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The diagnosis is based on biochemical findings and the gold-standard imaging technique is 18F-DOPA PET/CT scanning.
4) years) who underwent 18F-DOPA PET/CT imaging were enrolled.
From our institutional experience, in 29 patients, we found that sensitivity, specificity and accuracy of 18F-DOPA PET/CT in HGG were 100% (95% confidence interval- 95%CI - 81-100%), 63% (95%CI: 39-82%) and 62% (95%CI: 39-81%), respectively.
18F-DOPA PET/CT is commonly done in patients with persistent hyperinsulinemic hypoglycemia of infancy (PHHI) to look for any focal lesion in the pancreas.
The 18F-DOPA PET/CT showed a pancreatic lesion, which was subsequently partially removed.
Therefore, we compared 68Ga-DOTA-TOC and 18F-DOPA PET/CT with 123I-MIBG planar and SPECT/CT imaging, for the detection of HNPGL.