Tumor Cells - Scientific Sentence Examples

Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling β1-integrins into large punctate clusters at the leading edge of tumor cells to promote an “adhesive switch,” decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes. PDF

这里,我们显示 NDRG4 调制 的 表观遗传 沉默 整联 通过在 肿瘤细胞 的前缘 组装 β1 整合素 成大 点状 簇 以促进 信令 “ 粘合剂 开关 , ” 减少 细胞粘附到 纤连蛋白和 增加 对 玻连蛋白 的细胞粘附和 迁移, 人淋巴结的重要组成部分。

NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients 10.1038/s41523-019-0106-x

Tumor Cells - Scientific Sentence Examples

Circulating tumor cells (CTCs) and cell-free DNA (cfDNA) were evaluated in 89 previously treated NSCLC patients receiving nivolumab. PDF


Prognostic Relevance of Circulating Tumor Cells and Circulating Cell-Free DNA Association in Metastatic Non-Small Cell Lung Cancer Treated with Nivolumab 10.3390/jcm8071011

Tumor Cells - Scientific Sentence Examples

iRGD (CRGDK/RGPD/EC) is a kind of tumor-penetrating peptide which can contribute CNs to increasing cancer vascular and tissue permeability in a αv integrin and neuropilin1(expressing at the surface of tumor blood vessel endothelial cells and tumor cells)–dependent manner. PDF

IRGD(CRGDK / RGPD / EC)是一种肿瘤渗透肽,可贡献CNS以增加αv整合蛋白和神经疏松素1中的癌症血管和组织渗透率(在肿瘤血管内皮细胞和肿瘤细胞表面表达) - 依赖性 方式。

Curcumin nanocrystallites are an ideal nanoplatform for cancer chemotherapy 10.15761/fnn.1000186

Tumor Cells - Scientific Sentence Examples

Correlation of BRD4 binding and drug-mediated displacement at RNA Pol II pause sites with gene expression revealed a differential behavior of sensitive and resistant tumor cells to I-BET and identified a BRD4 signature at promoters of sensitive coding and non-coding genes. PDF

BRD4结合和药物介导位移在RNA POL II暂停位点与基因表达的相关性显示敏感和抗性肿瘤细胞对I-BET的差异行为,并在敏感编码和非编码基因的启动子鉴定了BRD4签名。

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity 10.1186/s13072-019-0286-5

Tumor Cells - Scientific Sentence Examples

Complex 1 containing alanine inhibited the cell viability of A549 and K562 tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive cells and the induction of DNA damage and cell cycle arrest. PDF


Ru(II)-Based Amino Acid Complexes Show Promise for Leukemia Treatment: Cytotoxicity and Some Light on their Mechanism of Action 10.1007/s12011-019-01976-0

Tumor Cells - Scientific Sentence Examples

Together we substantiate the identification of novel lead molecules, which may provide a new treatment to overcome selectivity issues and enhance the radiosensitivity of tumor cells, opening a conceptually novel strategy of CDK-targeting for different cancer types. PDF


CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity. 10.1021/jacs.8b10207

Tumor Cells - Scientific Sentence Examples

Its overexpression is one of the main reasons for the multidrug resistance (MDR) of tumor cells. PDF


Exploring movement and energy in human P-glycoprotein conformational rearrangement 10.1080/07391102.2018.1461133

Tumor Cells - Scientific Sentence Examples

We found multiple correlations between parameters characterizing the immune profiles of tumor cells and TILs in both baseline and on-treatment samples. PDF


Abstract A154: Flow cytometric analysis of immune responses in the melanoma tissue biopsies before or during anti-PD1 immunotherapy 10.1158/2326-6074.CRICIMTEATIAACR18-A154

Tumor Cells - Scientific Sentence Examples

Our first-in-class NKp30xBCMA NK cells engager, CTX-4419, binds to BCMA on MM cells and to NKp30 and CD16A (FcγRIIIA) on NK cells, specifically redirecting NK cells towards tumor cells expressing BCMA. PDF

我们的第一级NKP30XBCMA NK细胞CTX-4419与BCMA粘合在MM细胞上并在NK细胞上与NKP30和CD16a(FCγRIIIA)结合,特别是将NK细胞重定向表达BCMA的肿瘤细胞。

Abstract 4972: Preclinical development of a first-in-class NKp30xBCMA NK cell engager for the treatment of multiple myeloma 10.1158/1538-7445.AM2019-4972

Tumor Cells - Scientific Sentence Examples

However, these methods are unable to eradicate tumor cells completely, and easily lead to the recurrence and progression of tumor. PDF


[Function of tumor infiltrating lymphocytes in solid tumors - a review]. 10.13345/j.cjb.190300

Tumor Cells - Scientific Sentence Examples

Background: Tumor budding is defined as small cluster of tumor cells located at the invasive edge of tumor and was assumed to be linked with epithelial-mesenchymal transition (EMT), which is an early event in metastasis. PDF

背景:肿瘤芽定义为位于肿瘤的侵袭性边缘的小肿瘤细胞簇,并被假设与上皮 - 间充质转换(EMT)连接,这是转移的早期事件。

Evaluation of clinicopathologic significance of tumor budding in breast carcinoma 10.33545/PATHOL.2019.V2.I1C.25

Tumor Cells - Scientific Sentence Examples

The combination analysis of UHPLC-QTOF/MS and DESI-MSI revealed that the different molecular species of TGs were associated with tumor distribution and were useful for characterizing the progression of tumor cells and discovering prospective biomarkers. PDF

UHPLC-QTOF / MS和DESI-MSI的组合分析表明,不同的TGS的不同分子物种与肿瘤分布有关,可用于表征肿瘤细胞的进展并发现前瞻性生物标志物。

Identification of novel biomarkers of hepatocellular carcinoma by a high definition mass spectrometry; UHPLC-QTOF/MS and DESI-MSI. 10.1002/rcm.8551

Tumor Cells - Scientific Sentence Examples

PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor cells achieve their expression remains to be addressed. PDF


A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2. 10.1016/j.celrep.2019.10.093

Tumor Cells - Scientific Sentence Examples

In vitro, activities against B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), HL-60 (human promyelocytic leukemia) and K562 (human chronic myelocytic leukemia) and non-tumor cells: PBMC (human peripheral blood mononuclear cells activated with concanavalin A - human lymphoblast) were carried out. PDF

体外,针对B16-F10(小鼠黑色瘤),HepG2(人肝细胞癌),HL-60(人幼儿细胞白血病)和K562(人慢性骨髓细胞白血病)和非肿瘤细胞的活动:PBMC(人外周血单核细胞活化 进行了康丹林A - 人淋巴细胞)。

Ru(II) complexes containing uracil nucleobase analogs with cytotoxicity against tumor cells. 10.1016/j.jinorgbio.2019.110751

Tumor Cells - Scientific Sentence Examples

Immunohistochemical staing showed complete loss of SMARCA4 in tumor cells. PDF


Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events. 10.1016/J.LUNGCAN.2019.03.029

Tumor Cells - Scientific Sentence Examples

Additionally, cytotoxicity experiments showed that the Cur/FA-AmCS-TPP nanoparticles had good targeting ability for tumor cells. PDF

另外,细胞毒性实验表明,Cur / Fa-AMCS-TPP纳米颗粒具有良好的肿瘤细胞靶向能力。

Fabrication of Ion-Crosslinking Aminochitosan Nanoparticles for Encapsulation and Slow Release of Curcumin 10.3390/pharmaceutics11110584

Tumor Cells - Scientific Sentence Examples

The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. PDF


Numerical Analysis of Motion and Stress Distribution of Circulating Tumor Cells in Micro Vessels 10.32604/mcb.2019.07111

Tumor Cells - Scientific Sentence Examples

Besides their direct activity against tumor cells, monoclonal antibodies and tyrosine kinase inhibitors (TKIs) also influence the antitumoral activity of immune cells, which has important implications for the design of immunotherapies. PDF


EGFR-Specific Tyrosine Kinase Inhibitor Modifies NK Cell-Mediated Antitumoral Activity against Ovarian Cancer Cells 10.3390/ijms20194693

Tumor Cells - Scientific Sentence Examples

VPS9D1-AS1/MEF2D and miR-4739 were inversely correlated in tumor cells. PDF

VPS9D1-AS1 / MEF2D和MIR-4739在肿瘤细胞中均相相关。

ZEB1 activated-VPS9D1-AS1 promotes the tumorigenesis and progression of prostate cancer by sponging miR-4739 to upregulate MEF2D. 10.1016/j.biopha.2019.109557

Tumor Cells - Scientific Sentence Examples

Conversely, the knocking down of GOLPH3 in GOLPH3-overexpressing tumor cells reduces tumorigenic features, such as cell proliferation and cell migration and invasion. PDF


The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner 10.1371/journal.pone.0212321

Tumor Cells - Scientific Sentence Examples

In this enhancement, the edges of the tumor cells and its dead cells are magnified efficiently. PDF


A novel prognosis and segmentation of necrosis (dead cells) in contrast enhanced T1‐weighted glioblastoma tumor with automatic contextual clustering 10.1002/ima.22295

Tumor Cells - Scientific Sentence Examples

Poorly functional tumor vessels inefficiently deliver chemotherapy to tumor cells; vessel hyper-permeability promotes chemotherapy delivery primarily to a tumor’s periphery. PDF

功能差的肿瘤血管效果低下递送到肿瘤细胞的化疗; 血管超渗透性促进化学疗法,主要递送到肿瘤的周边。

Modulating Sphingosine-1-Phosphate receptors to improve chemotherapy delivery to Ewing sarcoma 10.1101/805655

Tumor Cells - Scientific Sentence Examples

However, only a small fraction of cell-free DNA (cfDNA) fragments originate from tumor cells, requiring an ultra-sensitive method to detect MSI status from cfDNA. PDF


Evaluation of microsatellite instability testing through cell-free DNA sequencing 10.1093/annonc/mdz239.026

Tumor Cells - Scientific Sentence Examples

4); hence, NCs became cationic in the tumor area, what facilitates their internalization into tumor cells. PDF

4); 因此,NCS成为肿瘤区域的阳离子,有利于将其内化进入肿瘤细胞。

Novel polyurea/polyurethane nanocapsules loaded with a tambjamine analog to improve cancer chemotherapy delivery and safety in lung cancer 10.1093/annonc/mdz268.088

Tumor Cells - Scientific Sentence Examples

Meanwhile, the in vitro cytotoxicity assays indicated that these nanoparticles coencapsulated with PTX and Ce6 showed a combined cell-killing effect toward MDA-MB-231 tumor cells, exhibiting great potential for drug delivery systems that realize the synergistic chemo-photodynamic therapy for cancer treatment. PDF

同时,体外细胞毒性测定结果表明,与PTX和CE6的这些纳米颗粒载有朝向MDA-MB-231肿瘤细胞的组合细胞杀伤作用,对药物递送系统具有很大的潜力,该递送系统实现了癌症治疗的协同化学光动力学治疗 。

Synthesis of an Oxidation-Sensitive Polyphosphoester Bearing Thioether Group for Triggered Drug Release. 10.1021/acs.biomac.9b00101

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