Tumor Cells - Scientific Sentence Examples

Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling β1-integrins into large punctate clusters at the leading edge of tumor cells to promote an “adhesive switch,” decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes. PDF

这里,我们显示 NDRG4 调制 的 表观遗传 沉默 整联 通过在 肿瘤细胞 的前缘 组装 β1 整合素 成大 点状 簇 以促进 信令 “ 粘合剂 开关 , ” 减少 细胞粘附到 纤连蛋白和 增加 对 玻连蛋白 的细胞粘附和 迁移, 人淋巴结的重要组成部分。

NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients 10.1038/s41523-019-0106-x

Tumor Cells - Scientific Sentence Examples

Circulating tumor cells (CTCs) and cell-free DNA (cfDNA) were evaluated in 89 previously treated NSCLC patients receiving nivolumab. PDF

在89例接受Nivolumab的89例中,评估循环肿瘤细胞(CTCS)和无细胞DNA(CFDNA)。

Prognostic Relevance of Circulating Tumor Cells and Circulating Cell-Free DNA Association in Metastatic Non-Small Cell Lung Cancer Treated with Nivolumab 10.3390/jcm8071011

Tumor Cells - Scientific Sentence Examples

iRGD (CRGDK/RGPD/EC) is a kind of tumor-penetrating peptide which can contribute CNs to increasing cancer vascular and tissue permeability in a αv integrin and neuropilin1(expressing at the surface of tumor blood vessel endothelial cells and tumor cells)–dependent manner. PDF

IRGD(CRGDK / RGPD / EC)是一种肿瘤渗透肽,可贡献CNS以增加αv整合蛋白和神经疏松素1中的癌症血管和组织渗透率(在肿瘤血管内皮细胞和肿瘤细胞表面表达) - 依赖性 方式。

Curcumin nanocrystallites are an ideal nanoplatform for cancer chemotherapy 10.15761/fnn.1000186

Tumor Cells - Scientific Sentence Examples

Correlation of BRD4 binding and drug-mediated displacement at RNA Pol II pause sites with gene expression revealed a differential behavior of sensitive and resistant tumor cells to I-BET and identified a BRD4 signature at promoters of sensitive coding and non-coding genes. PDF

BRD4结合和药物介导位移在RNA POL II暂停位点与基因表达的相关性显示敏感和抗性肿瘤细胞对I-BET的差异行为,并在敏感编码和非编码基因的启动子鉴定了BRD4签名。

BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity 10.1186/s13072-019-0286-5

Tumor Cells - Scientific Sentence Examples

Complex 1 containing alanine inhibited the cell viability of A549 and K562 tumor cells by inducing apoptosis, as evidenced by an increased number of Annexin V-positive cells and the induction of DNA damage and cell cycle arrest. PDF

含有丙氨酸的复合物1通过诱导细胞凋亡抑制A549和K562肿瘤细胞的细胞活力,如吞咽蛋白V阳性细胞数量增加和DNA损伤和细胞循环骤停的诱导所证明。

Ru(II)-Based Amino Acid Complexes Show Promise for Leukemia Treatment: Cytotoxicity and Some Light on their Mechanism of Action 10.1007/s12011-019-01976-0

Tumor Cells - Scientific Sentence Examples

Together we substantiate the identification of novel lead molecules, which may provide a new treatment to overcome selectivity issues and enhance the radiosensitivity of tumor cells, opening a conceptually novel strategy of CDK-targeting for different cancer types. PDF

我们共同证实了新型铅分子的鉴定,这可能提供克服选择性问题的新待遇,提高肿瘤细胞的放射敏感性,开启不同癌症类型的CDK靶向靶向的新策略。

CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity. 10.1021/jacs.8b10207

Tumor Cells - Scientific Sentence Examples

Its overexpression is one of the main reasons for the multidrug resistance (MDR) of tumor cells. PDF

其过表达是肿瘤细胞多药抗性(MDR)的主要原因之一。

Exploring movement and energy in human P-glycoprotein conformational rearrangement 10.1080/07391102.2018.1461133

Tumor Cells - Scientific Sentence Examples

We found multiple correlations between parameters characterizing the immune profiles of tumor cells and TILs in both baseline and on-treatment samples. PDF

我们发现在基线和接受治疗样品中表征肿瘤细胞的免疫谱和直线的参数之间的多种相关性。

Abstract A154: Flow cytometric analysis of immune responses in the melanoma tissue biopsies before or during anti-PD1 immunotherapy 10.1158/2326-6074.CRICIMTEATIAACR18-A154

Tumor Cells - Scientific Sentence Examples

Our first-in-class NKp30xBCMA NK cells engager, CTX-4419, binds to BCMA on MM cells and to NKp30 and CD16A (FcγRIIIA) on NK cells, specifically redirecting NK cells towards tumor cells expressing BCMA. PDF

我们的第一级NKP30XBCMA NK细胞CTX-4419与BCMA粘合在MM细胞上并在NK细胞上与NKP30和CD16a(FCγRIIIA)结合,特别是将NK细胞重定向表达BCMA的肿瘤细胞。

Abstract 4972: Preclinical development of a first-in-class NKp30xBCMA NK cell engager for the treatment of multiple myeloma 10.1158/1538-7445.AM2019-4972

Tumor Cells - Scientific Sentence Examples

However, these methods are unable to eradicate tumor cells completely, and easily lead to the recurrence and progression of tumor. PDF

然而,这些方法不能完全消除肿瘤细胞,并且容易导致肿瘤的复发和进展。

[Function of tumor infiltrating lymphocytes in solid tumors - a review]. 10.13345/j.cjb.190300

Tumor Cells - Scientific Sentence Examples

Background: Tumor budding is defined as small cluster of tumor cells located at the invasive edge of tumor and was assumed to be linked with epithelial-mesenchymal transition (EMT), which is an early event in metastasis. PDF

背景:肿瘤芽定义为位于肿瘤的侵袭性边缘的小肿瘤细胞簇,并被假设与上皮 - 间充质转换(EMT)连接,这是转移的早期事件。

Evaluation of clinicopathologic significance of tumor budding in breast carcinoma 10.33545/PATHOL.2019.V2.I1C.25

Tumor Cells - Scientific Sentence Examples

The combination analysis of UHPLC-QTOF/MS and DESI-MSI revealed that the different molecular species of TGs were associated with tumor distribution and were useful for characterizing the progression of tumor cells and discovering prospective biomarkers. PDF

UHPLC-QTOF / MS和DESI-MSI的组合分析表明,不同的TGS的不同分子物种与肿瘤分布有关,可用于表征肿瘤细胞的进展并发现前瞻性生物标志物。

Identification of novel biomarkers of hepatocellular carcinoma by a high definition mass spectrometry; UHPLC-QTOF/MS and DESI-MSI. 10.1002/rcm.8551

Tumor Cells - Scientific Sentence Examples

PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor cells achieve their expression remains to be addressed. PDF

PD-L1和PD-L2是免疫检查点阻断的重要靶标,但肿瘤细胞如何实现其表达仍有待解决。

A Tumor-Specific Super-Enhancer Drives Immune Evasion by Guiding Synchronous Expression of PD-L1 and PD-L2. 10.1016/j.celrep.2019.10.093

Tumor Cells - Scientific Sentence Examples

In vitro, activities against B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), HL-60 (human promyelocytic leukemia) and K562 (human chronic myelocytic leukemia) and non-tumor cells: PBMC (human peripheral blood mononuclear cells activated with concanavalin A - human lymphoblast) were carried out. PDF

体外,针对B16-F10(小鼠黑色瘤),HepG2(人肝细胞癌),HL-60(人幼儿细胞白血病)和K562(人慢性骨髓细胞白血病)和非肿瘤细胞的活动:PBMC(人外周血单核细胞活化 进行了康丹林A - 人淋巴细胞)。

Ru(II) complexes containing uracil nucleobase analogs with cytotoxicity against tumor cells. 10.1016/j.jinorgbio.2019.110751

Tumor Cells - Scientific Sentence Examples

Immunohistochemical staing showed complete loss of SMARCA4 in tumor cells. PDF

免疫组织化学表现出肿瘤细胞中的Smarca4完全丧失。

Patients with SMARCA4-deficient thoracic sarcoma and severe skeletal-related events. 10.1016/J.LUNGCAN.2019.03.029

Tumor Cells - Scientific Sentence Examples

Additionally, cytotoxicity experiments showed that the Cur/FA-AmCS-TPP nanoparticles had good targeting ability for tumor cells. PDF

另外,细胞毒性实验表明,Cur / Fa-AMCS-TPP纳米颗粒具有良好的肿瘤细胞靶向能力。

Fabrication of Ion-Crosslinking Aminochitosan Nanoparticles for Encapsulation and Slow Release of Curcumin 10.3390/pharmaceutics11110584

Tumor Cells - Scientific Sentence Examples

The motion of circulating tumor cells (CTCs) in microcirculatory system is one of the critical steps during cancer metastasis. PDF

循环肿瘤细胞(CTC)在微循环系统中的运动是癌症转移期间的关键步骤之一。

Numerical Analysis of Motion and Stress Distribution of Circulating Tumor Cells in Micro Vessels 10.32604/mcb.2019.07111

Tumor Cells - Scientific Sentence Examples

Besides their direct activity against tumor cells, monoclonal antibodies and tyrosine kinase inhibitors (TKIs) also influence the antitumoral activity of immune cells, which has important implications for the design of immunotherapies. PDF

除了对肿瘤细胞的直接活动外,单克隆抗体和酪氨酸激酶抑制剂(TKI)还影响免疫细胞的抗肿瘤活性,这对免疫疗法的设计具有重要意义。

EGFR-Specific Tyrosine Kinase Inhibitor Modifies NK Cell-Mediated Antitumoral Activity against Ovarian Cancer Cells 10.3390/ijms20194693

Tumor Cells - Scientific Sentence Examples

VPS9D1-AS1/MEF2D and miR-4739 were inversely correlated in tumor cells. PDF

VPS9D1-AS1 / MEF2D和MIR-4739在肿瘤细胞中均相相关。

ZEB1 activated-VPS9D1-AS1 promotes the tumorigenesis and progression of prostate cancer by sponging miR-4739 to upregulate MEF2D. 10.1016/j.biopha.2019.109557

Tumor Cells - Scientific Sentence Examples

Conversely, the knocking down of GOLPH3 in GOLPH3-overexpressing tumor cells reduces tumorigenic features, such as cell proliferation and cell migration and invasion. PDF

相反,在GOLPH3过表达肿瘤细胞中敲击巨噬细胞的爆震减少了致瘤特征,例如细胞增殖和细胞迁移和侵袭。

The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner 10.1371/journal.pone.0212321

Tumor Cells - Scientific Sentence Examples

In this enhancement, the edges of the tumor cells and its dead cells are magnified efficiently. PDF

在这种增强中,有效地放大肿瘤细胞及其死细胞的边缘。

A novel prognosis and segmentation of necrosis (dead cells) in contrast enhanced T1‐weighted glioblastoma tumor with automatic contextual clustering 10.1002/ima.22295

Tumor Cells - Scientific Sentence Examples

Poorly functional tumor vessels inefficiently deliver chemotherapy to tumor cells; vessel hyper-permeability promotes chemotherapy delivery primarily to a tumor’s periphery. PDF

功能差的肿瘤血管效果低下递送到肿瘤细胞的化疗; 血管超渗透性促进化学疗法,主要递送到肿瘤的周边。

Modulating Sphingosine-1-Phosphate receptors to improve chemotherapy delivery to Ewing sarcoma 10.1101/805655

Tumor Cells - Scientific Sentence Examples

However, only a small fraction of cell-free DNA (cfDNA) fragments originate from tumor cells, requiring an ultra-sensitive method to detect MSI status from cfDNA. PDF

然而,只有一小部分的无细胞DNA(CFDNA)片段源自肿瘤细胞,需要超敏感方法来检测来自CFDNA的MSI状态。

Evaluation of microsatellite instability testing through cell-free DNA sequencing 10.1093/annonc/mdz239.026

Tumor Cells - Scientific Sentence Examples

4); hence, NCs became cationic in the tumor area, what facilitates their internalization into tumor cells. PDF

4); 因此,NCS成为肿瘤区域的阳离子,有利于将其内化进入肿瘤细胞。

Novel polyurea/polyurethane nanocapsules loaded with a tambjamine analog to improve cancer chemotherapy delivery and safety in lung cancer 10.1093/annonc/mdz268.088

Tumor Cells - Scientific Sentence Examples

Meanwhile, the in vitro cytotoxicity assays indicated that these nanoparticles coencapsulated with PTX and Ce6 showed a combined cell-killing effect toward MDA-MB-231 tumor cells, exhibiting great potential for drug delivery systems that realize the synergistic chemo-photodynamic therapy for cancer treatment. PDF

同时,体外细胞毒性测定结果表明,与PTX和CE6的这些纳米颗粒载有朝向MDA-MB-231肿瘤细胞的组合细胞杀伤作用,对药物递送系统具有很大的潜力,该递送系统实现了癌症治疗的协同化学光动力学治疗 。

Synthesis of an Oxidation-Sensitive Polyphosphoester Bearing Thioether Group for Triggered Drug Release. 10.1021/acs.biomac.9b00101

Highly Related Keywords from Tumor Cells