Introduction to Controlled Randomized

Plasma miR-16, miR-21 and miR-155 were measured by Real-Time PCR before and after two double blinded and placebo-controlled randomized clinical trials with Mastiha.

The aim of this controlled randomized crossover study was to assess post-treatment pain and the need for root canal treatment after the use of a traditional caries removal method followed by restoration, or after an ozone method of more conservatively managing the deep caries and a restoration.

This is a secondary analysis of the placebo-controlled randomized clinical “MAGNA VICTORIA” trials in Western European (WE) and South Asian (SA) people with T2DM.

Material and methods A search was conducted for all controlled randomized/non-randomized studies that measured the efficacy and safety of NAC in adult patients with non-acetaminophen-induced acute liver failure (NAI-ALF).

A controlled randomized clinical trial (NCT04391010) was carried out, analyzing a sample of 63 healthcare providers.

Since there are no controlled randomized trials comparing different antiarrhythmic drugs (AADs) in AMI, optimal decision making is based on medical societies guidelines recommendations and clinical judgement.

Method This controlled randomized clinical trial was conducted on 56 pregnant women with a history of primary infertility referred to Infertility Clinic of Al-Zahra Teaching Hospital of Tabriz.

In addition, a meta-analysis of the available placebo and non-placebo-controlled randomized clinical trials [RCTs] investigating the effects of TRT in T2DM or MetS in several outcomes has been also performed.

evaluated the AstraZeneca COVID-19 vaccine efficacy on two placebo-controlled randomized controlled trials (RCTs) conducted in the United Kingdom and Brazil.

METHODS We explored the intensity and short-term duration of the analgesic effects produced in pNeP patients by 5 days of neuronavigated deep rTMS targeting the posterior superior insula (PSI) with a double-cone coil in a sham-controlled randomized cross-over trial.

We performed a meta-analysis on the rates of placebo response, AEs, severe AEs (SAEs), and withdrawal owing to AEs in placebo-controlled randomized clinical trials (RCTs) of non-TNF biologics and JAK inhibitors in patients with RA showing an insufficient response to TNF inhibitors.

5537 Background: ARIEL3 is a placebo-controlled randomized trial of the PARP inhibitor (PARPi) rucaparib as maintenance treatment in HGOC patients (pts) who responded to the latest line of platinum therapy (NCT01968213).

More and larger sham-controlled randomized trials are needed, preferably with mechanistic informed stimulation protocols, to further advance tDCS therapy in the management of epilepsy.

Results: Among the 5444 published and 316 registration records, nine placebo-controlled randomized clinical trials met our selection criteria, and included data from 5560 patients.

Current principles of surgical treatment of type A dissections are for the most part based on best evidence practice for the lack of controlled randomized studies providing definitive scientific evidence.

We searched for placebo-controlled randomized clinical trials investigating opioids for refractory dyspnea caused by COPD.

Placebo-controlled randomized trials are needed before its use can definitively be recommended.

Methods: This is a controlled randomized study done on 100 patients suffering of rectal cancer who had low anterior resection of the rectum and covering ileostomy at Menofiya University Hospital between April 2016 to august 2019.

METHODS A follow-up with participants (n = 3414) in a controlled randomized trial was performed in a primary health care service.

METHODS We systematically identified all blinded placebo-controlled randomized trials of catheter-based renal denervation for hypertension.

Nonetheless, progress has been limited by a number of factors such as the low number of controlled randomized trials, small sample sizes, variety of stimulation parameters precluding comparability and incomplete or questionable sham-conditions.

Conclusion: Even optimistic simulated hemostatic effects suggest that the costs and potential benefits of andexanet alfa should be carefully considered, and placebo-controlled randomized trials are needed before its use can definitively be recommended.

We included double-blind, active-comparator/placebo-controlled randomized trials, open-label trials, and observational studies.

Methods This placebo-controlled randomized controlled trial compared 0.

Methods: This open-label two open placebo-controlled randomized clinical trial was conducted in a tertiary care hospital in Sukkur, Pakistan from April 2016 to September 2019.

In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the routine regimen, for 8 weeks.

Letter to the Editor-in-Chief in response to JOSPT article "Dry needling adds no benefit to the treatment of neck pain: a sham-controlled randomized clinical trial with 1-year follow-up" by Gattie et al.

In a controlled randomized experiment, we asked (N = 66) participants to draw a CAM before and after a walk.

To reaffirm this observation, we performed a double‐blind placebo‐controlled randomized clinical trial (RCT).

METHODS A controlled randomized study was conducted.

The quality of available evidence is low, based for the most part on observational studies, with only 1 double-masked placebo-controlled randomized trial.

This is a controlled randomized trial for a multidisciplinary telehealth intervention in Southern Brazil, with social distancing measures.

Twenty-nine placebo-controlled randomized trials (3,393 men) met inclusion criteria for analysis of mean hematocrit change after testosterone therapy.

This led some to question the accuracy of the criteria, especially the clinical arm, by referencing studies which demonstrated that patients fulfilling only the clinical arm did not demonstrate progression to radiographic sacroiliitis and did not respond to TNFi in placebocontrolled randomized controlled trials (RCT) unless objective features of inflammation in the form of an elevated Creactive protein (CRP) or MRI inflammation were evident [6, 7].

Placebo-controlled randomized studies are advised to corroborate this finding.

However, because of the absence of placebo-controlled randomized trials on IVC efficacy in advanced-stage cancer patients, the placebo effect cannot be excluded.

Expert opinion: In two placebo-controlled randomized multicenter phase 2 trials adjunct CNB showed unusually high efficacy with rates of seizure-free people with epilepsy (PWE) partially beyond 20%.

SUMMARY Real life study provided novel information and evidenced those aspects of immunotherapy that worth a more detailed approach, without the strict limitations usually imposed by controlled randomized trials.

Methods: Multicenter, blinded, placebo-controlled randomized trial of losartan (50 mg PO twice daily for 10 days) versus placebo.

Controlled randomized and non-randomized human clinical studies assessing the effect of biological substances on the rate of OTM were included.

This review discusses the results of three recently published placebo-controlled randomized trials evaluating the effect of urate-lowering treatment on the progression of CKD with at least 2 years of follow-up.

METHODS AND RESULTS In a controlled randomized cross-over dietary intervention study, 12 healthy volunteers consumed different processed and non-processed meats for 3 consecutive days each.

On the other hand, prospective placebo-controlled randomized trials investigating clinically relevant endpoints are limited.

METHODS Within a triple-blinded (patients, intervention administrators, and outcome assessors) placebo-controlled randomized clinical trial, we evaluated the effects of Amantadine (100mg BD (twice a day) for 14 days, then 150mg BD for another 7 days, and 200mg BD for another 21 days) on outcome measurements of weekly mean Glasgow Outcome Scale (GOS) and Disability Rating Scale (DRS), through six weeks of trial for 57 patients (29 Amantadine, 28 placeboes) with severe TBI admitted in our hospital.

Trial design This quadruple-blinded, placebo-controlled randomized clinical trial will be a multiarmed multi-centered study with superiority framework.

Methods In this controlled randomized study first year, undergraduate students were allocated in the intervention group and the control group.

PURPOSE OF REVIEW This review examines recent contradictory large, well-controlled randomized control trials assessing the effects of omega-3 fatty acids and colchicine on cardiovascular (CV) outcomes.

In clinical settings with limited or no access to known effective vaccines, placebo-controlled randomized trials of new vaccines remain a preferred approach to maximize the reliability, efficiency and interpretability of results.

This controlled randomized clinical trial was conducted on 58 patients admitted to the burn center of XXX.

Results: We identified 66 placebo-controlled randomized controlled trials (RCTs) comprising 4400 patients undergoing elective cesarean section.

Patients and Methods: The current study was conducted as controlled randomized trial on 200 women recruited from labor ward in Assiut Al -Azhar university Hospital.

A controlled randomized prospective study was conducted on the basis of a private rehabilitation center «Ezramed-Clinic» in Omsk in the period from February 2019 to December 2019.

METHOD A three-site 8-week placebo-controlled randomized clinical trial of micronutrients was conducted in unmedicated children ages 6-12 with ADHD and at least one impairing irritability symptom by parent report on the Child and Adolescent Symptom Inventory-5 (CASI-5).

STUDY DESIGN This is a double blind phase II/III placebo-controlled randomized trial of the safety and efficacy of GH treatment in incomplete chronic traumatic spinal cord injury.

4 The findings also inspired two landmark doubleblind and placebocontrolled randomized clinical trials (RCTs) to test HT use (conjugated equine estrogens [CEEs]/with and without medroxyprogesterone acetate) for primary (Women’s Health Initiative [WHI])5 and secondary prevention (Heart and Estrogen/Progestin Replacement Study [HERS])6 of CVD in the 1990s.

In December 2020, Pfizer-BioNTech (9) and Moderna (10) reported safety and efficacy data from placebocontrolled randomized clinical trials of their COVID-19 vaccines to the U.