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Clear Space sentence examples within simplex virus 1
Background: Capsids of herpes simplex virus 1 (HSV-1) are assembled in the nucleus, translocated either to the perinuclear space by budding at the inner nuclear membrane acquiring tegument and envelope, or released to the cytosol in a “naked” state via impaired nuclear pores that finally results in impairment of the nuclear envelope.
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Studies with porcine herpesvirus demonstrated that primary enveloped particles accumulated in the perinuclear space in the presence of brefeldin A, while studies with herpes simplex virus 1 documented an impaired secondary assembly of enveloped viral particles in the presence of monensin.
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Clear Space sentence examples within tibio fibular overlap
The tibio-fibular clear space (TFCS), tibio-fibular overlap (TFO), and medial clear space (MCS) were measured on each reconstructed DRR and axial CT image.
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The medial clear space (MCS), the tibio-fibular clear space (TFCS), and the tibio-fibular overlap (TFO) were assessed on digitally reconstructed radiographs (DRRs), and on axial CT images.
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Clear Space sentence examples within inner nuclear membrane
ABSTRACT During nuclear egress of nascent progeny herpesvirus nucleocapsids, the nucleocapsids acquire a primary envelope by budding through the inner nuclear membrane of infected cells into the perinuclear space between the inner and outer nuclear membranes.
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In particular, the perinuclear space between the inner nuclear membrane (INM) and the outer nuclear membrane (ONM) of the nuclear envelope (NE) likely serves as an intracellular store for Ca2+ ions.
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Clear Space sentence examples within Medial Clear Space
Indications for surgical intervention for isolated syndesmotic injuries include frank syndesmosis diastasis, medial clear space widening on plain radiographs, significant radiographic syndesmosis diastasis during stress examination, or subtle syndesmotic diastasis detected by arthroscopic evaluation.
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Clear Space sentence examples within Tibiofibular Clear Space
There was no significant difference when comparing weight bearing status and change in radiographic measurements intra-operatively compared to 6 and 12 week follow up radiographs (tibiofibular clear space p = 0.
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Using 3D-US volume data, axial images were reconstructed at the level of the lateral prominence of the anterior tibial tubercle to ensure consistent measurements of the tibiofibular clear space (TFCS) by two radiologists.
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Clear Space sentence examples within Retroplacental Clear Space
INTRODUCTION
Visualization of the retroplacental clear space (RPCS) may provide critical insight into the development of abnormally invasive placenta (AIP).
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At univariate analysis, loss of retroplacental clear space, myometrial thinning (MT) and placenta lacunar spaces on US, intraplacental dark bands (IDBs), focal interruption of myometrial border (FIMB) and abnormal vascularity (AV) on MR were statistically significant (p < 0.
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Clear Space sentence examples within Fibular Clear Space
The tibio-fibular clear space (TFCS), tibio-fibular overlap (TFO), and medial clear space (MCS) were measured on each reconstructed DRR and axial CT image.
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Excellent agreement was evident for the tibio- fibular clear space (TFCS) and tibio-fibular overlap (TFO) with an intra-observer agreement of 0.
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Clear Space sentence examples within clear space widening
Indications for surgical intervention for isolated syndesmotic injuries include frank syndesmosis diastasis, medial clear space widening on plain radiographs, significant radiographic syndesmosis diastasis during stress examination, or subtle syndesmotic diastasis detected by arthroscopic evaluation.
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Conclusion: In predicting syndesmotic injury at the preoperative period in SER-type III and IV, medial clear space widening and fragment angle of the fibular posterior cortex showed significant correlations.
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7 During surgery, due to the creation of cystic and clear space as a result of the endoscopic removal of SSC, it is possible to observe such spectacular skull base structures.
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Chromatin, DNA wrapped around histone proteins, helps in packaging long DNA within tiny nuclear spaces.
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The positioning of a gene within the nuclear space has been implicated in gene regulation.
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falciparum, the heterochromatic virulence gene cluster had a strong repressive effect on the surrounding nuclear space, while this was less pronounced in Plasmodium vivax and Plasmodium berghei, and absent in Plasmodium yoelii.
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ABSTRACT Dynamic organization of chromatin within the three-dimensional nuclear space has been postulated to regulate gene expression and cell fate.
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) probe the spatial structure of the genome by identifying physical contacts between genomic loci within the nuclear space.
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Three morphological types of the associations of the nurse cell chromosome pericentromeric regions in the nuclear space are observed: (1) the pericentromeric regions of chromosomes 2, 3, and 4 contact the nuclear membrane at one pole of the nucleus, while the pericentromeric region of the X chromosome does so at the other pole (morphotype I); (2) the pericentromeric regions of chromosomes X, 2, and 3 are separated from each other in the nuclear space and contact the nuclear membrane (morphotype II); and (3) the pericentromeric region of chromosome 2 contacts the nuclear membrane at one pole of the nucleus, while the pericentromeric regions of chromosomes X, 3, and 4 contact the membrane at the other pole (morphotype III).
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This work contributes to enable and develop technologies to mount fast microreactors, to generate heat and electric energy, for the purpose to warm and to supply electrically spacecraft equipment and, also, the production of nuclear space propulsion effect.
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The major cellular impairments were intense vacuolization, dilatation of the cisterns of the rough endoplasmic reticulum and Golgi bodies, increase of perinuclear space, necrosis, concentric membrane formation and mitochondria crest loss.
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This work is devoted to the study of semimartingales on the dual of a general nuclear space.
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Abbreviations: Atg7: autophagy related 7; BECN1: beclin 1; CDA: cell death-induced autophagy; Cre: Cre-recombinase; DAPI: 4′,6-diamidino-2-phenylindole; ER: endoplasmatic reticulum; GFP: green fluorescent protein; HaGl: haderian gland; IVL: involucrin; KRT14: keratin 14; LD: lipid droplet; LSM: laser scanning microscope; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PN: perinuclear space; RB: residual body; rER: rough endoplasmatic reticulum; SB: sebum; SG-SC: stratum granulosum – stratum corneum; SGl: sebaceous gland; SQSTM1: sequestosome 1; TEM: transmission electron microscopy; TUNEL: terminal deoxynucleotidyl transferase dUTP nick end labelling.
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Chromosome conformation capture (3C) is a method used to study such long-range interaction between two different loci in the 3D nuclear space.
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by poor prognosis and survival rate� Its genetic hallmark is the translocation t(11;14) which leads to the overexpression of cyclin D1 (CCND1) gene which becomes juxtaposed to the immunoglobulin heavy chain (IGH) gene on the newly formed der14 chromosome� This recurrent feature is however not sufficient to promote the development of the disease as expression of CCND1 under different known IgH enhancers in transgenic mice is not sufficient for tumor development� Additional alterations are necessary to develop a malignant phenotype� When a translocation occurs, it can induce overall nuclear reorganization, epigenetic changes and altered gene expression that may contribute to oncogenesis� Here we investigated changes in nuclear positioning of gene loci and their transcription after the t(11;14) focusing our attention on the events occurring on the der11 chromosome� Methods� 3D-immunoFISH and image analysis software were used to analyze gene loci position in nuclear space� To analyze changes of transcriptional level of genes located on the der11, quantitative RT-PCR, bioinformatic analysis and data mining were performed� ChIP was carried out to analyze specific interactions between nucleolin and the genome in MCL� Results� We demonstrated that the expression of many genes located close to the translocation breakpoint was deregulated in MCL compared to other lymphomas and to B-cells from healthy donors� Most of these genes were located on the der11 after the t(11;14)� We found that the der11 is relocated in close proximity to the nucleolus� Here the nucleolin, that is part of the transcriptional factor LR-1 can deregulate gene expression by direct binding to promoters� We found that the LR-1 consensus sequence and the nucleolin binding sites are significantly enriched in the regions covered by the deregulated genes compared to the rest of chromosme11 and to cells without the t(11;14).
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Hepatocyte nuclear LDs derive from precursors of very low-density lipoprotein lacking apolipoprotein B-100, which form in the endoplasmic reticulum lumen and accumulate in intranuclear extensions of the perinuclear space called type I nucleoplasmic reticulum.
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Other properties of LINC complexes, such as the helices preceding the SUN domain, the longer coiled-coils spanning the perinuclear space and higher-order organization may also function to transmit mechanical forces generated by the cytoskeleton across the nuclear envelope.
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Retrograde trafficking is a well-regulated, multi-component pathway that can result in endosomal trafficking to the trans-Golgi network, the perinuclear space, or the nucleus.
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Soluble small and other nuclear localization sequence (NLS)-targeted proteins then swiftly enter the expanding nuclear space.
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SIGNIFICANCE STATEMENT Eukaryotic chromatin occupies a few micrometers of nuclear space while remaining dynamic and accessible for gene regulation.
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Construction of 3D nucleus based on allele-specific interaction frequency revealed symmetric positioning of homologous chromosomes in the 3D nuclear space.
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While cells uninfected or infected with a lentivirus expressing a 3a protein defective in ion channel activity expressed NLRP3 uniformly throughout the cytoplasm, NLRP3 was redistributed to the perinuclear space in cells infected with a lentivirus expressing the 3a protein.
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Third, in the desmoplastic area of the submucosa, caldesmon stained the cytoplasm strongly with a clear space or groove seen at the middle of the cytoplasm (tram-tracking appearance).
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Leydig cells had large oval euchromatic nuclei with widened perinuclear space.
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The histology showed the presence of an infiltrating tumor with neoplastic cells ar‐ ranged in multiple varying sized morula‐like clusters separated from the stroma by a clear space (Figure 1).
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Hsp25 was predominantly localized to the cytoplasm of myoblasts and myotubes but formed distinct aggregates in perinuclear spaces of myoblasts after heat-shock.
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The logarithmic fractal model predicts that the nuclear space is exactly half-filled with chromatin, and the second half consists of interchromatin voids filled with nucleoplasma in which various nuclear processes occur.
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The way that chromatin is organized in three-dimensional nuclear space is now acknowledged as a factor critical for the major cell processes, like transcription, replication and cell division.
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In addition, CSE exposure led to the impairment of proteostasis and autophagy, which resulted in the accumulation of ubiquitinated proteins as aggregates in peri-nuclear spaces.
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Patients with GERD are characterized by a large thickness of the epithelium, higher connective tissue papillae, wider internuclear spaces in epithelium layers, enlarged intercellular spaces in the epithelium of the esophagus in contrast to the patients of the comparison group.
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It is now clear that chromatin regions with high transcriptional activity assemble into Mb-scale compartments in the nuclear space, distinct from transcriptionally silent regions.
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Skin biopsies from four body sites showed normal epidermis and thickened reticular dermis with swollen collagen bundles separated from one another by clear spaces, resulting in fenestration.
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They play key roles in mediating the translocation of capsids from the nucleus to the cytoplasm by facilitating the budding of capsids into the perinuclear space (PNS).
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We discuss Hi-C data at both population and single-cell levels, thus providing criteria to interpret genomic function in the 3D-nuclear space.
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Interestingly, the microRNA has been reported as one of the miRNAs that is reimported to the nucleus but has not been ascribed a role in the nuclear space.
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In Arabidopsis, clustering of repetitive heterochromatic loci into so-called chromocenters is an important determinant of chromosome organization in nuclear space.
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The mammalian Golgi apparatus is a highly dynamic organelle, which is normally localized in the juxtanuclear space and plays an essential role in the regulation of cellular homeostasis.
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The porous layers and clear space of the enclosure are filled with PCM.
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During the early postoperative period severe corneal edema, anterior chamber cellularity and iris inflammation presented, accompanied by a clear space along the LASIK interface.
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The pho- toreceptor nuclei became degenerated and the perinuclear space was widened.
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The intracellular niches that are occupied by endosymbionts are manifold; some examples include the nucleus (Schulz and Horn, 2015), the perinuclear space (Schulz et al.
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A spatial analysis further revealed that NCp7-TC release is more pronounced in the perinuclear space, where capsid disassembly is thought to be completed.
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Mechanistically, we show that PML bodies play a novel role in 3D nuclear organization by providing specific nuclear spaces that the de novo DNA methyltransferase DNMT3A cannot access, which results in the robust maintenance of the hypo-methylated states at the Y-linked gene promoters.
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When conservative treatment is invalid, patients with severe symptoms, recurrent episodes and clear space-occupying lesions are suitable for surgical treatment, including neurolysis, nerve transposition, nerve repair, neurotomy, and functional reconstruction surgery.
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All the scatterers distribute in oceans randomly, which makes reverberation as a stochastic process, while it also has clear space correlation characteristic, which is an important characteristic of reverberation.
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There is a clear space in the field for a simple, inexpensive, quantitative way to measure various gait parameters.
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We described different defects in a micronuclear envelope: lack of peripheral heterochromatin, swelling of the perinuclear space, micronuclear membrane breaks, and complete or partial absence of a nuclear lamina.
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1α,2α-Epoxyscillirosidine induced extensive vacuolization in both cell types, with swollen RER (rough endoplasmic reticulum) and perinuclear spaces.
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) probe the spatial structure of the genome by identifying physical contacts between genomic loci within the nuclear space.
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TREX1 localizes to the perinuclear space in cells and degrades cytosolic DNA to prevent aberrant nucleic acid sensing and immune activation in humans and mice.
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The upper part of the cavity is a clear space with no porous or solid materials and is filled with hybrid nanofluid.
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Clear spaces in this zone indicated tissue destruction and cellular death.
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Moreover, t-tubules were contacting the nuclear envelope and they were seemingly filled from the perinuclear space.
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To achieve this, regulatory landscapes fold in nuclear space, creating complex 3D structures that influence enhancer-promoter communication and gene expression and that, when disrupted, can cause disease.
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During late infection stages, middle lamellae of mesophyll cells were dissolved locally to clear space for the pustule-building hyphae.
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Chromosomes are non-randomly positioned occupying specific chromosome territories in the 3D nuclear space and circumventing several nuclear landmarks the Nuclear Envelope with embedded Nuclear Pore Complexes, Splicing Speckles, PML bodies and many others.
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LAP1 binds to and activates torsinA, an AAA+ ATPase that resides in the perinuclear space and continuous main ER.
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