Molecular Cell
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Journal Impact IF




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Molecular Cell

The 2019-2020 Journal Impact IF of Molecular Cell is 15.584, which is just updated in 2020.

Molecular Cell Impact Factor
Highest IF
Highest Journal Impact IF

The highest Journal Impact IF of Molecular Cell is 15.584.

Lowest IF
Lowest Journal Impact IF

The lowest Journal Impact IF of Molecular Cell is 13.958.

Total Growth Rate
IF Total Growth Rate

The total growth rate of Molecular Cell IF is 9.9%.

Annual Growth Rate
IF Annual Growth Rate

The annual growth rate of Molecular Cell IF is 1.1%.

Journal Impact IF Ranking

Subcategory Quartile Rank Percentile
Cell Biology Q1 10/274

Cell Biology 96%

Molecular Biology Q1 10/381

Molecular Biology 97%

Journal Impact IF Ranking

· In the Cell Biology research field, the Quartile of Molecular Cell is Q1. Molecular Cell has been ranked #10 over 274 related journals in the Cell Biology research category. The ranking percentile of Molecular Cell is around 96% in the field of Cell Biology.
· In the Molecular Biology research field, the Quartile of Molecular Cell is Q1. Molecular Cell has been ranked #10 over 381 related journals in the Molecular Biology research category. The ranking percentile of Molecular Cell is around 97% in the field of Molecular Biology.

Molecular Cell Impact Factor 2020-2021 Prediction

Molecular Cell Impact Factor Predition System

Molecular Cell Impact Factor Prediction System is now online. You can start share your valuable insights with the community.

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Total Publications
Total Citations

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Journal Impact IF History

Year Journal Impact IF
Year Journal Impact IF
2019-2020 15.584
2018-2019 14.548
2017-2018 14.248
2016-2017 14.714
2015-2016 13.958
2014-2015 14.018
2013-2014 14.464
2012-2013 15.28
2011-2012 14.178
Journal Impact IF History

· The 2019-2020 Journal Impact IF of Molecular Cell is 15.584
· The 2018-2019 Journal Impact IF of Molecular Cell is 14.548
· The 2017-2018 Journal Impact IF of Molecular Cell is 14.248
· The 2016-2017 Journal Impact IF of Molecular Cell is 14.714
· The 2015-2016 Journal Impact IF of Molecular Cell is 13.958
· The 2014-2015 Journal Impact IF of Molecular Cell is 14.018
· The 2013-2014 Journal Impact IF of Molecular Cell is 14.464
· The 2012-2013 Journal Impact IF of Molecular Cell is 15.28
· The 2011-2012 Journal Impact IF of Molecular Cell is 14.178

Publications Cites Dataset

Year Publications Citations
Year Publications Citations
1994 0 2
1997 18 25
1998 195 1439
1999 194 6298
2000 253 11634
2001 269 17938
2002 348 24472
2003 360 30434
2004 369 37644
2005 348 42939
2006 365 49044
2007 363 53035
2008 355 57076
2009 374 63475
2010 386 71845
2011 373 77401
2012 369 86111
2013 366 91213
2014 365 91592
2015 406 89092
2016 394 88904
2017 390 93570
2018 387 86792
2019 417 99588
2020 444 122315
2021 36 8536
Publications Cites Dataset

· The Molecular Cell has published 0 reports and received 2 citations in 1994.
· The Molecular Cell has published 18 reports and received 25 citations in 1997.
· The Molecular Cell has published 195 reports and received 1439 citations in 1998.
· The Molecular Cell has published 194 reports and received 6298 citations in 1999.
· The Molecular Cell has published 253 reports and received 11634 citations in 2000.
· The Molecular Cell has published 269 reports and received 17938 citations in 2001.
· The Molecular Cell has published 348 reports and received 24472 citations in 2002.
· The Molecular Cell has published 360 reports and received 30434 citations in 2003.
· The Molecular Cell has published 369 reports and received 37644 citations in 2004.
· The Molecular Cell has published 348 reports and received 42939 citations in 2005.
· The Molecular Cell has published 365 reports and received 49044 citations in 2006.
· The Molecular Cell has published 363 reports and received 53035 citations in 2007.
· The Molecular Cell has published 355 reports and received 57076 citations in 2008.
· The Molecular Cell has published 374 reports and received 63475 citations in 2009.
· The Molecular Cell has published 386 reports and received 71845 citations in 2010.
· The Molecular Cell has published 373 reports and received 77401 citations in 2011.
· The Molecular Cell has published 369 reports and received 86111 citations in 2012.
· The Molecular Cell has published 366 reports and received 91213 citations in 2013.
· The Molecular Cell has published 365 reports and received 91592 citations in 2014.
· The Molecular Cell has published 406 reports and received 89092 citations in 2015.
· The Molecular Cell has published 394 reports and received 88904 citations in 2016.
· The Molecular Cell has published 390 reports and received 93570 citations in 2017.
· The Molecular Cell has published 387 reports and received 86792 citations in 2018.
· The Molecular Cell has published 417 reports and received 99588 citations in 2019.
· The Molecular Cell has published 444 reports and received 122315 citations in 2020.
· The Molecular Cell has published 36 reports and received 8536 citations in 2021.
· The total publications of Molecular Cell is 8145.
· The total citations of Molecular Cell is 1402414.

What is Impact Factor?

The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly average number of citations of articles published in the last two years in a given journal. It is frequently used as a proxy for the relative importance of a journal within its field; journals with higher impact factor values are often deemed to be more important, or carry more intrinsic prestige in their respective fields, than those with lower values.

Molecular Cell | Academic Accelerator - About the Impact Factor

Impact factor is commonly used to evaluate the relative importance of a journal within its field and to measure the frequency with which the “average article” in a journal has been cited in a particular time period. Journal which publishes more review articles will get highest IFs. Journals with higher IFs believed to be more important than those with lower ones. According to Eugene Garfield “impact simply reflects the ability of the journals and editors to attract the best paper available.” Journal which publishes more review articles will get maximum IFs. The Impact Factor of an academic journal is a scientometric Metric that reflects the yearly average number of citations that recent articles published in a given journal received. It is frequently used as a Metric for the relative importance of a journal within its field; journals with higher Impact Factor are often deemed to be more important than those with lower ones. The Molecular Cell Impact Factor IF measures the average number of citations received in a particular year (2020) by papers published in the Molecular Cell during the two preceding years (2018-2019). Note that 2020 Impact Factor are reported in 2021; they cannot be calculated until all of the 2020 publications have been processed by the indexing agency. New journals, which are indexed from their first published issue, will receive an impact factor after two years of indexing; in this case, the citations to the year prior to Volume 1, and the number of articles published in the year prior to Volume 1, are known zero values. Journals that are indexed starting with a volume other than the first volume will not get an impact factor until they have been indexed for three years. Occasionally, Journal Citation Reports assigns an impact factor to new journals with less than two years of indexing, based on partial citation data. The calculation always uses two complete and known years of item counts, but for new titles one of the known counts is zero. Annuals and other irregular publications sometimes publish no items in a particular year, affecting the count. The impact factor relates to a specific time period; it is possible to calculate it for any desired period. In addition to the 2-year Impact Factor, the 3-year Impact Factor, 4-year Impact Factor, 5-year Impact Factor, Real-Time Impact Factor can provide further insights and factors into the impact of Molecular Cell.


The impact factor was devised by Eugene Garfield, the founder of the Institute for Scientific Information (ISI). Impact factors are calculated yearly starting from 1975 for journals listed in the Journal Citation Reports (JCR). ISI was acquired by Thomson Scientific & Healthcare in 1992, and became known as Thomson ISI. In 2018, Thomson ISI was sold to Onex Corporation and Baring Private Equity Asia. They founded a new corporation, Clarivate, which is now the publisher of the JCR.


The impact factor is used to compare different journals within a certain field. The Web of Science indexes more than 11,500 science and social science journals. Journal impact factors are often used to evaluate the merit of individual articles and individual researchers. This use of impact factors was summarised by Hoeffel:

Impact Factor is not a perfect tool to measure the quality of articles but there is nothing better and it has the advantage of already being in existence and is, therefore, a good technique for scientific evaluation. Experience has shown that in each specialty the best journals are those in which it is most difficult to have an article accepted, and these are the journals that have a high impact factor. Most of these journals existed long before the impact factor was devised. The use of impact factor as a measure of quality is widespread because it fits well with the opinion we have in each field of the best journals in our specialty....In conclusion, prestigious journals publish papers of high level. Therefore, their impact factor is high, and not the contrary.

Eugene Garfield

In brief, Impact factors may be used by:
  • Authors to decide where to submit an article for publication.
  • Libraries to make collection development decisions
  • Academic departments to assess academic productivity
  • Academic departments to make decisions on promotion and tenure.
As impact factors are a journal-level metric, rather than an article- or individual-level metric, this use is controversial. Garfield agrees with Hoeffel,but warns about the "misuse in evaluating individuals" because there is "a wide variation [of citations] from article to article within a single journal". Other things to consider about Impact Factors:
  • Many journals do not have an impact factor.
  • The impact factor cannot assess the quality of individual articles. Even if citations were evenly distributed among articles, the impact factor would only measure the interests of other researchers in an article, not its importance and usefulness.
  • Only research articles, technical notes and reviews are “citable” items. Editorials, letters, news items and meeting abstracts are “non-citable items”.
  • Only a small percentage of articles are highly cited and they are found in a small subset of journals. This small proportion accounts for a large percentage of citations.
  • Controversial papers, such as those based on fraudulent data, may be highly cited, distorting the impact factor of a journal.
  • Citation bias may exist. For example, English language resources may be favoured. Authors may cite their own work.
Moreover, informed and careful use of these impact data is essential, and should be based on a thorough understanding of the methodology used to generate impact factors. There are controversial aspects of using impact factors:
  • It is not clear whether the number of times a paper is cited measures its actual quality.
  • Some databases that calculate impact factors fail to incorporate publications including textbooks, handbooks and reference books.
  • Certain disciplines have low numbers of journals and usage. Therefore, one should only compare journals or researchers within the same discipline.
  • Review articles normally are cited more often and therefore can skew results.
  • Self-citing may also skew results.
  • Some resources used to calculate impact factors have inadequate international coverage.
  • Editorial policies can artificially inflate an impact factor.
Impact factors have often been used in advancement and tenure decision-making. Many recognize that this is a coarse tool for such important decisions, and that a multitude of factors should be taken into account in these deliberations. When considering the use of the impact factor (IF), keep these aspects in mind:
  • IF analysis is limited to citations from the journals indexed by the Web of Science/Web of Knowledge. Currently, the Web of Science indexes only 8621 journals across the full breadth of the sciences, and just 3121 in the social sciences.
  • A high IF/citation rate says nothing about the quality -- or even, validity -- of the references being cited. Notorious or even retracted articles often attract a lot of attention, hence a high number of citations. The notority related to the first publication on "cold fusion" is one such example.
  • Journals that publish more "review articles" are often found near the top of the rankings. While not known for publishing new, creative findings, these individual articles tend to be heavily cited.
  • The IF measures the average number of citations to articles in the journal -- given this, a small number of highly-cited articles will skew the figure.
  • It takes several years for new journals to be added to the list of titles indexed by the Web of Science/Web of Knowledge, so these newer titles will be under-represented.
  • It's alleged that journal editors have learned to "game" the system, encouraging authors to cite their works previously published in the same journal.
Comparing Journals Across Disciplines? Not a good idea! Using Impact Factors within a given discipline should only be done with great care, as described above. Using impact factor data to compare journals across disciplines is even more problematic. Here are some of the reasons:
  • Disciplines where older literature is still referenced, such as Chemistry and Mathematics, offer challenges to the methodolgy since older citations (older than two years) are not used to calculate the impact factor for a given journal. (Five-year impact factor analysis, which can be calculated using the Journal Citation Index database, helps smooth out this problem only to some degree.)
  • Different disciplines have different practices regarding tendency to cite larger numbers of references. Higher overall citation rates will bump upward impact factor measurements.
  • Where it's common for large numbers of authors to collaborate on a single paper, such as in Physics, the tendency of authors to cite themselves (and in this case, more authors) will result in increased citation rates.

Pros and Cons of the Impact Factor


  • A vetted, established metric for measuring journal impact within a discipline.
  • Designed to eliminate bias based on journal size and frequency.
  • Individual articles makes an uneven contribution to overall Impact Factor.
  • Impact Factor does not account for certain things, things like context (postive or negative citaion) and intentionality (self-citation).
  • The metric is proprietary to and bound by the contents of the Thomson Reuters database.
  • Citations, on which the Impact Factor is based, count for less than 1% of an article's overall use.


Numerous critiques have been made regarding the use of impact factors. A 2007 study noted that the most fundamental flaw is that impact factors present the mean of data that are not normally distributed, and suggested that it would be more appropriate to present the median of these data. There is also a more general debate on the validity of the impact factor as a measure of journal importance and the effect of policies that editors may adopt to boost their impact factor (perhaps to the detriment of readers and writers). Other criticism focuses on the effect of the impact factor on behavior of scholars, editors and other stakeholders. Others have made more general criticisms, arguing that emphasis on impact factor results from negative influence of neoliberal policies on academia claiming that what is needed is not just replacement of the impact factor with more sophisticated metrics for science publications but also discussion on the social value of research assessment and the growing precariousness of scientific careers in higher education.
Experts stress that there are limitations in using impact factors to evaluate a scholar's work. There are many reasons cited for not relying on impact factor alone to evaluate the output of a particular individual. Among these are the following:

  • A single factor is not sufficient for evaluating an author's work.
  • Journal values are meaningless unless compared within the same discipline. Impact factors vary among disciplines.
  • The impact factor was originally devised to show the impact of a specific journal, not a specific scholar. The quality and impact of the author's work may extend beyond the impact of a particular journal.
According to Jim Testa, a researcher for ThomsonReuters Scientific, the most widespread misuse of the Impact Factor is to evaluate the work of an individual author (instead of a journal). "To say that because a researcher is publishing in a certain journal, he or she is more influential or deserves more credit is not necessarily true. There are many other variables to consider." (interview 6/26/2008 in Thomson Reuters blog entry)

Molecular Cell
Journal Profile


Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly, Molecular Cell defines the field of molecular biology with a relatively small number of significant papers, up to 15 articles per issue. Coverage will extend from structure to human diseases, concentrating on molecular analyses. Topics that will be represented in the first issues include gene expression, RNA processing, replication, recombination and repair, structure, chaperones, receptors, signal transduction, cell cycle, and tumorigenesis. Molecular Cell is a peer-reviewed scientific journal that covers research on cell biology at the molecular level, with an emphasis on new mechanistic insights. It was established in 1997 and is published two times per month. Its 2018 impact factor is 14.548.

Highly Cited Keywords


The ISSN of Molecular Cell is 1097-2765 . An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media–print and electronic.

ISSN (Online)
ISSN (Online)

The ISSN (Online) of Molecular Cell is 1097-4164 . An ISSN is an 8-digit code used to identify newspapers, journals, magazines and periodicals of all kinds and on all media–print and electronic.

Cell Press

Molecular Cell is published by Cell Press .

Publication Frequency
Publication Frequency

Molecular Cell publishes reports Monthly .

1997 - Present

The Publication History of Molecular Cell covers 1997 - Present .

Open Access
Open Access

Molecular Cell is Subscription-based (non-OA) Journal. Publishers own the rights to the articles in their journals. Anyone who wants to read the articles should pay by individual or institution to access the articles. Anyone who wants to use the articles in any way must obtain permission from the publishers.

Publication Fee
Publication Fee

There is no publication fee for submiting manuscript to Molecular Cell. Molecular Cell is Subscription-based (non-OA) Journal. Publishers own the rights to the articles in their journals. Anyone who wants to read the articles should pay by individual or institution to access the articles.


The language of Molecular Cell is English .

United States

The publisher of Molecular Cell is Cell Press , which locates in United States .

Selected Articles

Full Title Authors
Full Title Authors
Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery Yahli Lorch · Barbara Maier-Davis · Roger D. Kornberg · Roger D. Kornberg
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing Silvia Escudero · Elma Zaganjor · Susan Lee · Christopher P. Mill · Ann M. Morgan · Emily B. Crawford · Jiahao Chen · Thomas E. Wales · Rida Mourtada · James Luccarelli · Gregory H. Bird · Ulrich Steidl · John R. Engen · Marcia C. Haigis · Joseph T. Opferman · Loren D. Walensky · Loren D. Walensky
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding Bomyi Lim · Tyler Heist · Michael S. Levine · Takashi Fukaya · Takashi Fukaya
SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylate Julia K. Nussbacher · Gene W. Yeo · Gene W. Yeo
The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel Yusuke Tarumoto · Bin Lu · Tim D.D. Somerville · Yu-Han Huang · Joseph P. Milazzo · Xiaoli S. Wu · Xiaoli S. Wu · Olaf Klingbeil · Osama El Demerdash · Junwei Shi · Christopher R. Vakoc · Christopher R. Vakoc
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD Siming Chen · Lianying Jiao · Murtada Shubbar · Xin Yang · Xin Liu · Xin Liu
LIN28 Selectively Modulates a Subclass of Let-7 MicroRNAs Xiaoyu Li · Xushen Xiong · Meiling Zhang · Kun Wang · Ying Chen · Jun Zhou · Yuanhui Mao · Jia Lv · Danyang Yi · Xiao-Wei Chen · Chu Wang · Shu-Bing Qian · Chengqi Yi · Chengqi Yi
Impeding DNA Break Repair Enables Oocyte Quality Control Daniel C. Scott · Brenda A. Schulman · Brenda A. Schulman · Brenda A. Schulman
Sequence, Structure, and Context Preferences of Human RNA Binding Proteins Ying-Chou Chen · Fahim Farzadfard · Nava Gharaei · William W. Chen · Jicong Cao · Timothy K. Lu · Timothy K. Lu
CDK and MAPK Synergistically Regulate Signaling Dynamics via a Shared Multi-site Phosphorylation Region on the Scaffold Protein Ste5 Soung-Hun Roh · Soung-Hun Roh · Nicholas J. Stam · Corey F. Hryc · Sergio Couoh-Cardel · Grigore Pintilie · Wah Chiu · Wah Chiu · Wah Chiu · Stephan Wilkens · Stephan Wilkens
RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing Huanyu Qiao · Huanyu Qiao · H.B.D. Prasada Rao · H.B.D. Prasada Rao · Yan Yun · Yan Yun · Sumit Sandhu · Sumit Sandhu · Jared H. Fong · Jared H. Fong · Manali Sapre · Manali Sapre · Michael Nguyen · Michael Nguyen · Addy Tham · Addy Tham · Benjamin W. Van · Benjamin W. Van · Tiffany Y.H. Chng · Tiffany Y.H. Chng · Amy E. Lee · Amy E. Lee · Neil Hunter · Neil Hunter
Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels Hayun Lee · Yi Zhou · David W. Taylor · Dipali G. Sashital · Dipali G. Sashital
Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus María Victoria Repetto · María Victoria Repetto · Matthew J. Winters · Alan Bush · Alan Bush · Wolfgang Reiter · David Maria Hollenstein · Gustav Ammerer · Peter M. Pryciak · Alejandro Colman-Lerner · Alejandro Colman-Lerner · Alejandro Colman-Lerner
Accessibility of the Shine-Dalgarno Sequence Dictates N-Terminal Codon Bias in E. coli Nadine M. Shaban · Ke Shi · Kate V. Lauer · Michael A. Carpenter · Christopher M. Richards · Daniel J. Salamango · Jiayi Wang · Michael W. Lopresti · Surajit Banerjee · Rena Levin-Klein · William L. Brown · Hideki Aihara · Reuben S. Harris · Reuben S. Harris
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein Tao Zhang · Yen Ching Wu · Patrick Mullane · Yon Ju Ji · H.-X. L. Liu · Lu He · Amit Arora · Ho Yon Hwang · Amelia F. Alessi · Amirhossein Ghanbari Niaki · Goran Periz · Lin Guo · Hejia Wang · Elad Elkayam · Leemor Joshua-Tor · Sua Myong · John Kim · James Shorter · Shao En Ong · Anthony K. L. Leung · Jiou Wang · Jiou Wang
Protein Dynamics in Complex DNA Lesions Jin Young Kang · Tatiana V. Mishanina · Michael J. Bellecourt · Rachel A. Mooney · Seth A. Darst · Robert Landick · Robert Landick
The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism Wei Wan · Zhiyuan You · Yinfeng Xu · Li Zhou · Zhunlv Guan · Chao Peng · Catherine C. L. Wong · Hua Su · Tianhua Zhou · Hongguang Xia · Wei Liu · Wei Liu
Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability Xiang Qiu · Gita Kumari · Tatiana Gerasimova · Hansen Du · Lawal Labaran · Amit Singh · Supriyo De · William H. Wood · Kevin G. Becker · Weiqiang Zhou · Hongkai Ji · Ranjan Sen · Ranjan Sen
Inter-chromosomal Contact Properties in Live-Cell Imaging and in Hi-C Winston X. Yan · Shaorong Chong · Huaibin Zhang · Kira S. Makarova · Eugene V. Koonin · David R. Cheng · David Arthur Scott · David Arthur Scott
Genomic Copy-Number Loss Is Rescued by Self-Limiting Production of DNA Circles Radoslav Aleksandrov · Anton Dotchev · Ina Poser · Dragomir B. Krastev · Georgi Georgiev · Greta Panova · Yordan Babukov · Yordan Babukov · Georgi Danovski · Teodora Dyankova · Lars Hubatsch · Aneliya Ivanova · Aleksandar Atemin · Marina N. Nedelcheva-Veleva · Susanne Hasse · Mihail Sarov · Frank Buchholz · Frank Buchholz · Anthony A. Hyman · Stephan W. Grill · Stoyno S. Stoynov · Stoyno S. Stoynov
LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia Gundula Streubel · Gundula Streubel · Ariane Watson · Sri Ganesh Jammula · Andrea Scelfo · Darren J. Fitzpatrick · Giorgio Oliviero · Rachel McCole · Eric Conway · Eleanor Glancy · Gian Luca Negri · Eugene Dillon · Kieran Wynne · Diego Pasini · Diego Pasini · Nevan J. Krogan · Nevan J. Krogan · Adrian P. Bracken · Gerard Cagney · Gerard Cagney
Visualization of Transvection in Living Drosophila Embryos Hijai R. Shin · Roberto Zoncu · Roberto Zoncu
Maintaining a Healthy Proteome during Oxidative Stress Yogitha Thattikota · Yogitha Thattikota · Sylvain Tollis · Sylvain Tollis · Roger Palou · Justine Vinet · Mike Tyers · Damien D’Amours · Damien D’Amours · Damien D’Amours
Galectins Control mTOR in Response to Endomembrane Damage Min Sung Kim · Min Sung Kim · W Chuenchor · X Chen · Y Cui · X Zhang · X Zhang · Z.H Zhou · M Gellert · Wei Yang · Wei Yang
α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies Constantin Cretu · Anant A. Agrawal · Andrew Cook · Cindy L. Will · Peter Fekkes · P.G.R. Smith · Reinhard Lührmann · Nicholas Larsen · Silvia Buonamici · Vladimir Pena · Vladimir Pena
Separating Actin-Dependent Chemokine Receptor Nanoclustering from Dimerization Indicates a Role for Clustering in CXCR4 Signaling and Function Hyeshik Chang · Jinah Yeo · Jeong-gyun Kim · Hyunjoon Kim · Jaechul Lim · Mihye Lee · Hyun Ho Kim · Jiyeon Ohk · Hee-Yeon Jeon · Hyunsook Lee · Hosung Jung · Kyu-Won Kim · V. Narry Kim · V. Narry Kim
MitoCPR: Meticulous Monitoring of Mitochondrial Proteostasis Chen Cheng Lee · Shih Huan Peng · Shih Huan Peng · Li Shen · Chung Fan Lee · Ting Huei Du · Ming Lun Kang · Guoliang Xu · Anup K. Upadhyay · Xiaodong Cheng · Xiaodong Cheng · Yu Ting Yan · Yi Zhang · Li-Jung Juan · Li-Jung Juan
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site Scott C. Blanchard · Scott C. Blanchard
Capturing the Onset of PRC2-Mediated Repressive Domain Formation Nadra Al-Husini · Dylan T. Tomares · Obaidah Bitar · W. Seth Childers · Jared M. Schrader · Jared M. Schrader
A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation Laura Martínez-Muñoz · José Miguel Rodríguez-Frade · Rubén Barroso · Carlos Oscar S. Sorzano · Juan A. Torreno-Pina · César Santiago · Carlo Manzo · Pilar Lucas · Eva M. García-Cuesta · Enric Gutierrez · Laura Barrio · Javier Vargas · Javier Vargas · Graciela Cascio · Yolanda R. Carrasco · Francisco Sánchez-Madrid · Maria F. Garcia-Parajo · Mario Mellado · Mario Mellado
Cracking the DNA Code for V(D)J Recombination Lucile Pantel · Tanja Florin · Malgorzata Dobosz-Bartoszek · Emilie Racine · Matthieu Sarciaux · Marine Serri · Jessica Houard · Jean-Marc Campagne · Renata Marcia de Figueiredo · Camille Midrier · Alain Givaudan · Anne Lanois · Steve Forst · André Aumelas · Christelle Cotteaux-Lautard · Jean-Michel Bolla · Carina Vingsbo Lundberg · Douglas L. Huseby · Diarmaid Hughes · Philippe Villain-Guillot · Alexander S. Mankin · Yury S. Polikanov · Maxime Gualtieri · Maxime Gualtieri
Injury Activates Ca2+/Calmodulin-Dependent Phosphorylation of JAV1-JAZ8-WRKY51 Complex for Jasmonate Biosynthesis Yan Zhang · David H. Burkhardt · Silvi Rouskin · Gene-Wei Li · Jonathan S. Weissman · Carol A. Gross · Carol A. Gross
In a Class of Its Own: A New Family of Deubiquitinases Promotes Genome Stability Alise J. Ponsero · Aeid Igbaria · Maxwell A. Darch · Samia Miled · Caryn E. Outten · Jakob R. Winther · Gaël Palais · Benoit D’Autréaux · Agnès Delaunay-Moisan · Michel B. Toledano · Michel B. Toledano
The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells Eric Conway · Emilia Jerman · Evan Healy · Shinsuke Ito · Daniel Holoch · Giorgio Oliviero · Orla Deevy · Eleanor Glancy · Darren J. Fitzpatrick · Marlena Mucha · Ariane Watson · Alan M. Rice · Paul Chammas · Christine S. Huang · Indigo Pratt-Kelly · Manabu Nakayama · Tomoyuki Ishikura · Gundula Streubel · Kieran Wynne · Karsten Hokamp · Aoife McLysaght · Claudio Ciferri · Luciano Di Croce · Gerard Cagney · Raphaël Margueron · Haruhiko Koseki · Adrian P. Bracken · Adrian P. Bracken
JMJD6 Licenses ERα-Dependent Enhancer and Coding Gene Activation by Modulating the Recruitment of the CARM1/MED12 Co-activator Complex Chun Yan · Meng Fan · Mai Yang · Jinping Zhao · Wenhao Zhang · Yi Su · Langtao Xiao · Haiteng Deng · Daoxin Xie · Daoxin Xie
Mechanistic View and Genetic Control of DNA Recombination during Meiosis Sohail Malik · Robert G. Roeder · Robert G. Roeder
Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5′ Promoters in Yeast Jingyue Jia · Yakubu Princely Abudu · Aurore Claude-Taupin · Yuexi Gu · Suresh Kumar · Seong Won Choi · Ryan Peters · Michal H. Mudd · Lee Allers · Michelle Salemi · Brett S. Phinney · Terje Johansen · Vojo Deretic · Vojo Deretic
Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site Kate E. Coleman · Tony T. Huang · Tony T. Huang
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities Wei-wei Gao · Rong-quan Xiao · Wen-juan Zhang · Yiren Hu · Bing-ling Peng · Wen-juan Li · Yao-hui He · Hai-feng Shen · Jian-cheng Ding · Qi-xuan Huang · Tian-yi Ye · Ying Li · Zhi-ying Liu · Rong Ding · Michael G. Rosenfeld · Wen Liu · Wen Liu
Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage Yashpal Rawal · Răzvan V. Chereji · Vishalini Valabhoju · Hongfang Qiu · Josefina Ocampo · David J. Clark · Alan G. Hinnebusch · Alan G. Hinnebusch
Cas4-Dependent Prespacer Processing Ensures High-Fidelity Programming of CRISPR Arrays Kristoffer S. Winther · Mohammad Roghanian · Kenn Gerdes · Kenn Gerdes
Rapid and Scalable Characterization of CRISPR Technologies Using an E. coli Cell-Free Transcription-Translation System Daniela M. Arduino · Jennifer Wettmarshausen · Horia Vais · Paloma Navas-Navarro · Yiming Cheng · Anja Leimpek · Zhongming Ma · Alba Delrio-Lorenzo · Andrea Giordano · Cecilia Garcia-Perez · Guillaume Médard · Bernhard Kuster · Bernhard Kuster · Javier García-Sancho · Dejana Mokranjac · J. Kevin Foskett · M. Teresa Alonso · Fabiana Perocchi · Fabiana Perocchi
Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior Kuang Shen · Abigail Choe · David M. Sabatini · David M. Sabatini
Systematic Characterization of Stress-Induced RNA Granulation Dominika Kwasna · Syed Arif Abdul Rehman · Jayaprakash Natarajan · Stephen P. Matthews · Ross Madden · Virginia De Cesare · Simone Weidlich · Satpal Virdee · Ivan Ahel · Ian Gibbs-Seymour · Yogesh Kulathu · Yogesh Kulathu
No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases Philipp G. Maass · A. Rasim Barutcu · A. Rasim Barutcu · Catherine L. Weiner · Catherine L. Weiner · John L. Rinn · John L. Rinn
Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation Alexander Harms · Ditlev E. Brodersen · Ditlev E. Brodersen · Namiko Mitarai · Kenn Gerdes · Kenn Gerdes
Beyond the Histone Code: A Physical Map of Chromatin States Sonya E. Neal · Philipp A. Jaeger · Sascha H.C. Duttke · Christopher Benner · Christopher K. Glass · Trey Ideker · Randolph Y. Hampton · Randolph Y. Hampton
Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters Jinlong Wang · Lauren E. Grubb · Jiayu Wang · Xiangxiu Liang · Lin Li · Chulei Gao · Miaomiao Ma · Feng Feng · Meng Li · Lei Li · Xiaojuan Zhang · Feifei Yu · Qi Xie · She Chen · Cyril Zipfel · Jacqueline Monaghan · Jian-Min Zhou · Jian-Min Zhou
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function Netta Shemesh · Anat Ben-Zvi · Anat Ben-Zvi
The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins David Jee · David Jee · Jr-Shiuan Yang · Jr-Shiuan Yang · Sun-Mi Park · D’Juan T. Farmer · Jiayu Wen · Timothy Chou · Arthur Chow · Michael T. McManus · Michael G. Kharas · Eric C. Lai · Eric C. Lai · Eric C. Lai
A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase Denisse Sepulveda · Diego Rojas-Rivera · Diego A. Rodriguez · Diego A. Rodriguez · Jody Groenendyk · Andrés Kohler · Cynthia Lebeaupin · Shinya Ito · Hery Urra · Amado Carreras-Sureda · Younis M. Hazari · Mireille Vasseur-Cognet · Maruf M.U. Ali · Eric Chevet · Gisela Campos · Patricio Godoy · Tomas Vaisar · Béatrice Bailly-Maitre · Kazuhiro Nagata · Marek Michalak · Jimena Sierralta · Claudio Hetz · Claudio Hetz
No Excess Baggage: New Life Starts with a Clean Slate Priyanka Sahasrabudhe · Julia Rohrberg · Maximillian M. Biebl · Daniel A. Rutz · Johannes Buchner · Johannes Buchner
Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals Richard A. Young · Richard A. Young
Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α Logan R. Myler · Ignacio F. Gallardo · Michael M. Soniat · Rajashree A. Deshpande · Xenia B. Gonzalez · Yoori Kim · Tanya T. Paull · Ilya J. Finkelstein · Ilya J. Finkelstein
Bacterial RNA Biology on a Genome Scale Lydia Lamriben · Daniel N. Hebert · Daniel N. Hebert
N6-Methyladenine DNA Modification in the Human Genome Vera D. Rinaldi · Ewelina Bolcun-Filas · Hiroshi Kogo · Hiroki Kurahashi · John C. Schimenti · John C. Schimenti
Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed? Clayton Schwarz · Amy Johnson · Mardo Kõivomägi · Evgeny Zatulovskiy · Carolyn J. Kravitz · Andreas Doncic · Jan M. Skotheim · Jan M. Skotheim
Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology Shinichi Machida · Yoshimasa Takizawa · Masakazu Ishimaru · Yukihiko Sugita · Satoshi Sekine · Jun-ichi Nakayama · Matthias Wolf · Hitoshi Kurumizaka · Hitoshi Kurumizaka
Activating and Repressing IRE1α: The Hsp47 and BiP Tug of War Ana María León-Ortiz · Stephanie Panier · Grzegorz Sarek · Jean-Baptiste Vannier · Harshil Patel · Peter J. Campbell · Simon J. Boulton · Simon J. Boulton
A Precise Cdk Activity Threshold Determines Passage through the Restriction Point Philipp A. Jaeger · Lilia Ornelas · Cameron McElfresh · Lily R. Wong · Randolph Y. Hampton · Trey Ideker · Trey Ideker
Structural Basis of Heterochromatin Formation by Human HP1 Axel Mogk · Bernd Bukau · Harm H. Kampinga · Harm H. Kampinga
A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination Ji-Young Youn · Wade H. Dunham · Seo Jung Hong · James D.R. Knight · Mikhail Bashkurov · Ginny I. Chen · Ginny I. Chen · Halil Bagci · Bhavisha Rathod · Graham MacLeod · Simon W. M. Eng · Stephane Angers · Quaid Morris · Marc R. Fabian · Marc R. Fabian · Jean-François Côté · Anne-Claude Gingras · Anne-Claude Gingras · Anne-Claude Gingras
Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping Dana Reichmann · Wilhelm Voth · Ursula Jakob · Ursula Jakob
Cellular Handling of Protein Aggregates by Disaggregation Machines Kathryn Wolhuter · Harry Whitwell · Christopher H. Switzer · Joseph R. Burgoyne · John F. Timms · Philip Eaton · Philip Eaton
Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals Lixin Wan · Kexin Xu · Kexin Xu · Yongkun Wei · Jinfang Zhang · Tao Han · Christopher J Fry · Zhao Zhang · Yao Vickie Wang · Liyu Huang · Liyu Huang · Min Yuan · Weiya Xia · Wei-Chao Chang · Wen-Chien Huang · Chien-Liang Liu · Yuan-Ching Chang · Jinsong Liu · Yun Wu · Victor X. Jin · Xiangpeng Dai · Jianfeng Guo · Jianfeng Guo · Jia Liu · Jia Liu · Shulong Jiang · Jin Li · John M. Asara · Myles Brown · Myles Brown · Mien Chie Hung · Mien Chie Hung · Wenyi Wei · Wenyi Wei
Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter Christopher Grunseich · Isabel X. Wang · Jason A. Watts · Joshua T. Burdick · Robert D. Guber · Zhengwei Zhu · Alan Bruzel · Tyler Lanman · Ke-lian Chen · Alice B. Schindler · Nancy A. Edwards · Abhik Ray-Chaudhury · Jianhua Yao · Tanya J. Lehky · Grzegorz Piszczek · Barbara J. Crain · Kenneth H. Fischbeck · Vivian G. Cheung · Vivian G. Cheung · Vivian G. Cheung
Glutamate Dehydrogenase to the Rescue Iva Tchasovnikarova · Robert E. Kingston · Robert E. Kingston
Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3) Nilay Shah · Muhammad Ahmad Maqbool · Yousra Yahia · Amal Zine El Aabidine · Cyril Esnault · Ignasi Forné · Tim-Michael Decker · David Martin · Roland Schüller · Stefan Krebs · Helmut Blum · Axel Imhof · Dirk Eick · Jean-Christophe Andrau · Jean-Christophe Andrau
Lamins organize the global three-dimensional genome from the nuclear periphery Ann Boija · Dig Bijay Mahat · Aman Zare · Per Henrik Holmqvist · Philge Philip · David J. Meyers · Philip A. Cole · John T. Lis · Per Stenberg · Per Stenberg · Mattias Mannervik · Mattias Mannervik
Ubiquilin 2: Shuttling Clients Out of Phase? Andres Mansisidor · Temistocles Molinar · Priyanka Srivastava · Demetri D. Dartis · Adriana Pino Delgado · Hannah G. Blitzblau · Hannah L. Klein · Andreas Hochwagen · Andreas Hochwagen
ZUFSP Deubiquitylates K63-Linked Polyubiquitin Chains to Promote Genome Stability Sim Namkoong · Allison Ho · Yu Mi Woo · Hojoong Kwak · Jun Hee Lee · Jun Hee Lee
Substrate Insolubility Dictates Hsp104-Dependent Endoplasmic-Reticulum-Associated Degradation Peter Haahr · Nikoline Borgermann · Xiaohu Guo · Dimitris Typas · Divya Achuthankutty · Saskia Hoffmann · Robert Shearer · Titia K. Sixma · Niels Mailand · Niels Mailand
Repetitive DNA Reeling by the Cascade-Cas3 Complex in Nucleotide Unwinding Steps Yuhei Chadani · Tatsuya Niwa · Takashi Izumi · Nobuyuki Sugata · Asuteka Nagao · Tsutomu Suzuki · Shinobu Chiba · Koreaki Ito · Hideki Taguchi · Hideki Taguchi
Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin Xu Wang · Johan Auwerx · Johan Auwerx
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2 Anthony Khong · Anthony Khong · Tyler Matheny · Saumya Jain · Sarah F. Mitchell · Joshua R. Wheeler · Roy Parker · Roy Parker · Roy Parker
Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase Greta Pintacuda · Guifeng Wei · Chloë Roustan · Burcu Anil Kirmizitas · Nicolae Solcan · Andrea Cerase · Alfredo Castello · Shabaz Mohammed · Benoit Moindrot · Tatyana B. Nesterova · Neil Brockdorff · Neil Brockdorff
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions Kobi Simpson-Lavy · Tianchang Xu · Mark Johnston · Martin Kupiec · Martin Kupiec
The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer Peng Hu · Emily Fabyanic · Deborah Y. Kwon · Sheng Tang · Zhaolan Zhou · Hao Wu · Hao Wu
Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation Thomas J. Nicholls · Cristina A. Nadalutti · Elisa Motori · Ewen W. Sommerville · Grainne S. Gorman · Swaraj Basu · Emily Hoberg · Doug M. Turnbull · Patrick F. Chinnery · Nils-Göran Larsson · Nils-Göran Larsson · Erik Larsson · Maria Falkenberg · Robert W. Taylor · Jack D. Griffith · Claes M. Gustafsson · Claes M. Gustafsson
Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity Pengcheng Wang · Pengcheng Wang · Yang Zhao · Zhongpeng Li · Chuan-Chih Hsu · Xue Liu · Liwen Fu · Yueh-Ju Hou · Yanyan Du · Shaojun Xie · Chunguang Zhang · Jinghui Gao · Minjie Cao · Xiaosan Huang · Yingfang Zhu · Yingfang Zhu · Kai Tang · Kai Tang · Xingang Wang · W. Andy Tao · Yan Xiong · Jian-Kang Zhu · Jian-Kang Zhu · Jian-Kang Zhu
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics Ivaylo P. Ivanov · Ivaylo P. Ivanov · Byung Sik Shin · Gary Loughran · Ioanna Tzani · Sara K. Young-Baird · Chune Cao · John F. Atkins · Thomas E. Dever · Thomas E. Dever
Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response Yuta Shinohara · Yohei M. Koyama · Maki Ukai-Tadenuma · Takatsugu Hirokawa · Takatsugu Hirokawa · Masaki Kikuchi · Rikuhiro G. Yamada · Hideki Ukai · Hiroshi Fujishima · Takashi Umehara · Kazuki Tainaka · Kazuki Tainaka · Hiroki R. Ueda · Hiroki R. Ueda · Hiroki R. Ueda
The Ebola virus nucleoprotein recruits the host PP2A-B56 phosphatase to activate transcriptional support activity of VP30 Wei Lin · Kalyan Das · David Degen · Abhishek Mazumder · Diego Duchi · Dongye Wang · Yon W. Ebright · Richard Y. Ebright · Elena Sineva · Matthew Gigliotti · Aashish Srivastava · Sukhendu Mandal · Yi Jiang · Yu Liu · Ruiheng Yin · Zhening Zhang · Edward T. Eng · Dennis Thomas · Stefano Donadio · Haibo Zhang · Changsheng Zhang · Achillefs N. Kapanidis · Richard H. Ebright · Richard H. Ebright
N6-Methyladenosines Modulate A-to-I RNA Editing Jonathan L. Coloff · Jonathan L. Coloff
To Grow or Not to Grow: TOR and SnRK2 Coordinate Growth and Stress Response in Arabidopsis Qiang Zhang · Hai Huang · Luqing Zhang · Roland S. Wu · Chan-I Chung · Shao-Qing Zhang · Joaquim Torra · Antonino Schepis · Shaun R. Coughlin · Thomas B. Kornberg · Xiaokun Shu · Xiaokun Shu
A Much-Needed Boost for the Dwindling Antibiotic Pipeline Alban Ordureau · Joao A. Paulo · Wei Zhang · Tim Ahfeldt · Jiuchun Zhang · Erin F. Cohn · Zhonggang Hou · Jin-Mi Heo · Lee L. Rubin · Sachdev S. Sidhu · Steven P. Gygi · J. Wade Harper · J. Wade Harper
Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos Hannah E. Mischo · Hannah E. Mischo · Hannah E. Mischo · Yujin Chun · Kevin M. Harlen · Brendan M. Smalec · Somdutta Dhir · L. Stirling Churchman · Stephen Buratowski · Stephen Buratowski
Targeted Enhancer Activation by a Subunit of the Integrator Complex Michel Nofal · Kevin Zhang · Seunghun Han · Joshua D. Rabinowitz · Joshua D. Rabinowitz
p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis Erik Holmqvist · Erik Holmqvist · Lei Li · Thorsten Bischler · Lars Barquist · Jörg Vogel · Jörg Vogel
SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation Kotaro Tsuboyama · Hisashi Tadakuma · Yukihide Tomari · Yukihide Tomari
Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells Hye Ran Koh · Hye Ran Koh · Rahul Roy · Maria Sorokina · Guo Qing Tang · Divya Nandakumar · Smita S. Patel · Taekjip Ha · Taekjip Ha · Taekjip Ha · Taekjip Ha
The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca2+ Channels and Mast Cell Migration through PAR4 Receptors Hsiu-Chuan Lin · Hsiu-Chuan Lin · Chi-Wei Yeh · Yen-Fu Chen · Ting-Ting Lee · Pei-Yun Hsieh · Domnita V. Rusnac · Sung-Ya Lin · Sung-Ya Lin · Stephen J. Elledge · Ning Zheng · Hsueh-Chi S. Yen · Hsueh-Chi S. Yen · Hsueh-Chi S. Yen
Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems Emily Nicole Powers · Gloria Ann Brar · Gloria Ann Brar
Correlating Transcription Initiation and Conformational Changes by a Single-Subunit RNA Polymerase with Near Base-Pair Resolution Anil K. Panigrahi · Charles E. Foulds · Rainer B. Lanz · Ross A. Hamilton · Ping Yi · David M. Lonard · Ming-Jer Tsai · Sophia Y. Tsai · Bert W. O’Malley · Bert W. O’Malley
C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases He Huang · Shuang Tang · Ming Ji · Zhanyun Tang · Miho Shimada · Xiaojing Liu · Shankang Qi · Jason W. Locasale · Robert G. Roeder · Yingming Zhao · Xiaoling Li · Xiaoling Li
m 6 A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress Yoav Voichek · Karin Mittelman · Yulia Gordon · Raz Bar-Ziv · David Lifshitz Smit · Rom Shenhav · Naama Barkai · Naama Barkai
SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription Daniele Piccini · Christopher Bruhn · Sara Ricciardi · Paolo Soffientini · Walter Carotenuto · Stefano Biffo · Marco Foiani · Marco Foiani
Epigenetic Control of Expression Homeostasis during Replication Is Stabilized by the Replication Checkpoint Yahav Yosefzon · Despina Soteriou · Alona Feldman · Lana Kostic · Elle Koren · Samara Brown · Roi Ankawa · Egor Sedov · Fabian Glaser · Yaron Fuchs · Yaron Fuchs
The Quest for Stability during Times of Change Cole M. Dovey · Jonathan Diep · Bradley P. Clarke · Andrew T. Hale · Dan E. McNamara · Hongyan Guo · Nathaniel W. Brown · Jennifer Yinuo Cao · Christy Rani R. Grace · Peter J. Gough · John Bertin · Scott J. Dixon · Dorothea Fiedler · Edward S. Mocarski · William J. Kaiser · Tudor Moldoveanu · John D. York · Jan E. Carette · Jan E. Carette
A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress En Powers · Ga Brar · Ga Brar
Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3′ Ends Michael Elbaum · Michael Elbaum
Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Eva K. Brinkman · Tao Chen · Marcel de Haas · Hanna Aleida Holland · Waseem Akhtar · Bas van Steensel · Bas van Steensel
m(6)A and eIF2 alpha-(sic) Team Up to Tackle ATF4 Translation during Stress Takao Ishidate · Takao Ishidate · Ahmet R. Ozturk · Daniel J. Durning · Rita Sharma · En-zhi Shen · Hao Chen · Meetu Seth · Masaki Shirayama · Masaki Shirayama · Craig C. Mello · Craig C. Mello · Craig C. Mello
Forms and Phases in Huntingtin Protein Aggregation Ankit Turakhiya · Susanne R. Meyer · Gabriella Marincola · Stefanie Böhm · Jens T. Vanselow · Andreas Schlosser · Kay Hofmann · Alexander Buchberger · Alexander Buchberger
Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks Marc Rullan · Dirk Benzinger · Gregor W. Schmidt · Andreas Milias-Argeitis · Mustafa Khammash · Mustafa Khammash
ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals Quincey Justman · Quincey Justman
ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules Andrew Chatr-aryamontri · Almer M. van der Sloot · Mike Tyers · Mike Tyers
Genome-wide Control of Heterochromatin Replication by the Telomere Capping Protein TRF2 Yu-Ping Lin · Charmaine Nelson · Holger B. Kramer · Anant B. Parekh · Anant B. Parekh
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination Chi Kwan Tsang · Chi Kwan Tsang · Miao Chen · Xin Cheng · Yanmei Qi · Yin Chen · Ishani Das · Xiao-Xing Li · Brinda Vallat · Li Wu Fu · Chao Nan Qian · Hui Yun Wang · Hui Yun Wang · Eileen White · Stephen K. Burley · X. F. Steven Zheng · X. F. Steven Zheng
Chilled in Translation: Adapting to Bacterial Climate Change Aaron Mendez-Bermudez · Aaron Mendez-Bermudez · Liudmyla Lototska · Serge Bauwens · Marie-Josèphe Giraud-Panis · Olivier Croce · Karine Jamet · Agurtzane Irizar · Macarena Mowinckel · Stéphane Koundrioukoff · Stéphane Koundrioukoff · Nicolas Nottet · Geneviève Almouzni · Mare-Paule Teulade-Fichou · Michael Schertzer · Mylène Perderiset · Arturo Londoño-Vallejo · Michelle Debatisse · Eric Gilson · Eric Gilson · Jing Ye · Jing Ye
The Traffic Jam: Polyamine Prevalence Pauses Protein Production Elaine Fuchs · Elaine Fuchs
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks Annemieke T. van der Goot · Margaret M.P. Pearce · Dara E. Leto · Thomas A. Shaler · Ron R. Kopito · Ron R. Kopito
Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing Anne Zirkel · Milos Nikolic · Konstantinos Sofiadis · Jan-Philipp Mallm · Chris A. Brackley · Henrike Johanna Gothe · Oliver Drechsel · Christian Becker · Janine Altmüller · Natasa Josipovic · Theodore Georgomanolis · Lilija Brant · Julia Franzen · Mirjam Koker · Eduardo G. Gusmao · Eduardo G. Gusmao · Ivan G. Costa · Roland T. Ullrich · Wolfgang Wagner · Vassilis Roukos · Peter Nürnberg · Davide Marenduzzo · Karsten Rippe · Argyris Papantonis · Argyris Papantonis
To Claim Growth Turf, mTOR Says SOD Off Ilia Kats · Anton Khmelinskii · Marc Kschonsak · Florian Huber · Robert A. Knieß · Anna Bartosik · Michael Knop · Michael Knop
Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation Vadim Molodtsov · Elena V. Sineva · Lu Zhang · Xuhui Huang · Michael Cashel · Sarah E. Ades · Katsuhiko S. Murakami · Katsuhiko S. Murakami
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types Roberto Bellelli · Valérie Borel · Clare V. Logan · Jennifer Svendsen · Danielle E. Cox · Emma Nye · Kay Metcalfe · Susan M. O’Connell · Gordon Stamp · Helen R. Flynn · Ambrosius P. Snijders · Francois Lassailly · Andrew P. Jackson · Simon J. Boulton · Simon J. Boulton
Mapping Degradation Signals and Pathways in a Eukaryotic N-terminome Feng Li · Hyeung Kim · Zhejian Ji · Tianpeng Zhang · Bohong Chen · Yuanlong Ge · Yang Hu · Xuyang Feng · Xin Han · Huimin Xu · Youwei Zhang · Hongtao Yu · Dan Liu · Wenbin Ma · Zhou Songyang · Zhou Songyang · Zhou Songyang
Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA Thomas R. Peskett · Frédérique Rau · Jonathan O’Driscoll · Rickie Patani · Rickie Patani · Alan R. Lowe · Alan R. Lowe · Helen R. Saibil · Helen R. Saibil
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis Giulia Furlan · Nancy Gutierrez Hernandez · Christophe Huret · Rafael Galupa · Joke Gerarda van Bemmel · Joke Gerarda van Bemmel · Antonio Romito · Edith Heard · Céline Morey · Claire Rougeulle · Claire Rougeulle
The BUB3-BUB1 Complex Promotes Telomere DNA Replication Camille V. Goemans · Didier Vertommen · Rym Agrebi · Jean-François Collet · Jean-François Collet
A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation Robert H. Singer · Justin Crocker · Justin Crocker
The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products Mark R. Lundquist · Marcus D. Goncalves · Ryan M. Loughran · Elite Possik · Tarika Vijayaraghavan · Annan Yang · Chantal Pauli · Chantal Pauli · Archna Ravi · Akanksha Verma · Zhiwei Yang · Jared L. Johnson · Jenny C.Y. Wong · Yilun Ma · Katie Seo-Kyoung Hwang · David Weinkove · Nullin Divecha · John M. Asara · Olivier Elemento · Mark A. Rubin · Mark A. Rubin · Alec C. Kimmelman · Arnim Pause · Lewis C. Cantley · Brooke M. Emerling · Brooke M. Emerling
CnoX Is a Chaperedoxin: A Holdase that Protects Its Substrates from Irreversible Oxidation Tania Morán Luengo · Roman Kityk · Matthias P. Mayer · Stefan Rüdiger · Stefan Rüdiger
Transvection Goes Live—Visualizing Enhancer-Promoter Communication between Chromosomes Jong Ho Lee · Rui Liu · Rui Liu · Jing Li · Jing Li · Yugang Wang · Lin Tan · Xinjian Li · Xu Qian · Chuanbao Zhang · Yan Xia · Daqian Xu · Wei Guo · Zhiyong Ding · Linyong Du · Yanhua Zheng · Qianming Chen · Philip L. Lorenzi · Gordon B. Mills · Tao Jiang · Zhimin Lu · Zhimin Lu · Zhimin Lu
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy Hiroki Hayashi · Douglas T. Hess · Rongli Zhang · Keiki Sugi · Huiyun Gao · Bea L. Tan · Dawn E. Bowles · Carmelo A. Milano · Mukesh K. Jain · Walter J. Koch · Jonathan S. Stamler · Jonathan S. Stamler · Jonathan S. Stamler
Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System Srivats Venkataramanan · Stephen N. Floor · Stephen N. Floor
EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation Susan Gottesman · Susan Gottesman
S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence Claudia Ribeiro de Almeida · Somdutta Dhir · Ashish Dhir · Amin E. Moghaddam · Quentin J. Sattentau · Anton Meinhart · Nick J. Proudfoot · Nick J. Proudfoot
An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation Zhonggang Hou · Yan Zhang · Yan Zhang
At Long Last, a C-Terminal Bookend for the Ubiquitin Code Shilpa S. Dhar · Dongyu Zhao · Dongyu Zhao · Tao Lin · Bingnan Gu · Khusboo Pal · Sarah J. Wu · Sarah J. Wu · Hunain Alam · Jie Lv · Jie Lv · Kyuson Yun · Kyuson Yun · Vidya Gopalakrishnan · Elsa R. Flores · Paul A. Northcott · Veena Rajaram · Wei Li · Ali Shilatifard · Roy V. Sillitoe · Kaifu Chen · Kaifu Chen · Min Gyu Lee · Min Gyu Lee · Min Gyu Lee
S-Nitrosylation Targets GSNO Reductase for Selective Autophagy during Hypoxia Responses in Plants Tiago Baptista · Sebastian Grünberg · Nadège Minoungou · Nadège Minoungou · Maria J.E. Koster · H. T. Marc Timmers · H. T. Marc Timmers · Steve Hahn · Didier Devys · Laszlo Tora · Laszlo Tora
Structures of Bacterial RNA Polymerase Complexes Reveal the Mechanism of DNA Loading and Transcription Initiation Szilvia Juhász · Amira Elbakry · Arthur Mathes · Markus Löbrich · Markus Löbrich
Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation Weihua Zhou · Jie Xu · Mingjia Tan · Haomin Li · Hua Li · Wenyi Wei · Yi Sun · Yi Sun · Yi Sun
PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay Stefan M. Bresson · David Tollervey · David Tollervey
Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks Naomi Petela · Thomas G. Gligoris · Jean Metson · Byung Gil Lee · Menelaos Voulgaris · Bin Hu · Sotaro Kikuchi · Christophe Chapard · Wentao Chen · Eeson Rajendra · Madhusudhan Srinivisan · Hongtao Yu · Jan Löwe · Kim Nasmyth · Kim Nasmyth
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F Michael W. Webster · Ying Hsin Chen · James A.W. Stowell · Najwa Alhusaini · Thomas J. Sweet · Brenton R. Graveley · Jeff Coller · Lori A. Passmore · Lori A. Passmore
Tailing Off: PABP and CNOT Generate Cycles of mRNA Deadenylation Oliver Weichenrieder · Oliver Weichenrieder
Scc2 Is a Potent Activator of Cohesins ATPase that Promotes Loading by Binding Scc1 without Pds5 Robert Glyde · Fuzhou Ye · Milija Jovanovic · Ioly Kotta-Loizou · Martin Buck · Xiaodong Zhang · Xiaodong Zhang
mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases Richard G. Gardner · Tommer Ravid · Tommer Ravid
Elisa Izaurralde (1959–2018) Raghuvar Dronamraju · Austin J. Hepperla · Yoichiro Shibata · Alexander T. Adams · Terry Magnuson · Ian J. Davis · Ian J. Davis
From Precise Slicing to General SHREDding: The Ubiquitin Ligase Ubr1 Roqs as a Multipurpose Protein Terminator Deirdre H. McLachlan · Ashley J. Pridgeon · Alistair M. Hetherington · Alistair M. Hetherington
Insights into a Mysterious CRISPR Adaptation Factor, Cas4 Long He · Long He · Long He · Ana P. Gomes · Ana P. Gomes · Xin Wang · Sang-Oh Yoon · Sang-Oh Yoon · Gina Lee · Gina Lee · Michal J. Nagiec · Michal J. Nagiec · Sungyun Cho · Andre Chavez · Tasnia Islam · Yonghao Yu · Yonghao Yu · John M. Asara · Bo Yeon Kim · John Blenis · John Blenis · John Blenis · John Blenis
Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription Martin R. Higgs · Koichi Sato · John J. Reynolds · Shabana Begum · Rachel Bayley · Amalia Goula · Audrey Vernet · Karissa L. Paquin · David G. Skalnik · Wataru Kobayashi · Minoru Takata · Niall G. Howlett · Hitoshi Kurumizaka · Hiroshi Kimura · Grant S. Stewart · Grant S. Stewart
ATRX Promotes DNA Repair Synthesis and Sister Chromatid Exchange during Homologous Recombination Yuki Ogiyama · Bernd Schuettengruber · Giorgio L. Papadopoulos · Jia-Ming Chang · Giacomo Cavalli · Giacomo Cavalli
How Arabidopsis Talks to Itself about Its Water Supply Susanne Bornelöv · Nicola Reynolds · Maria Xenophontos · Maria Xenophontos · Sarah Gharbi · Ewan Johnstone · Ewan Johnstone · Robin Floyd · Meryem Ralser · Jason Signolet · Remco Loos · Remco Loos · Sabine Dietmann · Paul Bertone · Paul Bertone · Brian Hendrich · Brian Hendrich
Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2 Isabel Strohkendl · Fatema A. Saifuddin · James R. Rybarski · Ilya J. Finkelstein · Rick Russell · Rick Russell
Polycomb-Dependent Chromatin Looping Contributes to Gene Silencing during Drosophila Development Bennie Lemmens · Bennie Lemmens · Nadia Hégarat · Karen Akopyan · Joan Sala-Gaston · Jiri Bartek · Helfrid Hochegger · Arne Lindqvist · Arne Lindqvist
The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression Ni Zhan · Chun Wang · Chun Wang · Lichao Chen · Huanjie Yang · Jian Feng · Xinqi Gong · Bo Ren · Rong Wu · Jinye Mu · Yansha Li · Zhonghua Liu · Ying Zhou · Juli Peng · Kejian Wang · Xun Huang · Shi Xiao · Jianru Zuo · Jianru Zuo
Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a Elisa Barbieri · Marco Trizzino · Sarah Ann Welsh · Sarah Ann Welsh · Tori Alexandra Owens · Bruno Calabretta · Martin Carroll · Kavitha Sarma · Alessandro Gardini · Alessandro Gardini
DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation Linda Warfield · Tiago Baptista · Didier Devys · Laszlo Tora · Steven Hahn · Steven Hahn
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds Ryan Clarke · Robert Heler · Matthew S. MacDougall · Nan Cher Yeo · Alejandro Chavez · Maureen Regan · Leslyn Hanakahi · George M. Church · Luciano A. Marraffini · Bradley J. Merrill · Bradley J. Merrill
Re-SET for Transcription Hyerim Yi · Joha Park · Minju Ha · Jaechul Lim · Hyeshik Chang · V. Narry Kim · V. Narry Kim
Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons Tomohiro Yamazaki · Sylvie Souquere · Takeshi Chujo · Simon Kobelke · Yee Seng Chong · Archa H. Fox · Charles S. Bond · Shinichi Nakagawa · Gérard Pierron · Tetsuro Hirose · Tetsuro Hirose
Spt6 Is Required for the Fidelity of Promoter Selection Jan Bednar · Isabel Garcia-Saez · Amber R. Cutter · Gabor Papai · Anna Reymer · Sajad Hussain Syed · Imtiaz Nisar Lone · Ognyan Tonchev · Corinne Crucifix · Hervé Menoni · Christophe Papin · Dimitrios A. Skoufias · Hitoshi Kurumizaka · Richard Lavery · Ali Hamiche · Jeffrey J. Hayes · Patrick Schultz · Dimitar Angelov · Carlo Petosa · Stefan Dimitrov · Stefan Dimitrov
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis Maarten Fauvart · Bram Van den Bergh · Bram Van den Bergh · Jan Michiels · Jan Michiels
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes Lei Lv · Qi Wang · Yanping Xu · Li Chung Tsao · Tadashi Nakagawa · Haitao Guo · Lishan Su · Yue Xiong · Yue Xiong
mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation Rainer Nikolay · Tarek Hilal · Bo Qin · Thorsten Mielke · Jörg Bürger · Jörg Bürger · Justus Loerke · Kathrin Textoris-Taube · Knud H. Nierhaus · Knud H. Nierhaus · Christian M. T. Spahn · Christian M. T. Spahn
Stabbed while Sleeping: Synthetic Retinoid Antibiotics Kill Bacterial Persister Cells Masami Shiimori · Sandra C. Garrett · Brenton R. Graveley · Michael P. Terns · Michael P. Terns
Vpr Targets TET2 for Degradation by CRL4VprBP E3 Ligase to Sustain IL-6 Expression and Enhance HIV-1 Replication Quan Zhu · Nien Hoong · Aaron Aslanian · Aaron Aslanian · Toshiro Hara · Christopher Benner · Sven Heinz · Karen H. Miga · Eugene Ke · Sachin Verma · Jan Soroczynski · John R. Yates · Tony Hunter · Inder M. Verma · Inder M. Verma
Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution Kimberly S. Vasquez · Anthony L. Shiver · Kerwyn Casey Huang · Kerwyn Casey Huang
Cas4 Nucleases Define the PAM, Length, and Orientation of DNA Fragments Integrated at CRISPR Loci Martin R.G. Taylor · Joseph T.P. Yeeles · Joseph T.P. Yeeles
Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer Peter H. Culviner · Michael T. Laub · Michael T. Laub
Cutting the Gordian Knot of the Microbiota Eugene V. Koonin · Eugene V. Koonin
The Initial Response of a Eukaryotic Replisome to DNA Damage Tamas Szoradi · Katharina Schaeff · Enrique M. Garcia-Rivera · Daniel N Itzhak · Rolf M. Schmidt · Peter W. Bircham · Kevin Leiss · Juan Diaz-Miyar · Vivian K. Chen · Dale Muzzey · Georg Hh Borner · Sebastian Schuck · Sebastian Schuck
Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis Allen R. Buskirk · Allen R. Buskirk
Hunting for Treasure Chests in Microbial Defense Islands Vittorio Sartorelli · Pier Lorenzo Puri · Pier Lorenzo Puri
SHRED Is a Regulatory Cascade that Reprograms Ubr1 Substrate Specificity for Enhanced Protein Quality Control during Stress Seung Won Choi · Han Hee Park · Soyeon Kim · Jee Min Chung · Hyun Jin Noh · Sue Kyung Kim · Hyun Kyu Song · Chang-Woo Lee · Michael J. Morgan · Ho Chul Kang · You-Sun Kim · You-Sun Kim
Toxins that Trash Translation Itziar Serna Martin · Narin Hengrung · Max Renner · Jane Sharps · Mónica Martínez-Alonso · Simonas Masiulis · Jonathan M. Grimes · Ervin Fodor · Ervin Fodor
Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master Stephen M. Doris · James Chuang · James Chuang · Olga Viktorovskaya · Magdalena Murawska · Dan Spatt · L. Stirling Churchman · Fred Winston · Fred Winston
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation Bing Yao · Yujing Li · Zhiqin Wang · Li Chen · Mickael Poidevin · Can Zhang · Li Lin · Feng Wang · Han Bao · Bin Jiao · Junghwa Lim · Ying Cheng · Luoxiu Huang · Brittany Lynn Phillips · Tianlei Xu · Ranhui Duan · Kenneth H. Moberg · Hao Wu · Peng Jin · Peng Jin
A Mechanism for the Activation of the Influenza Virus Transcriptase Yifan Liu · Yali Dou · Yali Dou
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies Divya Seth · Douglas T. Hess · Alfred Hausladen · Liwen Wang · Ya-juan Wang · Jonathan S. Stamler · Jonathan S. Stamler · Jonathan S. Stamler
Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA Pierre Billon · Eric E. Bryant · Sarah A. Joseph · Tarun S. Nambiar · Samuel B. Hayward · Rodney Rothstein · Alberto Ciccia · Alberto Ciccia
Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation Anthony Chun-yin Chiu · Hiroshi I. Suzuki · Xuebing Wu · Dig B. Mahat · Andrea J. Kriz · Phillip A. Sharp · Phillip A. Sharp
An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication Nazaret Reverón-Gómez · Cristina González-Aguilera · Kathleen R. Stewart-Morgan · Nataliya Petryk · Valentin Flury · Simona Graziano · Jens Vilstrup Johansen · Janus S. Jakobsen · Constance Alabert · Anja Groth · Anja Groth
Bacterial Protein Reshapes Host Defense toward Antiviral Responses Jonathan G. Van Vranken · Sara M. Nowinski · Katie J. Clowers · Mi Young Jeong · Yeyun Ouyang · Jordan Berg · Jeremy P. Gygi · Steven P. Gygi · Dennis R. Winge · Jared Rutter · Jared Rutter
Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging Xavier Pichon · Mounia Lagha · Florian Mueller · Edouard Bertrand · Edouard Bertrand · Edouard Bertrand
ERADicate Tumor Progression with Metformin Bennett Penn · Zoe Netter · Jeffrey R. Johnson · Jeffrey R. Johnson · John Von Dollen · John Von Dollen · Gwendolyn M. Jang · Gwendolyn M. Jang · Tasha Johnson · Tasha Johnson · Yamini M. Ohol · Cyrus Maher · Samantha L. Bell · Kristina Geiger · Guillaume Golovkine · Xiaotang Du · Alex Choi · Trevor Parry · Bhopal Mohapatra · Matthew D. Storck · Hamid Band · Chen Chen · Stefanie Jäger · Stefanie Jäger · Michael Shales · Michael Shales · Dan A. Portnoy · Ryan D. Hernandez · Laurent Coscoy · Jeffery S. Cox · Jeffery S. Cox · Nevan J. Krogan · Nevan J. Krogan · Nevan J. Krogan
ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly Naomi R. Genuth · Maria Barna · Maria Barna
A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges Alexander J. Meeske · Luciano A. Marraffini · Luciano A. Marraffini
An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses Leeanne McGurk · Edward Gomes · Lin Guo · Jelena Mojsilovic-Petrovic · Van Tran · Robert G. Kalb · James Shorter · Nancy M. Bonini · Nancy M. Bonini
The Discovery of Ribosome Heterogeneity and Its Implications for Gene Regulation and Organismal Life John W. Pham · Brian S. Plosky · Allyson Evans · Miao-Chih Tsai · Nicole Neuman · Julie Sollier · Julie Sollier
RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems Andrea Brigitta Alber · Eric Paquet · Martina Biserni · Felix Naef · David M. Suter · David M. Suter
Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization Yuliang Tan · Chunyu Jin · Wubin Ma · Yiren Hu · Bogdan Tanasa · Soohwan Oh · Amir Gamliel · Qi Ma · Lu Yao · Lu Yao · Jie Zhang · Kenny Ohgi · Wen Liu · Wen Liu · Aneel K. Aggarwal · Michael G. Rosenfeld · Michael G. Rosenfeld
20 Years of Shaping Molecular Biology Hannah A. Pliner · Jonathan S. Packer · José L. McFaline-Figueroa · Darren A. Cusanovich · Riza Daza · Delasa Aghamirzaie · Sanjay Srivatsan · Xiaojie Qiu · Dana Jackson · Anna Minkina · Andrew Adey · Jay Shendure · Jay Shendure · Cole Trapnell · Cole Trapnell
Single live cell monitoring of protein turnover reveals intercellular variability and cell cycle dependence of degradation rates Megan H. Orzalli · Avi Smith · Kellie Ann Jurado · Kellie Ann Jurado · Akiko Iwasaki · Akiko Iwasaki · Jonathan A. Garlick · Jonathan C. Kagan · Jonathan C. Kagan
Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program Mridula Nambiar · Gerald R. Smith · Gerald R. Smith
Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data Jonas A. Schmid · Matteo Berti · Franziska Walser · Maria Chiara Raso · Fabian Schmid · Jana Krietsch · Henriette Stoy · Katharina Zwicky · Sebastian Ursich · Raimundo Freire · Massimo Lopes · Lorenza Penengo · Lorenza Penengo
Pericentromere-Specific Cohesin Complex Prevents Meiotic Pericentric DNA Double-Strand Breaks and Lethal Crossovers Ivelisse Cajigas · Abhijit Chakraborty · Kelsey R. Swyter · Hao Luo · Monique Bastidas · Maximilliano Nigro · Elizabeth R. Morris · Sean Chen · Michael J.W. VanGompel · David E. Leib · Sara J. Kohtz · Marco Martina · Sooky Koh · Ferhat Ay · Ferhat Ay · Jhumku D. Kohtz · Jhumku D. Kohtz
A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation Dong Ha Kim · Hye Jin Nam · Wonhwa Lee · Hwa Young Yim · Jun-Yeong Ahn · Se Won Park · Hi-Jai R. Shin · Reynold Yu · Kyoung-Jae Won · Jong-Sup Bae · Keun Il Kim · Sung Hee Baek · Sung Hee Baek
Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase David J. Young · Desislava S. Makeeva · Fan Zhang · Aleksandra S. Anisimova · Elena Stolboushkina · Fardin Ghobakhlou · Ivan N. Shatsky · Sergey E. Dmitriev · Sergey E. Dmitriev · Alan G. Hinnebusch · Nicholas R. Guydosh · Nicholas R. Guydosh
Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication Aishe A. Sarshad · Aster H. Juan · Ana Iris Correa Muler · Dimitrios G. Anastasakis · Xiantao Wang · Pavol Genzor · Xuesong Feng · Pei-Fang Tsai · Hong-Wei Sun · Astrid D. Haase · Vittorio Sartorelli · Markus Hafner · Markus Hafner
The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain Shu-Lin Liu · Zhi-Gang Wang · Yusi Hu · Yao Xin · Indira Singaram · Sukhamoy Gorai · Xin Zhou · Yoonjung Shim · Jung Hyun Min · Liang-Wei Gong · Nissim Hay · Jin Zhang · Wonhwa Cho · Wonhwa Cho · Wonhwa Cho
Tma64/eIF2D, Tma20/MCT-1, and Tma22/DENR Recycle Post-termination 40S Subunits In Vivo Mandy S. Wong · Justin B. Kinney · Adrian R. Krainer · Adrian R. Krainer
Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells Orlando Argüello-Miranda · Yanjie Liu · N. Ezgi Wood · Piya Kositangool · Andreas Doncic · Andreas Doncic
Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt Yoosik Kim · Joha Park · Sujin Kim · MinA Kim · Myeong-Gyun Kang · Chulhwan Kwak · Minjeong Kang · Baekgyu Kim · Hyun-Woo Rhee · V. Narry Kim · V. Narry Kim
Quantitative Activity Profile and Context Dependence of All Human 5′ Splice Sites Matthew F. Wipperman · Matthew F. Wipperman · Brook E. Heaton · Astha Nautiyal · Oyindamola Adefisayo · Henry W. Evans · Richa Gupta · Dave van Ditmarsch · Rajesh Soni · Ron Hendrickson · Jeffrey R. Johnson · Nevan J. Krogan · Michael S. Glickman · Michael S. Glickman · Michael S. Glickman · Michael S. Glickman
Integration of Multiple Metabolic Signals Determines Cell Fate Prior to Commitment Marion E. Pesenti · Daniel Prumbaum · Philip Auckland · Charlotte Smith · Alex C. Faesen · Arsen Petrovic · Muriel Erent · Stefano Maffini · Satyakrishna Pentakota · John R. Weir · Yu-Chih Lin · Stefan Raunser · Andrew D. McAinsh · Andrea Musacchio · Andrea Musacchio
PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs Adam E. Field · Neil A. Robertson · Tina Wang · Aaron Havas · Trey Ideker · Peter D. Adams · Peter D. Adams
Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease John E. Burke · John E. Burke
Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80 Haiyun Gan · Albert Serra-Cardona · Xu Hua · Hui Zhou · Karim Labib · Chuanhe Yu · Zhiguo Zhang · Zhiguo Zhang
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences Elsa Lauwers · Elsa Lauwers · Yu-Chun Wang · Yu-Chun Wang · Rodrigo Gallardo · Rob van der Kant · Emiel Michiels · Jef Swerts · Jef Swerts · Pieter Baatsen · Pieter Baatsen · Samantha S. Zaiter · Shelli R. McAlpine · Natalia V. Gounko · Natalia V. Gounko · Frederic Rousseau · Joost Schymkowitz · Patrik Verstreken · Patrik Verstreken · Patrik Verstreken
Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease Alex Toker · Christian C. Dibble · Christian C. Dibble
Quality Control of Orphaned Proteins Lena-Sophie Dreher · Thorsten Hoppe · Thorsten Hoppe
Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress Michael D. Arensman · Christina H. Eng · Christina H. Eng
Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response Hyungjin Eoh · Jae U. Jung · Jae U. Jung
Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein Szymon Juszkiewicz · Ramanujan S. Hegde · Ramanujan S. Hegde
Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation Chao Yan · Hengye Chen · Lu Bai · Lu Bai
HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA Steven Henikoff · Steven Henikoff · Steven Henikoff
The Biogenesis, Functions, and Challenges of Circular RNAs José Reyes · Jia-Yun Chen · Jacob Stewart-Ornstein · Kyle W. Karhohs · Caroline Mock · Galit Lahav · Galit Lahav
Systematic Study of Nucleosome-Displacing Factors in Budding Yeast Adam Buckle · Chris A. Brackley · Shelagh Boyle · Davide Marenduzzo · Nick Gilbert · Nick Gilbert
Pioneers Invade the Nucleosomal Landscape Mary McMahon · Davide Ruggero · Davide Ruggero
Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest Putzer J. Hung · Putzer J. Hung · Britney Johnson · Bo-Ruei Chen · Andrea K. Byrum · Andrea L. Bredemeyer · William T. Yewdell · Tanya E. Johnson · Brian J. Lee · Shruthi Deivasigamani · Issa Hindi · Parmeshwar Amatya · Michael L. Gross · Tanya T. Paull · David Pisapia · Jayanta Chaudhuri · John J.H. Petrini · Nima Mosammaparast · Gaya K. Amarasinghe · Shan Zha · Jessica K. Tyler · Barry P. Sleckman · Barry P. Sleckman
Polymer Simulations of Heteromorphic Chromatin Predict the 3D Folding of Complex Genomic Loci Tanya T. Paull · Tanya T. Paull · Tanya T. Paull
A Translation Tuning HuDdle for Neurons Anaid Benitez · Wenjun Liu · Anna Palovcak · Guanying Wang · Jaewon Moon · Kevin An · Anna Kim · Kevin Zheng · Yu Zhang · Feng Bai · Alexander V. Mazin · Xin-Hai Pei · Fenghua Yuan · Yanbin Zhang · Yanbin Zhang
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining Stephanie Santarriaga · Holly N. Haver · Adam J. Kanack · Alicia S. Fikejs · Samantha L. Sison · John M. Egner · Jonathan R. Bostrom · Emily R. Seminary · R. Blake Hill · Brian A. Link · Allison D. Ebert · K. Matthew Scaglione · K. Matthew Scaglione
20 Years of Mre11 Biology: No End in Sight Ping Chen · Liping Dong · Mingli Hu · Yi-Zhou Wang · Xue Xiao · Zhongliang Zhao · Jie Yan · Peng-Ye Wang · Danny Reinberg · Ming Li · Wei Li · Guohong Li · Guohong Li
FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange Haibin Wang · Wen-Ting Lo · Andreja Vujičić Žagar · Federico Gulluni · Martin Lehmann · Leonardo Scapozza · Volker Haucke · Oscar Vadas · Oscar Vadas
SRCP1 Conveys Resistance to Polyglutamine Aggregation Chrysa Nikopoulou · Giorgos Panagopoulos · Georgios Sianidis · Eleni Psarra · Ethan Ford · Dimitris Thanos · Dimitris Thanos
Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level Xin Jin · Xin Jin · Yuqian Yan · Dejie Wang · Donglin Ding · Tao Ma · Zhenqing Ye · Rafael E. Jimenez · Liguo Wang · Heshui Wu · Haojie Huang · Haojie Huang
Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module Hitoshi Nakatogawa · Hitoshi Nakatogawa
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression Yajuan Zhang · Guanzhen Yu · Huiying Chu · Xiongjun Wang · Lingling Xiong · Guoqing Cai · Ruilong Liu · Hong Gao · Bangbao Tao · Wenfeng Li · Guohui Li · Ji Liang · Weiwei Yang · Weiwei Yang
DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4 Jia Shou · Jia Shou · Jia Shou · Jinhuan Li · Jinhuan Li · Jinhuan Li · Yingbin Liu · Qiang Wu · Qiang Wu · Qiang Wu · Qiang Wu
Spoon-Feeding Ribosomes to Autophagy Tsun-Kai Chang · David A. Lawrence · Min Lu · Jenille Tan · Jonathan M. Harnoss · Scot A. Marsters · Peter Liu · Wendy Sandoval · Scott E. Martin · Avi Ashkenazi · Avi Ashkenazi
Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis Lorenzo Costantino · Douglas Koshland · Douglas Koshland
Precise and Predictable CRISPR Chromosomal Rearrangements Reveal Principles of Cas9-Mediated Nucleotide Insertion Xindan Wang · Xindan Wang · Anna C. Hughes · Hugo B. Brandão · Benjamin Walker · Carrie Lierz · Jared C. Cochran · Martha G. Oakley · Andrew C. Kruse · David Z. Rudner · David Z. Rudner
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate Jong-Ho Cha · Jong-Ho Cha · Wenhao Yang · Weiya Xia · Yongkun Wei · Li-Chuan Chan · Li-Chuan Chan · Seung Oe Lim · Chia-Wei Li · Taewan Kim · Shih-Shin Chang · Heng-Huan Lee · Jennifer L. Hsu · Jennifer L. Hsu · Jennifer L. Hsu · Hung-Ling Wang · Chu-Wei Kuo · Wei-Chao Chang · Wei-Chao Chang · Sirwan Hadad · Colin A. Purdie · Aaron McCoy · Shirong Cai · Yizheng Tu · Jennifer K. Litton · Elizabeth A. Mittendorf · Stacy L. Moulder · W. F. Symmans · Alastair M. Thompson · Helen Piwnica-Worms · Helen Piwnica-Worms · Chung-Hsuan Chen · Kay-Hooi Khoo · Mien Chie Hung · Mien Chie Hung
Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability Xiaolan Zhao · Xiaolan Zhao
In Vivo Evidence for ATPase-Dependent DNA Translocation by the Bacillus subtilis SMC Condensin Complex Scott D. Pope · Ruslan Medzhitov · Ruslan Medzhitov
Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1 Sydney L. Campbell · Kathryn E. Wellen · Kathryn E. Wellen
SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes Gabriel J. Sandoval · Gabriel J. Sandoval · John L. Pulice · John L. Pulice · Hubert Pakula · Hubert Pakula · Monica Schenone · David Y. Takeda · David Y. Takeda · Marius S. Pop · Marius S. Pop · Gaylor Boulay · Gaylor Boulay · Kaylyn Williamson · Kaylyn Williamson · Matthew J. McBride · Matthew J. McBride · Joshua Pan · Joshua Pan · Roodolph St. Pierre · Emily Hartman · Levi A. Garraway · Levi A. Garraway · Steven A. Carr · Miguel Rivera · Miguel Rivera · Zhe Li · Zhe Li · Lucienne Ronco · William C. Hahn · William C. Hahn · Cigall Kadoch · Cigall Kadoch · Cigall Kadoch
Emerging Principles of Gene Expression Programs and Their Regulation Michael R. Lawson · Wen Ma · Michael J. Bellecourt · Irina Artsimovitch · Andreas Martin · Robert Landick · Klaus Schulten · James M. Berger · James M. Berger · James M. Berger
Metabolic Signaling to the Nucleus in Cancer Roberto Covino · Gerhard Hummer · Gerhard Hummer · Robert Ernst · Robert Ernst
Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis Xiaowen Lyu · M. Jordan Rowley · Victor G. Corces · Victor G. Corces
The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands Niek van Wietmarschen · André Nussenzweig · André Nussenzweig
Hsp90 Mediates Membrane Deformation and Exosome Release Mateusz Mendel · Kuan-Ming Chen · David Homolka · Pascal Gos · Radha Raman Pandey · Andrew A. McCarthy · Ramesh S. Pillai · Ramesh S. Pillai
PI 3-Kinase Signaling: AKTing up inside the Cell Hamed Mosaei · Vadim Molodtsov · Bernhard Kepplinger · John Harbottle · Christopher William Moon · Rose E. Jeeves · Lucia Ceccaroni · Yeonoh Shin · Stephanie Morton-Laing · Emma Claire Louise Marrs · Corinne Wills · William Clegg · Yulia Yuzenkova · John D. Perry · Joanna Bacon · Jeff Errington · Nicholas E. E. Allenby · Michael J. Hall · Katsuhiko S. Murakami · Nikolay Zenkin · Nikolay Zenkin
The Proto-oncogene c-Kit Inhibits Tumor Growth by Behaving as a Dependence Receptor Nishita Shastri · Yu-Chen Tsai · Suzanne E. Hile · Deondre Jordan · Barrett Powell · Jessica Chen · Dillon Maloney · Marei Dose · Yancy Lo · Theonie Anastassiadis · Osvaldo Rivera · Taehyong Kim · Sharvin Shah · Piyush Borole · Kanika Asija · Xiang Wang · Kevin D. Smith · Darren Finn · Jonathan Schug · Rafael Casellas · Liliya A. Yatsunyk · Kristin A. Eckert · Eric J. Brown · Eric J. Brown
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination Szymon Juszkiewicz · Viswanathan Chandrasekaran · Zhewang Lin · Sebastian Kraatz · V. Ramakrishnan · Ramanujan S. Hegde · Ramanujan S. Hegde
Genome-wide Identification of Structure-Forming Repeats as Principal Sites of Fork Collapse upon ATR Inhibition Juanjuan Yuan · Yunqing Ma · Tao Huang · Yanhao Chen · Yuanzheng Peng · Bing Li · Jia Li · Yuchen Zhang · Bing Song · Xiaofang Sun · Qiurong Ding · Yan Song · Xing Chang · Xing Chang
Entering the Pocket: Crystal Structure of a Prostaglandin D2 Receptor K.B. Bandyra · J. Wandzik · Ben F. Luisi · Ben F. Luisi
ZNF598 Is a Quality Control Sensor of Collided Ribosomes Han Han · Ruxi Qi · Jeff Jiajing Zhou · Albert Ta · Bing Yang · Hiroki J. Nakaoka · Gayoung Seo · Kun-Liang Guan · Ray Luo · Wenqi Wang · Wenqi Wang
Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase H. Th. Marc Timmers · Laszlo Tora · Laszlo Tora
RNase E in complex with sRNA RrpA Valentine Svensson · Lior Pachter · Lior Pachter
Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction Orel Mizrahi · Aharon Nachshon · Alina Shitrit · Idit Anna Gelbart · Martina Dobesova · Shirly Brenner · Chaim Kahana · Noam Stern-Ginossar · Noam Stern-Ginossar
Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation David R. Raleigh · Navdar Sever · Pervinder K. Choksi · Monika Abedin Sigg · Kelly M. Hines · Bonne M. Thompson · Daniel Elnatan · Priyadarshini Jaishankar · Paola Bisignano · Francesc R. Garcia-Gonzalo · Alexis Leigh Krup · Markus Eberl · Eamon Fx Byrne · Christian Siebold · Sunny Y. Wong · Adam R. Renslo · Michael Grabe · Jeffrey G. McDonald · Libin Xu · Philip A. Beachy · Jeremy F. Reiter · Jeremy F. Reiter
RNA Velocity: Molecular Kinetics from Single-Cell RNA-Seq Lee Zou · Hai Dang Nguyen · Hai Dang Nguyen
Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression Georg Mohr · Sukrit Silas · Jennifer L. Stamos · Kira S. Makarova · Laura M. Markham · Jun Yao · Patricia Lucas-Elío · Antonio Sanchez-Amat · Andrew Fire · Eugene V. Koonin · Alan M. Lambowitz · Alan M. Lambowitz
Cilia-Associated Oxysterols Activate Smoothened Wei Wan · Zhiyuan You · Li Zhou · Yinfeng Xu · Chao Peng · Tianhua Zhou · Cong Yi · Yin Shi · Wei Liu · Wei Liu
Getting a Genomic View of DNA Replication Stress Zhengxin Ying · Chenjie Pan · Tianyu Shao · Liqing Liu · Lin Li · Dejia Guo · Sitao Zhang · Tianyi Yuan · Ran Cao · Zhaodi Jiang · She Chen · Fengchao Wang · Xiaodong Wang · Xiaodong Wang
A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition Matthias Weith · Jonas Seiler · Johannes van den Boom · Matthias Kracht · Julia Hülsmann · Ivana Primorac · Javier del Pino Garcia · Farnusch Kaschani · Markus Kaiser · Andrea Musacchio · Mathieu Bollen · Hemmo Meyer · Hemmo Meyer
mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux Karen Yap · Svetlana Mukhina · Gen Zhang · Jason S.C. Tan · Hong Sheng Ong · Eugene V. Makeyev · Eugene V. Makeyev
Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury Gunjan D. Mehta · David A. Ball · Peter R. Eriksson · Razvan Chereji · David J. Clark · James G. McNally · Tatiana S. Karpova · Tatiana S. Karpova
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation Takayuki Nojima · Kenny Rebelo · Tomás Gomes · Tomás Gomes · Ana Rita Grosso · Nick J. Proudfoot · Maria Carmo-Fonseca · Maria Carmo-Fonseca
A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival Sara Przetocka · Antonio Porro · Hella A. Bolck · Christina Walker · Aleksandra Lezaja · Anika Trenner · Christine von Aesch · Sarah-Felicitas Himmels · Alan D. D’Andrea · Raphael Ceccaldi · Matthias Altmeyer · Alessandro A. Sartori · Alessandro A. Sartori
Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast Zarmik Moqtaderi · Joseph V. Geisberg · Kevin Struhl · Kevin Struhl
RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing Eleni Stampouloglou · Xaralabos Varelas · Xaralabos Varelas
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress Sandra Piquet · Florent Le Parc · Siau-Kun Bai · Odile Chevallier · Salomé Adam · Sophie E. Polo · Sophie E. Polo
Extensive Structural Differences of Closely Related 3′ mRNA Isoforms: Links to Pab1 Binding and mRNA Stability Alison L. Antes · James M. DuBois · James M. DuBois
Phosphatidic Acid Signals via the Hippo Pathway Timothy Marsh · Jayanta Debnath · Jayanta Debnath
The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage Hagar Malcov-Brog · Ayelet Alpert · Tamar Golan · Shivang Parikh · Alice Nordlinger · Francesca Netti · Danna Sheinboim · Iris Dror · Laetitia Thomas · Camille Cosson · Pinchas Gonen · Yury Stanevsky · Ronen Mordechay Brenner · Tomer Perluk · Jacob Frand · Sharona Elgavish · Yuval Nevo · Dolev Rahat · Yuval Tabach · Mehdi Khaled · Shai S. Shen-Orr · Carmit Levy · Carmit Levy
Cultivating the Human Dimension in Research György Csordás · Kai-Ting Huang · Péter Várnai · Suresh K. Joseph · György Hajnóczky · György Hajnóczky
WIPIng the Brakes off Autophagy Induction Gonzalo Millan-Zambrano · Helena Santos-Rosa · Fabio Puddu · Samuel Robson · Tony Kouzarides · Tony Kouzarides
UV-Protection Timer Controls Linkage between Stress and Pigmentation Skin Protection Systems Mikhail A. Kostylev · Marcus D. Tuttle · Suho Lee · Lauren E. Klein · Hideyuki Takahashi · Timothy O. Cox · Erik C. Gunther · Kurt W. Zilm · Stephen M. Strittmatter · Stephen M. Strittmatter
MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360 Rotem Ben-Tov Perry · Hadas Hezroni · Micah Jonathan Goldrich · Igor Ulitsky · Igor Ulitsky
Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops Mithu Baidya · Punita Kumari · Arun K. Shukla · Arun K. Shukla
ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer Verónica Delgado-Benito · Daniel B. Rosen · Qiao Wang · Anna Gazumyan · Joy Pai · Thiago Y. Oliveira · Devakumar Sundaravinayagam · Wenzhu Zhang · Matteo Andreani · Lisa Keller · Kyong-Rim Kieffer-Kwon · Aleksandra Pekowska · Seolkyoung Jung · Madlen Driesner · Roman I. Subbotin · Rafael Casellas · Brian T. Chait · Michel C. Nussenzweig · Michel C. Nussenzweig · Michela Di Virgilio · Michela Di Virgilio
Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind Kazushige Kuroha · Alexandra Zinoviev · Christopher U.T. Hellen · Tatyana V. Pestova · Tatyana V. Pestova
Automated Design of Efficient and Functionally Diverse Enzyme Repertoires Julia F. Riley · Thuy P. Dao · Carlos A. Castañeda · Carlos A. Castañeda
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development Lei Ji · Bo Lu · Zhizhi Wang · Zinger Yang · John S. Reece-Hoyes · Carsten Russ · Wenqing Xu · Feng Cong · Feng Cong
Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis Rohan Shah · Adrian T. Grzybowski · Evan M. Cornett · Andrea L. Johnstone · Bradley M. Dickson · Brandon A. Boone · Marcus A. Cheek · Martis W. Cowles · Danielle Maryanski · Matthew J. Meiners · Rochelle L. Tiedemann · Robert M. Vaughan · Neha Arora · Zu-Wen Sun · Scott B. Rothbart · Michael-Christopher Keogh · Alexander J. Ruthenburg · Alexander J. Ruthenburg
Release of Ubiquitinated and Non-ubiquitinated Nascent Chains from Stalled Mammalian Ribosomal Complexes by ANKZF1 and Ptrh1 Steven Boeynaems · Aaron D. Gitler · Aaron D. Gitler
Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction Kelsey E. Bettridge · Ashley L. Cook · Roy C. Ziegelstein · Peter J. Espenshade · Peter J. Espenshade
Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies Young-min Han · Tatiana Bedarida · Ye Ding · Brian K. Somba · Qiulun Lu · Qilong Wang · Ping Song · Ming-Hui Zou · Ming-Hui Zou
Pour Some Sugar on TDP(-43) David Billing · Michiko Horiguchi · Foon Wu-Baer · Angelo Taglialatela · Giuseppe Leuzzi · Silvia Alvarez Nanez · Wenxia Jiang · Shan Zha · Matthias Szabolcs · Chyuan-Sheng Lin · Alberto Ciccia · Richard Baer · Richard Baer
A Scientists Oath Pedro Latorre-Muro · Josue Baeza · Eric A. Armstrong · Ramon Hurtado-Guerrero · Francisco Corzana · Lindsay E. Wu · David A. Sinclair · David A. Sinclair · Pascual López-Buesa · José Alberto Carrodeguas · John M. Denu · John M. Denu · John M. Denu
β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4 Ildar Gainetdinov · Cansu Colpan · Amena Arif · Katharine Cecchini · Phillip D. Zamore · Phillip D. Zamore
The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection Ling‐Jie Sang · Huai-qiang Ju · Guang-ping Liu · Tian Tian · Guolin Ma · Yun-xin Lu · Zexian Liu · Ruo‐Lang Pan · Rui‐Hua Li · Hai-long Piao · Jeffrey R. Marks · Luo‐Jia Yang · Qingfeng Yan · Wenqi Wang · Jian-zhong Shao · Yubin Zhou · Tianhua Zhou · Aifu Lin · Aifu Lin
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions Roberto Bellelli · Ondrej Belan · Valerie E. Pye · Camille Clément · Camille Clément · Sarah L. Maslen · J. Mark Skehel · Peter Cherepanov · Geneviève Almouzni · Geneviève Almouzni · Simon J. Boulton · Simon J. Boulton
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals Jill J. Bouchard · Joel H. Otero · Daniel C. Scott · Elzbieta Szulc · Erik W. Martin · Nafiseh Sabri · Daniele Granata · Melissa R. Marzahn · Kresten Lindorff-Larsen · Xavier Salvatella · Brenda A. Schulman · Brenda A. Schulman · Tanja Mittag · Tanja Mittag
LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling Lei Wang · Dandan Yao · R.N.V. Krishna Deepak · Heng Liu · Qingpin Xiao · Qingpin Xiao · Hao Fan · Weimin Gong · Weimin Gong · Zhiyi Wei · Cheng Zhang · Cheng Zhang
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication Koshi Imami · Koshi Imami · Miha Milek · Boris Bogdanow · Tomoharu Yasuda · Nicolai Kastelic · Henrik Zauber · Yasushi Ishihama · Markus Landthaler · Markus Landthaler · Matthias Selbach · Matthias Selbach · Matthias Selbach
Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments Anne Ast · Alexander Buntru · Franziska Schindler · Regine Hasenkopf · Aline Schulz · Lydia Brusendorf · Konrad Klockmeier · Gerlinde Grelle · Benjamin McMahon · Hannah Niederlechner · Isabelle Jansen · Lisa Diez · Juliane Edel · Annett Boeddrich · Sophie A. Franklin · Barbara Baldo · Sigrid Schnoegl · Séverine Kunz · Bettina Purfürst · Annette Gaertner · Harm H. Kampinga · A. Jennifer Morton · Åsa Petersén · Janine Kirstein · Gillian P. Bates · Erich E. Wanker · Erich E. Wanker
Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition Jiangbo Wei · Jiangbo Wei · Fange Liu · Fange Liu · Zhike Lu · Zhike Lu · Qili Fei · Qili Fei · Yuxi Ai · Yuxi Ai · P. Cody He · P. Cody He · Hailing Shi · Hailing Shi · Xiaolong Cui · Xiaolong Cui · Rui Su · Arne Klungland · Guifang Jia · Jianjun Chen · Chuan He · Chuan He · Chuan He
Phosphorylation of the Ribosomal Protein RPL12/uL11 Affects Translation during Mitosis Kiran Vanaja · Kiran Vanaja · Winston Timp · Andrew P. Feinberg · Andrew P. Feinberg · Andre Levchenko · Andre Levchenko · Andre Levchenko
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntingtons Disease Timothy Sterne-Weiler · Robert J. Weatheritt · Robert J. Weatheritt · Robert J. Weatheritt · Andrew J. Best · Kevin C.H. Ha · Benjamin J. Blencowe · Benjamin J. Blencowe
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm Katelyn A. Doxtader · Ping Wang · Anna M. Scarborough · Dahee Seo · Nicholas K. Conrad · Yunsun Nam · Yunsun Nam
A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network Søren Lykke-Andersen · Britt Kidmose Ardal · Anne Kruse Hollensen · Christian Kroun Damgaard · Torben Heick Jensen · Torben Heick Jensen
Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop Gillian Dunphy · Sinead M. Flannery · Jessica F. Almine · Dympna J. Connolly · Christina Paulus · Kasper L. Jønsson · Martin R. Jakobsen · Michael Nevels · Andrew G. Bowie · Leonie Unterholzner · Leonie Unterholzner
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor Anastassios Vourekas · Zissimos Mourelatos · Zissimos Mourelatos
Box C/D snoRNP Autoregulation by a cis-Acting snoRNA in the NOP56 Pre-mRNA Thomas Clouaire · Vincent Rocher · Anahita Lashgari · Coline Arnould · Marion Aguirrebengoa · Anna Biernacka · Magdalena Skrzypczak · François Aymard · Bernard Fongang · Norbert Dojer · Norbert Dojer · Jason S. Iacovoni · Maga Rowicka · Krzysztof Ginalski · Jacques Côté · Gaëlle Legube · Gaëlle Legube
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Katarzyna J. Bandyra · Joanna M. Wandzik · Ben F. Luisi · Ben F. Luisi
Set Phasers to Cleave: PIWI Cleavage Directs All piRNA Biogenesis Swapnil C. Devarkar · Brandon Schweibenz · Chen Wang · Joseph Marcotrigiano · Smita S. Patel · Smita S. Patel
Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures Olga Khersonsky · Rosalie Lipsh · Ziv Avizemer · Yacov Ashani · Moshe Goldsmith · Haim Leader · Orly Dym · Shelly Rogotner · Devin L. Trudeau · Jaime Prilusky · Pep Amengual-Rigo · Victor Guallar · Dan S. Tawfik · Sarel J. Fleishman · Sarel J. Fleishman
Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E Ling Cai · Yi-Hsuan Tsai · Ping Wang · Jun Wang · Dongxu Li · Huitao Fan · Yilin Zhao · Rohan Bareja · Rui Lu · Elizabeth M. Wilson · Andrea Sboner · Young E. Whang · Deyou Zheng · Joel S. Parker · H. Shelton Earp · Gang Greg Wang · Gang Greg Wang
RIG-I Uses an ATPase-Powered Translocation-Throttling Mechanism for Kinetic Proofreading of RNAs and Oligomerization Hong Wang · Amina Boussouar · Laetitia Mazelin · Servane Tauszig-Delamasure · Yan Sun · David Goldschneider · Andrea Paradisi · Patrick Mehlen · Patrick Mehlen
An Enhancer-Derived RNA Muscles In to Regulate Myogenin In trans Xiang Li · Li Yang · Li Yang · Ling-Ling Chen · Ling-Ling Chen · Ling-Ling Chen
A First Glimpse of Nucleation of Phase Transitions in Living Cells Toma Tebaldi · Paola Zuccotti · Daniele Peroni · Marcel Köhn · Lisa Gasperini · Valentina Potrich · Veronica Bonazza · Tatiana Dudnakova · Annalisa Rossi · Guido Sanguinetti · Luciano Conti · Paolo Macchi · Vito G. D’Agostino · Gabriella Viero · David Tollervey · Stefan Hüttelmaier · Alessandro Quattrone · Alessandro Quattrone
A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation Shuibin Lin · Shuibin Lin · Shuibin Lin · Qi Liu · Qi Liu · Victor S. Lelyveld · Junho Choe · Junho Choe · Jack W. Szostak · Jack W. Szostak · Richard I. Gregory · Richard I. Gregory
Telomere Loop Dynamics in Chromosome End Protection Gaurav Dugar · Ryan T. Leenay · Sara K. Eisenbart · Thorsten Bischler · Belinda U. Aul · Chase L. Beisel · Cynthia M. Sharma · Cynthia M. Sharma
A Metabolic Basis for Endothelial-to-Mesenchymal Transition Emily Nicole Powers · Gloria Ann Brar · Gloria Ann Brar
Protein S-Nitrosylation: Enzymatically Controlled, but Intrinsically Unstable, Post-translational Modification Ting-Hsiang Huang · Faith Fowler · Chin-Chuan Chen · Zih-Jie Shen · Barry P. Sleckman · Jessica K. Tyler · Jessica K. Tyler
Guilty by Association: Mapping Out the Molecular Sociology of Droplet Compartments Alessandro Annibaldi · Sidonie Wicky John · Tom Vanden Berghe · Kirby N. Swatek · Jianbin Ruan · Gianmaria Liccardi · Katiuscia Bianchi · Katiuscia Bianchi · Paul R. Elliott · Sze Men Choi · Samya Van Coillie · John Bertin · Hao Wu · David Komander · Peter Vandenabeele · John Silke · John Silke · Pascal Meier · Pascal Meier
m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress Giuseppe Arena · Giuseppe Arena · Madi Y. Cissé · Samuel Pyrdziak · Laurent Chatre · Romain Riscal · Maryse Fuentes · Jamie J. Arnold · Markus Kastner · Laurie Gayte · Christelle Bertrand-Gaday · Kevin Nay · Claire Angebault-Prouteau · Kerren Murray · Béatrice Chabi · Christelle Koechlin-Ramonatxo · Béatrice Orsetti · Charles Vincent · François Casas · Jean-Christophe Marine · Sandrine Etienne-Manneville · Florence Bernex · Anne Lombès · Craig E. Cameron · Hervé Dubouchaud · Miria Ricchetti · Laetitia Karine Linares · Laurent Le Cam · Laurent Le Cam
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells Boubou Diagouraga · Julie A.J. Clément · Laurent Duret · Jan Kadlec · Bernard de Massy · Frédéric Baudat · Frédéric Baudat
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2 Maria Cardamone · Bogdan Tanasa · Carly T. Cederquist · Jiawen Huang · Kiana Mahdaviani · Wenbo Li · Michael G. Rosenfeld · Marc Liesa · Valentina Perissi · Valentina Perissi
Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53 Ruiting Lin · Siyuan Xia · Changliang Shan · Dong Chen · Yijie Liu · Xue Gao · Mei Wang · Hee-Bum Kang · Yaozhu Pan · Shuangping Liu · Shuangping Liu · Young Rock Chung · Omar Abdel-Wahab · Taha Merghoub · Michael R. Rossi · Ragini R. Kudchadkar · David H. Lawson · Fadlo R. Khuri · Sagar Lonial · Jing Chen · Jing Chen
PRDM9 Methyltransferase Activity Is Essential for Meiotic DNA Double-Strand Break Formation at Its Binding Sites Irina Artsimovitch · Georgiy A. Belogurov · Georgiy A. Belogurov
Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation Xieyang Guo · Alexander G. Myasnikov · James Chen · Corinne Crucifix · Gabor Papai · Maria Takacs · Patrick Schultz · Albert Weixlbaumer · Albert Weixlbaumer
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells Thuy P. Dao · Regina-Maria Kolaitis · Hong Joo Kim · Kevin O’Donovan · Brian Martyniak · Erica G. Colicino · Heidi Hehnly · J. Paul Taylor · J. Paul Taylor · Carlos A. Castañeda · Carlos A. Castañeda
Uneven Braking Spins RNA Polymerase into a Pause Sarah Sertic · Antonio Mollica · Ilaria Campus · Stefania Roma · Emanuela Tumini · Andrés Aguilera · Marco Muzi-Falconi · Marco Muzi-Falconi
Structural Basis for NusA Stabilized Transcriptional Pausing Guillaume Dubeaux · Julie Neveu · Enric Zelazny · Grégory Vert · Grégory Vert
Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions David Van Ly · David Van Ly · Ronnie Ren Jie Low · Sonja Frölich · Tara K. Bartolec · Georgia R. Kafer · Hilda A. Pickett · Katharina Gaus · Anthony J. Cesare · Anthony J. Cesare
Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions Rhea Kang · Maciej J. Zelazowski · Francesca Cole · Francesca Cole
A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans Myles G. Garstang · Myles G. Garstang · Madapura M. Pradeepa · Madapura M. Pradeepa · Madapura M. Pradeepa
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response Simon Alberti · Simon Alberti
SLFN11 Blocks Stressed Replication Forks Independently of ATR Ivan Gusarov · Evgeny Nudler · Evgeny Nudler
Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation Jianhua Xiong · Hiroyuki Kawagishi · Ye Yan · Jie Liu · Quinn S. Wells · Lia R. Edmunds · Maria M. Fergusson · Zu Xi Yu · Ilsa I. Rovira · Evan L. Brittain · Michael J. Wolfgang · Michael J. Jurczak · Joshua P. Fessel · Toren Finkel · Toren Finkel
Inflammation NODs to Antagonists of RIP2-XIAP Interaction Edoardo Gaude · Christina Schmidt · Payam A. Gammage · Aurelien Dugourd · Thomas S. Blacker · Sew Y. Peak Chew · Julio Saez-Rodriguez · Julio Saez-Rodriguez · John S. O’Neill · Michal Minczuk · Christian Frezza · Christian Frezza
Cdc48/VCP Promotes Chromosome Morphogenesis by Releasing Condensin from Self-Entrapment in Chromatin Denise R. Minton · Minwoo Nam · Daniel J. McLaughlin · Jong Shin · Erol C. Bayraktar · Samantha W. Alvarez · Vladislav O. Sviderskiy · Thales Papagiannakopoulos · David M. Sabatini · Kivanc Birsoy · Richard Possemato · Richard Possemato
Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP Yu Zhao · Miranda C. Mudge · Jennifer M. Soll · Rachel B. Rodrigues · Andrea K. Byrum · Elizabeth A. Schwarzkopf · Tara R. Bradstreet · Steven P. Gygi · Brian T. Edelson · Nima Mosammaparast · Nima Mosammaparast
PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response Dongxin Zhao · Mehmet G. Badur · Jens Luebeck · Jose H. Magaña · Amanda Birmingham · Roman Sasik · Christopher S. Ahn · Trey Ideker · Christian M. Metallo · Prashant Mali · Prashant Mali
Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs Shiyu Xia · Shiyu Xia · Tian-Min Fu · Tian-Min Fu · Hao Wu · Hao Wu · Hao Wu
OTUD4 Is a Phospho-Activated K63 Deubiquitinase that Regulates MyD88-Dependent Signaling Beth A. Rousseau · Zhonggang Hou · Max J. Gramelspacher · Yan Zhang · Yan Zhang
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis Flora C.Y. Lee · Flora C.Y. Lee · Jernej Ule · Jernej Ule · Jernej Ule
Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis Tatiana Goncharov · Stefanie Hedayati · Melinda M. Mulvihill · Anita Izrael-Tomasevic · Kerry Zobel · Surinder Jeet · Anna V. Fedorova · Céline Eidenschenk · Jason DeVoss · Kebing Yu · Andrey S. Shaw · Donald S. Kirkpatrick · Wayne J. Fairbrother · Kurt Deshayes · Domagoj Vucic · Domagoj Vucic
PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions Jun Zhou · Ji Wan · Xin Erica Shu · Yuanhui Mao · Xiao-Min Liu · Xin Yuan · Xingqian Zhang · Martin E. Hess · Jens C. Brüning · Shu-Bing Qian · Shu-Bing Qian
Advances in CLIP Technologies for Studies of Protein-RNA Interactions Liang Chen · Jia-Yu Chen · Yi-Jou Huang · Ying Gu · Jinsong Qiu · Hao Qian · Changwei Shao · Xuan Zhang · Jing Hu · Hairi Li · Shunmin He · Yu Zhou · Omar Abdel-Wahab · Dong-Er Zhang · Xiang-Dong Fu · Xiang-Dong Fu
NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction Nicolas G. Bologna · Raphael Iselin · Luciano A. Abriata · Luciano A. Abriata · Alexis Sarazin · Nathan Pumplin · Nathan Pumplin · Florence Jay · Thomas Grentzinger · Matteo Dal Peraro · Matteo Dal Peraro · Olivier Voinnet · Olivier Voinnet
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling Cindy Meyer · Aitor Garzia · Michael Mazzola · Stefanie Gerstberger · Henrik Molina · Thomas Tuschl · Thomas Tuschl
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations Pei I. Tsai · Chin-Hsien Lin · Chung Han Hsieh · Amanda M. Papakyrikos · Min Joo Kim · Valerio Napolioni · Carmen Schoor · Julien Couthouis · Ruey-Meei Wu · Zbigniew K. Wszolek · Dominic Winter · Michael D. Greicius · Owen A. Ross · Xinnan Wang · Xinnan Wang
Nucleo-cytosolic Shuttling of ARGONAUTE1 Prompts a Revised Model of the Plant MicroRNA Pathway Xiao-xue Li · Zhi-jing Wang · Yu Zheng · Yun-feng Guan · Peng-bo Yang · Xiang Chen · Cong Peng · Jian-ping He · Yuan-li Ai · Sheng-fu Wu · Kun-Yi Chien · Qiao Wu · Hang-zi Chen · Hang-zi Chen
The TIA1 RNA-binding-protein family regulates EIF2AK2-mediated stress response and cell cycle progression Junko Murai · Sai-Wen Tang · Elisabetta Leo · Simone A. Baechler · Christophe E. Redon · Hongliang Zhang · Muthana Al Abo · Vinodh N. Rajapakse · Eijiro Nakamura · Lisa M. Miller Jenkins · Mirit I. Aladjem · Yves Pommier · Yves Pommier
Metal Sensing by the IRT1 Transporter-Receptor Orchestrates Its Own Degradation and Plant Metal Nutrition Keren Baranes-Bachar · Adva Levy-Barda · Judith Oehler · Dylan A. Reid · Isabel Soria-Bretones · Ty C. Voss · Dudley Chung · Yoon Ah Park · Chao Liu · Jong Bok Yoon · Wei Li · Graham Dellaire · Tom Misteli · Pablo Huertas · Eli Rothenberg · Kristijan Ramadan · Yael Ziv · Yosef Shiloh · Yosef Shiloh
Cell-cycle modulation of transcription termination factor Sen1 Hyewon Kong · Navdeep S. Chandel · Navdeep S. Chandel
Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression Hana Hanzlikova · Ilona Kalasova · Annie A. Demin · Lewis E. Pennicott · Zuzana Cihlarova · Keith W. Caldecott · Keith W. Caldecott
UntRIG(er)ing lncRNAs Ammon E. Posey · Rohit V. Pappu · Rohit V. Pappu
Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome Eran Kotler · Odem Shani · Guy Goldfeld · Maya Lotan-Pompan · Ohad Tarcic · Anat Gershoni · Thomas A. Hopf · Debora S. Marks · Moshe Oren · Eran Segal · Eran Segal
Sequence-Directed Action of RSC Remodeler and General Regulatory Factors Modulates +1 Nucleosome Position to Facilitate Transcription Pei-Fang Tsai · Stefania Dell’Orso · Joseph Rodriguez · Karinna O. Vivanco · Kyung-Dae Ko · Kan Jiang · Aster H. Juan · Aishe A. Sarshad · Laura Vian · Michelle Tran · Darawalee Wangsa · A. Hongjun Wang · Jelena Perovanovic · Dimitrios G. Anastasakis · Evelyn Ralston · Thomas Ried · Hong-Wei Sun · Markus Hafner · Daniel R. Larson · Vittorio Sartorelli · Vittorio Sartorelli
The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication Dominique Garcin · Dominique Garcin
Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors Jack Fu · Thomas B. Schaffer · Chan Hyun Na · Michael Delannoy · Seth S. Margolis · Seth S. Margolis
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal Slawomir Kubik · Eoghan O’Duibhir · Wim de Jonge · Stefano Mattarocci · Benjamin Albert · Jean-Luc Falcone · Maria Jessica Bruzzone · Frank C. P. Holstege · David Shore · David Shore
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair Jing Wen · Ruitu Lv · Honghui Ma · H. Shen · Chenxi He · Jiahua Wang · Fangfang Jiao · Hang Liu · Pengyuan Yang · Li Tan · Fei Lan · Yujiang Geno Shi · Yujiang Geno Shi · Chuan He · Chuan He · Yang Shi · Jianbo Diao · Jianbo Diao
CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9 Tales Rocha de Moura · Sina Mozaffari-Jovin · Csaba Zoltán Kibédi Szabó · Jana Schmitzová · Olexandr Dybkov · Constantin Cretu · Michael Kachala · Dmitri I. Svergun · Henning Urlaub · Henning Urlaub · Reinhard Lührmann · Vladimir Pena · Vladimir Pena
Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting Xing Liu · Justin M. Reitsma · Jennifer L. Mamrosh · Yaru Zhang · Ronny Straube · Raymond J. Deshaies · Raymond J. Deshaies · Raymond J. Deshaies
A Rapid Induction Mechanism for Lin28a in Trophic Responses Elayanambi Sundaramoorthy · Marilyn Leonard · Raymond H. Mak · Jeffrey Liao · Amitkumar Fulzele · Eric J. Bennett · Eric J. Bennett
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination Joschka Willemsen · Joschka Willemsen · Oliver Wicht · Julia Wolanski · Nina Baur · Sandra Bastian · Darya A. Haas · Petr Matula · Petr Matula · Bettina Knapp · Laurène Meyniel-Schicklin · Chen Wang · Ralf Bartenschlager · Volker Lohmann · Karl Rohr · Holger Erfle · Lars Kaderali · Joseph Marcotrigiano · Andreas Pichlmair · Marco Binder · Marco Binder · Marco Binder
Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17 Alexander P. Hynes · Sylvain Moineau · Sylvain Moineau
Tethered Oligonucleotide-Primed Sequencing, TOP-Seq: A High-Resolution Economical Approach for DNA Epigenome Profiling Ronja Biehs · Monika Steinlage · Olivia Barton · Szilvia Juhász · Julia Künzel · Julian Spies · Atsushi Shibata · Atsushi Shibata · Penny A. Jeggo · Markus Löbrich · Markus Löbrich
Programmed Ribosomal Frameshifting Generates a Copper Transporter and a Copper Chaperone from the Same Gene Alexandra M. Amen · Claudia R. Ruiz-Garzon · Jay Shi · Megha Subramanian · Daniel L. Pham · Mollie K. Meffert · Mollie K. Meffert
Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening Michael Kramer · Jean-Claude Farré · Koyel Mitra · Michael Ku Yu · Keiichiro Ono · Barry Demchak · Katherine Licon · Mitchell Flagg · Rama Balakrishnan · J. Michael Cherry · Suresh Subramani · Trey Ideker · Trey Ideker
ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation Molly Godfrey · Sandra A. Touati · Meghna Kataria · Andrew W. Jones · Ambrosius P. Snijders · Frank Uhlmann · Frank Uhlmann
Active Interaction Mapping Reveals the Hierarchical Organization of Autophagy Julyun Oh · Julyun Oh · Amr Al-Zain · Amr Al-Zain · Elda Cannavo · Petr Cejka · Lorraine S. Symington · Lorraine S. Symington
PP2ACdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation Ryan VanderLinden · Casey W. Hemmis · Benjamin Schmitt · Frank G. Whitby · Howard Robinson · Robert E. Cohen · Tingting Yao · Christopher P. Hill · Christopher P. Hill
Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells Conor J. Kearney · Seamus J. Martin · Seamus J. Martin
Prokaryotic Argonaute Uses an All-in-One Mechanism to Provide Host Defense Nicolas Demaurex · Manon Rosselin · Manon Rosselin
Redox Control of Mitochondrial Calcium Uptake Ziyan Liu · Yuxin Jia · Yanglin Ding · Yiting Shi · Zhen Li · Yan Guo · Zhizhong Gong · Shuhua Yang · Shuhua Yang
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Xueyin Wang · Karen J. Goodrich · Anne R. Gooding · Haroon Naeem · Stuart K. Archer · Richard D. Paucek · Daniel T. Youmans · Daniel T. Youmans · Thomas R. Cech · Chen Davidovich · Chen Davidovich · Chen Davidovich
Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip Ozgur Oksuz · Varun Narendra · Chul-Hwan Lee · Nicolas Descostes · Gary LeRoy · Ramya Raviram · Lili Blumenberg · Kelly R. Karch · Pedro P. Rocha · Pedro P. Rocha · Benjamin A. Garcia · Jane A. Skok · Danny Reinberg · Danny Reinberg
Transcription without XPB Establishes a Unified Helicase-Independent Mechanism of Promoter Opening in Eukaryotic Gene Expression Tian Min Fu · Tian Min Fu · Yang Li · Yang Li · Alvin Lu · Alvin Lu · Zongli Li · Zongli Li · Parimala R. Vajjhala · Anthony C. Cruz · Devendra B. Srivastava · Devendra B. Srivastava · Frank DiMaio · Pawel A. Penczek · Richard M. Siegel · Katryn J. Stacey · Edward H. Egelman · Hao Wu · Hao Wu · Hao Wu
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines Thomas C. Boothby · Hugo Tapia · Alexandra H. Brozena · Samantha Piszkiewicz · Austin E. Smith · Ilaria Giovannini · Lorena Rebecchi · Gary J. Pielak · Dough Koshland · Bob Goldstein · Bob Goldstein
Translation of CircRNAs Sophie Barral · Yuichi Morozumi · Yuichi Morozumi · Hiroki Tanaka · Emilie Montellier · Jérôme Govin · Maud de Dieuleveult · Guillaume Charbonnier · Yohann Couté · Denis Puthier · Thierry Buchou · Fayçal Boussouar · Takashi Urahama · François Fenaille · Sandrine Curtet · Patrick Héry · Nicolas Fernandez-Nunez · Hitoshi Shiota · Matthieu Gérard · Sophie Rousseaux · Hitoshi Kurumizaka · Saadi Khochbin · Saadi Khochbin
An Inflammatory Perspective on Necroptosis Advaitha Madireddy · Settapong Kosiyatrakul · Rebecca A. Boisvert · Emilia Herrera-Moyano · María L. García-Rubio · Jeannine Gerhardt · Elizabeth A. Vuono · Nichole Owen · Zi Yan · Susan B. Olson · Andrés Aguilera · Niall G. Howlett · Carl L. Schildkraut · Carl L. Schildkraut
Metazoan Nuclear Pores Provide a Scaffold for Poised Genes and Mediate Induced Enhancer-Promoter Contacts Ivayla Ivanova · Ivayla Ivanova · Christian Much · Christian Much · Monica Di Giacomo · Chiara Azzi · Marcos Morgan · Marcos Morgan · Pedro N. Moreira · Pedro N. Moreira · Jack Monahan · Claudia Carrieri · Claudia Carrieri · Anton J. Enright · Dónal O’Carroll · Dónal O’Carroll · Dónal O’Carroll
Evolving Models of Heterochromatin: From Foci to Liquid Droplets Stephen P. Muench · Martin van der Laan · Martin van der Laan
The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence Ipsita Subudhi · James Shorter · James Shorter
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress Xin Luo · Keun Woo Ryu · Dae Seok Kim · Tulip Nandu · Carlos J. Medina · Rebecca Gupte · Bryan A. Gibson · Raymond E. Soccio · Yonghao Yu · Rana K. Gupta · W. Lee Kraus · W. Lee Kraus
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion Honglian Zhang · Haiyun Gan · Zhiquan Wang · Jeong Heon Lee · Hui Zhou · Tamas Ordog · Marc S. Wold · Mats Ljungman · Zhiguo Zhang · Zhiguo Zhang
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity Sezen Meydan · Dorota Klepacki · Subbulakshmi Karthikeyan · Tõnu Margus · Paul M. Thomas · John E. Jones · Yousuf A. Khan · Joseph W. Briggs · Jonathan D. Dinman · Nora Vázquez-Laslop · Alexander S. Mankin · Alexander S. Mankin
An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome Antonis Tatarakis · Reza Behrouzi · Danesh Moazed · Danesh Moazed
Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation G. Michael Preston · Christopher J. Guerriero · Meredith B. Metzger · Susan Michaelis · Jeffrey L. Brodsky · Jeffrey L. Brodsky
Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation Xu Xiao · Jing-Jie Tang · Chao Peng · Chao Peng · Yan Wang · Lin Fu · Zhi-Ping Qiu · Yue Xiong · Lian-Fang Yang · Hai-Wei Cui · Xiao-Long He · Lei Yin · Wei Qi · Catherine C. L. Wong · Catherine C. L. Wong · Yun Zhao · Bo-Liang Li · Wenwei Qiu · Bao-Liang Song · Bao-Liang Song
Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells Evan Worden · Evan Worden · Ken C. Dong · Ken C. Dong · Andreas Martin · Andreas Martin · Andreas Martin
A Metabolic Function for Phospholipid and Histone Methylation Pau Pascual-Garcia · Brian M. Debo · Jennifer R. Aleman · Jessica A. Talamas · Yemin Lan · Nha H. Nguyen · Kyoung J. Won · Maya Capelson · Maya Capelson
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis Ameet Shetty · Scott P. Kallgren · Carina Demel · Kerstin C. Maier · Dan Spatt · Burak H. Alver · Patrick Cramer · Peter J. Park · Fred Winston · Fred Winston
Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes Nitika Taneja · Martin Zofall · Vanivilasini Balachandran · Gobi Thillainadesan · Tomoyasu Sugiyama · David Wheeler · Ming Zhou · Shiv I. S. Grewal · Shiv I. S. Grewal
Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling Cunqi Ye · Benjamin M. Sutter · Yun Wang · Zheng Kuang · Benjamin P. Tu · Benjamin P. Tu
Plasma Membrane CRPK1-Mediated Phosphorylation of 14-3-3 Proteins Induces Their Nuclear Import to Fine-Tune CBF Signaling during Cold Response Nagarjuna Reddy Pamudurti · Osnat Bartok · Marvin Jens · Christin Stottmeister · Larissa Ruhe · Mor Hanan · Emanuel Wyler · Daniel Perez-Hernandez · Evelyn Ramberger · Shlomo Shenzis · Moshe Samson · Gunnar Dittmar · Markus Landthaler · Marina Chekulaeva · Nikolaus Rajewsky · Sebastian Kadener · Sebastian Kadener
PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes Răzvan V. Chereji · Josefina Ocampo · David J. Clark · David J. Clark
When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position Katherine N. Choe · George-Lucian Moldovan · George-Lucian Moldovan
Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors Julia Kamenz · James E. Ferrell · James E. Ferrell
ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription Gunnar Dittmar · Matthias Selbach · Matthias Selbach · Matthias Selbach
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2 Xu Qian · Xinjian Li · Qingsong Cai · Chuanbao Zhang · Qiujing Yu · Yuhui Jiang · Yuhui Jiang · Jong Ho Lee · David H. Hawke · Yugang Wang · Yan Xia · Yan Xia · Yanhua Zheng · Yanhua Zheng · Bing-Hua Jiang · David X. Liu · Tao Jiang · Zhimin Lu · Zhimin Lu · Zhimin Lu
The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling Frank Bürmann · Alrun Basfeld · Roberto Vazquez Nunez · Marie-Laure Diebold-Durand · Larissa Wilhelm · Stephan Gruber · Stephan Gruber · Stephan Gruber
Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy Haley D.M. Wyatt · Rob C. Laister · Stephen R. Martin · C.H. Arrowsmith · Stephen C. West · Stephen C. West
Tuned SMC Arms Drive Chromosomal Loading of Prokaryotic Condensin Jerome Jullien · Munender Vodnala · Vincent Pasque · Mami Oikawa · Kei Miyamoto · George E. Allen · Sarah Anne David · Vincent Brochard · Stan Wang · Charles R. Bradshaw · Haruhiko Koseki · Vittorio Sartorelli · Nathalie Beaujean · John B. Gurdon · John B. Gurdon
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination Thomas P. Garner · Denis E. Reyna · Amit Priyadarshi · Hui Chen Chen · Sheng Li · Yang Wu · Yogesh Tengarai Ganesan · Vladimir N. Malashkevich · Emily H. Cheng · Evripidis Gavathiotis · Evripidis Gavathiotis
The SMX DNA Repair Tri-nuclease Agnieszka Tudek · Manfred Schmid · Torben Heick Jensen · Torben Heick Jensen
Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways Cyril Esnault · Francesco Gualdrini · Stuart Horswell · Gavin Kelly · Aengus Stewart · Phil East · Nik Matthews · Richard Treisman · Richard Treisman
Nuclear Decay Factors Crack Up mRNA Sung Hee Baek · Keun Il Kim · Keun Il Kim
Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation Zhiwei Dong · Zhiwei Dong · Santhanam Shanmughapriya · Dhanendra Tomar · Naveed Siddiqui · Solomon Lynch · Neeharika Nemani · Sarah L. Breves · Xue-Qian Zhang · Aparna Tripathi · Palaniappan Palaniappan · Massimo F. Riitano · Alison M. Worth · Ajay Seelam · Edmund Carvalho · Ramasamy Subbiah · Fabián Jaña · Jonathan Soboloff · Yizhi Peng · Joseph Y. Cheung · Suresh K. Joseph · Jeffrey L. Caplan · Sudarsan Rajan · Peter B. Stathopulos · Muniswamy Madesh · Muniswamy Madesh
Expanding the CRISPR Toolbox: Targeting RNA with Cas13b Alexander R. van Vliet · Francesca Giordano · Sarah Gerlo · Inmaculada Segura · Sofie Van Eygen · Geert Molenberghs · Susana Rocha · Audrey Houcine · Rita Derua · Tom Verfaillie · Jeroen Vangindertael · Herlinde De Keersmaecker · Etienne Waelkens · Jan Tavernier · Johan Hofkens · Wim Annaert · Peter Carmeliet · Afshin Samali · Hideaki Mizuno · Patrizia Agostinis · Patrizia Agostinis
Epigenetic Control of Autophagy: Nuclear Events Gain More Attention Célia Jeronimo · Marie-France Langelier · Alain R. Bataille · John M. Pascal · B. Franklin Pugh · François Robert · François Robert
Deciphering the Ubiquitin Code John F. Dankert · Gergely Rona · Linda Clijsters · Phillip Geter · Jeffrey R. Skaar · Keria Bermudez-Hernandez · Elizabeth Sassani · David Fenyö · Beatrix Ueberheide · Robert J. Schneider · Michele Pagano · Michele Pagano · Michele Pagano
Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity Ana Rita Araujo · Lendert Gelens · Rahuman S.M. Sheriff · Rahuman S.M. Sheriff · Silvia D.M. Santos · Silvia D.M. Santos
Autonomous Generation and Loading of DNA Guides by Bacterial Argonaute Olga Sin · Olga Sin · Tristan de Jong · Alejandro Mata-Cabana · Michelle Kudron · Mohamad A. Zaini · Francesco A. Aprile · Renée I. Seinstra · Esther Stroo · Roméo Willinge Prins · Celine N. Martineau · Hai Hui Wang · Wytse Hogewerf · Anne Steinhof · Erich E. Wanker · Michele Vendruscolo · Cornelis F. Calkhoven · Valerie Reinke · Victor Guryev · Ellen A. A. Nollen · Ellen A. A. Nollen
Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 Carlo Baejen · Jessica Andreani · Phillipp Torkler · Sofia Battaglia · Bjoern Schwalb · Michael Lidschreiber · Kerstin C. Maier · Andrea Boltendahl · Petra Rus · Stephanie Esslinger · Johannes Söding · Patrick Cramer · Patrick Cramer
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation Nathan T. Ihle · Robert T. Abraham · Robert T. Abraham
SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues Xiawei Cheng · Xiuling Ma · Xianming Ding · Lin Li · Xiao Jiang · Zhirong Shen · She Chen · Wei Liu · Weihua Gong · Qiming Sun · Qiming Sun
Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation Amit Gupta · Sara Anjomani-Virmouni · Nikos Koundouros · Nikos Koundouros · Maria Dimitriadi · Maria Dimitriadi · Rayman Choo-Wing · Adamo Valle · Adamo Valle · Yuxiang Zheng · Yu-Hsin Chiu · Sameer Agnihotri · Gelareh Zadeh · John M. Asara · John M. Asara · Dimitrios Anastasiou · Mark J. Arends · Lewis C. Cantley · George Poulogiannis · George Poulogiannis · George Poulogiannis
Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1 Mauricio H. Pontes · Jinki Yeom · Eduardo A. Groisman · Eduardo A. Groisman
Jekyll & Hyde: The Other Life of the Death Ligand TRAIL Torsten Hartwig · Antonella Montinaro · Silvia von Karstedt · Alexandra Sevko · Silvia Surinova · Ankur Chakravarthy · Lucia Taraborrelli · Peter Draber · Elodie Lafont · Frederick Arce Vargas · Mona El-Bahrawy · Sergio A. Quezada · Henning Walczak · Henning Walczak
MNase-Sensitive Complexes in Yeast: Nucleosomes and Non-histone Barriers Deqing Hu · Deqing Hu · Xin Gao · Kaixiang Cao · Marc A. Morgan · Gloria Mas · Edwin R. Smith · Andrew Volk · Elizabeth Bartom · John D. Crispino · Luciano Di Croce · Ali Shilatifard · Ali Shilatifard · Ali Shilatifard
An Interaction Landscape of Ubiquitin Signaling Ulas Tenekeci · Michael Poppe · Knut Beuerlein · Christin Buro · Helmut Müller · Hendrik Weiser · Daniela Kettner-Buhrow · Katharina Porada · Doris Newel · Ming Xu · Zhijian J. Chen · Julia Busch · M. Lienhard Schmitz · Michael Kracht · Michael Kracht
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics Joshua D. Stender · Jerome C. Nwachukwu · Irida Kastrati · Yohan Kim · Tobias Strid · Maayan Yakir · Sathish Srinivasan · Jason Nowak · Tina Izard · Erumbi S. Rangarajan · Kathryn E. Carlson · John A. Katzenellenbogen · Xin Qiu Yao · Barry J. Grant · Hon S. Leong · Chin Yo Lin · Jonna Frasor · Kendall W. Nettles · Christopher K. Glass · Christopher K. Glass
The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration Dipali G. Sashital · Dipali G. Sashital
Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork Zongyang Lv · Kimberly A. Rickman · Lingmin Yuan · Katelyn M. Williams · Shanmugam Panneer Selvam · Alec N. Woosley · Philip H. Howe · Besim Ogretmen · Agata Smogorzewska · Shaun K. Olsen · Shaun K. Olsen
The Temporal Ordering of Cell-Cycle Phosphorylation Sharmistha Kundu · Fei Ji · Hongjae Sunwoo · Gaurav Jain · Jeannie T. Lee · Ruslan I. Sadreyev · Job Dekker · Job Dekker · Robert E. Kingston · Robert E. Kingston
Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification Xiaofei Zhang · Arne H. Smits · Gabriëlle Ba van Tilburg · Gabriëlle Ba van Tilburg · Pascal W. T. C. Jansen · Matthew Makowski · Huib Ovaa · Huib Ovaa · Michiel Vermeulen · Michiel Vermeulen
Phagebook: The Social Network Mari Yamada · Yuto Watanabe · Jonathan S. Gootenberg · Hisato Hirano · F. Ann Ran · F. Ann Ran · Takanori Nakane · Ryuichiro Ishitani · Feng Zhang · Hiroshi Nishimasu · Hiroshi Nishimasu · Osamu Nureki · Osamu Nureki
S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity Harry Fischl · Françoise S. Howe · Andre Furger · Jane Mellor · Jane Mellor
Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation Juan José Bonfiglio · Pietro Fontana · Qi Zhang · Thomas Colby · Ian Gibbs-Seymour · Ilian Atanassov · Edward Bartlett · Roko Zaja · Ivan Ahel · Ivan Matic · Ivan Matic
Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate Stefan M. Bresson · Alex Tuck · Alex Tuck · Desislava Staneva · David Tollervey · David Tollervey
Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery Rong Tan · Satoshi Nakajima · Qun Wang · Hongxiang Sun · Jing Xue · Jian Wu · Sabine Hellwig · Xuemei Zeng · Nathan A. Yates · Thomas E. Smithgall · Ming Lei · Yu Jiang · Arthur S. Levine · Bing Su · Bing Su · Bing Su · Li Lan · Li Lan
Serine ADP-Ribosylation Depends on HPF1 Joung Hyuck Joo · Bo Wang · E.B. Frankel · Liang Ge · Lu Xu · Rekha Iyengar · Xiu Jie Li-Harms · Christopher Wright · Timothy I. Shaw · Tullia Lindsten · Douglas R. Green · Junmin Peng · Linda M. Hendershot · Fusun Kilic · Ji Ying Sze · Anjon Audhya · Mondira Kundu · Mondira Kundu
Nuclear RNA Decay Pathways Aid Rapid Remodeling of Gene Expression in Yeast Ziying Liu · W. Lee Kraus · W. Lee Kraus
PARP1 and Sox2: An Unlikely Team of Pioneers to Conquer the Nucleosome Conor M. Henry · Seamus J. Martin · Seamus J. Martin
Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci Rekha Rai · Chunyi Hu · Cayla Broton · Yong Chen · Ming Lei · Sandy Chang · Sandy Chang
Systematic Investigation of Transcription Factor Activity in the Context of Chromatin Using Massively Parallel Binding and Expression Assays Olga Minkina · Craig P. Hunter · Craig P. Hunter
Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatoryFADDosomeComplex upon TRAIL Stimulation Meng S. Choy · Yang Li · Luciana E. S. F. Machado · Micha Ben Achim Kunze · Christopher R. Connors · Xingyu Wei · Kresten Lindorff-Larsen · Rebecca Page · Wolfgang Peti · Wolfgang Peti
SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication Steven Boeynaems · Elke Bogaert · Denes Kovacs · Albert Konijnenberg · Evy Timmerman · Alex Volkov · Mainak Guharoy · Mathias De Decker · Tom Jaspers · Veronica H. Ryan · Abigail M. Janke · Pieter Baatsen · Thomas Vercruysse · Regina-Maria Kolaitis · Dirk Daelemans · J. Paul Taylor · Nancy Kedersha · Paul Anderson · Francis Impens · Frank Sobott · Frank Sobott · Joost Schymkowitz · Frederic Rousseau · Nicolas L. Fawzi · Wim Robberecht · Philip Van Damme · Peter Tompa · Peter Tompa · Ludo Van Den Bosch · Ludo Van Den Bosch
Stable Heritable Germline Silencing Directs Somatic Silencing at an Endogenous Locus Rodolphe Barrangou · Charles A. Gersbach · Charles A. Gersbach
NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres Najoua Lalaoui · Najoua Lalaoui · John Silke · John Silke · John Silke
Macromolecular Assemblies of the Mammalian Circadian Clock Luuk Loeff · Stan J. J. Brouns · Stan J. J. Brouns · Chirlmin Joo · Chirlmin Joo
Erratum: Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1 (Molecular Cell (2017) 66 (384–397)(S109727651730268X)(10.1016/j.molcel.2017.04.012) Ugo Dionne · François J.-M. Chartier · Yossef López de los Santos · Noémie Lavoie · David N. Bernard · Sara L. Banerjee · François Otis · Kévin Jacquet · Michel G. Tremblay · Mani Jain · Sylvie Bourassa · Gerald Gish · Jean-Philippe Gagné · Guy G. Poirier · Patrick Laprise · Normand Voyer · Christian R. Landry · Nicolas Doucet · Nicolas Bisson · Nicolas Bisson
CorrectionTPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres Jacqueline Cherfils · Jacqueline Cherfils
Structural Basis for Shelterin Bridge Assembly Annabel Quinet · Delphine Lemaçon · Alessandro Vindigni · Alessandro Vindigni
NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis Tatsuya Kibe · Michal Zimmermann · Titia de Lange · Titia de Lange
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design Barbara Fontanals-Cirera · Dan Hasson · Chiara Vardabasso · Raffaella Di Micco · Praveen Agrawal · Asif H. Chowdhury · Madeleine Gantz · Ana de Pablos-Aragoneses · Ari Morgenstern · Pamela Wu · Dan Filipescu · David Valle-Garcia · Farbod Darvishian · Jae-Seok Roe · Michael A. Davies · Christopher R. Vakoc · Eva Hernando · Emily Bernstein · Emily Bernstein
Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription Jin-Kwang Kim · Jinqiang Liu · Xichan Hu · Clinton Yu · Kyle W. Roskamp · Banumathi Sankaran · Lan Huang · Elizabeth A. Komives · Feng Qiao · Feng Qiao
The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting Hidefumi Fukushima · Kouhei Shimizu · Kouhei Shimizu · Asami Watahiki · Seira Hoshikawa · Tomoki Kosho · Daiju Oba · Seiji Sakano · Makiko Arakaki · Aya Yamada · Katsuyuki Nagashima · Koji Okabe · Satoshi Fukumoto · Eijiro Jimi · Anna Bigas · Keiichi I. Nakayama · Keiko Nakayama · Yoko Aoki · Wenyi Wei · Hiroyuki Inuzuka · Hiroyuki Inuzuka
Structure of a Thermostable Group II Intron Reverse Transcriptase with Template-Primer and Its Functional and Evolutionary Implications Jason M. Brouwer · Jason M. Brouwer · Ping Lan · Ping Lan · Angus D. Cowan · Angus D. Cowan · Jonathan P. Bernardini · Jonathan P. Bernardini · Richard W. Birkinshaw · Richard W. Birkinshaw · Mark F. van Delft · Mark F. van Delft · Brad E. Sleebs · Brad E. Sleebs · Adeline Y. Robin · Adeline Y. Robin · Ahmad Wardak · Iris K. L. Tan · Boris Reljic · Boris Reljic · Erinna F. Lee · W. Douglas Fairlie · Melissa J. Call · Melissa J. Call · Brian J. Smith · Grant Dewson · Grant Dewson · Guillaume Lessene · Guillaume Lessene · Peter M. Colman · Peter M. Colman · Peter E. Czabotar · Peter E. Czabotar · Peter E. Czabotar
Dynamics under the Telomeric Bridge M. Behfar Ardehali · Anthony Anselmo · Jesse C. Cochrane · Sharmistha Kundu · Ruslan I. Sadreyev · Robert E. Kingston · Robert E. Kingston
Protein-Based Inheritance: Epigenetics beyond the Chromosome Dongming Liang · Deirdre C. Tatomer · Zheng Luo · Huang Wu · Li Yang · Li Yang · Ling-Ling Chen · Ling-Ling Chen · Sara Cherry · Jeremy E. Wilusz · Jeremy E. Wilusz
Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway Jennifer L. Stamos · Alfred M. Lentzsch · Alan M. Lambowitz · Alan M. Lambowitz
CorrectionNoncanonical Mismatch Repair as a Source of Genomic Instability in Human Cells Sabrina Pisano · Eric Gilson · Eric Gilson · Marie-Josèphe Giraud-Panis · Marie-Josèphe Giraud-Panis
VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling Zachary H. Harvey · Yiwen Chen · Daniel F. Jarosz · Daniel F. Jarosz
Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH François Le Guerroué · François Le Guerroué · Franziska Eck · Jennifer Jung · Tatjana Starzetz · Michel Mittelbronn · Manuel Kaulich · Christian Behrends · Christian Behrends · Christian Behrends
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria Javier Peña-Diaz · Stephanie Bregenhorn · Medini Ghodgaonkar · Cindy Follonier · Mariela Artola-Borán · Dennis Castor · Massimo Lopes · Alessandro A. Sartori · Josef Jiricny · Josef Jiricny
Mitochondrial Sterol Oxidation Marks the Spot Johannes van den Boom · Hemmo Meyer · Hemmo Meyer
Determinants of Histone H3K4 Methylation Patterns Abdelghani Mazouzi · Federica Battistini · Sarah C. Moser · Joana Ferreira da Silva · Marc Wiedner · Michel Owusu · Charles-Hugues Lardeau · Anna Ringler · Beatrix Weil · Jürgen Neesen · Modesto Orozco · Stefan Kubicek · Joanna I. Loizou · Joanna I. Loizou
Cell Cycle Control by Nuclear Sequestration of CDC20 and CDH1 mRNA in Plant Stem Cells Jason R. Nielson · Eric K. Fredrickson · T. Cameron Waller · Olga Zurita Rendón · Heidi L. Schubert · Zhenjian Lin · Christopher P. Hill · Jared Rutter · Jared Rutter
The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules Lilian Lamech · Cole M. Haynes · Cole M. Haynes
Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics Luis M. Soares · P. Cody He · Yujin Chun · Hyunsuk Suh · Tae Soo Kim · Stephen Buratowski · Stephen Buratowski
An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint Weibing Yang · Raymond Wightman · Elliot M. Meyerowitz · Elliot M. Meyerowitz · Elliot M. Meyerowitz
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex Camilla Frattini · Camilla Frattini · Sara Villa-Hernández · Sara Villa-Hernández · Grazia Pellicanò · Rachel Jossen · Yuki Katou · Katsuhiko Shirahige · Rodrigo Bermejo · Rodrigo Bermejo · Rodrigo Bermejo
Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress Junbin Qian · Maria Adelaida Garcia-Gimeno · Monique Beullens · Maria Giulia Manzione · Gerd Van der Hoeven · Juan Carlos Igual · Miguel López de Heredia · Pascual Sanz · Lendert Gelens · Mathieu Bollen · Mathieu Bollen
A Seed Mismatch Enhances Argonaute2-Catalyzed Cleavage and Partially Rescues Severely Impaired Cleavage Found in Fish Chul-Hwan Lee · Chul-Hwan Lee · Marlene Holder · Daniel Grau · Ricardo Saldaña-Meyer · Ricardo Saldaña-Meyer · Jia-Ray Yu · Jia-Ray Yu · Rais Ahmad Ganai · Rais Ahmad Ganai · Jenny Zhang · Miao Wang · Gary LeRoy · Gary LeRoy · Marc-Werner Dobenecker · Danny Reinberg · Danny Reinberg · Karim-Jean Armache · Karim-Jean Armache
Smc3 Deacetylation by Hos1 Facilitates Efficient Dissolution of Sister Chromatid Cohesion during Early Anaphase Ming-Yuan Su · Kyle L. Morris · Do Jin Kim · Yangxue Fu · Rosalie Lawrence · Goran Stjepanovic · Goran Stjepanovic · Roberto Zoncu · Roberto Zoncu · James H. Hurley · James H. Hurley · James H. Hurley
The Unfolded Protein Response and Cell Fate Control Grace Chen · Grace Chen · Hazel Sive · David P. Bartel · David P. Bartel · David P. Bartel
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling Shuyu Li · Zuojun Yue · Tomoyuki U. Tanaka · Tomoyuki U. Tanaka
The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells Chul Hwan Lee · Chul Hwan Lee · Jia Ray Yu · Jia Ray Yu · Sunil Kumar · Ying Jin · Gary LeRoy · Gary LeRoy · Natarajan V. Bhanu · Syuzo Kaneko · Syuzo Kaneko · Benjamin A. Garcia · Andrew D. Hamilton · Danny Reinberg · Danny Reinberg · Danny Reinberg
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance Claudio Hetz · Feroz R. Papa · Feroz R. Papa
Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene Richard D. Cummings · Richard D. Cummings
Replication Fork Reversal: Players and Guardians Michal Rabani · Lindsey Pieper · Guo-Liang Chew · Alexander F. Schier · Alexander F. Schier
Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing Ivana Horvathova · Ivana Horvathova · Franka Voigt · Anna V. Kotrys · Yinxiu Zhan · Yinxiu Zhan · Caroline G Artus-Revel · Jan Eglinger · Michael B. Stadler · Michael B. Stadler · Luca Giorgetti · Jeffrey A. Chao · Jeffrey A. Chao
The Haystack Is Full of Needles: Technology Rescues Sugars! Laura C. Lehmann · Graeme Hewitt · Shintaro Aibara · Alexander Leitner · Emil Marklund · Sarah L. Maslen · Varun Maturi · Yang Chen · David van der Spoel · J. Mark Skehel · Aristidis Moustakas · Simon J. Boulton · Sebastian Deindl · Sebastian Deindl
Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair Dönem Avci · Marius K. Lemberg · Marius K. Lemberg
New Insights into Genome Structure: Genes of a Feather Stick Together Jens Hör · Stanislaw A. Gorski · Jörg Vogel · Jörg Vogel
The Plasticity of the Hsp90 Co-chaperone System Veronica H. Ryan · Gregory L. Dignon · Gül H. Zerze · Charlene V. Chabata · Rute Silva · Alexander E. Conicella · Joshua Amaya · Kathleen A. Burke · Jeetain Mittal · Nicolas L. Fawzi · Nicolas L. Fawzi
Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes Christina L. Rosenberger · Jie Chen · Jie Chen
Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones Jian-Feng Xiang · Jian-Feng Xiang · Qin Yang · Chu-Xiao Liu · Man Wu · Man Wu · Ling-Ling Chen · Ling-Ling Chen · Li Yang · Li Yang · Li Yang
Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins Thomas Kruse · Nadine Biedenkopf · Emil Peter Thrane Hertz · Erik Dietzel · Gertrud Stalmann · Blanca López-Méndez · Norman E. Davey · Jakob Nilsson · Stephan Becker · Stephan Becker
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection Justin S. Becker · Ryan L. McCarthy · Simone Sidoli · Greg Donahue · Kelsey E. Kaeding · Zhiying He · Shu Lin · Benjamin A. Garcia · Kenneth S. Zaret · Kenneth S. Zaret
Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock Roman Kityk · Jürgen Kopp · Matthias P. Mayer · Matthias P. Mayer
CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons Jay C. Dunlap · Jennifer J. Loros · Jennifer J. Loros
The ATPase Fap7 Tests the Ability to Carry Out Translocation-like Conformational Changes and Releases Dim1 during 40S Ribosome Maturation Thomas Vierbuchen · Emi Ling · Christopher J. Cowley · Cameron H. Couch · Xiaofeng Wang · David A. Harmin · Charles W. M. Roberts · Michael E. Greenberg · Michael E. Greenberg
A Droplet to Sense Sugar Drops Homa Ghalei · Juliette Trepreau · Jason C. Collins · Hari Bhaskaran · Bethany S. Strunk · Katrin Karbstein · Katrin Karbstein
On the Race to Starvation: How Do Bacteria Survive High Doses of Antibiotics? Yves Barral · Fabrice Caudron · Fabrice Caudron
AID and Reactive Oxygen Species Can Induce DNA Breaks within Human Chromosomal Translocation Fragile Zones Molly C. Kottemann · Brooke A. Conti · Francis P. Lach · Agata Smogorzewska · Agata Smogorzewska
Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq Yong Zhu · Xiuye Wang · Elmira Forouzmand · Joshua Jeong · Feng Qiao · Gregory A. Sowd · Alan Engelman · Xiaohui Xie · Klemens J. Hertel · Yongsheng Shi · Yongsheng Shi
The Std1 Activator of the Snf1/AMPK Kinase Controls Glucose Response in Yeast by a Regulated Protein Aggregation Yusuf Talha Tamer · Erdal Toprak · Erdal Toprak
A Unique ISR Program Determines Cellular Responses to Chronic Stress Nicholas R. Pannunzio · Michael R. Lieber · Michael R. Lieber
hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing Bo Jhih Guan · Vincent van Hoef · Raul Jobava · Orna Elroy-Stein · Leoš Shivaya Valášek · Marie Cargnello · Xing Huang Gao · Dawid Krokowski · William C. Merrick · Scot R. Kimball · Anton A. Komar · Antonis E. Koromilas · Anthony Wynshaw-Boris · Ivan Topisirovic · Ola Larsson · Maria Hatzoglou · Maria Hatzoglou
Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding Lingtao Jin · Jaemoo Chun · Chaoyun Pan · Avi Kumar · Guojing Zhang · Youna Ha · Dan Li · Gina N. Alesi · Yibin Kang · Lu Zhou · Wen Mei Yu · Kelly R. Magliocca · Fadlo R. Khuri · Cheng Kui Qu · Christian M. Metallo · Taofeek K. Owonikoko · Sumin Kang · Sumin Kang
Transcription and Remodeling Produce Asymmetrically Unwrapped Nucleosomal Intermediates Jeongkyu Kim · David Sturgill · Robin Sebastian · Simran Khurana · Andy D. Tran · Garrett B. Edwards · Alex Kruswick · Sandra Burkett · Eri K. Hosogane · William W. Hannon · Urbain Weyemi · William M. Bonner · Karolin Luger · Philipp Oberdoerffer · Philipp Oberdoerffer
Loud and Clear Epitranscriptomic m1A Signals: Now in Single-Base Resolution Peng Liao · Shelya X. Zeng · Xiang Zhou · Tianjian Chen · Fen Zhou · Bo Cao · Ji Hoon Jung · Giannino Del Sal · Shiwen Luo · Hua Lu · Hua Lu
A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene Kami Ahmad · Steven Henikoff · Steven Henikoff · Steven Henikoff
Understanding and Sensitizing Density-Dependent Persistence to Quinolone Antibiotics Jenny L. Weon · Seung Wook Yang · Patrick Ryan Potts · Patrick Ryan Potts
MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD Dan Dominissini · Dan Dominissini · Gideon Rechavi · Gideon Rechavi · Gideon Rechavi
SnapShot: Lysine Methylation beyond Histones Hari R. Singh · Aurelio P. Nardozza · Ingvar Rúnar Möller · Gunnar Knobloch · Hans A. V. Kistemaker · Markus Hassler · Markus Hassler · Nadine Harrer · Charlotte Blessing · Sebastian Eustermann · Christiane Kotthoff · Sébastien Huet · Sébastien Huet · Felix Mueller-Planitz · Dmitri V. Filippov · Gyula Timinszky · Kasper D. Rand · Andreas G. Ladurner · Andreas G. Ladurner · Andreas G. Ladurner
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1 Arnaud Gutierrez · Arnaud Gutierrez · Saloni R. Jain · Saloni R. Jain · Saloni R. Jain · Prerna Bhargava · Prerna Bhargava · Meagan Hamblin · Michael A. Lobritz · James J. Collins · James J. Collins
A Massively Parallel Reporter Assay of 3′ UTR Sequences Identifies In Vivo Rules for mRNA Degradation Nathan Yurko · Xiaochuan Liu · Takashi Yamazaki · Mainul Hoque · Bin Tian · James L. Manley · James L. Manley
Encoding Allostery in mTOR Signaling: The Structure of the Rag GTPase/Ragulator Complex Kyle K. Biggar · Kyle K. Biggar · Zhentian Wang · Shawn S.-C. Li · Shawn S.-C. Li
R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters Peng Tan · Peng Tan · Lian He · Jun Cui · Chen Qian · Xin Cao · Meng Lin · Qingyuan Zhu · Yinyin Li · Yinyin Li · Changsheng Xing · Xiao Yu · Helen Y. Wang · Rong Fu Wang · Rong Fu Wang · Rong Fu Wang · Rong Fu Wang
Trick or TREAT: A Scary-Good New Approach for Single-Molecule mRNA Decay Analysis Satoshi Ishiyama · Atsuya Nishiyama · Atsuya Nishiyama · Yasushi Saeki · Kei Moritsugu · Daichi Morimoto · Luna Yamaguchi · Naoko Arai · Rumie Matsumura · Toru Kawakami · Yuichi Mishima · Hironobu Hojo · Shintaro Shimamura · Fuyuki Ishikawa · Shoji Tajima · Keiji Tanaka · Mariko Ariyoshi · Masahiro Shirakawa · Mitsunori Ikeguchi · Akinori Kidera · Isao Suetake · Kyohei Arita · Kyohei Arita · Makoto Nakanishi · Makoto Nakanishi · Makoto Nakanishi
Transcription of Nearly All Yeast RNA Polymerase II-Transcribed Genes Is Dependent on Transcription Factor TFIID Jonathan Jagodnik · Claude Chiaruttini · Maude Guillier · Maude Guillier
Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts John D. Hayes · Albena T. Dinkova-Kostova · Albena T. Dinkova-Kostova
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes Daniel Dominguez · Peter Freese · Maria S. Alexis · Amanda Su · Myles Hochman · Tsultrim Palden · Cassandra Bazile · Nicole J. Lambert · Eric L. Van Nostrand · Gabriel A. Pratt · Gene W. Yeo · Brenton R. Graveley · Christopher B. Burge · Christopher B. Burge
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit Haiyun Gan · Chuanhe Yu · Sujan Devbhandari · Sujan Devbhandari · Sushma Sharma · Junhong Han · Andrei Chabes · Dirk Remus · Zhiguo Zhang · Zhiguo Zhang
NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression Dmytro Ustianenko · Hua-Sheng Chiu · Thomas Treiber · Sebastien M. Weyn-Vanhentenryck · Nora Treiber · Gunter Meister · Pavel Sumazin · Chaolin Zhang · Chaolin Zhang
Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells Gaelen T. Hess · Josh Tycko · David Yao · Michael C. Bassik · Michael C. Bassik
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome Karthik Murugan · Kesavan Babu · Ramya Sundaresan · Rakhi Rajan · Dipali G. Sashital · Dipali G. Sashital
The Continuing SAGA of TFIID and RNA Polymerase II Transcription Delin Chen · Omid Tavana · Bo Chu · Luke Erber · Yue Chen · Richard Baer · Wei Gu · Wei Gu
A Peptide encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth Kai Liu · Kai Liu · Jiyoung Lee · Ja Yeon Kim · Linya Wang · Yongjun Tian · Stephanie T. Chan · Cecilia Cho · Keigo Machida · Dexi Chen · Jing-hsiung James Ou · Jing-hsiung James Ou
Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response Antonino Montalbano · Matthew C. Canver · Neville E. Sanjana · Neville E. Sanjana
Untangling P-Bodies: Dissecting the Complex Web of Interactions that Enable Tiered Control of Gene Expression Dylan J. Taatjes · Dylan J. Taatjes
CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis Jin-Zhou Huang · Jin-Zhou Huang · Min Chen · De Chen · Xing-Cheng Gao · Song Zhu · Hongyang Huang · Min Hu · Huifang Zhu · Guang-Rong Yan · Guang-Rong Yan
The Anti-CRISPR Story: A Battle for Survival Joshua R. Porter · Brian E. Fisher · Laura Baranello · Julia C. Liu · Diane M. Kambach · Zuqin Nie · Woo Seuk Koh · Ji Luo · Jayne M. Stommel · David Levens · Eric Batchelor · Eric Batchelor
Picky Hsp90—Every Game with Another Mate Christopher J. Kershaw · Mark P. Ashe · Mark P. Ashe

Phosphorylation of Histone H4T80 Triggers DNA Damage Checkpoint Recovery
Molecular Cell | 2018
Yahli Lorch · Barbara Maier-Davis · Roger D. Kornberg · Roger D. Kornberg
FUS Regulates Activity of MicroRNA-Mediated Gene Silencing
Molecular Cell | 2018
Silvia Escudero · Elma Zaganjor · Susan Lee · Christopher P. Mill · Ann M. Morgan · Emily B. Crawford · Jiahao Chen · Thomas E. Wales · Rida Mourtada · James Luccarelli · Gregory H. Bird · Ulrich Steidl · John R. Engen · Marcia C. Haigis · Joseph T. Opferman · Loren D. Walensky · Loren D. Walensky
Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding
Molecular Cell | 2018
Bomyi Lim · Tyler Heist · Michael S. Levine · Takashi Fukaya · Takashi Fukaya
The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel
Molecular Cell | 2018
Yusuke Tarumoto · Bin Lu · Tim D.D. Somerville · Yu-Han Huang · Joseph P. Milazzo · Xiaoli S. Wu · Xiaoli S. Wu · Olaf Klingbeil · Osama El Demerdash · Junwei Shi · Christopher R. Vakoc · Christopher R. Vakoc