Introduction to Disease Meta Analysis

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10.1016/j.jaci.2021.01.006

Methods We conducted an epidemiological study and then compared gene expression across nine different inflammatory skin conditions and SARS-CoV-2 infected bronchial epithelial cell lines, then performed a GWAS trans-disease meta-analysis between COVID-19 susceptibility and two skin diseases (psoriasis and atopic dermatitis).

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10.1093/rheumatology/keab443

RESULTS A genetic variant, rs3743841, located in an intron of the NAGPA gene, reached genome-wide significance in the cross-disease meta-analysis (p= 8.

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10.1136/annrheumdis-2019-eular.402

Methods We performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3,477 systemic sclerosis (SSc), and 6,670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET.

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10.1093/carcin/bgz153

We took a three-staged approach to conduct cross-disease meta-analysis of GWAS for NB and CMM (2101 NB cases and 4202 controls; 12 874 CMM cases and 23 203 controls) to identify shared loci.

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Disease Meta Analysis

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Oct 06, 2024

What is/are Disease Meta Analysis?

Disease Meta Analysis - Methods We conducted an epidemiological study and then compared gene expression across nine different inflammatory skin conditions and SARS-CoV-2 infected bronchial epithelial cell lines, then performed a GWAS trans-disease meta-analysis between COVID-19 susceptibility and two skin diseases (psoriasis and atopic dermatitis). ^[1] RESULTS A genetic variant, rs3743841, located in an intron of the NAGPA gene, reached genome-wide significance in the cross-disease meta-analysis (p= 8. ^[2] Methods We performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3,477 systemic sclerosis (SSc), and 6,670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET. ^[3] We took a three-staged approach to conduct cross-disease meta-analysis of GWAS for NB and CMM (2101 NB cases and 4202 controls; 12 874 CMM cases and 23 203 controls) to identify shared loci. ^[4]