Introduction to Clinical Toxicology
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This was a retrospective observational study of unintentional iron poisoning in children (<7 years old) referred to either a state-wide poisons information service or a tertiary clinical toxicology unit from 1 January 2015 to 16 February 2020.
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Methods This is a retrospective case series of patients presenting following oral potassium overdose of ≥6000mg between January 2009 and December 2020 in Queensland, Australia as recorded in the state’s Poisons Information Centre database and a tertiary Clinical Toxicology Unit database.
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Clinical Toxicology sentence examples within Existing Clinical Toxicology
The proposed "teaching old drugs new tricks" strategy shortens the time and cuts the cost required for clinical application of nanoagents based on existing clinical toxicology testing and trial results, and lays down a low-cost, time-saving and energy-saving way for the development of multifunctional nanoagents toward clinical applications.
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Conclusion: Our findings contribute to the existing clinical toxicology literature by describing specific characteristics and outcomes of patients with acute bupropion overdoses.
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No cardiotoxicities (valvulopathy) were observed with SRK-181 in 4-week GLP nonclinical toxicology studies.
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As monotherapy, ALPN-202 has demonstrated superiority to CPI-only therapies in tumor models, while demonstrating a favorable safety profile in preclinical toxicology studies.
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Here we present clinical data from 19 patients who requested referral to our clinical toxicology service for assessment of potential “Gd toxicity.
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The creation of an emergency clinical toxicology service in our country led to the need to train clinical toxicologists and to create a specialized Department for this purpose, which was opened in 1985 at the Central Institute of Advanced Medical Training.
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This is an observational prospective study of body stuffers presenting to a clinical toxicology center in Tehran (Iran) in 2016–2019, irrespective of the drug ingested.
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MATERIAL AND METHODS
The Pomeranian Center of Toxicology in Gdańsk is the Regional Clinical Toxicology Center for a population of more than 3.
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Clinical Toxicology sentence examples within clinical toxicology research
We included all patients (>11 years) who had presented to a South Asian Clinical Toxicology Research Collaboration study hospital during the study period.
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comShafeajafar ZoofaghariDepartment of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Khorshid hospital, Isfahan, Iranshafeajafar@med.
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METHODS
This was a retrospective observational study of unintentional iron poisoning in children (<7 years old) referred to either a state-wide poisons information service or a tertiary clinical toxicology unit from 1 January 2015 to 16 February 2020.
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Methods This is a retrospective case series of patients presenting following oral potassium overdose of ≥6000mg between January 2009 and December 2020 in Queensland, Australia as recorded in the state’s Poisons Information Centre database and a tertiary Clinical Toxicology Unit database.
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Clinical Toxicology sentence examples within clinical toxicology case
In order to expand the current knowledge, we report a non-fatal clinical toxicology case involving the synthetic tryptamine 4-HO-MET (4-hydroxy-N-methyl-N-ethyl-tryptamine, 3-{2-[ethyl(methyl)amino]ethyl}-1H-indol-4-ol, metocin, or methylcybin).
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Clinical Toxicology sentence examples within clinical toxicology testing
E-cigarettes reached the market without either extensive preclinical toxicology testing or long term safety trials that would be required of conventional therapeutics or medical devices.
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The proposed "teaching old drugs new tricks" strategy shortens the time and cuts the cost required for clinical application of nanoagents based on existing clinical toxicology testing and trial results, and lays down a low-cost, time-saving and energy-saving way for the development of multifunctional nanoagents toward clinical applications.
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Clinical Toxicology sentence examples within clinical toxicology assessment
MethodsThe preclinical toxicology assessment following weekly intravenous (IV) or intramuscular (IM) administration of K1-70™ in rats and cynomolgus monkeys for 29 days was carried out.
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5 ng/mL or with safety concerns should undergo nonclinical toxicology assessment including systemic carcinogenicity and additional developmental and reproductive studies.
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No cardiotoxicities (valvulopathy) were observed with SRK-181 in 4-week GLP nonclinical toxicology studies.
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METHODS
This was a retrospective observational study of unintentional iron poisoning in children (<7 years old) referred to either a state-wide poisons information service or a tertiary clinical toxicology unit from 1 January 2015 to 16 February 2020.
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As monotherapy, ALPN-202 has demonstrated superiority to CPI-only therapies in tumor models, while demonstrating a favorable safety profile in preclinical toxicology studies.
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A bulk of evidences in the field of translational medicine applied to clinical toxicology and rehabilitation have highlighted the possibility of using biomarkers as a support in the diagnosis of alcohol-related diseases and in monitoring of withdrawal.
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Here we present clinical data from 19 patients who requested referral to our clinical toxicology service for assessment of potential “Gd toxicity.
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Data of substance abuse from PICs could supplement official annual drug reports in aspects of Clinical Toxicology.
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The creation of an emergency clinical toxicology service in our country led to the need to train clinical toxicologists and to create a specialized Department for this purpose, which was opened in 1985 at the Central Institute of Advanced Medical Training.
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In the nonclinical toxicology studies of sotorasib, the kidney was identified as a target organ of toxicity in the rat but not the dog.
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Consequently, the PVA improves the predictivity of nonclinical toxicology, increasing the potential impact of hazard identifications based on preclinical data only.
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This pharmacology practice review has been summarized from a public debate between the authors at the International TDM and Clinical Toxicology meeting in Banff, 2020, regarding the potential roles of TDM in the Mab/ICI setting.
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Hair analysis is routinely used to detect drug abuse in forensic cases and clinical toxicology, whereas it is rarely used at addiction clinics to monitor the clinical efficacy of therapeutic interventions.
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Additionally, this paper recommends a strategy for ADA assay validation and sample analysis for those cases when it is considered necessary to include an immunogenicity assessment in nonclinical toxicology studies.
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Based on the animal studies proof-of-concept has been established and preclinical toxicology (PCT) studies were conducted in rat and rabbit model.
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On 1690 slides with rat tissue samples from 6 preclinical toxicology studies, tissue regions were outlined and annotated by pathologists into 46 different tissue classes.
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The methods are recommended for using in the practice of forensic and clinical toxicology.
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We believe that the flexible plasmonic patch fabrication strategy would be widely applicable to any plasmonic nanostructure for SERS-based chemical sensing for clinical toxicology and therapeutic drug monitoring.
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Poisoning caused by natural products is common in clinical toxicology cases.
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The developed assay is a simple and efficient strategy for determination of target psychotropic drugs and metabolites in forensic and clinical toxicology.
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Differences in receptor expression pattern and/or binding affinities between animal species and humans, as well as the potential for eliciting complementdependent cytotoxicity (CDC) or antibody-dependent cellmediated cytotoxicity (ADCC), may result in exaggerated safety findings in humans that may not be observed in non-clinical toxicology studies [2–4].
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Immunoassay techniques are commonly used for urine drug screening in forensic and clinical toxicology laboratories.
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20484 Received: 2021-01-14 Accepted: 2021-03-03 Published Online: 2021-03-16 Printed: 2021-08-01 Ann Clin Anal Med 2021;12(8):888-894 Corresponding Author: Heba Abdel Samie Mohamed Hussein, Lecturer of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Alexandria University, Egypt.
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Here, in collaboration with the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology, a novel interlaboratory proficiency program for the quantitation, pharmacokinetic modeling, and dosing of busulfan in plasma was designed.
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Conclusion: This is a protocol specified for systematic reviews that use case reports/studies and case series to evaluate the quality of evidence and strength of recommendations in disciplines like clinical toxicology, where case reports/studies are the norm.
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However, it is common practice in clinical toxicology to perform restricted data analysis to avoid examining and/or reporting data not requested for examination.
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We included all patients (>11 years) who had presented to a South Asian Clinical Toxicology Research Collaboration study hospital during the study period.
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The article describes a specialized software application developed by the authors that summarizes the long-term experience of analyzing clinical and laboratory data in clinical toxicology using Microsoft’s Visual Basic for Applications object-oriented programming tools in Excel.
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Based on the animal studies proof-of-concept has been established and preclinical toxicology (PCT) studies were conducted in rat and rabbit model.
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This review aims to provide a critique of the suitability of current ambient ionization techniques for the analysis of NPS in the forensic and clinical toxicology fields.
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Following the publication of the joint position statements on the use of single-dose and multiple-dose activated charcoal by the American Academy of Clinical Toxicology and the European Association of Poison Centres and Clinical Toxicologists, the routine use of activated charcoal declined.
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Therefore, the fact that a pharmaco-toxicological consultation was necessary to deal with adverse drug reactions and that drug–drug interactions were identified, both in the clinical toxicology evaluation phase and in the data analysis phase (through the application of the respective tools), makes these interactions real and not potential.
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It has demonstrated superiority to CPI-only therapies in tumor models, while demonstrating favorable safety in preclinical toxicology studies.
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Neither this study nor the PVA aimed to encourage indiscriminate animal testing but the contrary, to reduce unnecessary and redundant in vivo testing by powering nonclinical toxicology predictivity.
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Material and Method(s): This analytical study was conducted in Clinical Toxicology Laboratory in Sohag University Hospitals.
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The tight window of detectability in biological matrices and the difficultly to read symptoms of polydrug overdose represent the modern challenges in forensic and clinical toxicology.
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The method was applied to the analysis of real cases and proved to be a valuable tool in forensic and clinical toxicology.
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To determine the suitability of this approach, we have compared the results of urine analysis by point-of-care testing with another NHS specialist clinical toxicology service that uses confirmation mass spectrometry.
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In this study, we established a preclinical toxicology model using same-origin hPSC-differentiated cardiomyocytes (hPSC-CMs) and endothelial cells (hPSC-ECs).
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SJP1602 is currently undergoing preclinical toxicology studies and in vitro safety evaluation.
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