Introduction to Conjugates Targeting

Sentence Examples

Discover more insights into Conjugates Targeting

Keywords frequently search together with Conjugates Targeting

Narrow sentence examples with built-in keyword filters

Conjugates Targeting sentence examples within Drug Conjugates Targeting

Drug Conjugates Targeting

In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors.

Peptide-drug conjugate-based novel molecular drug delivery system in cancer.

Drug Conjugates Targeting

Purpose: Recently, phase I studies with novel antibody drug conjugates targeting HER2 suggested benefit in HER2-low patients – defined as immunohistochemistry(IHC) +1 or +2 FISH/ISH non-amplified, with advanced breast cancer(BC).

HER2-Low Status and Response to Neoadjuvant Chemotherapy in HER2 Negative Early Breast Cancer

More Drug Conjugates Targeting sentences More Sentences

Conjugates Targeting sentence examples within Peptide Conjugates Targeting

Peptide Conjugates Targeting

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery.

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

Peptide Conjugates Targeting

Applying an easy accessible synthetic route, we provided a small series of heteromultimeric peptide conjugates targeting the nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) and mu opioid receptors.

Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and mu Opioid Receptors.

More Peptide Conjugates Targeting sentences More Sentences

Conjugates Targeting sentence examples within Acid Conjugates Targeting

Acid Conjugates Targeting

Furthermore, four types of promising active site inhibitors of plasmin have been developed: tranexamic acid conjugates targeting the S1 pocket and primed sites, substrate-analogue linear homopiperidylalanine-containing 4-amidinobenzylamide derivatives, macrocyclic inhibitors addressing nonprimed binding regions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed and nonprimed binding sites of plasmin.

Fibrinolysis Inhibitors - Potential Drugs for the Treatment and Prevention of Bleeding.

Acid Conjugates Targeting

Herein, we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages.

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

More Acid Conjugates Targeting sentences More Sentences

Learn more from Conjugates Targeting

Conjugates Targeting sentence examples within conjugates targeting essential

conjugates targeting essential

, based on the nucleic acid mimic PNA (peptide nucleic acid) have shown promise in this respect in the form of PNA-BPP (bacteria penetrating peptide) conjugates targeting essential bacterial genes.

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials

conjugates targeting essential

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery.

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

More conjugates targeting essential sentences More Sentences

Conjugates Targeting sentence examples within conjugates targeting variou

conjugates targeting variou

In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors.

Peptide-drug conjugate-based novel molecular drug delivery system in cancer.

conjugates targeting variou

Emerging compelling pre-clinical data with novel antibody-drug conjugates targeting various surface receptors in ovarian cancer alone and in combination with immune checkpoint blockade generate a strong enthusiasm for rapid translation of these strategies to clinic.

Novel therapeutics: response and resistance in ovarian cancer

More conjugates targeting variou sentences More Sentences

More Conjugates Targeting sentence examples
10.3390/biomedicines9040429

, based on the nucleic acid mimic PNA (peptide nucleic acid) have shown promise in this respect in the form of PNA-BPP (bacteria penetrating peptide) conjugates targeting essential bacterial genes.

Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials

More Conjugates Targeting sentence examples
10.1016/j.tips.2021.07.001

In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors.

Peptide-drug conjugate-based novel molecular drug delivery system in cancer.

More Conjugates Targeting sentence examples
10.7150/ijbs.57038

In the present study, we employed antibody-antigen conjugates targeting a specific DC C-type lectin receptor.

Antigen Delivery to DEC205+ Dendritic Cells Induces Immunological Memory and Protective Therapeutic Effects against HPV-Associated Tumors at Different Anatomical Sites

More Conjugates Targeting sentence examples
10.3390/biomedicines9080978

In this paper, we summarize the results obtained with immunoconjugates targeting sarcoma surface antigens, considering both preclinical and clinical studies.

Antibody Conjugates for Sarcoma Therapy: How Far along Are We?

More Conjugates Targeting sentence examples
10.21203/RS.3.RS-420934/V1

Purpose: Recently, phase I studies with novel antibody drug conjugates targeting HER2 suggested benefit in HER2-low patients – defined as immunohistochemistry(IHC) +1 or +2 FISH/ISH non-amplified, with advanced breast cancer(BC).

HER2-Low Status and Response to Neoadjuvant Chemotherapy in HER2 Negative Early Breast Cancer

More Conjugates Targeting sentence examples
10.1158/1538-7445.AM2021-LB096

We report the development of novel, differentiated protein drug conjugates targeting ROR1 based on Variable New Antigen Receptor domains (VNARs).

Abstract LB096: Development of a next generation ROR1 targeting Protein Drug Conjugate (PDC)

More Conjugates Targeting sentence examples
10.1016/j.bmc.2021.116185

In this study, we designed and synthesized a series of novel dual-functional conjugates targeting both ERα degradation and histone deacetylase inhibiton by combining a privileged SERD skeleton 7-oxabicyclo[2.

Novel hybrid conjugates with dual estrogen receptor α degradation and histone deacetylase inhibitory activities for breast cancer therapy.

More Conjugates Targeting sentence examples
10.3390/ijms222111470

Antibody-drug conjugates targeting different B-cell antigens (CD30, CD79b, CD19) seem to be effective in combination with mAbs, standard chemoimmunotherapy, or immune checkpoint inhibitors.

Promising Immunotherapeutic Modalities for B-Cell Lymphoproliferative Disorders

More Conjugates Targeting sentence examples
10.2147/BTT.S290294

The immune-conjugates targeting CD22 have also had a similarly impressive role in improving the outcome in such patients.

Emerging Monoclonal Antibody Therapy for the Treatment of Acute Lymphoblastic Leukemia

More Conjugates Targeting sentence examples
10.1016/j.ijrobp.2021.07.946

PURPOSE/OBJECTIVE(S) Brentuximab vedotin (BV) and polatuzumab vedotin (PV) are antibody-drug conjugates targeting CD30 and CD79B, respectively, approved for the treatment of select T- and B-cell lymphomas.

Concurrent Radiation Therapy With the Antibody-Drug Conjugates Brentuximab Vedotin and Polatuzumab Vedotin.

More Conjugates Targeting sentence examples
10.3390/molecules26061591

This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells.

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

More Conjugates Targeting sentence examples
10.3389/fmicb.2019.01032

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery.

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

More Conjugates Targeting sentence examples
10.3389/fchem.2019.00369

Among the several strategies considered to overcome these drawbacks, very appealing appears the design of hybrid small-molecule conjugates targeting AR to drive drug action on receptor-positive PC cells.

Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer

More Conjugates Targeting sentence examples
10.1097/CCO.0000000000000532

More recently, development of inhibitors targeting the fibroblast growth factor receptor genetic alterations and antibody–drug conjugates targeting specific cell surface antigens (trop2, nectin4, and SLITRK6) resulted in several FDA breakthrough designations for urothelial carcinoma.

Targeting advanced urothelial carcinoma-developing strategies

More Conjugates Targeting sentence examples
10.14735/amko201990

Monoclonal antibodies and immunoconjugates targeting antigens CD19 and CD22 show greater efficacy and more favourable toxicity profiles than standard salvage chemotherapeutic protocols.

Therapy of Relapsed/Refractory Acute Lymphoblastic Leukemia Today and Tomorrow.

More Conjugates Targeting sentence examples
10.1021/acs.jmedchem.9b01060

Furthermore, four types of promising active site inhibitors of plasmin have been developed: tranexamic acid conjugates targeting the S1 pocket and primed sites, substrate-analogue linear homopiperidylalanine-containing 4-amidinobenzylamide derivatives, macrocyclic inhibitors addressing nonprimed binding regions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed and nonprimed binding sites of plasmin.

Fibrinolysis Inhibitors - Potential Drugs for the Treatment and Prevention of Bleeding.

More Conjugates Targeting sentence examples
10.1136/ijgc-2019-000456

Emerging compelling pre-clinical data with novel antibody-drug conjugates targeting various surface receptors in ovarian cancer alone and in combination with immune checkpoint blockade generate a strong enthusiasm for rapid translation of these strategies to clinic.

Novel therapeutics: response and resistance in ovarian cancer

More Conjugates Targeting sentence examples
10.1073/pnas.1820388116

Tregs express CD25 on their surface and can be killed by antibodies and immunoconjugates targeting CD25.

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

More Conjugates Targeting sentence examples
10.3390/antib8010007

To streamline the development of antibody-drug conjugates targeting gynecological cancers within our laboratory, we incorporated surface plasmon resonance analysis (Biacore™ T200) into our development toolkit.

A RAGE-Targeted Antibody-Drug Conjugate: Surface Plasmon Resonance as a Platform for Accelerating Effective ADC Design and Development

More Conjugates Targeting sentence examples
10.1016/j.ajps.2019.04.001

Herein, we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages.

A novel oral prodrug-targeting transporter MCT 1: 5-fluorouracil-dicarboxylate monoester conjugates

More Conjugates Targeting sentence examples
10.1021/acs.bioconjchem.9b00519

Applying an easy accessible synthetic route, we provided a small series of heteromultimeric peptide conjugates targeting the nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) and mu opioid receptors.

Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and mu Opioid Receptors.

Learn more from Conjugates Targeting

Keywords related to Targeting

Conjugates Targeting
Encyclopedia

What is/are Conjugates Targeting?

Conjugates Targeting - , based on the nucleic acid mimic PNA (peptide nucleic acid) have shown promise in this respect in the form of PNA-BPP (bacteria penetrating peptide) conjugates targeting essential bacterial genes. [1] In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors. [2] In the present study, we employed antibody-antigen conjugates targeting a specific DC C-type lectin receptor. [3] In this paper, we summarize the results obtained with immunoconjugates targeting sarcoma surface antigens, considering both preclinical and clinical studies. [4] Purpose: Recently, phase I studies with novel antibody drug conjugates targeting HER2 suggested benefit in HER2-low patients – defined as immunohistochemistry(IHC) +1 or +2 FISH/ISH non-amplified, with advanced breast cancer(BC). [5] We report the development of novel, differentiated protein drug conjugates targeting ROR1 based on Variable New Antigen Receptor domains (VNARs). [6] In this study, we designed and synthesized a series of novel dual-functional conjugates targeting both ERα degradation and histone deacetylase inhibiton by combining a privileged SERD skeleton 7-oxabicyclo[2. [7] Antibody-drug conjugates targeting different B-cell antigens (CD30, CD79b, CD19) seem to be effective in combination with mAbs, standard chemoimmunotherapy, or immune checkpoint inhibitors. [8] The immune-conjugates targeting CD22 have also had a similarly impressive role in improving the outcome in such patients. [9] PURPOSE/OBJECTIVE(S) Brentuximab vedotin (BV) and polatuzumab vedotin (PV) are antibody-drug conjugates targeting CD30 and CD79B, respectively, approved for the treatment of select T- and B-cell lymphomas. [10] This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. [11] Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. [12] Among the several strategies considered to overcome these drawbacks, very appealing appears the design of hybrid small-molecule conjugates targeting AR to drive drug action on receptor-positive PC cells. [13] More recently, development of inhibitors targeting the fibroblast growth factor receptor genetic alterations and antibody–drug conjugates targeting specific cell surface antigens (trop2, nectin4, and SLITRK6) resulted in several FDA breakthrough designations for urothelial carcinoma. [14] Monoclonal antibodies and immunoconjugates targeting antigens CD19 and CD22 show greater efficacy and more favourable toxicity profiles than standard salvage chemotherapeutic protocols. [15] Furthermore, four types of promising active site inhibitors of plasmin have been developed: tranexamic acid conjugates targeting the S1 pocket and primed sites, substrate-analogue linear homopiperidylalanine-containing 4-amidinobenzylamide derivatives, macrocyclic inhibitors addressing nonprimed binding regions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed and nonprimed binding sites of plasmin. [16] Emerging compelling pre-clinical data with novel antibody-drug conjugates targeting various surface receptors in ovarian cancer alone and in combination with immune checkpoint blockade generate a strong enthusiasm for rapid translation of these strategies to clinic. [17] Tregs express CD25 on their surface and can be killed by antibodies and immunoconjugates targeting CD25. [18] To streamline the development of antibody-drug conjugates targeting gynecological cancers within our laboratory, we incorporated surface plasmon resonance analysis (Biacore™ T200) into our development toolkit. [19] Herein, we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages. [20] Applying an easy accessible synthetic route, we provided a small series of heteromultimeric peptide conjugates targeting the nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) and mu opioid receptors. [21]

Drug Conjugates Targeting

In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors. [1] Purpose: Recently, phase I studies with novel antibody drug conjugates targeting HER2 suggested benefit in HER2-low patients – defined as immunohistochemistry(IHC) +1 or +2 FISH/ISH non-amplified, with advanced breast cancer(BC). [2] We report the development of novel, differentiated protein drug conjugates targeting ROR1 based on Variable New Antigen Receptor domains (VNARs). [3] Antibody-drug conjugates targeting different B-cell antigens (CD30, CD79b, CD19) seem to be effective in combination with mAbs, standard chemoimmunotherapy, or immune checkpoint inhibitors. [4] PURPOSE/OBJECTIVE(S) Brentuximab vedotin (BV) and polatuzumab vedotin (PV) are antibody-drug conjugates targeting CD30 and CD79B, respectively, approved for the treatment of select T- and B-cell lymphomas. [5] This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. [6] More recently, development of inhibitors targeting the fibroblast growth factor receptor genetic alterations and antibody–drug conjugates targeting specific cell surface antigens (trop2, nectin4, and SLITRK6) resulted in several FDA breakthrough designations for urothelial carcinoma. [7] Emerging compelling pre-clinical data with novel antibody-drug conjugates targeting various surface receptors in ovarian cancer alone and in combination with immune checkpoint blockade generate a strong enthusiasm for rapid translation of these strategies to clinic. [8] To streamline the development of antibody-drug conjugates targeting gynecological cancers within our laboratory, we incorporated surface plasmon resonance analysis (Biacore™ T200) into our development toolkit. [9]

Peptide Conjugates Targeting

Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. [1] Applying an easy accessible synthetic route, we provided a small series of heteromultimeric peptide conjugates targeting the nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) and mu opioid receptors. [2]

Acid Conjugates Targeting

Furthermore, four types of promising active site inhibitors of plasmin have been developed: tranexamic acid conjugates targeting the S1 pocket and primed sites, substrate-analogue linear homopiperidylalanine-containing 4-amidinobenzylamide derivatives, macrocyclic inhibitors addressing nonprimed binding regions, and bicyclic 14-mer SFTI-1 analogues blocking both, primed and nonprimed binding sites of plasmin. [1] Herein, we design three 5-FU-fatty acid conjugates targeting intestinal MCT1 with different lipophilic linkages. [2]

conjugates targeting essential

, based on the nucleic acid mimic PNA (peptide nucleic acid) have shown promise in this respect in the form of PNA-BPP (bacteria penetrating peptide) conjugates targeting essential bacterial genes. [1] Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. [2]

conjugates targeting variou

In this review, we explored ongoing clinical work on peptide-drug conjugates targeting various receptors. [1] Emerging compelling pre-clinical data with novel antibody-drug conjugates targeting various surface receptors in ovarian cancer alone and in combination with immune checkpoint blockade generate a strong enthusiasm for rapid translation of these strategies to clinic. [2]