Introduction to Data Meta Analysis

Design Systematic review and individual patient data meta-analysis.

Methods: We performed a patient-level data meta-analysis of 2 prospective and 2 retrospective cohorts of children ≤21 years of age with cerebrospinal fluid pleocytosis who underwent evaluation for Lyme disease.

Objective: Its efficacy and safety at 20mg/day was evaluated through an Individual patient data meta-analysis vs placebo.

To overcome the issue of limited power, an individual participant data meta-analysis of randomised trials evaluating forms of trauma-focused cognitive behavioural therapy in children and adolescents aged 6–18 years will be conducted.

Authors shared the raw data of their studies for incorporation into this individual participant data meta-analysis.

In this study, we aimed to systematically review the literature and perform individual patient data meta-analysis to estimate new disability weights for leprosy, using Health-Related Quality of Life (HRQOL) data.

METHODS We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis.

A two-stage combined individual patient and aggregate data meta-analysis evaluated the association between dominant-lateralized stroke and (a) short-term (≤ 3 months) and (b) long-term (> 3 months) outcome.

We conducted an individual participant data meta-analysis from RCTs in which women with a singleton, live gestation between 10+0 and 20+0 weeks and body mass index (BMI) ≥ 25 kg/m2 in early pregnancy were randomised to a diet and/or lifestyle intervention or continued standard antenatal care and in which longer-term maternal and child follow-up at 3–5 years of age had been undertaken.

METHODS A systematic review and individual patient data meta-analysis was conducted according to PRISMA guidelines.

Methods Individual-participant data meta-analysis of ten studies (n=1884) investigating infants’ antibody response to routine immunizations following Tdap immunization in pregnancy was performed.

Objective and design We performed an individual patient data meta-analysis to investigate the association of age on effects of PCT-guided antibiotic stewardship regarding antibiotic use and outcome.

A 2019 individual participant data meta-analysis of 6 studies from high-income countries found that maternal supine going-to-sleep position increased the risk of stillbirth.

We performed an individual participant data meta-analysis to assess the overall survival (OS) and progression free survival (PFS) after en bloc-gross total resection (GTR) and intralesional-GTR compared to subtotal resection (STR).

METHODS We did an individual participant data meta-analysis of large randomised controlled trials (each with ≥1000 participants and ≥2 years of follow-up) of a fixed-dose combination treatment strategy versus control in a primary cardiovascular disease prevention population.

DESIGN The study comprised (1) a qualitative study to establish the decisional needs of pregnant women and their caregivers, (2) an individual participant data meta-analysis of existing studies to develop a prognostic model for spontaneous preterm birth within 7 days in women with symptoms of preterm labour based on quantitative fetal fibronectin and clinical risk factors, (3) external validation of the prognostic model in a prospective cohort study across 26 UK centres, (4) a model-based economic evaluation comparing the prognostic model with qualitative fetal fibronectin, and quantitative fetal fibronectin with cervical length measurement, in terms of cost per QALY gained and (5) a qualitative assessment of the acceptability of quantitative fetal fibronectin.

We conducted an individual patient data meta-analysis (IPD-MA) using a one-stage multivariate mixed effect logistic regression model.

We aimed to use individual patient data meta-analysis (IPDMA) from multiple randomised controlled trials evaluating intermittent strategies to inform clinical practice.

This protocol outlines a systematic review and individual participant data meta-analysis (IPD-MA) to identify subgroups of adolescents for which therapeutic interventions for self-harm show some evidence of benefit.

We performed an individual participant data meta-analysis using generalized linear mixed-effect models to examine predictors of behavioral health service use and unmet need.

Design Individual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted.

Methods and analysisA systematic review and individual patient data meta-analysis on randomised placebo-controlled trials with a vitamin D3 intervention.

Materials and Methods: An individual patient-data meta-analysis was performed using 5 datasets on 828 evaluable women who were tested for gBRCA.

Aggregate data meta-analysis of all 10 studies was performed for outcomes unsuitable for IPD reconstruction.

The primary objective of this individual participant data meta-analysis was to investigate the effect of neoadjuvant chemotherapy on overall survival (OS).

In this study, we used individual participant data meta-analysis to assess whether early attachment networks with mothers and fathers are associated with children’s internalizing and externalizing symptoms.

We systematically reviewed published literature on renal toxicity among PrEP users and conducted an individual patient data meta-analysis (IPDMA) on kidney function among PrEP users in a global data set.

METHODS AND RESULTS An individual participant data meta-analysis was conducted across two randomized controlled trials in 30,507 participants over a mean follow up of 3.

Design Systematic review and individual participant data meta-analysis.

sativa using a transcriptome and degradome sequencing data meta-analysis approach.

METHODS We used an individual participant data meta-analysis (IPDMA) database compiled to assess the screening accuracy of the PHQ-9.

Additionally, a combined individual participant data and aggregate data meta-analysis showed an odds ratio in favor of OD for live birth.

We therefore undertook a systematic review and individual participant data meta-analysis to quantify the effects of NO 3 − supplementation on human muscle power.

Adjusted odds ratios were determined by multivariable logistic regression models and aggregated by the two-level individual participant data meta-analysis method.

We conducted a systematic review with individual patient-level data meta-analysis of published clinical cases to assess impact of various initial therapeutic modalities and adherence to NCCN guidelines on outcomes of immune-related myocarditis, associated with checkpoint inhibitors.

Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale.

The purpose of this study was to overview mechanisms of procedural stroke after carotid revascularization and establish reporting standards to facilitate more granular investigation and individual patient data meta-analysis in the future.

A time-to-event data meta-analysis was performed using the inverse-variance method and the result was reported as summary hazard ratio (HR) and associated 95% confidence intervals (CI).

STUDY DESIGN A systematic review with individual patient data meta-analysis was conducted, extending PROSPERO record CRD42018116188.

Outcome data were pooled with via meta-analysis for individual patient data (Individual Patient Data Meta-Analysis IPD-MA) using classical meta-analytical techniques (one-stage approach using mixed models and 2-stage approach with inverse variance estimation as fixed effects model).

Thus, we aimed to investigate this association in a large individual patient data meta-analysis of randomised clinical trials.

Methods We conducted a systematic review and individual participant data meta-analysis of studies that reported at least 50 individuals with peanut allergy reacting to peanut at double-blind, placebo-controlled food challenge (DBPCFC) and were published between January 2010 and September 2020.

We will perform Hartung-Knapp-Sidik-Jonkman random-effects aggregate data meta-analysis whenever it is feasible to do so.

Aggregate Data Meta-Analysis was performed to determine the effect of MSC-EVs on Bone Volume/Total Volume (BV/TV) and New Bone Formation (NBF).

We aimed to identify clinical predictors of mortality and tumor recurrence/progression by performing an individual patient data meta-analysis (IPDMA) of the literature.

We aimed to assess diagnostic properties and identify relevant covariates with use of an individual patient data meta-analysis.

To investigate the effects of antihypertensive drugs on long-term BP change and examine its variation over time and among people with different clinical characteristics Design: Individual participant-level data meta-analysis Setting and data source: The Blood Pressure Lowering Treatment Trialists Collaboration involving 51 large-scale long-term randomised clinical trials Participants: 352,744 people (42% women) with mean age of 65 years and mean baseline systolic/diastolic BP of 152/87 mmHg, of whom 18% were current smokers, 50% had cardiovascular disease, 29% had diabetes, and 72% were taking antihypertensive treatment at baseline Intervention: Pharmacological BP-lowering treatment Outcome: Difference in longitudinal changes in systolic and diastolic BP between randomised treatment arms over an average follow-up of four years Result: Drugs were effective in lowering BP, with the maximum effect becoming apparent after 12-month follow-up and with gradual attenuation towards later years.

METHODS Systematic review and individual patient data meta-analysis were performed.

Background In order to facilitate better international and cross-cultural comparisons of health professionals (HPs) attitudes towards Religiosity and/or Spirituality (R/S) using individual participant data meta-analysis we updated the NERSH Data Pool.

An individual patient data meta-analysis (Lamontagne F, Day AG, Meade MO, Cook DJ, Guyatt GH, Hylands M, et al.

DESIGN: Individual patient data meta-analysis of three studies of intracerebral hemorrhage.

METHODS An Individual Patient Data Meta-Analysis was performed.

This large individual patient data meta-analysis using 9937 patients obtained from cBioportal indicates that CNA of the IFN gene cluster is prevalent among 24 cancer types.

Design Individual participant data meta-analysis.

An individual patient data meta-analysis was conducted to estimate model probabilities of progression and survival risks.

We find the data pool suitable as a base for future cross-cultural comparisons using individual participant data meta-analysis.

Findings across cohorts will be analysed using a two-step, individual participant data meta-analysis methodology.

An individual patient-data meta-analysis of randomized trials evaluating liver pedicle clamping is urgently needed.

We performed a systematic review and individual patient data meta-analysis to evaluate the use of CNVs to classify intermediate melanocytic lesions.

Reddavid is certainly right when she affirms that the individual participant data meta-analysis did not take into consideration the influence of the experience of surgeons on the outcomes in rectal cancer surgery.

The purpose of this individual participant data meta-analysis was to compare the treatment effects of CPAP and titratable MAD on sleepiness, quality of life, sleep-disordered breathing severity and sleep structure in patients with severe OSA.

One-stage individual patient data meta-analysis models for the time-to-event and binary outcomes were used, accounting for trial differences, within-centre correlation, randomised treatment received, baseline variable imbalances, and potential confounding from relevant prognostic factors.

Relevant data were pooled to conduct an individual participant data meta-analysis.

We conducted an individual patient data meta-analysis to characterise the cardiovascular effects of amodiaquine and thereby support development of risk minimisation measures to improve the safety of this important antimalarial.

Hazard ratios (HRs) with 95% CIs were derived from a 1-stage individual patient data meta-analysis.

This individual participant data meta-analysis is the most intensive possible evaluation of the effectiveness of early intensive applied behaviour analysis–based interventions for pre-school autistic children compared with treatment as usual/eclectic interventions.

Conclusions and Relevance The findings of this individual participant data meta-analysis suggest that regardless of the clinical factors included in these studies, the sequential delivery of a psychological intervention during and/or after tapering may be an effective relapse prevention strategy instead of long-term use of antidepressants.

METHODS To clarify this debate, we performed an individual patient data meta-analysis of randomized studies that compared CE with WLE for the detection of adenomas in patients with Lynch syndrome.

Methods In this individual patient data meta-analysis, we searched EMBASE, Medline and Cochrane Central Register of Controlled Trials to identify potentially eligible randomized controlled trials published from database inception to October 2020.

Methods and analysis A systematic review and individual patient data meta-analysis will be performed on randomised placebo-controlled trials with a vitamin D3 intervention.

METHOD We conducted an individual participant data meta-analysis [IPDMA], including data of randomized controlled behavioral intervention trials for individuals with ADHD<18 years.

Importantly, BP lowering per se is one of the most impactful interventions in medicine with a recent patientlevel data meta-analysis demonstrating that a 5 mmHg office systolic BP reduction is associated with a 10% reduction in major cardiovascular events [2].

Aims To conduct an individual patient data meta-analysis of randomised controlled trials (RCTs) of manualised psychological treatments for obsessive-compulsive disorder (OCD), and examine the differential efficacy of psychological treatments by treatment type and format.

Methods In this systematic review and individual participant data meta-analysis, we searched PubMed, Web of Science, Embase, MEDLINE, CINAHL, Global Health, MIDIRS, and Cochrane without language restrictions for relevant articles published between database inception, and Jan 1, 2020, using search terms referencing intrahepatic cholestasis of pregnancy, ursodeoxycholic acid, and perinatal outcomes.

To further examine the efficacy and effectiveness of SQ-LNSs, and explore study-level and individual-level effect modifiers, we conducted an individual participant data meta-analysis of 14 randomized controlled trials of SQ-LNSs provided to children 6-24 mo of age (n > 37,000).

We report an individual patient data meta-analysis to characterize the safety and clinical benefit of MDT in oligorecurrent PCa.

This individual participant data meta-analysis will investigate a range of potential treatment effect modifiers of the efficacy of CBT.

Design and setting: Individual participant data meta-analysis of 15 prospective epidemiological cohort studies from countries situated in five continents.

Using a 2-step individual participant data meta-analysis framework, we applied Cox proportional hazards modelling to investigate the association between sex and mortality across different countries.

Time-to-event data meta-analysis was conducted using the inverse-variance method and reported as summary hazard ratio (HR) and associated 95% CI.

An individual patient-data meta-analysis of randomized trials evaluating liver pedicle clamping is urgently needed.

MATERIALS AND METHODS An individual patient-level data meta-analysis was performed using five data sets on 828 evaluable women who were tested for gBRCA.

METHODS We did a systematic review and individual patient data meta-analysis.

AIMS To illustrate a machine learning-based approach for identifying and investigating moderators of alcohol use intervention effects in aggregate-data meta-analysis.

Methods A systematic review and individual patient data meta-analysis was conducted according to PRISMA guidelines.

Methods We conducted an individual participant data meta-analysis of randomised controlled trials of three types of therapist delivered interventions for low back pain (active physical, passive physical and psychological treatments).