Introduction to Control Trials

Well-designed randomized control trials (RCTs) might help to identify the differences between these two techniques for the surgical treatment of right colon cancer.

Its safety and efficacy should be evaluated fully via well-designed, randomized, control trials.

Objectives To demonstrate a magnitude of the cardiovascular benefits, concomitantly analyzing the safety outcomes of sodium-glucose cotransporter 2 inhibitor (SGLT2-I) comprehensively, as a class effect in a larger sample size combined from recent randomized control trials.

Although the findings of this review support the effectiveness of serial casing application in CP children with equinus deformity, additional randomized control trials with a larger sample size are still required to confirm the present evidence.

However, large-scale randomized control trials are needed to establish the efficacy and safety of these techniques in the North American population.

Although many researchers have attempted to elucidate the optimal strategies for managing this disease, the lack of large-scale randomized control trials and the lack of agreement on disease staging have curtailed the development of clear-cut guidelines.

METHODS A systematic literature search was conducted in the databases of MEDLINE, Scopus, Web of Science, and Cochrane through March 2020 to identify all randomized control trials (RCTs) investigating the effects of synbiotic interventions on blood pressure parameter, including systolic (SBP) and diastolic blood pressure (DBP).

Methods A systematic literature search was performed in PubMed to identify relevant randomized control trials to be included in the meta-analysis.

Manuscripts describing randomized control trials should also include in the text of the manuscript the following information: The identity of those who designed the protocol and analyzed the data; A statement indicating that at least one author had access to all of the data and can vouch for the integrity of the data analyses; Disclosure of any funding sources and their role, if any, in the writing of the manuscript or the decision to submit it for publication; Statements of role, if any, of medical writer or editor.

Manuscripts describing randomized control trials should also include in the text of the manuscript the following information: The identity of those who designed the protocol and analyzed the data; A statement indicating that at least one author had access to all of the data and can vouch for the integrity of the data analyses; Disclosure of any funding sources and their role, if any, in the writing of the manuscript or the decision to submit it for publication; Statements of role, if any, of medical writer or editor.

Only systematic reviews, randomized control trials (RCTs), metaanalysis, and grey literature were included.

Only systematic reviews, randomized control trials (RCTs), meta-analysis, and grey literature were included.

Articles were included if they were randomized control trials, cohort studies, case-control studies, and case series (with more than five cases), which focused on the clinical outcomes of patients with plate osteosynthesis as a treatment for fracture of the patella and had a minimum follow-up of 3 months.

Randomized control trials (RCTs), cohort studies, case-control studies, and case series with over five cases were included.

All articles, including case-control/cohort studies, case series, case reports, randomized control trials, traditional/systematic reviews, were analyzed.

The eligibility criteria only included systematic reviews and studies with quantitative research methods (cross-sectional, case-control, cohort, and randomized-control trials).

We conducted a systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines for reporting to identify all neuroendocrine biomarkers used to evaluate psychological stress in randomized control trials involving music interventions.

This systematic literature review described randomized control trials of psychosocial smoking cessation interventions for people with SMI, rated their methodological rigor, evaluated the inclusion of racial/ethnic and sexual/gender minorities, and examined smoking cessation outcomes.

Our observed low recurrence in a large case series with long-term follow-up suggests the efficacy of topical 5% imiquimod for LM and emphasizes the need for randomized control trials comparing imiquimod with, or as an adjunct to, surgical treatment.

Research design and methods Meta-analysis of randomized control trials and large case series (more than 20 patients), were identified by searching Pubmed and Cochrane databases through 14 December 2020.

Twelve articles were found to be relevant including three evidence-based guidelines, two randomised control trials and one systematic review.

Study designs include one systematic review, one randomized control trial with pretest-posttest design, three small-scale randomized control trials, one quasi-experimental study with no control, one time-series study, and one case study.

Additional high-quality randomized control trials may further inform surgical decision making in the treatment of GERD.

More number of high quality randomized control trials are required to strengthen the evidence and incorporation of these tools in clinical practice.

However, more high-quality, double-blind, randomized control trials should be performed to explore the effects of RT to ensure successful implementation in rehabilitation.

All relevant double-blind randomized control trials (RCTs), on any antipsychotic used for 12 weeks or longer in any mental health/neurodevelopmental condition in this age group, were included.

High-quality and adequately powered randomized control trials (RCTs) are warranted.

Further adequately powered randomized control trials are needed to confirm the safety and efficacy of these oral anticoagulants in the morbidly obese and post bariatric surgery population.

Eligible studies included randomized control trials (RCTs), non-randomized studies, case-control studies, and cohort studies.

Eligible studies included randomized control trials of any learning burnout intervention conducted among students.

Materials and Methods: Thorough search was carried out on PUBMED, MEDLINE databases and Google on the association between periodontal disease and cardiovascular diseases and the mechanisms involved selected literature included review articles, observational studies, case control studies, randomized control trials and meta-analysis.

Randomised control trials, clinical studies, case control studies and animal studies were searched for osseointegration of hafnium coated titanium implants versus conventional titanium implants.

We performed a systematic electronic search for PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials (Cochrane CENTRAL), CNKI, and WANGFANG DATA to identify relevant randomized control trials (RCTs).

Methods We searched PubMed, Embase, and Scopus databases through August 15, 2020 to identify relevant randomized control trials, observational studies, and case series.

DATA SOURCES This review included 14 randomized control trials and one quasi-experimental interventional study, all published between 2014 and 2020.

SAMPLE A total of seven randomized control trials and one quasi-experimental study were included for analysis.

The findings from 51 autonomy-supportive teaching interventions (including 38 randomized control trials) collectively show that (1) teachers can learn how to become more autonomy supportive during instruction (autonomy-supportive teaching is malleable) and, once learned, (2) this greater autonomy-supportive teaching produces a wide range of educationally important student, teacher, and classroom climate benefits (autonomy-supportive teaching is beneficial).

Patent foramen ovale closure in the setting of stroke was debatable until the recent data from the long-term follow-up of multiple randomized control trials.

Randomized control trials, observational studies, case series, and reports investigating the clinical use of the capsaicin patch were searched through MEDLINE, EMBASE, AMED, Cochrane Library, CINAHL, Web of Science, and ROAD databases.

RESULTS The final review includes 20 manuscripts, 11 randomized control trials (RCTs), three secondary analyses of RCTs and six observational studies.

Eligible randomized control trials (RCTs) include RCTs reporting on the effects of low, moderate or high intensive exercise on leptin concentration.

Design We systematically searched randomised control trials investigating the effectiveness of early cholecystectomy compared with conservative management/delayed cholecystectomy.

Large randomised control trials have shown that renal revascularisation in patients with atherosclerotic renal artery disease does not confer any additional benefit to medical therapy alone.

The majority of evidence was qualitative research, which included 19 case studies; whereas, the most used quantitative research designs were Random Control Trials.

Thirty-five random control trials that evaluated systemic therapies for nail psoriasis were selected in the systemic review.

Our observed low recurrence in a large case series with long-term follow-up suggests the efficacy of topical 5% imiquimod for LM and emphasizes the need for randomized control trials comparing imiquimod with, or as an adjunct to, surgical treatment.

Randomized control trials comparing oil pulling using conventional cooking oil with any controls such as chlorhexidine (CHX), placebo or routine dental hygiene practice were included.

METHODS A systematic review and meta-analysis utilizing the MEDLINE, Cochrane, and Scopus database was performed to identify randomized and non-randomized control trials evaluating baseline characteristics and hospitalizations.

This review observed that there are no randomised control trials evaluating dual-surgeon versus single-surgeon operating for scoliosis.

Control trials showed that the participants followed the instructions and performed at ceiling in the 2IFC task, indicating that the specific non-perceptual cognitive requirements of the 2IFC task cannot explain the incorrect 2IFC decisions.

A preliminary meta-analysis of randomized control trials showed that tDCS was associated with significantly better improvement in surgical performance than the sham control; however, meta-analysis does not address the mechanistic understanding.

METHODS We conducted a meta-analysis on randomized control trials published during 1 January 2000 through 31 December 2019, from PubMed, Cochrane Library databases, EMBASE, Medline (ProQuest), CINAHL, PsycINFO, Chinese Electronic Periodical Service and Wan Fan Data with prespecified searching criteria.

Only randomized control trials published in English or French were included and had to compare yoga to another intervention group or a control group.

Cohort studies and randomized control trials examining AL events in NSAID-exposed, colorectal cancer patients were included.

The reporting of successful and safe treatment strategies are crucial to guide clinicians as it is unlikely that there will be large, randomized control trials examining optimal therapeutic strategies for patients with a lack of humoral protection.

Design We systematically searched randomised control trials investigating the effectiveness of early cholecystectomy compared with conservative management/delayed cholecystectomy.

The primary objective was to address this gap in evidence by undertaking a systematic review of all randomised control trials investigating pharmacological management of HDP to assess whether CCBs are the most effective anti-hypertensive agent in Black pregnant women.

However, results of high-quality research such as the GRECCAR II, TESAR and STAR-TREC randomised control trials may highlight a wider role for local excision surgery in the future, when used in combination with oncological therapies.

Additional high-quality randomized control trials may further inform surgical decision making in the treatment of GERD.

Here, we examine the biological activities of tumour necrosis factor inhibitors indicative of their potential in COVID-19 and briefly outline the randomised control trials assessing their benefit-risk profile in COVID-19 therapy.

PURPOSE OF REVIEW This review examines recent contradictory large, well-controlled randomized control trials assessing the effects of omega-3 fatty acids and colchicine on cardiovascular (CV) outcomes.

Further randomized control trials studies using a robust design with long-term cinnamon consumption are needed to further investigate any potential effect.

Results: The results from Randomized control trials studies will compare the benefits in control and cases using risk reduction strategy, drug intervention and are expected to show huge benefits in cases group.

This meta-analysis of 10, small, randomized control trials compared iron supplementation versus placebo in 1,404 patients with iron deficiency and systolic heart failure.

Results: Nine studies (1988–2020; 32 156 patients) involving 10 randomized control trials compared outcome ascertainment with RHD and CEC in patients with or at risk of cardiovascular disease.

Lastly, as most evidence has been derived from small and retrospective studies, results from randomized control trials could be of significant value.

Further studies with randomized control trials could be of great benefit.

We conducted a systematic literature review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement guidelines for reporting to identify all neuroendocrine biomarkers used to evaluate psychological stress in randomized control trials involving music interventions.

RESULTS A total of 9 clinical control trials involving 4,351 patients (2,123 in the Seprafilm group and 2,228 in the control group) were included.

Randomized control trials need to be done to see whether lowering serum uric acid level will ameliorate the level of blood pressure.

Randomised control trials need to be conducted though, in order to elucidate the true role of relaxin in these cases.

Methods We explored ICIs related SJS/TEN events in randomized control trials available in ClinicalTrials.

The effectiveness of azathioprine (AZA) in preventing relapse and maintaining autoimmune pancreatitis (AIP) remission has been reported; however, most of these studies are case series with no randomized control trials available in the literature.

Four randomized-control trials demonstrated a reduction in stroke recurrence with PFO closure.

Subsequent randomized control trials demonstrated vertebroplasty provided improved patient outcomes compared with sham procedures.