Introduction to Crossover Trials
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Crossover Trials sentence examples within Randomized Crossover Trials
Eight clinical studies, composed of six randomized controlled trials and two randomized crossover trials that involved 230 healthy participants were selected for analysis.
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In the analysis of stepped wedge and cluster-randomized crossover trials, it is possible to include terms in outcome regression models to allow for such treatment effect heterogeneity yet this is not frequently considered.
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Crossover Trials sentence examples within Randomised Crossover Trials
All studies were short duration (ranging from a single session up to 2 weeks) with small sample sizes (n≤32) and 11 of the 12 studies were randomised crossover trials.
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ELIGIBILITY CRITERIA
Randomised crossover trials, quasi-randomised trials, and parallel group trials where vascular function (flow-mediated dilation, FMD) was assessed before and after an acute period of sedentary behaviour.
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Crossover Trials sentence examples within Multiple Crossover Trials
Methods and analysis We will initiate an N-of-1 series of double-blind randomized and placebo-controlled multiple crossover trials in six patients aged ≥ 6 years with a genetically confirmed SMS diagnosis and a multidisciplinary established ADHD diagnosis, according to a power analysis based on a summary measures analysis of the treatment effect.
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N-of-1 trials are randomized, prospective, controlled, multiple crossover trials in a single patient.
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Crossover Trials sentence examples within Controlled Crossover Trials
Five articles studied psychedelic efficacy in the treatment of life-threatening diseases related to anxiety and depression: four were randomized controlled crossover trials (three with psilocybin for a total of 92 patients, and one with LSD, n=12), and one was a long-term follow-up study.
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Double-blind placebo-controlled crossover trials of sex steroids are required to address unproven behavioural concerns.
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Crossover Trials sentence examples within Sequence Crossover Trials
Two separate one-sequence crossover trials investigated the effects of oral semaglutide and SNAC on the pharmacokinetics of ethinylestradiol, levonorgestrel, furosemide and rosuvastatin.
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Two one-sequence crossover trials investigated the effect of oral semaglutide on the pharmacokinetics of lisinopril, warfarin, digoxin, and metformin.
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Crossover Trials sentence examples within crossover trials investigated
Two separate one-sequence crossover trials investigated the effects of oral semaglutide and SNAC on the pharmacokinetics of ethinylestradiol, levonorgestrel, furosemide and rosuvastatin.
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Two one-sequence crossover trials investigated the effect of oral semaglutide on the pharmacokinetics of lisinopril, warfarin, digoxin, and metformin.
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Crossover Trials sentence examples within crossover trials without
However, behavior intervention crossover trials without a washout period are likely vulnerable to strong carryover effects.
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However, many of previous studies on this topic represented crossover trials without appropriate washout periods, in which the diuretic effect and resistance were carried over to the other phase and patient-oriented outcomes were insufficiently discussed.
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In this article min–max crossover designs for binary and Poisson crossover trials with two treatments are proposed.
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Two phase 1, open-label, fixed-sequence, single-center, crossover trials enrolled healthy adults to receive ubrogepant 20 mg with/without verapamil 240 mg (a moderate CYP3A4 inhibitor) or ketoconazole 400 mg (a strong CYP3A4 and P-gp transporter inhibitor) (Study A), or ubrogepant 100 mg with/without rifampin 600 mg (a strong CYP3A4 inducer and P-gp inducer) (Study B).
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All studies were short duration (ranging from a single session up to 2 weeks) with small sample sizes (n≤32) and 11 of the 12 studies were randomised crossover trials.
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Here we divide such trials into three categories: multi-crossover trials aimed at individual patient management, multi-crossover trial series and pre-post trials.
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Eight clinical studies, composed of six randomized controlled trials and two randomized crossover trials that involved 230 healthy participants were selected for analysis.
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In the analysis of stepped wedge and cluster-randomized crossover trials, it is possible to include terms in outcome regression models to allow for such treatment effect heterogeneity yet this is not frequently considered.
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Study design and methods In two randomized crossover trials, the impact of pNIV on dyspnea and endurance capacity was investigated in patients with moderate to severe COPD.
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Five articles studied psychedelic efficacy in the treatment of life-threatening diseases related to anxiety and depression: four were randomized controlled crossover trials (three with psilocybin for a total of 92 patients, and one with LSD, n=12), and one was a long-term follow-up study.
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The two studies were double-blind, randomized crossover trials.
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Randomized controlled trials (RCTs) and crossover trials that compared NAVA and other modes were identified in this study.
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The eligibility criteria followed PICOS: Population - Humans ≥ 18 years old; Interventions - Sitting break strategies; Comparisons - Uninterrupted sitting; Outcomes - Cardiovascular parameters (blood pressure, heart rate, ambulatory blood pressure, vascular function, pulse-wave velocity, cerebral blood flow and biomarkers); Study design - Randomized controlled trials, non-randomized non-controlled trials and randomized crossover trials.
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From a clinical trial readiness perspective, we show that SF‐12v2 reliably measures physical function in adults with OI and can be utilized in crossover trials to detect meaningful physical HRQoL changes with small sample sizes.
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Until then, placebo-controlled, double-blind, crossover trials will continue to play a role in the development of new vaccine candidates.
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Data were extracted by 3 independent reviewers from randomized crossover trials (RCTs) that investigated the effect of microstructural factors on postprandial glucose, insulin, appetite-regulating hormone responses, and subjective satiety scores in healthy participants.
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We searched MEDLINE/PubMed and included all double-blinded, sham-controlled RCTs and crossover trials that used TMS or tDCS in adults with a unipolar or bipolar depression, bipolar disorder, schizophrenia spectrum disorder, or obsessive compulsive disorder.
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ELIGIBILITY CRITERIA
Randomised crossover trials, quasi-randomised trials, and parallel group trials where vascular function (flow-mediated dilation, FMD) was assessed before and after an acute period of sedentary behaviour.
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Introduction Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may not be suitable.
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A total of 54 articles were included in the review, in which 20 randomized controlled/crossover trials that reported the changes in indoor fine PM (PM2.
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We identified 57 citations (27 randomized controlled trials, 66 treatment arms, 27 open-label trials, and 3 crossover trials) that evaluated 33 interventions (3108 patients).
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Data were measured in 24-soldiers walking on a 10-m walkway under four randomized crossover trials: wearing two military boots (styrene-butadiene rubber midsole - SBR - 63 Shore A; and polyurethane midsole - PU - 48 Shore A); with and without a 15-kg backpack.
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Results We identified 15 randomized controlled trials, 3 randomized crossover trials, 2 cohort studies, and 2 controlled clinical trials.
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Two separate one-sequence crossover trials investigated the effects of oral semaglutide and SNAC on the pharmacokinetics of ethinylestradiol, levonorgestrel, furosemide and rosuvastatin.
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Methods and analysis We will initiate an N-of-1 series of double-blind randomized and placebo-controlled multiple crossover trials in six patients aged ≥ 6 years with a genetically confirmed SMS diagnosis and a multidisciplinary established ADHD diagnosis, according to a power analysis based on a summary measures analysis of the treatment effect.
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We performed an open-label, single-center study that consisted of 2 randomized, crossover trials, including a fasting trial and a fed trial.
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Thirteen studies met the inclusion criteria: two randomized controlled trials, three randomized crossover trials, and eight observational studies.
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N-of-1 trials are randomized, prospective, controlled, multiple crossover trials in a single patient.
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The CONSORT checklist for randomized crossover trials was followed.
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05) and MDA (crossover trials pooled net difference: -0.
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CONCLUSIONS
Although, PSD seems safer in patients with coronary interventions, the device should further be explored in crossover trials for the two access types to determine the overall safety profile.
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However, behavior intervention crossover trials without a washout period are likely vulnerable to strong carryover effects.
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N-of-1 trials, which are randomized, double-blinded, controlled, multiperiod, crossover trials on a single subject, have been applied to determine the heterogeneity of the individual's treatment effect in precision medicine settings.
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LITERATURE SURVEY
Randomized controlled trials (RCTs), randomized crossover trials, and cluster RCTs until May 2020 were researched through CENTRAL, MEDLINE, EMBASE, PEDro, CINAHL, and REHABDATA databases.
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Since publication of the updated Consolidated Standards of Reporting Trials (CONSORT) guidelines for reporting of parallel clinical trials in humans, extensions for reporting of abstracts and crossover trials have been published.
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This article touches on randomized control trials, post hoc analyses, randomized crossover trials, quasi-experimental trials, cohort studies, case-control studies, cross-sectional studies, case series, case reports, and expert opinion.
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Results After full-text review of 67 papers, eleven (two randomised controlled trials and nine crossover trials) involving 282 participants met the inclusion criteria.
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Supplementation with iron in pulmonary arterial hypertension: two randomized crossover trials.
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In these single-patient crossover trials, typically conducted in patients with chronic conditions, individual patients are given candidate treatments in a double-blinded, random sequence of alternating periods to determine the most effective treatment for that patient.
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Double-blind placebo-controlled crossover trials of sex steroids are required to address unproven behavioural concerns.
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The generalized estimating equations (GEE) methodology has been commonly used to analyze incomplete discrete outcomes from crossover trials.
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In this simulation of randomised crossover trials, we investigated the influence of PPE on the quality of chest compressions (CCs).
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Both studies were randomized, open label, laboratory-blinded, two-period, two-treatment, crossover trials.
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Results are presented for a variety of cluster trial designs including parallel arm, stepped-wedge and cluster crossover trials.
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Randomized controlled trials and crossover trials that compared NAVA and other modes were identified in this study.
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Pooled data from crossover trials (n = 8) favored intervention diets for urinary albumin excretion (ratio of means, 0.
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1% body fat) completed 2 randomized, double-blind, crossover trials consuming CM (8 g CM + 12 g dextrose) or placebo (12 g dextrose).
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ResultsOf 1415 articles screened, 20 studies had low risk of bias, seven were randomized crossover trials, 10 were randomized controlled trials (RCT) and three were RCT pilot trials.
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RESULTS
One positive (n = 50) and three negative (n = 10 each) crossover trials evaluated lidocaine versus placebo, and one trial (n = 16) compared lidocaine with dexmedetomidine.
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Objectives The main objective of our study was to survey the methodological features of crossover trials for infertility with in-vitro fertilization (IVF) based interventions.
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Then, the ability of grape phenolics to act as inhibitors of AGE formation is presented, including the efficacy ranking of various individual compounds measured in vitro and the outcome of in vivo double-blinded randomized crossover trials designed to prove the efficacy of grape phenolics as inhibitors of protein carbonylation.
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A simulation study is conducted to evaluate the customer risk (Type I error) and the empirical power of the nonparametric bootstrap method, Jaki’s method, and our proposed method in sparse sampling crossover trials.
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RESULTS
Nineteen RCTs and two randomized crossover trials reporting results from 3519 participants were included.
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Design N-of-1 multiple crossover trials with individual patient and pooled data analyses.
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In this study, we conducted two randomized, single-blind, crossover trials to investigate the effect of single ingestion of two processed foods composed of ss3a/be2b mutant rice on postprandial blood glucose and insulin response in healthy adults, compared to those of usual cultivar.
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Results We included 38 parallel trials (n=5111) and 147 crossover trials (n=7134).
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Methods In randomized crossover trials, eight resistance-trained participants (23 ± 1 yr, 81 ± 4.
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Incomplete block crossover trials with period-specific baseline and post-baseline (outcome) measures for each subject are often used in clinical drug development; without loss of generality, we focus on the three-treatment two-period ( 3 × 2 ) crossover.
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METHODS
We performed exploratory analyses using data from two randomized, clinical crossover trials, which primarily aimed to assess the effects of GLP-1 RAs on central satiety and reward circuits and subsequent related feeding behavior.
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Methods: We searched Medline (OVID), Embase, the Cochrane Library, and 2 Chinese databases for randomized controlled trials (RCTs) and randomized crossover trials (RTs) that evaluated the efficacy and safety of sertraline in patients with PE.
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