Introduction to Clinical Value

Purpose The present study aimed to evaluate the clinical value of the combined detection of soluble T cell immunoglobulinand mucin domain molecule 3 (sTim-3) and pepsinogen (PG) in sera for gastric cancer (GC) diagnosis.

The present study aimed to evaluate the distribution pattern and clinical value of the 21-gene RS in patients with MBC.

Receiver operating characteristic (ROC) analysis in the combination of subsets and function of lymphocytes presented a superior clinical value with an area under the curve (AUC) of 0.

The potential clinical value of DN T cells was then assessed by the receiver operating characteristic (ROC) curves.

OBJECTIVES To evaluate the clinical value of supine magnetic resonance imaging (MRI) for tumor localization in breast cancer patients with large or multifocal tumors detected by prone MRI, scheduled for oncoplastic breast conserving surgery (OBCS).

OBJECTIVES To assess the clinical value of periventricular white matter hyperintensity (PWMH) found on brain magnetic resonance imaging (MRI) in patients with sudden sensorineural hearing loss (SSNHL).

Whole-body multiparameter MRI and positron emission tomography (PET) with specific tracers, such as prostate-specific membrane antigen (PSMA), fluciclovine, fluorodeoxyglucose (FDG), and so on, has demonstrated promising clinical value for treatment response monitoring of patients with metastatic CRPC.

2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM).

The objective was to explore the clinical value of contrast-enhanced ultrasound (CEUS) in locating the sentinel lymph node (SLN) in patients with early breast cancer.

Objective To assess the clinical value of contrast-enhanced ultrasound (CEUS) technology in predicting axillary lymph nodes status before surgery, and to explore the feasibility of sentinel lymph nodes (SLNs) localization guided by CEUS combined with 125I implantation for breast cancer.

BACKGROUND Long noncoding RNAs (LncRNA) ADAMTS9-AS2 was recognized as a novel tumor suppressor and it plays an important role in the initiation and progression of malignant behavior in human cancers, but its plasma expression and clinical value in patients with non-small cell lung cancer (NSCLC) remain unknown.

Objective: This study aims to investigate the expression and clinical value of long non-coding RNA (lncRNA) HEIH in peripheral blood of patients with non-small cell lung cancer (NSCLC).

This study was to explore the feasibility of immunofluorescence based on fluorescent nanoparticles (FNP) in the detection of acute myocardial infarction (AMI) marker Cardiac troponin I (cTnI), and analyze the clinical value of optimized rescue measures in the emergency treatment of AMI.

The present study investigated the clinical value of myocardial contrast-delayed enhancement (DE) with multidetector computed tomography (MDCT) without iodine re-injection immediately after primary percutaneous coronary intervention (PCI) for predicting future cardiovascular events after acute myocardial infarction (AMI).

In this research, by detecting the expression of KLK7 in pancreatic cancer tissues and analyzing its relationship between clinicopathological characteristics and prognosis of patients with resectable pancreatic ductal adenocarcinoma (PDAC) as well as explore its clinical value in pancreatic cancer.

BACKGROUND The clinical value and predictors of a favorable histological response to preoperative chemoradiotherapy (CRT) in pancreatic ductal adenocarcinoma (PDAC) remains undefined.

Introduction The objective was to evaluate whether hybrid imaging combining single photon emission tomography with computed tomography (SPECT/CT) provides additional clinical value for dectection of sentinel lymph nodes (SLNs) compared with intraoperative combined mapping in uterine and cervical malignancies.

We explored the clinical value of 99mTc-Galacto-RGD2 single-photon emission computed tomography (SPECT/CT) in patients with lung cancer, Integrin αvβ3 expression, and neovascularization in lung cancer subtypes was also addressed.

This prospective study addressed the clinical value of a targeted-gene amplicon-based plasma next-generation sequencing (NGS) assay to detect actionable mutations in ctDNA in patients with newly diagnosed advanced lung adenocarcinoma.

This case highlights the clinical value of up-front next-generation sequencing in metastatic pancreatic cancer and the ability of pancreatic cancer with actionable molecular variants to develop atypical sites of disease and adaptive resistance.

OBJECTIVE To evaluate the clinical value of postreatment plasmatic levels of the squamous cell carcinoma antigen (SCC-Ag) as a survival independent prognostic factor in patients with LACC.

Objective: The goal of this study was to confirm the clinical value of pretreatment serum squamous cell carcinoma antigen (SCC-Ag) in the administration of consolidation chemotherapy in patients with cervical cancers undergoing postoperative extended-field radiotherapy (EFRT) and concurrent chemotherapy (CCRT).

N6-methyladenosine (m6A) has been involved in diverse biological processes in cancer, but its function and clinical value in clear cell renal cell carcinoma (ccRCC) remain largely unknown.

Background: This study aimed to explore N6-methyladenosine (m6A) methylation-related immune biomarkers and their clinical value in clear cell renal cell carcinoma (ccRCC).

OBJECTIVES To determine the optimal kiloelectron volt of noise-optimized virtual monoenergetic images [VMI (+)] for visualization of nasopharyngeal carcinoma (NPC) and nasopharyngeal lymphoma (NPL), and to explore the clinical value of quantitative parameters derived from dual-energy computed tomography (DECT) for distinguishing the two entities.

PURPOSE This study assesses the clinical value of dual-energy computed tomography (DECT) in the early diagnosis of intracranial hemorrhage and evaluates the risk of hemorrhagic transformation in patients with acute ischemic stroke (AIS) after mechanical thrombectomy.

The clinical value of positive family history of premature coronary artery disease (CAD) in risk prediction of cardiovascular diseases is controversial.

To investigate the clinical value of acoustic cardiography in the diagnosis of coronary artery disease (CAD) and post‐percutaneous coronary intervention (PCI) early asymptomatic left ventricular systolic dysfunction.

The clinical value of the model was verified using survival analysis, clinicopathological characteristics, presence of tumor-infiltrating immune cells, and chemotherapy efficacy evaluation.

The clinical value of the model was verified through the analysis of patient survival rates, clinicopathological characteristics, presence of tumor-infiltrating immune cells, and chemotherapy efficacy evaluation.

In order to analyze the serum tumor markers (CEA, β2-MG) combined serum CA50, AFP predict the clinical value of liver metastatic colorectal cancer, 80 cases of colorectal cancer patients with postoperative pathologic results were divided into control group and observation group, control group of 50 cases of liver metastasis in patients, observation group of 30 cases of patients with liver metastases.

Previous studies have linked elevated NLR to worse long-term survival outcomes among patients with metastatic colorectal cancer (mCRC), but its clinical value in the management of patients with resectable colorectal liver metastases (CRLM) remains unproven.

To evaluate the feasibility and clinical value of the combination of carbon nanoparticles (CNPs) and indocyanine green (ICG) for identifying sentinel lymph nodes (SLNs) in endometrial cancer.

STUDY OBJECTIVES To explore the technique and clinical value of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) in hysterectomy and sentinel lymph node (SLN) mapping for endometrial cancer by comparing its perioperative outcomes with those of laparoscopic staging.

Background To explore the clinical value of enhanced computed tomography (enhanced CT), magnetic resonance imaging (MRI), carcinoembryonic antigen (CEA), and cancer antigen 199 (CA199) in the diagnosis of rectal cancer (RC).

The purpose of the study was to evaluate the clinical value of quantitative liver perfusion parameters and corresponding histogram parameters derived from traditional triphasic enhanced computed tomography (CT) scans in predicting histological grade of HCC.

PURPOSE To investigate the clinical value of urine interleukin-18 (IL-8), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for the early diagnosis of acute kidney injury (AKI) in patients with ureteroscopic lithotripsy (URL) related urosepsis.

To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury.

The disease control remains heterogeneous and consequently, the ability to predict patient survival would be of great clinical value.

Conclusions Our results delineated immune landscape and subtypes in OSCC, consolidated their clinical values as robust biomarkers to predict patient survival and therapeutic benefits and reinforced key roles of TIIs and tumor-immune interactions underlying oral tumorigenesis, ultimately facilitating development of tailed immunotherapeutic strategies.

The ROC curve was also used to evaluate the clinical value of EGFR and SMC4 in the diagnosis of triple-negative breast cancer.

METHODS Therefore formalin fixed paraffin embedded tissue samples from 114 triple negative breast cancer patients and blood samples from 124 healthy donors were genotyped and subsequently extensive statistical analysis was performed in order to investigate the clinical value of this polymorphism in triple negative breast cancer.

In the context, we also speculated the promising manipulation of gut microbiota in OA management, such as exercise and fecal microbiota transplantation (FMT), highlighting the clinical values of gut microbiota.

In recent years, fecal microbiota transplantation attracted more attention since many studies have demonstrated that fecal microbiota transplantation has great clinical value in the treatment of inflammatory bowel disease, autoimmune disease, irritable bowel syndrome, metabolic syndrome and other diseases.

However, the clinical value of SII in acute ischemic stroke (AIS) patients had not been further investigated.

Recently, this scoring system have been demonstrated to have clinical value for predicting the severity of infarction and long-term clinical outcomes in acute ischemic stroke but the evidence is not strong enough due to limited numbers and single center data.

1007/s00428-020-02878-6) studied the clinical value of microsatellite instability (MSI) in gastric cancer and found MSI-low (L) as independent prognostic factor with respect to disease-free but not overall survival in the setting of neoadjuvant chemotherapy.

In addition, lncRNA CASC9 demonstrated a clinical value in predicting efficacy on patients and acted as one independent prognostic factor for PFS in patients with ACC.

The purpose of this article is to explore the clinical value of dynamic contrast-enhanced (DCE)-MRI in distinguishing benign and malignant tongue lesions and the internal heterogeneity of a tumour.

OBJECTIVE To investigate the clinical value of dynamic contrast enhanced ultrasound (D-CEUS) in predicting the microvascular invasion (MVI) of hepatocellular carcinoma (HCC).

To confirm the hypothesis and provide clinical value for the finding, we collected 18F-FDG PET images of breast cancers and non–small-cell lung cancers, where we measured the distance from the point of maximum activity to the tumor centroid, normalizing it by a surrogate of the volume.

This study was to evaluate the clinical value of serum TUM2‐PK in early‐stage non–small cell lung cancer (NSCLC) patients.

Efficacy of lung ultrasound-guided pulmonary congestion management for patients with acute heart failure is well documented, however, more evidence is needed to establish the clinical value of pulmonary congestion detection by lung ultrasound examination in patients with chronic heart failure.

OBJECTIVE To investigate clinical value for the risk model of acute heart failure index (AHFI) combined with emergency heart failure mortality risk grade (EHMRG) in evaluating clinical outcomes and prognosis of patients with acute heart failure (AHF).

For patients admitted to the emergency medical department, rapid emergency medicine score, modified early warning score and acute physiology and chronic health evaluation II score have certain clinical value in predicting the prognosis of patients at 28 d and the value of acute physiology and chronic health evaluation II score is relatively high.

AIM: The aim of this work is to investigate the clinical value of gelsolin plasma concentration in the diagnosis of sepsis and investigate the relationship between gelsolin plasma concentration and the severity of organ dysfunction assessed by the acute physiology and chronic health evaluation (APACHE II) and SOFA scores, and to study the mortality predictive power of gelsolin plasma concentration.

circRNA expression could be associated with prognostic factors and drug responses, consolidating the potential clinical value in melanoma.

It significantly improves on previous state-of-the-art and the achieved performance has potential clinical values considering the large multi-user variability in this challenging task.

This review provides additional insight into carcinogenesis and will be of great clinical value for developing novel early detection and treatment strategies for this deadly disease.

The use of noninvasive imaging modalities to monitor transplanted organs is of great clinical value, particularly as a tool for early detection of graft dysfunction or acute rejection.

Studies such as the one described here have important clinical value and contribute to personalised treatment decisions for patients with synchronous primaries and matched recurrences.

Our study provides a novel method for the progress prediction, clinical treatment and prognosis of NCP, and has important clinical value for timely treatment of severe NCP patients.

Therefore, psychological intervention has high clinical value.

After adaptation to our local dataset, the implemented segmentation model was able to delineate MS lesions with a high clinical value as rated by delineation experts while outperforming popular out of the box applications.

TTR in serum of patients was helpful for diagnosing LC and has certain clinical value.

In the absence of stage III clinical trial data, the real-world study might show certain clinical value.

Conclusions: The data suggest that FET-PET parameters are of significant clinical value to diagnose pseudoprogression related to lomustine–temozolomide chemoradiation.

The parameter TBRmean calculated from the FET-PET performed 10 ± 7 days after the equivocal MRI showed the highest accuracy (87%) to identify pseudoprogression (threshold, Conclusions: The data suggest that FET-PET parameters are of significant clinical value to diagnose pseudoprogression related to lomustine–temozolomide chemoradiation.

This does not simulate the oral environment where the dental implants are subjected to several factors that influence osseointegration; therefore, they can have limited clinical value.

While cost outperformed consistently and usability was adequate, the results also suggested that apps suffered from significant technical limitations, were of limited clinical value, and generally did not do what end users wanted.

Introduction The objective was to evaluate whether hybrid imaging combining single photon emission tomography with computed tomography (SPECT/CT) provides additional clinical value for dectection of sentinel lymph nodes (SLNs) compared with intraoperative combined mapping in uterine and cervical malignancies.

Knowledge of an individual patient's genetic predisposition to increased Lp(a) appears to impart little or not additional clinical value beyond Lp(a) particle concentration.

Conclusions: Our data suggest that hrHPV testing may be more accurate than co-testing in postmenopausal women and that cytology does not add clinical value in this population.

The ultimate goal of this pair of articles is to empower the radiologist to add clinical value in the care of pediatric patients with brainstem pathologies.

Bladder tumors are clinically characterized by their high recurrence rate once they invade the muscle layerwhich added clinical value as diagnostic and prognostic biomarkers in bladder cancer.

The overall study quality was rather poor; (5) Conclusion: Though VR in ADs provides ecologically valid environments to induce cue-reactivity and provide new treatment paradigms, the added clinical value in assessment and therapy remains to be elucidated before VR can be applied in clinical care.

The majority of respondents perceived the more expensive item as the item with the higher clinical value for 9/10 item pairs.

Conclusion HOMA-IR, VAI, and prepregnancy BMI in GMS have a high detection rate and certain diagnostic value, and the combination of the three has higher clinical value.

These findings also suggest that further research into the action of these plants could be of real clinical value in identifying potential alternative anticoagulant therapies.

Giving the chemotherapy neoadjuvantly has real clinical value.

Whole-body multiparameter MRI and positron emission tomography (PET) with specific tracers, such as prostate-specific membrane antigen (PSMA), fluciclovine, fluorodeoxyglucose (FDG), and so on, has demonstrated promising clinical value for treatment response monitoring of patients with metastatic CRPC.

In addition, a high level of Wnt5a was commonly detected in the serum of breast cancer patients and closely correlated with microvessel density in breast tumor tissues, suggesting a promising clinical value of Wnt5a for breast cancer diagnostics.

Based on the current study, massage intervention for MS patients could have possible clinical value for palliating pain and fatigue and improving quality of life; however, this matter needs further and more significant trial studies.

Purpose: The study aimed to predict and explore the possible clinical value and mechanism of genetic markers in adrenal cortical carcinoma using a bioinformatics analysis method.

Routine CXR in patient admitted with STEMI are often unnecessary and may add very little clinical value.

Since T2DM is a chronic disease, predicting efficacy on a metabolic outcome in the short term is of little clinical value.

While there is some promise in the use of fetal fibronectin (fFN), interleukin 6 (IL-6), or placental alpha microglobulin 1 (PAMG-1) for predicting preterm birth (PTB), their use is unlikely to provide considerable clinical value in populations with a low prevalence.

Introduction/Objectives Identification of groups of patients following similar trajectories of time-varying patient characteristics are often of considerable clinical value.

Comparison of margins from good versus bad responders receiving NAT may provide better clinical value.

Compared with a single index, the combination of the three indexes has a significant improvement in predicting the prognosis of APE and has better clinical value.

Computational decision support systems could provide clinical value in whole-body FDG-PET/CT workflows.

To confirm the hypothesis and provide clinical value for the finding, we collected 18F-FDG PET images of breast cancers and non–small-cell lung cancers, where we measured the distance from the point of maximum activity to the tumor centroid, normalizing it by a surrogate of the volume.

Despite the proven clinical value of CAC, the current clinical practice implementation for CAC has limitations such as the lack of insurance coverage for the test, need for capital-intensive CT machines, specialized imaging protocols, and accredited 3D imaging labs for analysis (including personnel and software).

Combination of radioligand imaging and therapy, so called radiotheranostics, is a novel tool of precision oncology with proven clinical value.

Understanding the PACU flow and culture, education of providers about dosages, along with completion of prospective studies, to correlate acceleromyograph values to reversal and postoperative ventilatory and deglutary function can help assess the true clinical value of sugammadex.

Conclusion Although local adjuvant use of mitomycin-C or hyaluronic acid and carboxymethylcellulose may carry clinical potential to improve urethral structure recurrence rates after endoscopic procedures, we believe that a large, well-designed RCT with a yearlong follow-up time is necessary to identify the true clinical value.

Although methodological problems exist in the determination of Ki67, because of its clearly established clinical value, wide availability, and low costs relative to the available multianalyte signatures, Ki67 may be used for determining prognosis, especially if values are low or high.

2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography/computed tomography (FDG PET/CT) has an established clinical value in the diagnosis and initial staging of multiple myeloma (MM).