Introduction to Clinical Reality

In a busy clinical reality, nurses will naturally give lower priority to recruiting for a research study if there are more urgent tasks waiting.

Future developments could also model a more complex clinical reality where the likelihood of alternative diagnoses is estimated from sets of clinical investigations.

This clinical reality led some surgeons to hypothesize that perihepatic and/or intraabdominal packing, used as a temporary maneuver with planned early reoperation to remove the packs, could be useful and avoid the problems seen with prolonged intrahepatic packing that had led to its prior abandonment.

Major caveats of the findings concerning methodological approaches, clinical reality of frequent comorbid psychopathology, and novel molecular targets are presented.

Cell-based therapies have been making great advances toward clinical reality.

However, the clinical reality is that these conditions often occur simultaneously.

Increasing ePRMs uptake will clearly be a catalyst propelling precision epilepsy from aspiration to clinical reality.

Overall, the available poor to moderate evidence suggests that 70-85% of patients with a chronic anastomotic leak, defined as stoma reversal, are treated successfully; however, there is some concern of a relevant publication bias of the published data so that the results may be less impressive in the clinical reality.

Rapid breakthroughs in the field during the past decade have brought the hope that neuroprostheses can soon become a clinical reality, in particular—as we will detail in this review—for the restoration of hand functions.

; DSM-5) failing to capture clinical reality (Sani and Swann, 2020).

Gene therapy using recombinant adeno‐associated virus (rAAV) vectors to treat blinding retinal dystrophies has become clinical reality.

The aim of this study was to evaluate TEVAR following FET in clinical reality.

Conclusions Our modified REAL CRIC Trainer model was rated high by experts in CT and participants in a simulated clinical scenario, and may be useful for a complete emergent CT training closer to the clinical reality than the models currently available.

However, in clinical reality, many patients with PVTT undergo different treatments, such as resection, transarterial chemoembolization (TACE), selective internal radiation therapy (SIRT), or best supportive care (BSC).

This review aims to identify whether patients who are less likely or unable to comply with telemonitoring and their instructions for use are represented by interventional telemonitoring studies, and if their exclusion from studies is resulting in study findings not representative of clinical reality.

The effects of concomitant treatment may mask effects, but our patient population reflects clinical reality in an inpatient setting.

Automated insulin delivery as a hybrid closed loop or dosing advice using artificial intelligence are becoming a clinical reality.

Compared to other omics, radiomics can be perfectly integrated with clinical data, even with the pathology and molecular biomarker, so that the study can be closer to the clinical reality and more revealing of the tumor development.

Because it better reflects clinical reality, it facilitates incorporating cost-utility information in clinical guidelines.

We plan to make hybrid navigation clinical reality to reduce radiation exposure for patients and surgeons, by compensating EMT error.

Although dental pulp stem cells are accessible autologously or probably allogeneically; it faces numerous scientific, regulatory, and commercialization barriers creating transplantation of these cells to be a research exercise as opposed to clinical reality.

These four easily distinguishable fracture characteristics have the potential to form the basis of an alternative classification system that matches clinical reality and captures prognostic aspects.

Further studies are warranted with a robust comparison arm with optimal contemporary medical therapy to translate regenerative therapies to a clinical reality.

Targeted therapy for the cancer immune system has become a clinical reality with remarkable success.

Harmonization of preclinical methods with clinical reality is necessary for the timely translation of stem cell therapies to the clinic.

Therefore, determining which test reflects clinical reality is an essential future step.

In this review, we will explore the recent technological advances that are designed to bring CMRA closer to clinical reality.

The results of this study provided the much-needed evidence of effectiveness for rFOV and RPG in clinical reality.

We, therefore, aimed to assess whether ADRCs can alleviate lymphedema in clinical reality with long‐term follow‐up.

Using a currently running trial, we describe possible concerns, considerations, and solutions to reconcile the conflicting interests of scientific inquiry, ethical principles, and clinical reality in emergency medicine research.

The authors encourage improvement in showing skin type diversity in new editions of these textbooks in order to better prepare medical students to face clinical reality.

This milestone in medicine was the beginning of a huge race for numerous physicians and researchers to make this operation a clinical reality.

Interprofessional case-based learning engages participants in a structured manner towards uncovering decisions processes and patterns of action that resemble the clinical reality in which various healthcare professionals handle multifaceted tasks related to the optimal patient treatment.

Each preclinical model is imperfect but complementary, suggesting that a more representative approach of the clinical reality could be obtained by combining them.

2 It is the historic reference point of all heart-lung machines and, after extensive laboratory work, made cardiopulmonary bypass a clinical reality.

This review highlights current research in this area and discusses the next steps required towards making muscle biofabrication a clinical reality.

However, our aim was to carry out a randomized clinical trial as close as possible to the clinical reality in Brazil, for the management of signs and symptoms of patients with knee osteoarthritis.

AI applications have begun to transition from a promising future to clinical reality in neurology.

Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality.

” Indeed, the authors rejected their unsupervised clusters because they did not “reflect the clinical reality andprevious knowledgeon the relevance of these lesions [g, peritubular capillaritis, and C4d] and [antibodymediated rejection].

OBJECTIVE In the following, the imaging methods commonly used for the diagnostic work-up and staging of diverticulitis are presented and classified in the context of the data situation and clinical reality.

This essay seeks to build upon this scholarship by examining the composition of the text as a ‘treatment’ in itself, thus centring the clinical reality of Carrington’s experience, but also re-asserting her authorial agency.

To reflect the clinical reality in managing this disease in Germany, a national register was established based on a questionnaire developed specifically for this purpose.

Next generation influenza vaccines that target conserved epitopes are becoming a clinical reality but still have challenges to overcome.

The retained native liver can be the potential target for future gene therapy when it becomes a clinical reality.

There is a discrepancy between optimal treatment as defined in relevant guidelines on clinical nutrition and the clinical reality.

This list includes a "theoretical" score from the reports in the databases or the corresponding literature, a "practical" score based on an expert evaluation of clinical reality and a cumulative score, classified in accordance with the Rote Liste".

The heterogeneity assumption moves us somewhat closer to our clinical reality of person-specific cancer experiences.

However, benign interoceptive sensations, which shape patients' clinical reality, may context-dependently become conditioned predictors of impending visceral pain.

Therefore, though artificial intelligence techniques aim to improve precision medicine approaches, there is concern on emerging concept of approaching a depersonalized patient, where diagnostic advice and therapeutic choices are centered on representations of the average stereotype of the patient who is hardly ever present in clinical reality.

In this work, we adapted this strategy to our clinical reality and derived calculations of the time per task multiplied by the expected number of tasks.

Although once daily anti-glaucoma drug therapy is a current clinical reality, most therapies require multiple dosing and there is an unmet need to develop convenient, safe, and effective sustained release drug delivery systems for long-term treatment to improve patient adherence and outcomes.

In the future, further research using more finely spaced electrodes, tailored patterns of stimulation, and longer term studies will shed light on the intricacies of sensory processing in humans as well as bring these neuroprosthetic applications closer to widespread clinical reality.

Advances in transplant immunology and surgical techniques have made face transplantation become a clinical reality in recent years (Siemionow, 2017; Siemionow & Ozturk, 2012; Sosin & Rodriguez, 2016).

FUTURE DIRECTIONS Further studies are required to develop clinically relevant chronic wound animal model which reflect the clinical reality of the various influences of age, disease, comorbidities and gender on delayed healing and enhance understanding of the biological processes of human wound healing.

Many of these aspects pertain to one overarching question: how can we ensure that preclinical results translate into trustworthy clinical reality? For the endoscopist, whether as a reader, a reviewer or a potential user of AI, it becomes increasingly important to understand the technical aspects of the systems and their performance measurements in order to realistically assess their practical value.

This clinical reality led to circumstances in which empiric therapeutic anticoagulation may be considered without radiographic confirmation [3, 4].

The model emanates from a caritative perspective and is based on theoretical studies and international research on advanced practice nursing, and knowledge of clinical reality in and experiences of different models of advanced practice nursing.

One reason for this lack of translation might be the discrepancy between preclinical models and the clinical reality: nonresuscitated young healthy rodents in contrast to elderly comorbid patients in an intensive care unit.

Conclusion Participants described a wide range of outcome constructs, which were relevant to and observable by patients and were in line with the clinical reality.

Clinical reality suggests that the presence of certain risk factors can alter the impact of other factors; in other words, risk modeling is not linear.

PharmaKU is anticipated to enable bench to bedside implementation of pharmacogenomics knowledge by bringing precision medicine closer to a clinical reality.

The prevalence of errors, consisting in either unjustified low dosage or inappropriate drugs combinations, with a consequent higher major bleeding risk, appears significantly high (33%), but not surprising, since adhering to clinical reality, as we similarly observe in our routine practice.

The noninvasive assessment of myocardial perfusion by echo contrast agents in patients with acute myocardial infarction with ST-segment elevation (STEMI) after successful revascularization is becoming a relevant clinical reality.

In the clinical reality of hospital emergency departments, however, its use is controversial.

Many psychiatric and psychological health care workers report the need to revise the current diagnostic manuals which, in order to favor a more operational approach, often set apart from the clinical reality.

In a bustling clinical reality, medical attendants will normally give lower need to selecting for an examination study if there are more earnest errands pausing.

However, surgeons might struggle interpreting CLM images intraoperatively due to different tissue characteristics of different tissue pathologies in clinical reality.

Discussion “Ordinary autism” seems to offer clinicians the opportunity to formalize the new contemporary and extensive clinical reality of autism.

This clinical reality is an open challenge to the oncologist because of those neoplasms which elaborate neuroendocrine differentiation (NED).

Translating conformable bioelectronic interface research into clinical reality foretells a promising future for an aging society.

The clinical reality is that two thirds of all PDAC patients succumb to local disease burden regardless of clinical stage at diagnosis.

Conclusion We identified biomarkers of defective autophagy as a mechanism of central homeostasis, which gives us a general vision of the disease mechanisms linked to OA clinical reality.

Actually, the gap between research and the clinical reality of schizophrenia—in terms of a biological explanation of the symptoms, or of predictors for course and treatment—rather appears to increase.

I was suddenly able to look at the clinical reality of dyslexics with fresh eyes and a new perspective.

Background Autologous hematopoietic stem cell transplantation (AHSCT) is nowadays a clinical reality as an effective and safe approach to treat systemic sclerosis patients’ refractory to conventional therapy using immune suppressive drugs, although its immune mechanisms are still not completely understood1,2,3.

While we appreciate the authors’ work on this study, we believe that the reported results are not fully representative of the available literature or clinical reality.

[4] In the 21st century, tolerance induction through chimerism (full or partial) is a clinical reality.

Identifying postadoption incest as a phenomenon with underexplored evidential value, the article sketches an explanatory strategy for reconciling the effect with the clinical reality of incest, concluding with an explicit argument against culture-first or conventionalist accounts of incest avoidance prevalent in anthropology.

The chemotherapy of tuberculosis has been practiced for 2000 years but it has been a clinical reality for last few years.

We are impressed with the sophisticated design and methods the authors have used but have certain doubts about the relevance of their results to the clinical reality.

New classifications that seek a paradigm shift (Rdoc) have been proposed to solve this last issue (2), but are also criticized because they imply a blurring of the clinical reality of the symptom that defines mental illness to a notion centered on the few neurobiological correlates of some mental activities (3).

Gene therapy has entered clinical reality with marketing authorizations in Europe and the US for the treatment of patients with inherited or acquired diseases, including inborn blindness, adenosine deaminase deficiency, and certain types of cancer.

The breach of the principle of self-determination appears as a central element of the critique; underlined both in clinical reality and in jurisprudence.

Automation represents a potential solution to these issues and has already made routine myocardial strain measurements and 2- and 3-dimensional left ventricular ejection fraction measurements a clinical reality.

Eliminating cancer by exploiting the immune system as a treatment modality is a long-standing idea that has now become a clinical reality.

If injections were deferred on three consecutive visits (after the first six visits), the follow-up interval was extended to 8–16 weeks, compatible with the clinical reality.

It has been made with national governmental support of "863" project grant, which gathers multidisciplinary people in China to work together towards the translation of basic/applied research achievements into clinical reality and the fulfillment of unmet medical needs.

The technological progress of these technologies has allowed precision medicine to become a clinical reality.

This intervention serves as a significant resource for those looking to develop local interventions and stands as a truly multi-disciplinary approach to handover education, mirroring the clinical reality.

Due to the rare incidence of this situation and the very low feasibility of such an evaluation in clinical reality, we decided to perform a randomised crossover simulation research study.

Feelings of inadequacy, being squeezed between ideals and clinical reality, and failing the patients create moral distress.

We highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

There is still a discrepancy between the public perceptions of robotic surgery and the clinical reality perceived by healthcare professionals.