Introduction to Clinical Advances
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Clinical Advances sentence examples within Latest Clinical Advances
Therefore, the objective of this review is to describe the latest clinical advances in ALS and MS as well as their results in clinical recovery in randomized clinical trials, meta-analyzes, and full-text systematic reviews conducted in humans and rats, published in English and Spanish in the last 5 years, using PubMed, SciELO, and Cochrane.
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Here, we evaluate the role of ANGPLT3 and Apo C-III in lipid metabolism, present the latest clinical advances targeting those molecules, and outline the remaining scientific challenges on residual lipid-associated cardiovascular risk.
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Clinical Advances sentence examples within Important Clinical Advances
Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in women worldwide and the most fatal gynecologic cancer.
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In 1952, John Gibbon performed the first successful cardiac procedure using cardiopulmonary bypass, which turned out to be one of the most important clinical advances of that year.
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Clinical Advances sentence examples within Significant Clinical Advances
Though significant clinical advances have been made, lung cancer remains the most lethal, with a low 5-year survival rate.
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Despite the development of new medical technologies and significant clinical advances allowing early diagnosis and treatment of laryngeal cancer, mortality is still on the rise.
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Clinical Advances sentence examples within These Clinical Advances
These clinical advances reflect pivotal discoveries in how the immune system interacts with the tumor microenvironment, leading to the identification of targetable pathways and rationally designed algorithms that account for pathology, patient, and iatrogenic factors.
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These clinical advances benefit from team decision-making and collaboration among various professional disciplines involved in the care of these patients.
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Clinical Advances sentence examples within Remarkable Clinical Advances
Clinical Advances sentence examples within Major Clinical Advances
Ever since its first documented live birth in 2014, the use of uterine transplantation (UTx) for the treatment of absolute uterine factor infertility (UFI) has seen major clinical advances, which include the use of alternative surgical approaches, different donor states, and diverse patient populations.
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RNA-polymerase II inhibition is a novel mechanism of action in cancer therapy and offers the possibility of breaking through drug resistance or destroying dormant tumour cells, which could produce major clinical advances.
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Clinical Advances sentence examples within Recent Clinical Advances
Background Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the multiple, multi-functional, inter-dependent, cellular and humoral mediators/regulators of the human immune system.
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e21058Background: Recent clinical advances in cancer immuno-therapeutics underscore the need for improved understanding of the complex relationship between cancer and the multiple, multi-functional.
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Clinical Advances sentence examples within Promising Clinical Advances
This review highlights some very promising clinical advances in cancer therapeutic technologies using telomerase‐specific oncolytic virotherapy.
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This article summarizes the most promising clinical advances by reviewing the data from recent clinical trials and discussing meaningful clinical endpoints, including the role of minimal residual disease assessment.
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Clinical Advances sentence examples within Despite Clinical Advances
Despite clinical advances in diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death, and is still associated with poor prognosis and dismal survival rates.
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Despite clinical advances, late onset pulmonary complications in adult recipients of allogenic stem cell transplantation are a major cause of morbidity and mortality.
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Clinical Advances sentence examples within clinical advances made
This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses.
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In this review, we summarize both the recent preclinical and clinical advances made in the development of PSMA-TAT, as well as the availability of therapeutic α-emitting radionuclides, the development of small molecules and antibodies targeting PSMA.
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Clinical Advances sentence examples within clinical advances through
Reviewers, working independently and in duplicate, assessed each study's risk of bias by using the CLARITY (Clinical Advances Through Research and Information Translation) risk-of-bias instrument for cohort studies, omitting an item related to co-interventions that was not relevant to our review (16).
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Reviewers, independently and in duplicate, assessed risk of bias of each eligible study by using a modified version of the CLARITY (Clinical Advances Through Research and Information Translation) instrument (23, 24), with omission of 1 item related to co-interventions that was not relevant to our review (Supplement Table 3).
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Clinical Advances sentence examples within clinical advances benefit
These clinical advances benefit from team decision-making and collaboration among various professional disciplines involved in the care of these patients.
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These clinical advances benefit from team decision-making and collaboration among various professional disciplines involved in the care of these patients.
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Despite research and clinical advances, babies with CDH still have high morbidity and mortality rates, which are directly related to the severity of lung underdevelopment.
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This review presents an update on the most recent clinical and preclinical advances with a focus on results from clinical trials in progress with BCMA-targeted immunotherapies or the development of other novel targets in MM.
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Here, we provide a critical overview of both clinical and preclinical advances using tumor organoids.
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Approaches to chloride transport-targeted drug discovery are reviewed herein, with focus on chloride channel and exchanger classes in which recent preclinical advances have been made in the identification of small molecule modulators and in proof of concept testing in experimental animal models.
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This review summarizes the relevant clinical data from recent clinical advances in CLL and aims to interpret the duvelisib trials while exploring strategies to improve its use and adverse event management in the era of novel targeted agents.
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Herein, we review the recent clinical advances of lumbosacral epidural stimulation for restoration of sensorimotor function in individuals with motor complete SCI and we discuss the putative neural pathways involved in this promising neurorehabilitative approach.
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In this review, we discuss conventional and unconventional immunological mechanisms underlying the development of immune tolerance in SOT recipients and how they can inform clinical advances.
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Recently, clinical advances in chemotherapy have prolonged the survival of CRC patients.
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Although laboratory and preclinical advances have, thus far, not led to oncologically relevant outcomes in the clinic, future studies offer great promise for gene therapy to become established in prostate cancer care.
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While remarkable clinical advances in adaptive immunity are occurring, modulation of innate immunity has proven more difficult.
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Next, the recent clinical advances regarding the anti-VEGF medications, including humanized monoclonal antibody, immunosuppressant, a tyrosine kinase inhibitor, and a cytokine inhibitor, have been addressed in the setting of COVID-19 treatment in critically ill patients.
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In this review, we provide an overview of the status and clinical advances in adoptive TCR-T-cell therapy for the treatment of AML.
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Here, we discuss recent clinical advances in vaccine development and highlight ongoing challenges for the future.
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Therefore, the objective of this review is to describe the latest clinical advances in ALS and MS as well as their results in clinical recovery in randomized clinical trials, meta-analyzes, and full-text systematic reviews conducted in humans and rats, published in English and Spanish in the last 5 years, using PubMed, SciELO, and Cochrane.
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Here, we evaluate the role of ANGPLT3 and Apo C-III in lipid metabolism, present the latest clinical advances targeting those molecules, and outline the remaining scientific challenges on residual lipid-associated cardiovascular risk.
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Based on pre-clinical and clinical advances in neuroblastoma and other malignancies, we assess both the strong potential and the associated risks of using mesenchymal stromal cells in the therapy for neuroblastoma.
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We also summarize clinical advances in MSC-based therapies.
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In this clinically focused review of thoracic aortic diseases, we demonstrate the clinical advances acquired with 4D flow MRI from published studies.
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This paper will provide a brief overview of current state of MRF technology including highlights of technical and clinical advances.
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Despite significant progress in our understanding of the etiologic heterogeneity of ovarian cancer, as well as important clinical advances, it remains the eighth most frequently diagnosed cancer in women worldwide and the most fatal gynecologic cancer.
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Despite clinical advances in diagnosis and treatment, pancreatic ductal adenocarcinoma (PDAC) remains the third leading cause of cancer death, and is still associated with poor prognosis and dismal survival rates.
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Lastly, we will provide an outlook on the latest clinical advances in the field of anti-fibrotic co-targeting in combination with chemotherapy or immunotherapy in PDAC, providing insight into the current challenges in treating this highly aggressive, fibrotic malignancy.
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This work historically reviews the variety of models that have emerged from the initial association of PTSD with FC, highlighting conceptual pitfalls that have limited the translation of animal research into clinical advances.
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We build on a previous review of the clinical presentation and surgical management of PDAC10 to discuss evidence supporting the most recent clinical advances in treatment (Box 1).
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In this review, we present an overview of the multiple complex roles of G-CSF and G-CSFR in tumors and their microenvironment and discuss how clinical advances and strategies may open new therapeutic avenues.
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The purpose of the program is to promote an educational environment that utilizes current technology to enhance the quality and efficiency of single-tooth dental treatment offered to patients, while also preparing graduating students to apply recent and future clinical advances.
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The aim of our article was to address the most recent clinical advances and findings of basic studies on the mTOR signaling pathway and the involved factors.
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Herein, to provide a bench-to-bedside understanding of cancer immunoprevention, we will review the role of the immune system in suppression and promotion of tumors, immunoprevention of virally-induced cancers, identification of tumor antigens in premalignant lesions, and clinical advances of cancer immunoprevention.
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Here, the review summarizes recent preclinical and clinical advances that have provided a novel insight into the pathogenesis of CARD9 deficiency in neutrophils.
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In this review, we describe the preclinical and clinical advances recently made in the use of CDKIs.
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Herein, we review the current clinical advances and experimental findings supporting the utility of an anti-inflammatory approach to the treatment of solid malignancies.
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This review presents major translational and clinical advances in research on pituitary and adrenal diseases, encompassing their epidemiology, pathogenesis, diagnosis, and clinical management.
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Here, we highlight the diversity and key advantages of cell therapies and discuss their current clinical advances.
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In this review, we will survey the underlying mechanisms and current clinical advances of anti-PD-(L)1 immunotherapy in the treatment of brain metastases in NSCLC.
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In particular, genome-wide sequencing analysis has deepened our understanding of mutations that underlie many monogenic disorders, which in turn has contributed to clinical advances involving adeno-associated virus (AAV) vector delivery of replacement genes to treat recessive disorders.
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In this review, we focus on clinical and preclinical advances in anti-IFN-α treatments in systemic lupus erythematosus (SLE), primary Sjögren syndrome (pSS), systemic sclerosis (SSc), and dermatomyositis (DM), for which a high medical need persists.
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The advent of interventional cardiology, first with percutaneous transcatheter coronary angioplasty, and more recently with the burgeoning field of structural heart disease, has required many scientific, technological, and clinical advances.
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This toolbox aims to accelerate the research and clinical advances made possible by longitudinal neural recordings and adaptive neurostimulation in people with neurological and psychiatric illnesses.
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Ever since its first documented live birth in 2014, the use of uterine transplantation (UTx) for the treatment of absolute uterine factor infertility (UFI) has seen major clinical advances, which include the use of alternative surgical approaches, different donor states, and diverse patient populations.
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Additionally, how this knowledge can be translated into clinical advances for patients with cancer is discussed.
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This review outlines recent preclinical and clinical advances in molecular imaging of abdominal aortic aneurysms (AAA) with a focus on molecular magnetic resonance imaging (MRI) of the extracellular matrix (ECM).
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Partnering with individuals who are prominent in pediatric cancer-related social media networks may be an innovative strategy for quickly disseminating new scientific and clinical advances that merits future research.
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In addition to technological advances related to experimental studies involving micro-computed tomography, the continuing clinical advances in magnification, illumination, imaging and intra-operative root canal treatment procedures have allowed clinicians to identify an increasingly wide range of anatomical variations in roots and canals in an attempt to achieve more predictable clinical outcomes.
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Clinical advances have been made in pharmacotherapeutic approaches to COPD.
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In this article, we will review the clinical advances for the use of HCQ and IFN in the prophylaxis and early treatment of Covid-19.
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