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Chondrocyte Implantation
Background: Autologous chondrocyte implantation (ACI) and microfracture are established treatments for large, full-thickness cartilage defects, but there is still a need to expand the clinical and health economic knowledge of these procedures.
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However, the major drawback of current treatments such as Autologous Chondrocyte Implantation or Microfracture is that they cannot guide the formation of a pure hyaline cartilage.
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autologous chondrocyte implantation (ACI) and osteochondral autograft transfer system (OATS ®; Arthrex, Naples, CA, USA) predominantly for the knee are summarized.
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METHODS
Patients scheduled for osteochondral autograft or allograft transplant, microfracture, autologous chondrocyte implantation, allograft cartilage resurfacing, and chondroplasty were prospectively enrolled in the study and completed PROMIS PF CAT, Knee Injury and Osteoarthritis Outcome Score (KOOS activities of daily living, pain, symptoms, sport, and quality of life), Short Form-36 Health Survey (SF-36 physical function [PF] and Physical Component Summary), and EuroQol-5 Dimension questionnaires.
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Purpose of the present study was to evaluate the outcome of patients treated with autologous chondrocyte implantation (ACI) for cartilage defects of the patella in comparison to patient with defects of the femoral condyles.
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The past two decades have brought about incredible advancements in the surgical intervention regarding cartilage injury including techniques such as osteochondral grafting, marrow stimulation, and autologous chondrocyte implantation.
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Matrix-induced autologous chondrocyte implantation is a 2-stage surgical procedure used to treat symptomatic, full-thickness chondral lesions of the knee.
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Seven different autologous chondrocyte implantation (ACI) grafts were used consecutively over a period of 18 years for the treatment of cartilage lesions in the knees.
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With myriad cartilage surgery techniques available, including marrow stimulation, autologous osteochondral transfer, osteochondral allograft transplantation, and autologous chondrocyte implantation, treatment of knee articular cartilage injuries has become increasingly complex.
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