Introduction to Clinical Drugs
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Clinical Drugs sentence examples within Effective Clinical Drugs
In summary, the results of this study suggest that COM-induced renal injury can be effectively improved via UA, providing powerful data support for the development of effective clinical drugs for renal injury in the future.
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The treatment of cerebral ischemia is refractory due to its short therapeutic window and lack of effective clinical drugs.
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Clinical Drugs sentence examples within Two Clinical Drugs
We have used three established human glioblastoma (GBM) cell lines—U87MG, A172, and T98G—as cellular systems to examine the plasticity of the drug-induced GBM cell phenotype, focusing on two clinical drugs, the phosphodiesterase PDE10A inhibitor Mardepodect and the multi-kinase inhibitor Regorafenib, using genome-wide drug-induced gene expression (DIGEX) to examine the drug response.
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Here we describe an example of applying single-molecule dynamic force spectroscopy to study the binding of epidermal growth factor (EGF) to its receptor EGFR, as well as the effect of two clinical drugs, Pertuzumab and Trastuzumab, on the interaction of EGF and EGFR.
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Clinical Drugs sentence examples within Common Clinical Drugs
Through research and analysis, it showed that common clinical drugs include leuprorelin (GnRH-a), danazol (androgen), gestrinone (progestin), mifepristone (progesterone receptor antagonist), and some cases of combination therapy.
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Clinical Drugs sentence examples within Existing Clinical Drugs
Our data identify existing clinical drugs that target KRAS4A splicing, and suggest that levels of the minor KRAS4A isoform in human tumors can be a biomarker of sensitivity to some existing cancer therapeutics.
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Moreover, some existing clinical drugs based on marine-derived natural product scaffolds are also discussed.
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Clinical Drugs sentence examples within Approved Clinical Drugs
Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows existing and approved clinical drugs to be innovatively repurposed to treat tumors.
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Although organic compounds account for more than 99% of currently approved clinical drugs, the established clinical use of cisplatin in cancer or auranofin in rheumatoid arthritis have paved the way to several research initiatives to identify metal-based drugs for a wide range of human diseases.
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Clinical Drugs sentence examples within Human Clinical Drugs
In this chapter we briefly review the CA research, beginning from the discovery of carbonic anhydrase enzyme through the development of specific CA inhibitors into human clinical drugs.
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In this chapter we briefly review the CA research, beginning from the discovery of carbonic anhydrase enzyme through the development of specific CA inhibitors into human clinical drugs.
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Clinical Drugs sentence examples within Variou Clinical Drugs
Various clinical drugs, including losartan, cefazolin, and alfentanil, contain the tetrazole moiety.
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In this proof-of-concept study, we aimed to introduce microscale porosity into macroporous scaffolds to allow for efficient yet simple soak-loading of various clinical drugs and control their release.
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Clinical Drugs sentence examples within Specific Clinical Drugs
Rotavirus (RV) infection is a leading cause of severe, dehydrating gastroenteritis in children < 5 years of age, and by now, the prevention and treatment of RV are still the major public health problems due to a lack of specific clinical drugs.
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Currently, there is a lack of specific clinical drugs for prevention and treatment of microinflammation in PD patients.
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Clinical Drugs sentence examples within Modern Clinical Drugs
Clinical Drugs sentence examples within Important Clinical Drugs
Although the membrane of fungi is the target of important clinical drugs and agricultural fungicides, the molecular mechanisms which mediate membrane repair in these organisms remain elusive.
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Clinical Drugs sentence examples within Multiple Clinical Drugs
Additionally, multiple clinical drugs for metastasis have quite limited therapeutic potential and even facilitate metastasis in preclinical models.
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Histone deacetylase (HDAC) proteins, which regulate the acetylation state of proteins, are the targets of multiple clinical drugs for cancer treatment.
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Clinical Drugs sentence examples within Targeted Clinical Drugs
This study advances the EET neuroprotection theory and provides a scientific basis for targeted clinical drugs that reduce neuronal parthanatos following cerebral ischemia and reperfusion.
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Therefore, the study is designed to analyze the drug resistance of pathogenic Escherichia coli isolated from large-scale pig farms in East China, which provides a theoretical basis for precisely targeted clinical drugs in swine farms.
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Clinical Drugs sentence examples within clinical drugs targeting
Demyelinating diseases of the central nervous system are characterized by recurrent demyelination and progressive neurodegeneration, but there are no clinical drugs targeting myelin regeneration or improving functional disability in the treatment of multiple sclerosis.
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The advances in the development of clinical drugs targeting ferroptosis provide growing silver linings for breast cancer treatment.
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Clinical Drugs sentence examples within clinical drugs mediated
CONCLUSION
Ginsenoside Rg1, ophiopogon D', and schizandrin A are potential inhibitors of NTCP and may interact with clinical drugs mediated by NTCP.
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We aim to study their hepatic uptake and their effects on the hepatic uptake of other clinical drugs mediated by OATP1B1 and OATP1B3.
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Clinical Drugs sentence examples within clinical drugs act
Clinical Drugs sentence examples within clinical drugs may
The potential herb-drug interactions (HDI) should be paid close attention when SF, NS or CNS with clinical drugs metabolized by CYP1A2, 2B1, 2E1, 2C11, 2C19, 2D4 and 3A1.
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Current clinical drugs used to treat hyperuricemia have many adverse effects.
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Most of market and clinical drugs act on blood schizonticide are in current therapy for malaria reduction.
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In addition to its anticancer activity as monotherapy, BZA has been shown to enhance the chemotherapeutic efficacy of clinical drugs such as paclitaxel, cisplatin, palbociclib and oxaliplatin in multiple neoplasms.
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Hence, their potential in being developed into clinical drugs are also discussed.
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Therefore, BP/LPPC is potentially a good candidate for clinical drug development or for use as an adjuvant for clinical drugs as a combination therapy for hepatocellular carcinoma.
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Taken together, the findings suggest that synergistic combination may have the potential in amplifying the therapeutic efficacies of clinical drugs and immune checkpoint blockade antibodies to overcome the therapeutic resistance of glioblastoma.
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At present, there are no good clinical drugs for many immune liver diseases.
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In summary, the results of this study suggest that COM-induced renal injury can be effectively improved via UA, providing powerful data support for the development of effective clinical drugs for renal injury in the future.
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Tiancimycin (TNM) A belongs to the anthraquinone-fused subfamily of enediyne natural products, and selected enediynes have been translated into clinical drugs.
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Moreover, we evaluated the efficacy of preclinical drugs and the safety of ZIKV vaccine candidate in this mouse model.
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Drug repositioning is a strategy for identifying new antitumor drugs; this strategy allows existing and approved clinical drugs to be innovatively repurposed to treat tumors.
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Utilizing the BSS model, we verified the clinical GP9 mutations by in vivo functional assay and tested clinical drugs for increasing platelets.
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Co-therapy with herbal extracts along with current clinical drugs is being increasingly recognized as a useful complementary treatment for cancer.
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At present, a variety of clinical drugs have been applied in the treatment of rheumatoid arthritis.
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To provide more precise guidance for the development of clinical drugs, further in-depth studies are warranted on the metabolism and signaling pathways associated with apelin/APJ system.
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Various chemotherapeutic drugs are currently available for treating blood cancer, but still, the use of these clinical drugs is limited due to a lack of tumor cell specificity and dose-related toxicity.
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Two-thirds of human hormones and one-third of clinical drugs activate ~350 G protein-coupled receptors belonging to four classes: A, B1, C and F.
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The strains were classified into two pathotypes: tlh + /tdh - /trh - /AP2 - (75%) and tlh + /tdh - /trh - /AP2 + (25%) and three resistant profiles to clinical drugs (ampicillin, amikacin, gentamicin, and netilmicin).
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The high infectivity, difficulty of obtaining a durable cure of disseminated disease and the emergence of drug resistance warrants investigation of new drugs that can be used alone and in combination with existing standard of care clinical drugs.
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The combination therapy for Chry with clinical drugs may deserve to further explore.
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As one of the superior first-line clinical drugs, 5-fluorouracil (5-FU) possesses certain disadvantages, such as fast drug metabolism and poor dose controllability.
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SIGNIFICANCE STATEMENT Human CYP1A2 not only metabolizes clinical drugs and pollutants but also mediates the biotransformation of endogenous substances and plays an important role in the development of many diseases.
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Scientists around the world are investigating few previously used clinical drugs for the treatment of COVID-19.
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Rotavirus (RV) infection is a leading cause of severe, dehydrating gastroenteritis in children < 5 years of age, and by now, the prevention and treatment of RV are still the major public health problems due to a lack of specific clinical drugs.
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In addition, this paper discusses further areas of research devoted to the development and validation of new improved models of doxorubicin cardiomyopathy suitable both for studying the mechanisms of its implementation and for the preclinical drugs effectiveness assessment.
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Morevover, the rapid spread of drug-resistant fungi has led to significant decreases in the therapeutic effects of clinical drugs.
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Due to the side effects of clinical drugs, there is still a need to develop novel and less toxic drugs to treat pulmonary fibrosis.
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Because CA isoforms are highly homologous, clinical drugs designed to inhibit enzymatic activity of a particular isoform, can also bind to others with similar affinity causing toxic side effects.
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Additionally, the combinations of the solid active combination with clinical drugs gave better antimicrobial efficiency with less dosage and broader antimicrobial spectrum than the separated use alone.
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In contrast to six clinical drugs with mast cell stabilizing properties (amlexanox, tranilast, ketotifen, cromolyn disodium salt, dexamethasone and pimecrolimus), aloe-emodin showed an impressive and potent inhibitory action on the mast cell degranulation.
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In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation.
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Two representatives of Q3Gs, rutin and troxerutin, have been developed into clinical drugs, demonstrating Q3Gs have become one of the important sources of innovative drugs.
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Recently, in addition to carboxylesterases (CESs), we found that arylacetamide deacetylase (AADAC) plays an important role in the metabolism of some clinical drugs.
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The use of clinical drugs for the treatment of PAH is limited to a great extent because of its single target and high price.
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To demonstrate Drugmonizome-ML, we constructed a machine learning pipeline to predict whether approved and preclinical drugs may induce peripheral neuropathy as a potential side effect.