Introduction to Anaplastic Wilms

What is/are Anaplastic Wilms?

Anaplastic Wilms - Rhabdoid tumor of the kidney (RTK) mimics other renal tumors histologically, but a rhabdoid tumor mimicking an anaplastic Wilms’ tumor has been rarely reported. ^[1] For functional studies, we used two anaplastic Wilms’ tumour cell-lines, WiT49 and 17. ^[2] In this context, we undertook a functional genomics approach to uncover novel therapeutic strategies for those patients with anaplastic Wilms’ tumor. ^[3] For functional studies, we used two anaplastic Wilms’ tumour cell-lines, WiT49 and 17. ^[4] As a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). ^[5] The differential diagnoses included anaplastic sarcoma of the kidney (ASK), anaplastic Wilms tumor, mesenchymal chondrosarcoma, sarcomatoid renal cell carcinoma, clear cell sarcoma of the kidney, rhabdoid tumor of the kidney, congenital mesoblastic nephroma, and synovial sarcoma. ^[6] Most of these patients will have favorable histology subtype with only 10% having anaplastic Wilms tumor. ^[7]

Two Anaplastic Wilms

For functional studies, we used two anaplastic Wilms’ tumour cell-lines, WiT49 and 17. ^[1] For functional studies, we used two anaplastic Wilms’ tumour cell-lines, WiT49 and 17. ^[2]

anaplastic wilms tumor

As a significant proportion of relapses occurred in the tumor bed or abdomen on patients with the fifth National Wilms Tumor Study stage I anaplastic Wilms tumor (WT), flank radiotherapy was added for stage I anaplastic WT in the subsequent study of the Children's Oncology Group (AREN0321). ^[1] The differential diagnoses included anaplastic sarcoma of the kidney (ASK), anaplastic Wilms tumor, mesenchymal chondrosarcoma, sarcomatoid renal cell carcinoma, clear cell sarcoma of the kidney, rhabdoid tumor of the kidney, congenital mesoblastic nephroma, and synovial sarcoma. ^[2] Most of these patients will have favorable histology subtype with only 10% having anaplastic Wilms tumor. ^[3]