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P160 The first phase 2A proof-of-concept study of a selective NLRP3 inflammasome inhibitor, dapansutrile™ (OLT1177™), in acute gout



Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.


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10.1016/j.ejca.2018.12.020

First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity.


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10.1177/1740774519890145

Adaptive dose-finding based on safety and feasibility in early-phase clinical trials of adoptive cell immunotherapy



Joint modelling of a binary and a continuous outcome measured at two cycles to determine the optimal dose



A Phase IIa Study Evaluating Safety, Pharmacokinetics, and Antiviral Activity of GSK2838232, a Novel, Second-generation Maturation Inhibitor, in Participants With Human Immunodeficiency Virus Type 1 Infection.



AAA: triple adaptive Bayesian designs for the identification of optimal dose combinations in dual-agent dose finding trials.


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10.1007/s00280-019-03796-4

First-in-human study to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of the anti-CD27L antibody-drug conjugate AMG 172 in patients with relapsed/refractory renal cell carcinoma


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10.1016/j.vaccine.2019.03.059

Controlled human infection for vaccination against Streptococcus pyogenes (CHIVAS): Establishing a group A Streptococcus pharyngitis human infection study.


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10.1136/annrheumdis-2018-EWRR2019.142

P160 The first phase 2A proof-of-concept study of a selective NLRP3 inflammasome inhibitor, dapansutrile™ (OLT1177™), in acute gout


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10.1016/j.bcp.2019.113670

Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.


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10.1016/j.ijrobp.2019.01.077

Tumor Voxel Dose-Response Matrix and Dose Prescription Function Derived Using 18F-FDG PET/CT Images for Adaptive Dose Painting by Number.


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10.1177/2168479019831240

Adaptive Design: A Review of the Technical, Statistical, and Regulatory Aspects of Implementation in a Clinical Trial.


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10.1080/02664763.2019.1649375

Bias induced by adaptive dose-finding designs


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10.1177/0962280219837737

An adaptive design for the identification of the optimal dose using joint modeling of continuous repeated biomarker measurements and time-to-toxicity in phase I/II clinical trials in oncology


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