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3 Trial sentence examples within randomized double blind



Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.



Cost-effectiveness of olaparib vs routine surveillance in the maintenance setting for patients with BRCA-mutated advanced ovarian cancer after response to first-line platinum-based chemotherapy in Singapore


3 Trial sentence examples within phase 2 trial



SUN-247 Once-Weekly Somapacitan in Childhood Growth Hormone Deficiency: Efficacy and Safety Results of a Randomized, Open-Label, Controlled Phase 2 Trial (REAL 3)



Commentary on “Applying CHW method to 2-in-1 design: gain or lose”


3 Trial sentence examples within progression free survival



Incidence of tumour BRCA1/2 variants in relapsed, platinum-sensitive ovarian, fallopian tube and primary peritoneal cancer



Faster and sustained improvement in health-related quality of life (HRQoL) for newly diagnosed multiple myeloma (NDMM) patients ineligible for transplant treated with daratumumab, lenalidomide, and dexamethasone (D-Rd) versus Rd alone: MAIA.




3 Trial sentence examples within open label phase



Genotype analysis and identification of novel mutations in a multicentre cohort of patients with hereditary factor X deficiency



Nivolumab + chemotherapy vs chemotherapy in EGFR-mutated NSCLC after 1L or 2L EGFR-TKIs (CheckMate 722)


3 Trial sentence examples within randomised double blind



Efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrug-resistant tuberculosis: a multicentre, randomised, double-blind, placebo-controlled, parallel group phase 3 trial.



Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial.


3 Trial sentence examples within randomized placebo controlled



Abstract LB-249: Marine omega-3 fatty acid supplementation and risk of colorectal adenomas and serrated polyps: A randomized placebo-controlled trial



Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial.


3 Trial sentence examples within open label randomized



Impact of pembrolizumab (pembro) versus paclitaxel on health-related quality of life (HRQoL) in patients with advanced gastric or gastroesophageal junction (GEJ) cancer that has progressed after first-line chemotherapy (KEYNOTE-061)



KEYNOTE-181: Pembrolizumab vs chemotherapy in patients (pts) with advanced/metastatic adenocarcinoma (AC) or squamous cell carcinoma (SCC) of the esophagus as second-line (2L) therapy


3 Trial sentence examples within randomized open label



Increased Efficacy of Stem Cell Chemomobilization with Intermediate-Dose Cytarabine Plus Granulocyte Colony-Stimulating Factor (G-CSF) Compared with G-CSF Alone in Patients with Multiple Myeloma: Results of a Randomized Trial.



Avelumab in platinum-resistant/refractory ovarian cancer (PRROC): phase 3 results from JAVELIN Ovarian 200


3 Trial sentence examples within low certainty evidence



Acupuncture for chronic hepatitis B.



Fetal biometry for guiding the medical management of women with gestational diabetes mellitus for improving maternal and perinatal health.


3 Trial sentence examples within randomised open label



Abstract OT3-05-02: ALEXANDRA/IMpassion030: A phase III study of standard adjuvant chemotherapy with or without atezolizumab in early triple negative breast cancer



Pembrolizumab plus pomalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma (KEYNOTE-183): a randomised, open-label, phase 3 trial.


3 Trial sentence examples within refractory multiple myeloma



Novel mutations in SPTA1 and SPTB identified by whole exome sequencing in eight Thai families with hereditary pyropoikilocytosis presenting with severe fetal and neonatal anaemia



Evaluation of the safety and efficacy of daratumumab outside of clinical trials


3 Trial sentence examples within multicenter open label



Single-Dose Ivermectin for Strongyloidiasis Works as Well as Multidose Treatment



EV-301: A phase III trial in progress evaluating enfortumab vedotin versus chemotherapy in patients with locally advanced or metastatic urothelial carcinoma


3 Trial sentence examples within phase 1 2



New BCR-ABL inhibitors in chronic myeloid leukemia



Near-Infrared Photoimmunotherapy of Cancer


3 Trial sentence examples within randomized controlled phase



Current Treatment Options for Metastatic Hormone-Sensitive Prostate Cancer



Impact of lixisenatide dose range on clinical outcomes with fixed-ratio combination iGlarLixi in patients with type 2 diabetes


3 Trial sentence examples within randomised controlled phase



Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial.



Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2-3 trial.


3 Trial sentence examples within low quality evidence



Interventions for preventing high altitude illness: Part 3. Miscellaneous and non-pharmacological interventions.



Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.


3 Trial sentence examples within double blind placebo



A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus.



P004 Solriamfetol for excessive daytime sleepiness in obstructive sleep apnoea: a randomised controlled trial


3 Trial sentence examples within moderate certainty evidence



General health checks in adults for reducing morbidity and mortality from disease.



Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries.


3 Trial sentence examples within randomized controlled trial



Converting habits of antibiotic use for respiratory tract infections in German primary care – study protocol of the cluster-randomized controlled CHANGE-3 trial



Vitamin D and Omega-3 Fatty Acid Trial 2017: Addressing Effects on Muscle and Bone


3 Trial sentence examples within non small cell



Effect on quality of life of cisplatin added to single-agent chemotherapy as first-line treatment for elderly patients with advanced non-small cell lung cancer: Joint analysis of MILES-3 and MILES-4 randomised phase 3 trials.



Unite for a Framework Convention for Alcohol Control


3 Trial sentence examples within multicentre randomised open



Cost-effectiveness analysis of gemcitabine plus cisplatin versus fluorouracil plus cisplatin for first-line treatment of recurrent or metastatic nasopharyngeal carcinoma.



Salvage Radiotherapy Versus Hormone Therapy for Prostate-specific Antigen Failure After Radical Prostatectomy: A Randomised, Multicentre, Open-label, Phase 3 Trial (JCOG0401)†.


3 Trial sentence examples within randomised placebo controlled



P051 The bigger you are the harder you fall? Short term effects of LUM/IVA (Orkambi) on lung function in children with cystic fibrosis



Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial.


3 Trial sentence examples within multicenter randomized double



Effectiveness of methotrexate in moderate to severe psoriasis patients: real-world registry data from the Swiss Dermatology Network for Targeted Therapies (SDNTT)



Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial.


3 Trial sentence examples within advanced soft tissue



Safety and efficacy of Pazopanib in advanced soft tissue sarcoma: PALETTE (EORTC 62072) subgroup analyses



NBTXR3, a first-in-class radioenhancer hafnium oxide nanoparticle, plus radiotherapy versus radiotherapy alone in patients with locally advanced soft-tissue sarcoma (Act.In.Sarc): a multicentre, phase 2-3, randomised, controlled trial.


3 Trial sentence examples within renal cell carcinoma



Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial



Association between age and sex and mortality after adjuvant therapy for renal cancer


3 Trial sentence examples within improve overall survival



MSI-H: a truly agnostic biomarker?



Immunotherapy, the Promise for Future of Mesothelioma Treatment?


3 Trial sentence examples within double blind randomised



Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial.



Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial.


3 Trial sentence examples within primary end point



Trial of Anifrolumab in Active Systemic Lupus Erythematosus.



Clinical Outcomes by Intended Goal of Therapy in the MOMENTUM 3 Clinical Trial: Final Analysis of the 1028 Patient Full Cohort


3 Trial sentence examples within improved overall survival



Management of anlotinib‐related adverse events in patients with advanced non‐small cell lung cancer: Experiences in ALTER‐0303



Outcomes by tumor location in patients with metastatic colorectal cancer (mCRC) treated with regorafenib (REG): Final analysis from the prospective, observational CORRELATE study.


3 Trial sentence examples within identically designed multicentre



Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials



Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials


3 Trial sentence examples within week placebo controlled



Dupilumab Suppresses Type 2 Biomarkers in Asthma Patients With and Without Comorbid Chronic Rhinosinusitis With or Without Nasal Polyposis (CRS/NP): Post Hoc Analysis of LIBERTY ASTHMA QUEST: 296



A High Proportion Of Exacerbation‐Prone Patients With Uncontrolled Eosinophilic Asthma Receiving IV Reslizumab Experienced Zero Asthma Exacerbations Through 52 Weeks (wks) Of Treatment: 295


3 Trial sentence examples within advanced breast cancer



Clinical Relevance of Collagen Protein Degradation Markers C3M and C4M in the Serum of Breast Cancer Patients Treated with Neoadjuvant Therapy in the GeparQuinto Trial



Comparison of BEAMing and Droplet Digital PCR for Circulating Tumor DNA Analysis.


3 Trial sentence examples within randomized sham controlled



Renal denervation. Importance of knowledge of sympathetic nervous system anatomy in refining the technique.



Changes in 24-Hour Patterns of Blood Pressure in Hypertension Following Renal Denervation Therapy


3 Trial sentence examples within prospective randomized phase



Normal BMI predicts the survival benefits of inductive docetaxel, cisplatin, and 5-fluorouracil in patients with locally advanced oral squamous cell carcinoma.



Medical treatment of advanced cutaneous squamous‐cell carcinoma


3 Trial sentence examples within hormone receptor positive



Abstract OT3-02-02: PATHWAY: Asian, multicenter, phase 3 trial of tamoxifen with or without palbociclib ± goserelin in women with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer



HDAC inhibitors tested in phase III trial


3 Trial sentence examples within long term extension



63 Long-term Outcomes with Aripiprazole Lauroxil for the Treatment of Schizophrenia: A 2-Year, Phase 3, Multicenter Extension Study.



Safety profile of baricitinib in Japanese patients with active rheumatoid arthritis with over 1.6 years median time in treatment: An integrated analysis of Phases 2 and 3 trials


3 Trial sentence examples within double blind phase



Rimegepant, an Oral Calcitonin Gene-Related Peptide Receptor Antagonist, for Migraine.



Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer.


3 Trial sentence examples within two double blind



Galcanezumab in episodic migraine: subgroup analyses of efficacy by high versus low frequency of migraine headaches in phase 3 studies (EVOLVE-1 & EVOLVE-2)



A new treatment for chronic rhinosinusitis with nasal polyps


3 Trial sentence examples within placebo controlled phase



Riociguat improves health-related quality of life for patients with pulmonary arterial hypertension: results from the phase 4 MOTION study



Fecal Calprotectin Responses Following Induction Therapy With Vedolizumab in Moderate to Severe Ulcerative Colitis: A Post Hoc Analysis of GEMINI 1


3 Trial sentence examples within median overall survival



Recent changes in overall survival of real-life stage IV colorectal cancer patients.



Role of cytoreductive nephrectomy in metastatic renal cell carcinoma patients with tumor thrombus: does it change with development of systemic therapy?


3 Trial sentence examples within multicenter randomized phase



Androgen Receptor Modulation Optimized for Response-Splice Variant: A Phase 3, Randomized Trial of Galeterone Versus Enzalutamide in Androgen Receptor Splice Variant-7-expressing Metastatic Castration-resistant Prostate Cancer.



Maintenance with lanreotide in small-cell lung cancer expressing somatostatine receptors: A multicenter, randomized, phase 3 trial.


3 Trial sentence examples within blinded endpoint phase



Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial



Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial


3 Trial sentence examples within conventional synthetic disease



Selective Janus kinase inhibitors: Promising drugs for rheumatoid arthritis



Upadacitinib bei Patienten mit rheumatoider Arthritis


3 Trial sentence examples within multicentre open label



Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial.



Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial.


3 Trial sentence examples within combined adjuvant chemotherapy



Prognostic relevance of the molecular classification in high-risk endometrial cancer: analysis of the PORTEC-3 trial



Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial


3 Trial sentence examples within overall response rate



Efficacy of Ibrutinib-Based Regimen in Chronic Lymphocytic Leukemia: A Systematic Review



Pomalidomide-Based Regimens for Treatment of Relapsed and Relapsed/Refractory Multiple Myeloma: Systematic Review and Meta-analysis of Phase 2 and 3 Clinical Trials.


3 Trial sentence examples within metastatic breast cancer



Abstract PD3-10: Higher serum PD-L1 predicts for increased overall survival to lapatinib vs trastuzumab in the phase 3 CCTG MA.31 trial



Abstract PD9-08: Breast cancer liver metastases vascularize by vessel co-option, not angiogenesis, and have a desert immune phenotype: A histopathological and gene expression study


3 Trial sentence examples within extensive stage small



Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer



First-line atezolizumab plus chemotherapy in treatment of extensive small cell lung cancer: a cost-effectiveness analysis from China.


3 Trial sentence examples within improved progression free



Abstract P6-16-01: Health-related quality of life in MONARCH 3: Abemaciclib plus an aromatase inhibitor as initial therapy in women with HR+, HER2- advanced breast cancer



PET Imaging of PARP Expression Using 18F-Olaparib


3 Trial sentence examples within multicentre double blind



Patient-reported outcomes with durvalumab after chemoradiotherapy in stage III, unresectable non-small-cell lung cancer (PACIFIC): a randomised, controlled, phase 3 study.



Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (RADIANCE): a multicentre, randomised, 24-month, phase 3 trial



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