcome data from high-risk patients aged 55 years or older with a history of cardiovascular disease, 70% of whom had hypertension, randomized to The Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and to Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease trials investigating telmisartan, ramipril and their combination with a median follow-up of 56 months.
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More Disease Trials sentence examples
10.3233/JPD-202184
Methods: We assessed all Parkinson’s disease trials in the WHO trials portal, from inception (1999) to September 2019.
Methods: We assessed all Parkinson’s disease trials in the WHO trials portal, from inception (1999) to September 2019.
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More Disease Trials sentence examples
10.1016/j.urolonc.2020.12.021
CONCLUSIONS
Comprehensive genomic profiling reveals GA that may be predictive of both targeted and immunotherapy benefit in patients with advanced UrthCa and that could potentially be used in future adjuvant, neoadjuvant, and metastatic disease trials.
CONCLUSIONS
Comprehensive genomic profiling reveals GA that may be predictive of both targeted and immunotherapy benefit in patients with advanced UrthCa and that could potentially be used in future adjuvant, neoadjuvant, and metastatic disease trials.
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More Disease Trials sentence examples
10.7326/M21-2603
This decision is of course their ethical privilege, and if aducanumab were effective, their collective action could revolutionize Alzheimer disease trials (8).
This decision is of course their ethical privilege, and if aducanumab were effective, their collective action could revolutionize Alzheimer disease trials (8).
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More Disease Trials sentence examples
10.1111/apt.16453
Although a small pilot, this study likely grappled with big decisions— decisions many researchers conducting coeliac disease trials must face when deciding on a study endpoint.
Although a small pilot, this study likely grappled with big decisions— decisions many researchers conducting coeliac disease trials must face when deciding on a study endpoint.
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More Disease Trials sentence examples
10.2174/1574884716666210316120615
Characterized by small, highly heterogeneous patient populations, rare disease trials magnify the challenges often encountered in traditional clinical trials.
Characterized by small, highly heterogeneous patient populations, rare disease trials magnify the challenges often encountered in traditional clinical trials.
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More Disease Trials sentence examples
10.1186/s13063-021-05080-4
This strategy has been used successfully in cardiovascular disease trials and therefore is applicable to the current trial.
This strategy has been used successfully in cardiovascular disease trials and therefore is applicable to the current trial.
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More Disease Trials sentence examples
10.3389/fpls.2019.00924
” A large-scale low-cost phenotyping platform was developed utilizing automated unmanned vehicles and near infrared imaging cameras to assess field-based disease trials.
” A large-scale low-cost phenotyping platform was developed utilizing automated unmanned vehicles and near infrared imaging cameras to assess field-based disease trials.
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More Disease Trials sentence examples
10.1080/14712598.2020.1702020
Whether new endpoints such as transmural and radiologic healing could become an endpoint and replace endoscopy in Crohn’s disease trials in the near future requires further investigation.
Whether new endpoints such as transmural and radiologic healing could become an endpoint and replace endoscopy in Crohn’s disease trials in the near future requires further investigation.
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More Disease Trials sentence examples
10.1111/hae.13717
Despite emerging novel haemostatic agents, challenges of rare disease trials are limited subjects and lack of an organized research organization with strategic resources and partnerships.
Despite emerging novel haemostatic agents, challenges of rare disease trials are limited subjects and lack of an organized research organization with strategic resources and partnerships.
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More Disease Trials sentence examples
10.1186/s13018-019-1242-6
BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel disease trials and recently in a multiple sclerosis trial.
BPC 157, of which the LD1 has not been achieved, has been implemented as an anti-ulcer peptide in inflammatory bowel disease trials and recently in a multiple sclerosis trial.
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More Disease Trials sentence examples
10.1016/j.jalz.2019.06.3918
There is keen interest in elucidating the biological mechanisms underlying recent failures of β‐site amyloid precursor protein–cleaving enzyme‐1 (BACE1) inhibitors in Alzheimer's disease trials.
There is keen interest in elucidating the biological mechanisms underlying recent failures of β‐site amyloid precursor protein–cleaving enzyme‐1 (BACE1) inhibitors in Alzheimer's disease trials.
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More Disease Trials sentence examples
10.1001/jamaneurol.2019.1632
Meaning Blood-based β-amyloid 42 and β-amyloid 40 ratio together with APOE genotype may be used as prescreening tests in primary care and in clinical Alzheimer disease trials to lower the costs and number of positron emission tomography scans and lumbar punctures.
Meaning Blood-based β-amyloid 42 and β-amyloid 40 ratio together with APOE genotype may be used as prescreening tests in primary care and in clinical Alzheimer disease trials to lower the costs and number of positron emission tomography scans and lumbar punctures.
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More Disease Trials sentence examples
10.1002/jcph.1530
In 2018, minority subjects were generally well represented in infectious disease product approvals (23% of subjects in infectious disease trials were African American, 17% were Hispanic, and 10%were Asian) but not in oncology product approvals (4% of subjects in oncology trials were African American, 4% were Hispanic, and 15% were Asian, although several trials had less than 5% Asian subjects).
In 2018, minority subjects were generally well represented in infectious disease product approvals (23% of subjects in infectious disease trials were African American, 17% were Hispanic, and 10%were Asian) but not in oncology product approvals (4% of subjects in oncology trials were African American, 4% were Hispanic, and 15% were Asian, although several trials had less than 5% Asian subjects).
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More Disease Trials sentence examples
10.1371/journal.pone.0222313
Searches of electronic databases (CENTRAL, MEDLINE, EMBASE, CINAHL, PUBMED and Web of Science) identified eight eligible independent trials (seven autoimmune disease trials, one trial of healthy subjects).
Searches of electronic databases (CENTRAL, MEDLINE, EMBASE, CINAHL, PUBMED and Web of Science) identified eight eligible independent trials (seven autoimmune disease trials, one trial of healthy subjects).
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More Disease Trials sentence examples
10.1371/journal.pmed.1002966
We analyzed 659 rare disease trials accounting for 70,305 enrolled patients.
We analyzed 659 rare disease trials accounting for 70,305 enrolled patients.
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More Disease Trials sentence examples
10.1136/jmedgenet-2019-106283
Background Classical randomisation of clinical trial patients creates a source of genetic variance that may be contributing to the high failure rate seen in neurodegenerative disease trials.
Background Classical randomisation of clinical trial patients creates a source of genetic variance that may be contributing to the high failure rate seen in neurodegenerative disease trials.
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10.1016/j.pcad.2019.11.019
Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials.
Endpoints utilized in left heart disease trials have been applied with success to TR trials, and innovative trial designs will allow the initiation of pivotal randomized trials.
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More Disease Trials sentence examples
10.1177/1740774518820814
The authors comment that these are larger than sample sizes for Alzheimer’s disease trials to date.
The authors comment that these are larger than sample sizes for Alzheimer’s disease trials to date.
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More Disease Trials sentence examples
10.1186/s12916-019-1427-1
For example, in asthma and psoriasis trials, 10–15% of participants had ≥ 3 conditions overall, while in osteoporosis and chronic obstructive pulmonary disease trials 40–60% of participants had ≥ 3 conditions overall.
For example, in asthma and psoriasis trials, 10–15% of participants had ≥ 3 conditions overall, while in osteoporosis and chronic obstructive pulmonary disease trials 40–60% of participants had ≥ 3 conditions overall.
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More Disease Trials sentence examples
10.1161/CIRCINTERVENTIONS.119.008231
We assessed whether billing claims accurately identify CVEs in place of clinical event adjudication in structural heart disease trials.
We assessed whether billing claims accurately identify CVEs in place of clinical event adjudication in structural heart disease trials.
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More Disease Trials sentence examples
10.1016/J.CJCA.2019.01.010
Women enrollment varied with clinical indication, comprising 37% for non-coronary artery disease vascular trials, 30% for coronary artery disease trials, 28% for heart failure trials, and 28% for arrhythmia trials (P < 0.
Women enrollment varied with clinical indication, comprising 37% for non-coronary artery disease vascular trials, 30% for coronary artery disease trials, 28% for heart failure trials, and 28% for arrhythmia trials (P < 0.
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10.1093/JCAG/GWZ006.249
Aims: To discuss the potential of adaptive clinical trials in Crohn’s disease trials.
Aims: To discuss the potential of adaptive clinical trials in Crohn’s disease trials.
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10.1186/s12874-019-0791-z
BackgroundMany prodromal Alzheimer’s disease trials collect two types of data: the time until clinical diagnosis of dementia and longitudinal patient information.
BackgroundMany prodromal Alzheimer’s disease trials collect two types of data: the time until clinical diagnosis of dementia and longitudinal patient information.
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More Disease Trials sentence examples
10.1093/cid/ciz984
The non-inferiority trial design and recent infectious disease trials of relevance are discussed in this viewpoint.
The non-inferiority trial design and recent infectious disease trials of relevance are discussed in this viewpoint.
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More Disease Trials sentence examples
10.1016/j.juro.2018.09.029
However, African American men were under enrolled in metastatic disease trials (enrollment difference –5.
However, African American men were under enrolled in metastatic disease trials (enrollment difference –5.
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