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10.1016/j.pharmthera.2019.07.002

ATM in DNA repair in cancer.


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10.1158/1078-0432.CCR-18-1821

ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment


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10.1158/1535-7163.TARG-19-A080

Abstract A080: Olaparib and the ATR inhibitor AZD6738 in relapsed, refractory cancer patients with homologous recombination (HR) repair mutations – OLAPCO


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10.1158/1535-7163.TARG-19-B052

Abstract B052: ATR inhibition potentiates ionizing radiation-induced innate immune response via sensing cytosolic RNAs



A consensus set of genetic vulnerabilities to ATR inhibition


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10.1093/annonc/mdz336.002

Latest development of PARP inhibitors in ovarian cancer


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10.1158/1557-3265.OVCASYMP18-AP10

Abstract AP10: REAL-TIME ASSESSMENT OF HGSC DNA DAMAGE REPAIR DEFECTS AND DEFECT-INDUCED RESPONSE TO THERAPY IN OVARIAN CANCER ORGANOIDS



A consensus set of genetic vulnerabilities to ATR inhibition


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10.1158/1538-7445.AM2019-3503

Abstract 3503: Biomarkers for inhibitors of the replication stress response proteins WEE1 and ATR in triple negative breast cancer


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10.1158/1535-7163.MCT-18-0972

Inhibition of the Replication Stress Response Is a Synthetic Vulnerability in SCLC That Acts Synergistically in Combination with Cisplatin


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10.1080/21505594.2019.1640035

Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections


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10.1038/s41419-019-1689-8

ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation


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10.1158/0008-5472.CAN-18-3394

Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors.


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10.1186/s13045-019-0733-6

Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand


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10.1158/1538-7445.AM2019-380

Abstract 380: Tumor suppressor retinoblastoma status as a predictor of ATR inhibitor sensitivity


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10.18632/oncotarget.26607

Know your limits: RPA availability and chemoresistance in ovarian cancer


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10.1002/1878-0261.12573

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells


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10.1158/1538-7445.AM2019-3507

Abstract 3507: LKB1 deficiency and KEAP1/NRF2 pathway alterations as biomarkers of response for ATR and ATM inhibitors and other inhibitors of DNA damage response (DDR) in NSCLC


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10.1074/jbc.RA118.005188

DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse


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10.1007/s00412-019-00723-7

ATR function is indispensable to allow proper mammalian follicle development


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10.3390/cancers11121913

Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells



Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis


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10.1038/s41467-019-09659-z

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers


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10.1016/j.pharmthera.2019.107450

Targeting ATR as Cancer Therapy: A new era for synthetic lethality and synergistic combinations?


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10.1158/1538-7445.AM2019-271

Abstract 271: The role of ATM and DNA-PK in responding to AZD6738-induced damage in pancreatic ductal adenocarcinoma cells


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10.1158/1538-7445.AM2019-3498

Abstract 3498: Highly specific macrocyclic ATR inhibitors for the targeted treatment of a broad spectrum of cancers showing lack of anemia or neutropenia in pre-clinical animal models


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10.1158/1078-0432.CCR-18-0968

PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers


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10.1158/1538-7445.AM2019-369

Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy


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10.1158/1538-7445.AM2019-276

Abstract 276: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress


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10.1158/1538-7445.SABCS18-8

Abstract 8: Targeting DNA-damage response pathway with a novel nano-liposomal ATR inhibitor in solid tumors


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10.1038/s41467-019-10993-5

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma


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10.1158/1535-7163.TARG-19-A096

Abstract A096: LKB1 deficiency and KEAP1/NRF2 pathway alterations as biomarkers of response for ATR and ATM inhibitors and other inhibitors of DNA damage response (DDR) in NSCLC



Inhibition of a Selective SWI/SNF Function Synergizes with ATR Inhibitors in Cancer Cell Killing



Synthetic Lethality Is a Novel and Potential Paradigm for Precision Medicine in Advanced Hepatocellular Carcinoma


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