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A total-body PET/CT scanner can provide high-sensitivity imaging and may provide unique opportunity for detecting lower disease burden.
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In order to identify an occult malignancy, a whole-body PET/CT or PET/MRI scan is recommended.
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Methods: Images from conventional scan by 68Ga-PSMA whole-body PET/CT or PET/MR followed by delayed pelvic PET/MR were retrospectively analyzed.
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He was diagnosed with stage IV B classical HL, and as part of the staging work-up, a full-body PET/CT scan was performed.
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Methods: Thirty patients with cancer were enrolled prospectively and underwent a total-body PET/CT examination with an ultra-low 18F-FDG activity (0.
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Purpose A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide total-body coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-activity curve (TAC) measurement of all investigated organs simultaneously with high temporal resolution.
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Comparison of FDG whole-body PET/CT and gadolinium-enhanced whole-body MRI for distant malignancies in patients with malignant tumors: a meta-analysis.
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7 years) who underwent a total-body PET/CT scan were retrospectively enrolled to develop the regimen.
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Methods: SMGGN patients who were diagnosed and treated in the Department of Thoracic Surgery in our hospital from October 2017 to May 2020 and underwent whole-body PET/CT and/or contrast-enhanced brain MRI examinations were enrolled in this study.
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Whole-body PET/CT with a field of view from the mandible to the carina was obtained.
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3, followed by two whole-body PET/CT scans acquired from 60 and 90 min post-injection.
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Visual Intestinal 18F-FDG uptake is variable in whole-body PET/CT.
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Twenty-nine paediatric oncology patients (12F/17M, 3–18 years old (median age 13y), weight 45±20 kg, BMI 19±4 kg/m2), who underwent routine whole-body PET/CT examinations on a Siemens Biograph mCT TrueV system with TOF capability (555ps) were included in this study.
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F-FDG whole body PET/CT (Fig.
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A 68Ga DOTA-TATE scan (whole body PET/CT scan), confirmed the right gluteal lump as the source of the FGF 23.
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The uEXPLORER total-body PET/CT system provides a very high level of detection sensitivity and simultaneous coverage of the entire body for dynamic imaging for quantification of tracer kinetics.
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Introduction Dynamic PET/CT allows visualization of pharmacokinetics over the time, in contrast to static whole body PET/CT.
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Contrast-enhanced MRI showed a doubtful lesion in the right obturator canal, which was further confirmed by 68Ga-DOTATOC whole body PET/CT.
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Methods Eight 89 Zr-immunoPET whole-body PET/CT scans from three 89 Zr-immunoPET clinical trials were selected for analysis.
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Relevant parameters, such as patient ID, patient mass and height, injected activity, and uptake time, were investigated in the case of adult 18 F-FDG whole-body PET/CT and 99m Tc-MDP gamma camera bone scans on a daily basis.
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To investigate the effects of dose reduction on image quality and lesion detectability of oncological 18F-FDG total-body PET/CT in pediatric oncological patients and explore the minimum threshold of administered tracer activity.
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This study was to evaluate the effects of an ultra-low dose of [18F]-FDG on the image quality of total-body PET/CT and its lesion detectability in colorectal cancer (CRC).
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Rather than total-body PET/CT scans from head to toe, regular whole-body scans (from skull-base to thighs on the SAFOV Biograph Vision scanner, or vertex to thighs on the LAFOV Biograph Vision Quadra scanner) were performed.
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Conventional whole-body PET/CT has limited specificity and sensitivity in the qualitative diagnosis of small lesions and micro-lymph nodes but total-body PET/CT, in which the entire body is scanned in a single shot using a 194-cm axial PET scanner, has opened new avenues for lesion detection [2].
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SCI consisted of contrast-enhanced (CE) computed tomography (CT) of the chest/abdomen/pelvis, abdominal/pelvic CE-MR, and/or CE whole-body PET/CT with diagnostic quality (i.
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9 years) who underwent whole-body PET/CT were included.
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Four sets of images were created by editing four-phase dynamic whole-body PET/CT images acquired at a bed speed of 6 and 14 mm/s in the trunk and lower extremities, respectively.
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These findings underline the potential predictive role of quantitative, dynamic, interim PET/CT—performed in combination with conventional, static, whole-body PET/CT—in metastatic melanoma patients under PD-1 blockade.
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Local control within the irradiated field and the state of metastatic spread were assessed by periodic whole-body PET/CT and/or MRI imaging.
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Methods and materials: 91 patients underwent whole-body PET/CT with either FAPI-04 (N = 25) or FAPI-46 (N = 66).
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We perform patient-independent fivefold cross-validation on 3D volumes collected from whole-body PET/CT scans of patients with lymphomas.
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As a result of recent advances in Positron Emission Tomography (PET) instrumentation, total-body PET/CT offers a longer axial field-of-view, higher geometric sensitivity, and higher spatial resolution compared with standard PET systems.
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The addition of neck PET/MR scan after whole-body PET/CT may provide more favorable diagnostic information.
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The study suggested that the risk–benefit proportions of any 18F-FDG whole body PET/CT scan should be clarified and carefully weighed.
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PURPOSE To explorer the optimal reconstruction parameters in oncologic 18 F-FDG total-body PET/CT studies with ultra-low activity injection.
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Following the dynamic acquisition, a whole-body PET/CT was acquired.
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The aim of the study was to determine a faster PET acquisition protocol for a total-body PET/CT scanner by assessing the image quality that is equivalent to a conventional digital PET/CT scanner from both a phantom and a clinical perspective.
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Whole-body PET/CT imaging of male and female mice were carried out 2 h after [18F]FDG ip administration under 3% isoflurane anesthesia.
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Then, the patient was transferred to total-body PET/CT for tentative imaging, in which the entire body is scanned in a single shot using a 194-cm axial PET scanner.
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A whole-body PET/CT examination entails approximately 14 mSv, whereas a labeled leukocyte scan entails approximately 7–8 mSv.
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Compared with conventional PET/CT, total-body PET/CT imaging provides more comprehensive information for evaluation of disease.
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MRI brain and full body PET/CT scan were without evidence of distant metastasis.
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1-100 ng/ml) (median ± SE), 16 showed positive in the whole body PET/CT.
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The technical validation phase of the equipment consisted of a pilot, prospective and observational study whose objective was to obtain the first images (40 patients), analyze them and make adjustments in the acquisition, reconstruction and correction parameters, comparing the image quality of the CareMiBrain equipment with that of the whole-body PET/CT.
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Moreover, whole body PET/CT revealed unknown inflammation foci outside VG in 73% (22/30) of cases.
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Jaccard Index (JI) was calculated by comparing the segmented lesion to alternative segmentations obtained from the QIN lung CT segmentation chall e nge, which is possible by registering the whole body PET/CT images to the corresponding thoracic CT images.
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Purpose To explore the feasibility of a low dose regimen with short acquisition time of 68Ga-DOTATATE total-body PET/CT without compromising image quality of patients with NETs.
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A total of 53 patients were included in the prospective study, and the whole body PET/CT and thoracic PET/MRI were performed on them respectively.
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Whole-body PET/CT imaging was performed 50-70 minutes after each injection.
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Methods First, 199 patients who received whole-body PET/CT examinations were retrospectively retrieved.
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Next, we highlight the latest developments within the field of PET/CT, including total body PET/CT, use of novel PET radiotracers, and potential future applications of PET/CT that will likely lead to increased capabilities for patient-tailored treatment of infectious diseases.
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BMB/BMS and whole-body PET/CT results were used as reference standards against which we calculated the diagnostic value of pelvic MRI for BMinv in DLBCL patients.
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This research aimed to assess the biokinetics and radiation dosimetry of [68Ga]Ga-iPSMA-BN in four healthy volunteers based on biodistribution data obtained from whole-body PET/CT studies, as well as to visualize the [68Ga]Ga-iPSMA-BN tumor uptake in a patient with PCa.
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After intravenous administration of 200 MBq (+/- 10%) 18F-FES, a 50-min dynamic PET/CT scan of the thorax was performed, followed by a whole body PET/CT scan 60 min post-injection.
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This work outlines the clinical implementation of total-body PET/CT from the time of installation at UC Davis EXPLORER Molecular Imaging Center in May 2019 to date (September 2020).
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All whole-body PET/CT reports from 1 January 2010 to 31 December 2013 were retrospectively reviewed and further analyzed if visually increased thyroidal FDG uptake was reported.
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At the same time, the whole-body PET/CT may detect additional foci of infection with impact on subsequent treatment strategy.
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7 years) who underwent a total-body PET/CT scan were retrospectively enrolled to develop the regimen.
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The patient underwent whole body PET/CT for restaging after total extirpation of a tumor formation originated from n.
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Further imaging examinations, such as CT or whole-body PET/CT, confirmed that the primary lesions of all the 5 patients were from the lung.
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The total-body PET/CT scanner can generate fine time-activity curves (TACs) in dPET imaging and provide tempo-spatially synchronized pharmacokinetics in the entire human body.
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The patient was urgently admitted for hospitalization and underwent 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) examination on a total-body PET/CT scanner (United Imaging Healthcare) with an injection dose of 8.
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5 MBq/kg): two regional head and neck and upper mediastinum studies at 5 min (first phase) and 120 min (third phase) and a whole-body PET/CT (from the skull vertex to mid-thighs) at 60 min (second phase).
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MATERIALS AND METHODS
Based on a random sampling method, the results of whole-body PET/CT scan with 18F-FDG glucose in 134 patients with various non-urological disorders were analyzed.
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All patient underwent primary whole-body PET/CT examinations at the time of initial staging and intermediate follow-up PET/CT scan after 2-cycle of chemotherapy.
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Although skeletal muscle metastasis remains a rare entity, its incidence rate should increase with the increased usage of whole-body PET CT for cancer staging.
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A whole-body PET CT scan did not reveal any metabolically active lesion in any part of the body.
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