Introduction to Crossover Interventional
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METHODS We use a 3-way crossover interventional study in healthy males to determine the effect of high-protein feeding on de novo lipogenesis, combined with in vitro models to determine the lipogenic effects of specific amino acids.
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To evaluate whether this time-honored concept may serve as a basis to systematically reduce the hangover burden, we undertook a randomized controlled multi-arm matched-triplet crossover interventional trial [3].
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